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Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R.

EMBO J. 2018 Mar 6. pii: e97902. doi: 10.15252/embj.201797902. [Epub ahead of print]


The Ticking CLOCK of HSV-2 Pathology.

Bayliss RJ, Piguet V.

J Invest Dermatol. 2018 Jan;138(1):17-19. doi: 10.1016/j.jid.2017.08.028.


Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M.

Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090.


Mitotic Regulation by NEK Kinase Networks.

Fry AM, Bayliss R, Roig J.

Front Cell Dev Biol. 2017 Dec 1;5:102. doi: 10.3389/fcell.2017.00102. eCollection 2017. Review.


Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R.

ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30.


EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients.

Sabir SR, Yeoh S, Jackson G, Bayliss R.

Cancers (Basel). 2017 Sep 5;9(9). pii: E118. doi: 10.3390/cancers9090118. Review.


Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM.

Cancer Res. 2017 Sep 15;77(18):4785-4796. doi: 10.1158/0008-5472.CAN-16-3233. Epub 2017 Jul 18.


Degradation Mechanisms of Magnesium Metal Anodes in Electrolytes Based on (CF3SO2)2N- at High Current Densities.

Yoo HD, Han SD, Bolotin IL, Nolis GM, Bayliss RD, Burrell AK, Vaughey JT, Cabana J.

Langmuir. 2017 Sep 19;33(37):9398-9406. doi: 10.1021/acs.langmuir.7b01051. Epub 2017 Jul 5.


A moving target: structure and disorder in pursuit of Myc inhibitors.

Bayliss R, Burgess SG, Leen E, Richards MW.

Biochem Soc Trans. 2017 Jun 15;45(3):709-717. doi: 10.1042/BST20160328. Review.


Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F.

Science. 2017 Jul 7;357(6346):83-88. doi: 10.1126/science.aam9243. Epub 2017 Jun 1.


Switching Aurora-A kinase on and off at an allosteric site.

Bayliss R, Burgess SG, McIntyre PJ.

FEBS J. 2017 Sep;284(18):2947-2954. doi: 10.1111/febs.14069. Epub 2017 Apr 18. Review.


Dosimetric Comparison of Real-Time MRI-Guided Tri-Cobalt-60 Versus Linear Accelerator-Based Stereotactic Body Radiation Therapy Lung Cancer Plans.

Wojcieszynski AP, Hill PM, Rosenberg SA, Hullett CR, Labby ZE, Paliwal B, Geurts MW, Bayliss RA, Bayouth JE, Harari PM, Bassetti MF, Baschnagel AM.

Technol Cancer Res Treat. 2017 Jun;16(3):366-372. doi: 10.1177/1533034617691407. Epub 2017 Feb 7.


Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer.

Woo CG, Seo S, Kim SW, Jang SJ, Park KS, Song JY, Lee B, Richards MW, Bayliss R, Lee DH, Choi J.

Ann Oncol. 2017 Apr 1;28(4):791-797. doi: 10.1093/annonc/mdw693.


Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy.

Burgess SG, Grazia Concilio M, Bayliss R, Fielding AJ.

ChemistryOpen. 2016 Nov 11;5(6):531-534. doi: 10.1002/open.201600101. eCollection 2016 Dec.


EML proteins in microtubule regulation and human disease.

Fry AM, O'Regan L, Montgomery J, Adib R, Bayliss R.

Biochem Soc Trans. 2016 Oct 15;44(5):1281-1288. Review.


Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.

Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731. Epub 2016 Nov 11.


Structure-guided design of purine-based probes for selective Nek2 inhibition.

Coxon CR, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C.

Oncotarget. 2017 Mar 21;8(12):19089-19124. doi: 10.18632/oncotarget.13249.


A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB.

Malar J. 2016 Nov 7;15(1):535.


"Rocking-Chair"-Type Metal Hybrid Supercapacitors.

Yoo HD, Han SD, Bayliss RD, Gewirth AA, Genorio B, Rajput NN, Persson KA, Burrell AK, Cabana J.

