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The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis.

Lindström E, Rizoska B, Tunblad K, Edenius C, Bendele AM, Maul D, Larson M, Shah N, Yoder Otto V, Jerome C, Grabowska U.

J Transl Med. 2018 Mar 9;16(1):56. doi: 10.1186/s12967-018-1425-7.


Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular.

Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD.

Int J Toxicol. 2018 Jan/Feb;37(1):4-27. doi: 10.1177/1091581817741840. Epub 2017 Dec 21.


RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease.

Jahagirdar R, Attwell S, Marusic S, Bendele A, Shenoy N, McLure KG, Gilham D, Norek K, Hansen HC, Yu R, Tobin J, Wagner GS, Young PR, Wong NCW, Kulikowski E.

Mol Pharmacol. 2017 Dec;92(6):694-706. doi: 10.1124/mol.117.110379. Epub 2017 Sep 29.


Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists.

Chandrasekhar S, Yu XP, Harvey AK, Oskins JL, Lin C, Wang X, Blanco MJ, Fisher MJ, Kuklish SL, Schiffler MA, Vetman T, Warshawsky AM, York JS, Bendele AM, Chambers MG.

Pharmacol Res Perspect. 2017 May 14;5(3):e00316. doi: 10.1002/prp2.316. eCollection 2017 Jun.


Human blood-based anti-inflammatory solution inhibits osteoarthritis progression in a meniscal-tear rat study.

King W, Bendele A, Marohl T, Woodell-May J.

J Orthop Res. 2017 Oct;35(10):2260-2268. doi: 10.1002/jor.23528. Epub 2017 Mar 23.


Intra-articular therapy with recombinant human GDF5 arrests disease progression and stimulates cartilage repair in the rat medial meniscus transection (MMT) model of osteoarthritis.

Parrish WR, Byers BA, Su D, Geesin J, Herzberg U, Wadsworth S, Bendele A, Story B.

Osteoarthritis Cartilage. 2017 Apr;25(4):554-560. doi: 10.1016/j.joca.2016.11.002. Epub 2016 Nov 13.


Beneficial effects of natural eggshell membrane (NEM) on multiple indices of arthritis in collagen-induced arthritic rats.

Wedekind KJ, Ruff KJ, Atwell CA, Evans JL, Bendele AM.

Mod Rheumatol. 2017 Sep;27(5):838-848. doi: 10.1080/14397595.2016.1259729. Epub 2016 Dec 21.


Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).

Fossey S, Vahle J, Long P, Schelling S, Ernst H, Boyce RW, Jolette J, Bolon B, Bendele A, Rinke M, Healy L, High W, Roth DR, Boyle M, Leininger J.

J Toxicol Pathol. 2016;29(3 Suppl):49S-103S. doi: 10.1293/tox.29.3S-2. Epub 2016 Jul 29. Review.


Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.

LaBranche TP, Bendele AM, Omura BC, Gropp KE, Hurst SI, Bagi CM, Cummings TR, Grantham LE 2nd, Shelton DL, Zorbas MA.

Ann Rheum Dis. 2017 Jan;76(1):295-302. doi: 10.1136/annrheumdis-2015-208913. Epub 2016 Jul 5.


Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis.

Kyostio-Moore S, Piraino S, Berthelette P, Moran N, Serriello J, Bendele A, Sookdeo C, Nambiar B, Ewing P, Armentano D, Matthews GL.

Arthritis Res Ther. 2015 Jan 16;17:5. doi: 10.1186/s13075-015-0519-3.


Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis.

Kumar A, Bendele AM, Blanks RC, Bodick N.

Osteoarthritis Cartilage. 2015 Jan;23(1):151-60. doi: 10.1016/j.joca.2014.09.019. Epub 2014 Sep 26.


Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis.

Rabinow B, Werling J, Bendele A, Gass J, Bogseth R, Balla K, Valaitis P, Hutchcraft A, Graham S.

Inflammation. 2015 Feb;38(1):40-60. doi: 10.1007/s10753-014-0006-z.


Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis.

Levine YA, Koopman FA, Faltys M, Caravaca A, Bendele A, Zitnik R, Vervoordeldonk MJ, Tak PP.

