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Items: 1 to 50 of 91

1.

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

Berndt N, Horger MS, Bulik S, Holzhütter HG.

PLoS Comput Biol. 2018 Feb 15;14(2):e1006005. doi: 10.1371/journal.pcbi.1006005. [Epub ahead of print]

2.

The importance of membrane microdomains for bile salt-dependent biliary lipid secretion.

Eckstein J, Holzhütter HG, Berndt N.

J Cell Sci. 2018 Feb 2. pii: jcs.211524. doi: 10.1242/jcs.211524. [Epub ahead of print]

3.

SMARCAD1 haploinsufficiency underlies Huriez Syndrome and associated skin cancer susceptibility.

Günther C, Lee-Kirsch MA, Eckhard J, Matanovic A, Kerscher T, Rüschendorf F, Klein B, Berndt N, Zimmermann N, Flachmeier C, Thuß T, Lucas N, Marenholz I, Esparza-Gordillo J, Hübner N, Traupe H, Delaporte E, Lee YA.

J Invest Dermatol. 2018 Jan 31. pii: S0022-202X(18)30035-6. doi: 10.1016/j.jid.2018.01.015. [Epub ahead of print] No abstract available.

PMID:
29409814
4.

Development of novel target modules for retargeting of UniCAR T cells to GD2 positive tumor cells.

Mitwasi N, Feldmann A, Bergmann R, Berndt N, Arndt C, Koristka S, Kegler A, Jureczek J, Hoffmann A, Ehninger A, Cartellieri M, Albert S, Rossig C, Ehninger G, Pietzsch J, Steinbach J, Bachmann M.

Oncotarget. 2017 Sep 18;8(65):108584-108603. doi: 10.18632/oncotarget.21017. eCollection 2017 Dec 12.

5.

Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.

Oncotarget. 2017 Nov 11;8(62):105882-105904. doi: 10.18632/oncotarget.22413. eCollection 2017 Dec 1.

6.

EVALUATION OF THE HTA CORE MODEL FOR NATIONAL HEALTH TECHNOLOGY ASSESSMENT REPORTS: COMPARATIVE STUDY AND EXPERIENCES FROM EUROPEAN COUNTRIES.

Kõrge K, Berndt N, Hohmann J, Romano F, Hiligsmann M.

Int J Technol Assess Health Care. 2017 Jan;33(6):644-653. doi: 10.1017/S026646231700099X. Epub 2017 Nov 21.

PMID:
29157316
7.

Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O.

J Cereb Blood Flow Metab. 2017 Jan 1:271678X17740091. doi: 10.1177/0271678X17740091. [Epub ahead of print]

PMID:
29099662
8.

Ubiquitylation-independent activation of Notch signalling by Delta.

Berndt N, Seib E, Kim S, Troost T, Lyga M, Langenbach J, Haensch S, Kalodimou K, Delidakis C, Klein T.

Elife. 2017 Sep 29;6. pii: e27346. doi: 10.7554/eLife.27346.

9.

Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.

Schoknecht K, Berndt N, Rösner J, Heinemann U, Dreier JP, Kovács R, Friedman A, Liotta A.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1925. doi: 10.3390/ijms18091925.

10.

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.

Zhu JY, Cuellar RA, Berndt N, Lee HE, Olesen SH, Martin MP, Jensen JT, Georg GI, Schönbrunn E.

J Med Chem. 2017 Sep 28;60(18):7863-7875. doi: 10.1021/acs.jmedchem.7b00996. Epub 2017 Sep 14.

PMID:
28792760
11.

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis.

Wallstab C, Eleftheriadou D, Schulz T, Damm G, Seehofer D, Borlak J, Holzhütter HG, Berndt N.

FEBS J. 2017 Oct;284(19):3245-3261. doi: 10.1111/febs.14189. Epub 2017 Sep 6.

PMID:
28763157
12.

Advances of small molecule targeting of kinases.

Berndt N, Karim RM, Schönbrunn E.

Curr Opin Chem Biol. 2017 Aug;39:126-132. doi: 10.1016/j.cbpa.2017.06.015. Epub 2017 Jul 18. Review.

PMID:
28732278
13.

Feasibility and acceptability of a telephone- and face-to-face-delivered counseling intervention for smoking cessation in Dutch patients with coronary heart disease.

Berndt N, Lechner L, Mudde A, De Vries H, Bolman C.

Res Nurs Health. 2017 Oct;40(5):444-458. doi: 10.1002/nur.21810. Epub 2017 Jul 17.

PMID:
28715122
14.

Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jul 27;60(14):6458. doi: 10.1021/acs.jmedchem.7b00943. Epub 2017 Jul 11. No abstract available.

PMID:
28696689
15.

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.

Wright G, Golubeva V, Remsing Rix LL, Berndt N, Luo Y, Ward GA, Gray JE, Schonbrunn E, Lawrence HR, Monteiro ANA, Rix U.

ACS Chem Biol. 2017 Jul 21;12(7):1883-1892. doi: 10.1021/acschembio.7b00147. Epub 2017 Jun 7.