ACS Appl Mater Interfaces. 2016 Nov 16;8(45):30853-30862. Epub 2016 Nov 2.


A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG.

ACS Chem Biol. 2016 Dec 16;11(12):3383-3390. Epub 2016 Nov 1.


Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R.

Open Biol. 2016 Jul;6(7). pii: 160089. doi: 10.1098/rsob.160089.


Synthetic analogues of Fe(ii)-Fe(iii) minerals containing a pentagonal 'Cairo' magnetic lattice.

Cumby J, Bayliss RD, Berry FJ, Greaves C.

Dalton Trans. 2016 Jul 19;45(29):11801-6. doi: 10.1039/c6dt01672c.


A closed conformation of the Caenorhabditis elegans separase-securin complex.

Bachmann G, Richards MW, Winter A, Beuron F, Morris E, Bayliss R.

Open Biol. 2016 Apr;6(4):160032. doi: 10.1098/rsob.160032. Epub 2016 Apr 13.


Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.

Hall G, Cullen E, Sawmynaden K, Arnold J, Fox S, Cowan R, Muskett FW, Matthews D, Merritt A, Kettleborough C, Cruikshank W, Taylor D, Bayliss R, Carr MD.

J Biol Chem. 2016 Aug 5;291(32):16840-8. doi: 10.1074/jbc.M115.709303. Epub 2016 May 26.


Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop.

Concilio MG, Fielding AJ, Bayliss R, Burgess SG.

Theor Chem Acc. 2016;135:97. Epub 2016 Mar 23.


Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

Khan S, Karmokar A, Howells L, Thomas AL, Bayliss R, Gescher A, Brown K.

Mol Nutr Food Res. 2016 Jun;60(6):1295-309. doi: 10.1002/mnfr.201500887. Epub 2016 May 11. Review.


Erratum: The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.

Flayhan A, Bergé C, Baïlo N, Doublet P, Bayliss R, Terradot L.

Sci Rep. 2016 Feb 3;6:20746. doi: 10.1038/srep20746. No abstract available.


Correlation of Local Structure and Diffusion Pathways in the Modulated Anisotropic Oxide Ion Conductor CeNbO(4.25).

Pramana SS, Baikie T, An T, Tucker MG, Wu J, Schreyer MK, Wei F, Bayliss RD, Kloc CL, White TJ, Horsfield AP, Skinner SJ.

J Am Chem Soc. 2016 Feb 3;138(4):1273-9. doi: 10.1021/jacs.5b11373. Epub 2016 Jan 25.


Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.

Bayliss R, Choi J, Fennell DA, Fry AM, Richards MW.

Cell Mol Life Sci. 2016 Mar;73(6):1209-24. doi: 10.1007/s00018-015-2117-6. Epub 2016 Jan 11. Review.


Gadoxetate for direct tumor therapy and tracking with real-time MRI-guided stereotactic body radiation therapy of the liver.

Wojcieszynski AP, Rosenberg SA, Brower JV, Hullett CR, Geurts MW, Labby ZE, Hill PM, Bayliss RA, Paliwal B, Bayouth JE, Harari PM, Bassetti MF.

Radiother Oncol. 2016 Feb;118(2):416-8. doi: 10.1016/j.radonc.2015.10.024. Epub 2015 Nov 25.


Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.

Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R.

Nat Commun. 2015 Nov 2;6:8771. doi: 10.1038/ncomms9771.


Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.

Winter A, Schmid R, Bayliss R.

PLoS Comput Biol. 2015 Oct 29;11(10):e1004548. doi: 10.1371/journal.pcbi.1004548. eCollection 2015 Oct.


The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.

Flayhan A, Bergé C, Baïlo N, Doublet P, Bayliss R, Terradot L.

Sci Rep. 2015 Sep 30;5:14602. doi: 10.1038/srep14602. Erratum in: Sci Rep. 2016;6:20746.


7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.

