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Items: 1 to 50 of 116

1.

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.

Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ.

Sci Transl Med. 2018 Apr 18;10(437). pii: eaar6759. doi: 10.1126/scitranslmed.aar6759.

PMID:
29669853
2.

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg J, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb M, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.

PLoS Pathog. 2018 Apr 13;14(4):e1006973. doi: 10.1371/journal.ppat.1006973. [Epub ahead of print]

3.

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes.

Wendel BS, Del Alcazar D, He C, Del Río-Estrada PM, Aiamkitsumrit B, Ablanedo-Terrazas Y, Hernandez SM, Ma KY, Betts MR, Pulido L, Huang J, Gimotty PA, Reyes-Terán G, Jiang N, Su LF.

Sci Immunol. 2018 Apr 6;3(22). pii: eaan8884. doi: 10.1126/sciimmunol.aan8884.

PMID:
29626170
4.

Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.

Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR, Prlic M.

JCI Insight. 2018 Apr 5;3(7). pii: 98487. doi: 10.1172/jci.insight.98487. [Epub ahead of print]

5.

Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.

Noyan K, Nguyen S, Betts MR, Sönnerborg A, Buggert M.

Front Immunol. 2018 Jan 22;9:19. doi: 10.3389/fimmu.2018.00019. eCollection 2018.

6.

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

Reuter MA, Del Rio Estrada PM, Buggert M, Petrovas C, Ferrando-Martinez S, Nguyen S, Sada Japp A, Ablanedo-Terrazas Y, Rivero-Arrieta A, Kuri-Cervantes L, Gunzelman HM, Gostick E, Price DA, Koup RA, Naji A, Canaday DH, Reyes-Terán G, Betts MR.

Cell Rep. 2017 Dec 19;21(12):3458-3470. doi: 10.1016/j.celrep.2017.11.075.

7.

T-bet-expressing B cells during HIV and HCV infections.

Knox JJ, Kaplan DE, Betts MR.

Cell Immunol. 2017 Nov;321:26-34. doi: 10.1016/j.cellimm.2017.04.012. Epub 2017 Jul 11. Review.

PMID:
28739077
8.

T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response.

Knox JJ, Buggert M, Kardava L, Seaton KE, Eller MA, Canaday DH, Robb ML, Ostrowski MA, Deeks SG, Slifka MK, Tomaras GD, Moir S, Moody MA, Betts MR.

JCI Insight. 2017 Apr 20;2(8). pii: 92943. doi: 10.1172/jci.insight.92943. [Epub ahead of print]

9.

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.

Calcedo R, Somanathan S, Qin Q, Betts MR, Rech AJ, Vonderheide RH, Mueller C, Flotte TR, Wilson JM.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1655-1659. doi: 10.1073/pnas.1617726114. Epub 2017 Jan 30.

10.

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.

11.

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, Betts MR, Buggert M, Karlsson AC.

Sci Rep. 2017 Jan 13;7:40354. doi: 10.1038/srep40354.

12.

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.

Roberts ER, Carnathan DG, Li H, Shaw GM, Silvestri G, Betts MR.

PLoS Pathog. 2016 Dec 30;12(12):e1006135. doi: 10.1371/journal.ppat.1006135. eCollection 2016 Dec.

13.

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection.

Buggert M, Frederiksen J, Lund O, Betts MR, Biague A, Nielsen M, Tauriainen J, Norrgren H, Medstrand P, Karlsson AC, Jansson M; SWEGUB CORE group.

AIDS. 2016 Oct 23;30(16):2415-2426.

14.

Corrigendum: Characterization of T-bet and Eomes in Peripheral Human Immune Cells.

Knox JJ, Cosma GL, Betts MR, McLane LM.

Front Immunol. 2016 Sep 8;7:337. doi: 10.3389/fimmu.2016.00337. eCollection 2016.

15.

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

Demers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, Li CK, Eller LA, Rono K, Maganga L, Nitayaphan S, Kibuuka H, Routy JP, Slifka MK, Haynes BF, McMichael AJ, Bernard NF, Robb ML, Betts MR.

PLoS Pathog. 2016 Aug 3;12(8):e1005805. doi: 10.1371/journal.ppat.1005805. eCollection 2016 Aug.

16.

Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders.

Yadav A, Betts MR, Collman RG.

J Neurovirol. 2016 Oct;22(5):584-596. Epub 2016 Mar 28.

17.

Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.

Swanstrom AE, Haggarty B, Jordan APO, Romano J, Leslie GJ, Aye PP, Marx PA, Lackner AA, Del Prete GQ, Robinson JE, Betts MR, Montefiori DC, LaBranche CC, Hoxie JA.

J Virol. 2016 Apr 29;90(10):4966-4980. doi: 10.1128/JVI.02851-15. Print 2016 May 15.

18.

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.