PLoS One. 2014 Aug 11;9(8):e104530. doi: 10.1371/journal.pone.0104530. eCollection 2014.


Comparison of the effect of intra-tendon applications of recombinant human platelet-derived growth factor-BB, platelet-rich plasma, steroids in a rat achilles tendon collagenase model.

Solchaga LA, Bendele A, Shah V, Snel LB, Kestler HK, Dines JS, Hee CK.

J Orthop Res. 2014 Jan;32(1):145-50. doi: 10.1002/jor.22483. Epub 2013 Sep 9.


Dose-response effect of an intra-tendon application of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in a rat Achilles tendinopathy model.

Shah V, Bendele A, Dines JS, Kestler HK, Hollinger JO, Chahine NO, Hee CK.

J Orthop Res. 2013 Mar;31(3):413-20. doi: 10.1002/jor.22222. Epub 2012 Aug 29.


The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig.

Kraus VB, Huebner JL, DeGroot J, Bendele A.

Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S35-52. doi: 10.1016/j.joca.2010.04.015.


The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat.

Gerwin N, Bendele AM, Glasson S, Carlson CS.

Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S24-34. doi: 10.1016/j.joca.2010.05.030.


CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model.

Zimmerman DH, Taylor P, Bendele A, Carambula R, Duzant Y, Lowe V, O'Neill SP, Talor E, Rosenthal KS.

Int Immunopharmacol. 2010 Apr;10(4):412-21. doi: 10.1016/j.intimp.2009.12.016. Epub 2010 Jan 13.


A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM Jr, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B.

Arthritis Rheum. 2009 Jul;60(7):2008-18. doi: 10.1002/art.24629.


Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.

Connor JR, LePage C, Swift BA, Yamashita D, Bendele AM, Maul D, Kumar S.

Osteoarthritis Cartilage. 2009 Sep;17(9):1236-43. doi: 10.1016/j.joca.2009.03.015. Epub 2009 Apr 5.


The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli.

Cecil DL, Appleton CT, Polewski MD, Mort JS, Schmidt AM, Bendele A, Beier F, Terkeltaub R.

J Immunol. 2009 Apr 15;182(8):5024-31. doi: 10.4049/jimmunol.0803603.


Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.

Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM, Morris EA, Glasson SS.

Arthritis Rheum. 2009 Mar;60(3):840-7. doi: 10.1002/art.24304.


Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells.

Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL.

J Immunol. 2007 Oct 15;179(8):5576-83.


Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota.

Dalby AB, Frank DN, St Amand AL, Bendele AM, Pace NR.

Appl Environ Microbiol. 2006 Oct;72(10):6707-15.


Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.

Edwards CK 3rd, Bendele AM, Reznikov LI, Fantuzzi G, Chlipala ES, Li L, Moldawer LL, Mountz JD, Li YY, Dinarello CA.

Arthritis Rheum. 2006 Sep;54(9):2872-85.


Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins.

Mesri M, Smithson G, Ghatpande A, Chapoval A, Shenoy S, Boldog F, Hackett C, Pena CE, Burgess C, Bendele A, Shimkets RA, Starling GC.

Int Immunol. 2006 Mar;18(3):473-84. Epub 2006 Feb 15.


Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis.

Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, Ellsworth JL.

Osteoarthritis Cartilage. 2005 Jul;13(7):623-31.


Animal models of rheumatoid arthritis.

Bendele A.

J Musculoskelet Neuronal Interact. 2001 Jun;1(4):377-85.


Animal models of osteoarthritis.

Bendele AM.

J Musculoskelet Neuronal Interact. 2001 Jun;1(4):363-76.


Animal models of osteoarthritis in an era of molecular biology.

Bendele AM.

J Musculoskelet Neuronal Interact. 2002 Dec;2(6):501-3.


Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein.

Cox GN, Smith DJ, Carlson SJ, Bendele AM, Chlipala EA, Doherty DH.

Exp Hematol. 2004 May;32(5):441-9.


Design of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) for chronic inflammatory diseases.

Edwards CK 3rd, Martin SW, Seely J, Kinstler O, Buckel S, Bendele AM, Ellen Cosenza M, Feige U, Kohno T.