Bavetsias V, Pérez-Fuertes Y, McIntyre PJ, Atrash B, Kosmopoulou M, O'Fee L, Burke R, Sun C, Faisal A, Bush K, Avery S, Henley A, Raynaud FI, Linardopoulos S, Bayliss R, Blagg J.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4203-9. doi: 10.1016/j.bmcl.2015.08.003. Epub 2015 Aug 6.


Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R.

PLoS Genet. 2015 Jul 2;11(7):e1005345. doi: 10.1371/journal.pgen.1005345. eCollection 2015 Jul.


Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

Rogerson DT, Sachdeva A, Wang K, Haq T, Kazlauskaite A, Hancock SM, Huguenin-Dezot N, Muqit MM, Fry AM, Bayliss R, Chin JW.

Nat Chem Biol. 2015 Jul;11(7):496-503. doi: 10.1038/nchembio.1823. Epub 2015 Jun 1.


Solution NMR assignment of the cryptic sixth TOG domain of mini spindles.

Burgess SG, Bayliss R, Pfuhl M.

Biomol NMR Assign. 2015 Oct;9(2):411-3. doi: 10.1007/s12104-015-9620-4. Epub 2015 May 14.


Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.

Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R.

Oncotarget. 2015 May 30;6(15):13019-35.


Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.


The Ys and wherefores of protein kinase autoinhibition.

Bayliss R, Haq T, Yeoh S.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1586-94. doi: 10.1016/j.bbapap.2015.04.025. Epub 2015 Apr 30. Review.


Direct Observation of Reversible Magnesium Ion Intercalation into a Spinel Oxide Host.

Kim C, Phillips PJ, Key B, Yi T, Nordlund D, Yu YS, Bayliss RD, Han SD, He M, Zhang Z, Burrell AK, Klie RF, Cabana J.

Adv Mater. 2015 Jun 10;27(22):3377-84. doi: 10.1002/adma.201500083. Epub 2015 Apr 17. No abstract available.


Impact of Node Negative Target Volume Delineation on Contralateral Parotid Gland Dose Sparing Using IMRT in Head and Neck Cancer.

Magnuson WJ, Urban E, Bayliss RA, Harari PM.

Technol Cancer Res Treat. 2015 Jun;14(3):315-9. doi: 10.1177/1533034614547456. Epub 2014 Sep 10.


The structure of C290A:C393A Aurora A provides structural insights into kinase regulation.

Burgess SG, Bayliss R.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):315-9. doi: 10.1107/S2053230X15002290. Epub 2015 Feb 19.


Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R.

Biochem J. 2015 May 1;467(3):529-36. doi: 10.1042/BJ20150039.


TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation.

Gutiérrez-Caballero C, Burgess SG, Bayliss R, Royle SJ.

Biol Open. 2015 Jan 16;4(2):170-9. doi: 10.1242/bio.201410843.


Selective omission of level V nodal coverage for patients with oropharyngeal cancer: Clinical validation of intensity-modulated radiotherapy experience and dosimetric significance.

Mohindra P, Urban E, Pagan JD, Geye HM, Patel VB, Bayliss RA, Bender ET, Harari PM.

Head Neck. 2016 Apr;38(4):499-505. doi: 10.1002/hed.23924. Epub 2015 Jun 16.


Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification.

Rowan F, Richards M, Widya M, Bayliss R, Blagg J.

PLoS One. 2014 Aug 5;9(8):e103935. doi: 10.1371/journal.pone.0103935. eCollection 2014.


The primary cilium: guardian of organ development and homeostasis.

Fry AM, Leaper MJ, Bayliss R.

Organogenesis. 2014 Jan 1;10(1):62-8. doi: 10.4161/org.28910. Epub 2014 Apr 17. Review.


Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.

Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi: 10.1073/pnas.1322892111. Epub 2014 Mar 24.


Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.

Bojar D, Martinez J, Santiago J, Rybin V, Bayliss R, Hothorn M.

Plant J. 2014 Apr;78(1):31-43. doi: 10.1111/tpj.12445. Epub 2014 Mar 12.

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