Eller MA, Goonetilleke N, Tassaneetrithep B, Eller LA, Costanzo MC, Johnson S, Betts MR, Krebs SJ, Slike BM, Nitayaphan S, Rono K, Tovanabutra S, Maganga L, Kibuuka H, Jagodzinski L, Peel S, Rolland M, Marovich MA, Kim JH, Michael NL, Robb ML, Streeck H.

J Virol. 2016 Mar 28;90(8):4005-4016. doi: 10.1128/JVI.02785-15. Print 2016 Apr.

19.

CD4 T-cell cytokine correlates of diagnostic tests for latent tuberculous infection in HIV-1-infected subjects.

Van Epps P, Sridaran S, Aung H, Wilson BM, Burant CJ, Nserko M, Mayanja-Kizza H, Betts MR, Toossi Z, Canaday DH.

Int J Tuberc Lung Dis. 2015 Aug;19(8):927-35. doi: 10.5588/ijtld.14.0896.

PMID:
26162359
20.

CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection.

Canaday DH, Sridaran S, Van Epps P, Aung H, Burant CJ, Nsereko M, Mayanja-Kizza H, Betts MR, Toossi Z.

Tuberculosis (Edinb). 2015 Jul;95(4):470-5. doi: 10.1016/j.tube.2014.12.008. Epub 2015 Jan 7.

21.

Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.

Kutzler MA, Wise MC, Hutnick NA, Moldoveanu Z, Hunter M, Reuter M, Yuan S, Yan J, Ginsberg A, Sylvester A, Pahar B, Carnathan D, Kathuria N, Khan AS, Montefiori D, Sardesai NY, Betts MR, Mestecky J, Marx P, Weiner DB.

Mucosal Immunol. 2016 Jan;9(1):13-23. doi: 10.1038/mi.2015.31. Epub 2015 May 6.

22.

Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.

Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR.

J Infect Dis. 2015 Nov 1;212(9):1376-86. doi: 10.1093/infdis/jiv226. Epub 2015 Apr 15.

23.

Age-related differences in polyfunctional T cell responses.

Van Epps P, Banks R, Aung H, Betts MR, Canaday DH.

Immun Ageing. 2014 Oct 23;11:14. doi: 10.1186/1742-4933-11-14. eCollection 2014.

24.

Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.

Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ.

J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29.

25.

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson MA, Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg A, Koup RA, Betts MR, Karlsson AC.

PLoS Pathog. 2014 Jul 17;10(7):e1004251. doi: 10.1371/journal.ppat.1004251. eCollection 2014 Jul.

26.

Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.

Christian DA, Koshy AA, Reuter MA, Betts MR, Boothroyd JC, Hunter CA.

Infect Immun. 2014 Oct;82(10):4056-67. doi: 10.1128/IAI.01643-14. Epub 2014 Jul 14.

27.

Characterization of T-bet and eomes in peripheral human immune cells.

Knox JJ, Cosma GL, Betts MR, McLane LM.

Front Immunol. 2014 May 14;5:217. doi: 10.3389/fimmu.2014.00217. eCollection 2014. Erratum in: Front Immunol. 2016;7:337.

28.

Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector.

Bukh I, Calcedo R, Roy S, Carnathan DG, Grant R, Qin Q, Boyd S, Ratcliffe SJ, Veeder CL, Bellamy SL, Betts MR, Wilson JM.

J Virol. 2014 Aug;88(15):8468-78. doi: 10.1128/JVI.03850-13. Epub 2014 May 14.

29.

Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.

Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, Koshy AA, Wagage S, Reuter MA, Sibley LD, Betts MR, Hunter CA.

PLoS Pathog. 2014 Apr 10;10(4):e1004047. doi: 10.1371/journal.ppat.1004047. eCollection 2014 Apr.

30.

Commentary on Shapiro: clinical development of candidate HIV vaccines: different problems for different vaccines.

Hope TJ, Betts MR.

AIDS Res Hum Retroviruses. 2014 Apr;30(4):330. doi: 10.1089/AID.2014.0047. No abstract available.

31.

Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

Manuel SL, Sehgal M, Connolly J, Makedonas G, Khan ZK, Gardner J, Betts MR, Jain P.

J Clin Immunol. 2013 Oct;33(7):1223-39. doi: 10.1007/s10875-013-9918-x. Epub 2013 Jul 26.

32.

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis.

Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P.

PLoS Pathog. 2013;9(7):e1003504. doi: 10.1371/journal.ppat.1003504. Epub 2013 Jul 18.

33.

CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis.

Demers KR, Reuter MA, Betts MR.

Immunol Rev. 2013 Jul;254(1):190-206. doi: 10.1111/imr.12069. Review.

34.

An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1.

Manuel SL, Sehgal M, Khan ZK, Goedert JJ, Betts MR, Jain P.

AIDS Res Hum Retroviruses. 2013 Sep;29(9):1273-85. doi: 10.1089/AID.2013.0054. Epub 2013 Jul 19.

35.

CD40L expression permits CD8+ T cells to execute immunologic helper functions.

Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, Jürchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A.