PMID:
28557434
16.

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jun 22;60(12):4805-4817. doi: 10.1021/acs.jmedchem.6b01336. Epub 2017 Jun 7.

17.

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.

Ember SW, Lambert QT, Berndt N, Gunawan S, Ayaz M, Tauro M, Zhu JY, Cranfill PJ, Greninger P, Lynch CC, Benes CH, Lawrence HR, Reuther GW, Lawrence NJ, Schönbrunn E.

Mol Cancer Ther. 2017 Jun;16(6):1054-1067. doi: 10.1158/1535-7163.MCT-16-0568-T. Epub 2017 Mar 23.

18.

Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy.

Aliperta R, Welzel PB, Bergmann R, Freudenberg U, Berndt N, Feldmann A, Arndt C, Koristka S, Stanzione M, Cartellieri M, Ehninger A, Ehninger G, Werner C, Pietzsch J, Steinbach J, Bornhäuser M, Bachmann MP.

Sci Rep. 2017 Feb 16;7:42855. doi: 10.1038/srep42855.

19.

High intensity smoking cessation interventions: Cardiac patients of low socioeconomic status and low intention to quit profit most.

Berndt N, de Vries H, Lechner L, Van Acker F, Froelicher ES, Verheugt F, Mudde A, Bolman C.

Neth Heart J. 2017 Jan;25(1):24-32. doi: 10.1007/s12471-016-0906-7.

20.

Mathematical Modeling of Cellular Metabolism.

Berndt N, Holzhütter HG.

Recent Results Cancer Res. 2016;207:221-32. doi: 10.1007/978-3-319-42118-6_10. Review.

PMID:
27557541
21.

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA.

Wolf C, Rapp A, Berndt N, Staroske W, Schuster M, Dobrick-Mattheuer M, Kretschmer S, König N, Kurth T, Wieczorek D, Kast K, Cardoso MC, Günther C, Lee-Kirsch MA.

Nat Commun. 2016 May 27;7:11752. doi: 10.1038/ncomms11752.

22.
23.

Smoking cessation in cardiac patients: the influence of action plans, coping plans and self-efficacy on quitting smoking.

de Hoog N, Bolman C, Berndt N, Kers E, Mudde A, de Vries H, Lechner L.

Health Educ Res. 2016 Jun;31(3):350-62. doi: 10.1093/her/cyv100. Epub 2016 Jan 30.

PMID:
26827369
24.

Self-Reporting of Smoking Cessation in Cardiac Patients: How Reliable Is It and Is Reliability Associated With Patient Characteristics?

Gerritsen M, Berndt N, Lechner L, de Vries H, Mudde A, Bolman C.

J Addict Med. 2015 Jul-Aug;9(4):308-16. doi: 10.1097/ADM.0000000000000137.

PMID:
26083956
25.

Regulation of liver metabolism by the endosomal GTPase Rab5.

Zeigerer A, Bogorad RL, Sharma K, Gilleron J, Seifert S, Sales S, Berndt N, Bulik S, Marsico G, D'Souza RCJ, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Holzhütter HG, Shevchenko A, Mann M, Koteliansky V, Zerial M.

Cell Rep. 2015 May 12;11(6):884-892. doi: 10.1016/j.celrep.2015.04.018. Epub 2015 Apr 30.

26.

Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients.

Berndt N, Kann O, Holzhütter HG.

J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506. doi: 10.1038/jcbfm.2015.70. Epub 2015 Apr 22.

27.

Economic evaluation of a telephone- and face-to-face-delivered counseling intervention for smoking cessation in patients with coronary heart disease.

Berndt N, Bolman C, Lechner L, Max W, Mudde A, de Vries H, Evers S.

Eur J Health Econ. 2016 Apr;17(3):269-85. doi: 10.1007/s10198-015-0677-x. Epub 2015 Mar 22.

PMID:
25796578
28.

Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion.

Eckstein J, Berndt N, Holzhütter HG.

PLoS Comput Biol. 2015 Feb 18;11(2):e1004033. doi: 10.1371/journal.pcbi.1004033. eCollection 2015 Feb.

29.

Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1).

Günther C, Berndt N, Wolf C, Lee-Kirsch MA.

JAMA Dermatol. 2015 Apr;151(4):426-31. doi: 10.1001/jamadermatol.2014.3438.

PMID:
25517357
30.

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

Günther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nöthen MM, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA.

J Clin Invest. 2015 Jan;125(1):413-24. doi: 10.1172/JCI78001. Epub 2014 Dec 15.

31.

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

Cheng C, Liu Y, Balasis ME, Garner TP, Li J, Simmons NL, Berndt N, Song H, Pan L, Qin Y, Nicolaou KC, Gavathiotis E, Sebti SM, Li R.

Mar Drugs. 2014 Jul 29;12(8):4311-25. doi: 10.3390/md12084311.

32.

Intention to abstain from smoking among cardiac rehabilitation patients: the role of attitude, self-efficacy, and craving.