Adv Drug Deliv Rev. 2003 Sep 26;55(10):1315-36. Review.


Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y.

Banda NK, Kraus DM, Muggli M, Bendele A, Holers VM, Arend WP.

J Immunol. 2003 Aug 15;171(4):2109-15.


Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.

Banda NK, Vondracek A, Kraus D, Dinarello CA, Kim SH, Bendele A, Senaldi G, Arend WP.

J Immunol. 2003 Feb 15;170(4):2100-5.


Mechanisms of effects of complement inhibition in murine collagen-induced arthritis.

Banda NK, Kraus D, Vondracek A, Huynh LH, Bendele A, Holers VM, Arend WP.

Arthritis Rheum. 2002 Nov;46(11):3065-75.


A novel human fibroblast growth factor treats experimental intestinal inflammation.

Jeffers M, McDonald WF, Chillakuru RA, Yang M, Nakase H, Deegler LL, Sylander ED, Rittman B, Bendele A, Sartor RB, Lichenstein HS.

Gastroenterology. 2002 Oct;123(4):1151-62.


Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor.

Janusz MJ, Bendele AM, Brown KK, Taiwo YO, Hsieh L, Heitmeyer SA.

Osteoarthritis Cartilage. 2002 Oct;10(10):785-91. Erratum in: Osteoarthritis Cartilage. 2003 Apr;11(4):299. Osteoarthritis Cartilage 2002 Nov;10(1):905.


Effect of MPC-11 myeloma and MPC-11 + IL-1 receptor antagonist treatment on mouse bone properties.

Ferguson VL, Simske SJ, Ayers RA, Bateman TA, Wang HT, Bendele A, Rich B, Collins D, Scherrer J, Sennello R, Colagiovanni DB.

Bone. 2002 Jan;30(1):109-16.


Treatment of rheumatoid arthritis with PEGylated recombinant human soluble tumour necrosis factor receptor type I: a clinical update.

Davis MW, Feige U, Bendele AM, Martin SW, Edwards CK 3rd.

Ann Rheum Dis. 2000 Nov;59 Suppl 1:i41-3. Review. No abstract available.


Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies.

Silbaugh SA, Stengel PW, Cockerham SL, Froelich LL, Bendele AM, Spaethe SM, Sofia MJ, Sawyer JS, Jackson WT.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361(4):397-404.


Phase I/II trial of recombinant methionyl human tumor necrosis factor binding protein PEGylated dimer in patients with active refractory rheumatoid arthritis.

Moreland LW, McCabe DP, Caldwell JR, Sack M, Weisman M, Henry G, Seely JE, Martin SW, Yee CL, Bendele AM, Frazier JL, Kohno T, Cosenza ME, Lyons SA, Dayer JM, Cohen AM, Edwards CK 3rd.

J Rheumatol. 2000 Mar;27(3):601-9.


Effects of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) alone and in combination with methotrexate in adjuvant arthritic rats.

Bendele AM, McComb J, Gould T, Frazier J, Chlipala E, Seely J, Kieft G, Edwards CK 3rd.

Clin Exp Rheumatol. 1999 Sep-Oct;17(5):553-60.


Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats.

Bendele AM, McComb J, Gould T, Frazier J, Chlipala ES, Seely J, Kieft G, Wolf J, Edwards CK 3rd.

Inflamm Res. 1999 Aug;48(8):453-60.


Antiarthritic activity of soluble tumor necrosis factor receptor type I forms in adjuvant arthritis: correlation of plasma levels with efficacy.

McComb J, Gould T, Chlipala E, Sennelo G, Frazier J, Kieft G, Seely J, Edwards CK 3rd, Bendele A.

J Rheumatol. 1999 Jun;26(6):1347-51.


Effects of interleukin 1 receptor antagonist alone and in combination with methotrexate in adjuvant arthritic rats.

Bendele A, Sennello G, McAbee T, Frazier J, Chlipala E, Rich B.

J Rheumatol. 1999 Jun;26(6):1225-9.


Animal models of arthritis: relevance to human disease.

Bendele A, McComb J, Gould T, McAbee T, Sennello G, Chlipala E, Guy M.

Toxicol Pathol. 1999 Jan-Feb;27(1):134-42.


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