Blood. 2013 Jul 18;122(3):405-12. doi: 10.1182/blood-2013-02-483586. Epub 2013 May 29.

36.

Differential localization of T-bet and Eomes in CD8 T cell memory populations.

McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR.

J Immunol. 2013 Apr 1;190(7):3207-15. doi: 10.4049/jimmunol.1201556. Epub 2013 Mar 1.

37.

The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.

Lelic A, Verschoor CP, Ventresca M, Parsons R, Evelegh C, Bowdish D, Betts MR, Loeb MB, Bramson JL.

PLoS Pathog. 2012;8(12):e1003076. doi: 10.1371/journal.ppat.1003076. Epub 2012 Dec 13.

38.

DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells.

Reuter MA, Yuan S, Marx PA, Kutzler MA, Weiner DB, Betts MR.

Hum Vaccin Immunother. 2012 Nov 1;8(11):1648-53. doi: 10.4161/hv.22247. Epub 2012 Oct 30.

39.

Cytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccines.

Reuter MA, Pombo C, Betts MR.

Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):181-91. doi: 10.1016/j.cytogfr.2012.05.005. Epub 2012 Jun 27. Review.

40.

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, Coleman C, Vermeulen M, Ding H, Ochsenbauer C, Tilton JC, Permar SR, Kappes JC, Betts MR, Busch MP, Gao F, Montefiori D, Haynes BF, Shaw GM, Hahn BH, Doms RW.

PLoS Pathog. 2012;8(5):e1002686. doi: 10.1371/journal.ppat.1002686. Epub 2012 May 31.

41.

Brilliant violet fluorophores: a new class of ultrabright fluorescent compounds for immunofluorescence experiments.

Chattopadhyay PK, Gaylord B, Palmer A, Jiang N, Raven MA, Lewis G, Reuter MA, Nur-ur Rahman AK, Price DA, Betts MR, Roederer M.

Cytometry A. 2012 Jun;81(6):456-66. doi: 10.1002/cyto.a.22043. Epub 2012 Apr 6.

42.

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection.

Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, Whale VE, Goonetilleke N, Borrow P, Ferrari G, Betts MR, Haynes BF, McMichael AJ, Gray CM.

J Immunol. 2012 Mar 1;188(5):2198-206. doi: 10.4049/jimmunol.1102813. Epub 2012 Jan 27.

43.

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.

van Montfrans JM, Hoepelman AI, Otto S, van Gijn M, van de Corput L, de Weger RA, Monaco-Shawver L, Banerjee PP, Sanders EA, Jol-van der Zijde CM, Betts MR, Orange JS, Bloem AC, Tesselaar K.

J Allergy Clin Immunol. 2012 Mar;129(3):787-793.e6. doi: 10.1016/j.jaci.2011.11.013. Epub 2011 Dec 24.

44.

Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.

Vanderford TH, Bleckwehl C, Engram JC, Dunham RM, Klatt NR, Feinberg MB, Garber DA, Betts MR, Silvestri G.

PLoS Pathog. 2011 May;7(5):e1002048. doi: 10.1371/journal.ppat.1002048. Epub 2011 May 19.

45.

Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression.

Haney D, Quigley MF, Asher TE, Ambrozak DR, Gostick E, Price DA, Douek DC, Betts MR.

J Immunol Methods. 2011 Jun 30;369(1-2):33-41. doi: 10.1016/j.jim.2011.04.003. Epub 2011 Apr 8.

46.

Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB.

El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH.

Tuberculosis (Edinb). 2011 May;91(3):224-30. doi: 10.1016/j.tube.2010.12.005. Epub 2011 Apr 2.

47.

Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.

Hersperger AR, Migueles SA, Betts MR, Connors M.

Curr Opin HIV AIDS. 2011 May;6(3):169-73. doi: 10.1097/COH.0b013e3283454c39. Review.

48.

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

Ferrari G, Korber B, Goonetilleke N, Liu MK, Turnbull EL, Salazar-Gonzalez JF, Hawkins N, Self S, Watson S, Betts MR, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras GD, Haynes BF, Gray CM, Borrow P, Roederer M, McMichael AJ, Weinhold KJ.

PLoS Pathog. 2011 Feb 10;7(2):e1001273. doi: 10.1371/journal.ppat.1001273.

49.

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.

Hersperger AR, Martin JN, Shin LY, Sheth PM, Kovacs CM, Cosma GL, Makedonas G, Pereyra F, Walker BD, Kaul R, Deeks SG, Betts MR.

Blood. 2011 Apr 7;117(14):3799-808. doi: 10.1182/blood-2010-12-322727. Epub 2011 Feb 2.

50.

Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality.

Hutnick NA, Carnathan DG, Dubey SA, Cox KS, Kierstead L, Makadonas G, Ratcliffe SJ, Lasaro MO, Robertson MN, Casimiro DR, Ertl HC, Betts MR.

PLoS One. 2010 Dec 22;5(12):e14385. doi: 10.1371/journal.pone.0014385.

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