Bakker EC, Nijkamp MD, Sloot C, Berndt NC, Bolman CA.

J Cardiovasc Nurs. 2015 Mar-Apr;30(2):172-9. doi: 10.1097/JCN.0000000000000156.

PMID:
24831728
33.

Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors.

Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schönbrunn E.

ACS Chem Biol. 2014 May 16;9(5):1160-71. doi: 10.1021/cb500072z. Epub 2014 Mar 13.

34.

TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity.

Cartellieri M, Arndt C, Feldmann A, von Bonin M, Ewen EM, Koristka S, Michalk I, Stamova S, Berndt N, Gocht A, Bornhäuser M, Ehninger G, Schmitz M, Bachmann M.

Oncoimmunology. 2013 Dec 1;2(12):e26770. Epub 2013 Oct 22.

35.

Deregulated type I IFN response in TREX1-associated familial chilblain lupus.

Peschke K, Friebe F, Zimmermann N, Wahlicht T, Schumann T, Achleitner M, Berndt N, Luksch H, Behrendt R, Lee-Kirsch MA, Roers A, Günther C.

J Invest Dermatol. 2014 May;134(5):1456-1459. doi: 10.1038/jid.2013.496. Epub 2013 Nov 22. No abstract available. Erratum in: J Invest Dermatol. 2014 Sep;134(9):2475. J Invest Dermatol. 2014 May;134(5). doi: 10.1038/jid.2014.136.

36.

Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: description of a novel modular targeting system.

Arndt C, Feldmann A, von Bonin M, Cartellieri M, Ewen EM, Koristka S, Michalk I, Stamova S, Berndt N, Gocht A, Bornhäuser M, Ehninger G, Schmitz M, Bachmann M.

Leukemia. 2014 Jan;28(1):59-69. doi: 10.1038/leu.2013.243. Epub 2013 Aug 20.

PMID:
23958923
37.
38.

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.

Berndt N, Patel R, Yang H, Balasis ME, Sebti SM.

Cell Cycle. 2013 Jul 1;12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6.

39.

Effectiveness of a telephone delivered and a face-to-face delivered counseling intervention for smoking cessation in patients with coronary heart disease: a 6-month follow-up.

Berndt N, Bolman C, Froelicher ES, Mudde A, Candel M, de Vries H, Lechner L.

J Behav Med. 2014 Aug;37(4):709-24. doi: 10.1007/s10865-013-9522-9. Epub 2013 Jun 13.

PMID:
23760610
40.

Metabolic gradients as key regulators in zonation of tumor energy metabolism: a tissue-scale model-based study.

König M, Holzhütter HG, Berndt N.

Biotechnol J. 2013 Sep;8(9):1058-69. doi: 10.1002/biot.201200393. Epub 2013 Jun 26.

PMID:
23589477
41.

The high energy demand of neuronal cells caused by passive leak currents is not a waste of energy.

Berndt N, Holzhütter HG.

Cell Biochem Biophys. 2013 Nov;67(2):527-35. doi: 10.1007/s12013-013-9538-3.

PMID:
23479331
42.

Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.

Huchzermeyer C, Berndt N, Holzhütter HG, Kann O.

J Cereb Blood Flow Metab. 2013 Feb;33(2):263-71. doi: 10.1038/jcbfm.2012.165. Epub 2012 Nov 21.

43.

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.

Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5961-5. doi: 10.1016/j.bmcl.2012.07.050. Epub 2012 Jul 24.

45.

Relationships of sun-protection habit strength with sunscreen use during outdoor sport and physical activity.

Lawler S, McDermott L, O'Riordan D, Spathonis K, Eakin E, Leslie E, Gallois C, Berndt N, Owen N.

Int J Environ Res Public Health. 2012 Mar;9(3):916-23. doi: 10.3390/ijerph9030916. Epub 2012 Mar 15.

46.

Self-efficacy mediates the impact of craving on smoking abstinence in low to moderately anxious patients: results of a moderated mediation approach.

Berndt NC, Hayes AF, Verboon P, Lechner L, Bolman C, De Vries H.

Psychol Addict Behav. 2013 Mar;27(1):113-24. doi: 10.1037/a0028737. Epub 2012 Jun 4.

PMID:
22663344
47.
48.

Risk groups and predictors of short-term abstinence from smoking in patients with coronary heart disease.

Berndt N, Bolman C, Mudde A, Verheugt F, de Vries H, Lechner L.

Heart Lung. 2012 Jul-Aug;41(4):332-43. doi: 10.1016/j.hrtlng.2012.03.001. Epub 2012 Apr 24.

PMID:
22534209
49.

Smoking cessation treatment practices: recommendations for improved adoption on cardiology wards.

Berndt NC, Bolman C, de Vries H, Segaar D, van Boven I, Lechner L.

J Cardiovasc Nurs. 2013 Jan-Feb;28(1):35-47. doi: 10.1097/JCN.0b013e318231f424.

PMID:
22048618
50.

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