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Items: 1 to 50 of 64

1.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J.

Lancet. 2018 May 10. pii: S0140-6736(18)30789-X. doi: 10.1016/S0140-6736(18)30789-X. [Epub ahead of print]

PMID:
29754777
2.

Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases.

Yang Q, Bavi P, Wang JY, Roehrl MH.

J Proteomics. 2017 Sep 25;168:53-65. doi: 10.1016/j.jprot.2017.06.021. Epub 2017 Jun 29.

PMID:
28669815
3.

Immune modulator-induced changes in the gastrointestinal tract.

Bavi P, Butler M, Serra S, Chetty R.

Histopathology. 2017 Sep;71(3):494-496. doi: 10.1111/his.13224. Epub 2017 May 16. No abstract available.

PMID:
28342232
4.

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.

5.

Subacute CNS Demyelination after Treatment with Nivolumab for Melanoma.

Maurice C, Schneider R, Kiehl TR, Bavi P, Roehrl MH, Mason WP, Hogg D.

Cancer Immunol Res. 2015 Dec;3(12):1299-302. doi: 10.1158/2326-6066.CIR-15-0141. Epub 2015 Sep 29.

6.

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS.

Cancer. 2015 Jun 1;121(11):1762-71. doi: 10.1002/cncr.29288. Epub 2015 Feb 24.

7.

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

Siraj AK, Bu R, Prabhakaran S, Bavi P, Beg S, Al Hazmi M, Al-Rasheed M, Alobaisi K, Al-Dayel F, AlManea H, Al-Sanea N, Uddin S, Al-Kuraya KS.

Mol Cancer. 2014 Jul 8;13:168. doi: 10.1186/1476-4598-13-168.

8.

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.

Ahmed M, Hussain AR, Bavi P, Ahmed SO, Al Sobhi SS, Al-Dayel F, Uddin S, Al-Kuraya KS.

Carcinogenesis. 2014 Jul;35(7):1564-72. doi: 10.1093/carcin/bgu051. Epub 2014 Feb 28.

PMID:
24583924
9.

ALK gene amplification is associated with poor prognosis in colorectal carcinoma.

Bavi P, Jehan Z, Bu R, Prabhakaran S, Al-Sanea N, Al-Dayel F, Al-Assiri M, Al-Halouly T, Sairafi R, Uddin S, Al-Kuraya KS.

Br J Cancer. 2013 Nov 12;109(10):2735-43. doi: 10.1038/bjc.2013.641. Epub 2013 Oct 15.

10.

Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release.

Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KS.

PLoS One. 2013;8(3):e60540. doi: 10.1371/journal.pone.0060540. Epub 2013 Mar 28.

11.

Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma.

Bavi P, Abubaker J, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Siraj AK, Al-Kuraya KS.

Clin Epigenetics. 2011 Aug;2(2):417-8. doi: 10.1007/s13148-011-0049-z. Epub 2011 Jul 14. No abstract available.

12.

Colorectal cancer risk is not associated with increased levels of homozygosity in Saudi Arabia.

Siraj AK, Khalak HG, Sultana M, Al-Rasheed M, Bavi P, Al-Sanea N, Al-Dayel F, Uddin S, Alkuraya FS, Al-Kuraya KS.

Genet Med. 2012 Apr 5. doi: 10.1038/gim.2012.27. [Epub ahead of print]

PMID:
22481135
13.

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.

Bu R, Bavi P, Abubaker J, Jehan Z, Al-Haqawi W, Ajarim D, Al-Dayel F, Uddin S, Al-Kuraya KS.

Leuk Lymphoma. 2012 Oct;53(10):1971-7. doi: 10.3109/10428194.2012.668286. Epub 2012 Apr 18.

PMID:
22397314
14.

Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Siddiqui K, Al-Dayel F, Bavi P, Al-Kuraya KS.

Haematologica. 2012 Jul;97(7):1092-100. doi: 10.3324/haematol.2011.053421. Epub 2012 Jan 22.

15.

c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death.

Bu R, Uddin S, Ahmed M, Hussain AR, Alsobhi S, Amin T, Al-Nuaim A, Al-Dayel F, Abubaker J, Bavi P, Al-Kuraya KS.

Mol Med. 2012 Mar 27;18:167-77. doi: 10.2119/molmed.2011.00238.

16.

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Uddin S, Hussain AR, Siraj AK, Khan OS, Bavi PP, Al-Kuraya KS.

Int J Clin Exp Pathol. 2011;4(7):637-43. Epub 2011 Oct 3. Review.

17.

A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia.

Al Tassan N, Khalil D, Shinwari J, Al Sharif L, Bavi P, Abduljaleel Z, Abu Dhaim N, Magrashi A, Bobis S, Ahmed H, Alahmed S, Bohlega S.

Hum Mutat. 2012 Feb;33(2):351-4. doi: 10.1002/humu.21650. Epub 2011 Dec 8.

PMID:
22065524
18.

FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma.

Ahmed M, Uddin S, Hussain AR, Alyan A, Jehan Z, Al-Dayel F, Al-Nuaim A, Al-Sobhi S, Amin T, Bavi P, Al-Kuraya KS.

J Clin Endocrinol Metab. 2012 Jan;97(1):E1-E13. doi: 10.1210/jc.2011-1506. Epub 2011 Nov 2.

PMID:
22049175
19.

Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma.

Uddin S, Hussain AR, Ahmed M, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Bavi P, Al-Kuraya KS.

Am J Pathol. 2011 Dec;179(6):3032-44. doi: 10.1016/j.ajpath.2011.08.007. Epub 2011 Oct 5.

20.

MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer.

Bavi PP, Bu R, Uddin S, Al-Kuraya KS.

Saudi J Gastroenterol. 2011 Sep-Oct;17(5):299-300. doi: 10.4103/1319-3767.84479. No abstract available.

21.

Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.

Bavi P, Uddin S, Ahmed M, Jehan Z, Bu R, Abubaker J, Sultana M, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Prabhakaran S, Hussain AR, Al-Kuraya KS.

Am J Pathol. 2011 May;178(5):2109-20. doi: 10.1016/j.ajpath.2011.01.034.

22.

The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL).

Bavi P, Uddin S, Bu R, Ahmed M, Abubaker J, Balde V, Qadri Z, Ajarim D, Al-Dayel F, Hussain AR, Al-Kuraya KS.

J Pathol. 2011 Jul;224(3):355-66. doi: 10.1002/path.2864. Epub 2011 Apr 19.

PMID:
21506127
23.

Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.

Uddin S, Jehan Z, Ahmed M, Alyan A, Al-Dayel F, Hussain A, Bavi P, Al-Kuraya KS.

Mol Med. 2011;17(7-8):635-45. doi: 10.2119/molmed.2011.00046. Epub 2011 Mar 21.

24.

Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.

Uddin S, Ahmed M, Hussain A, Abubaker J, Al-Sanea N, AbdulJabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Jehan Z, Bavi P, Siraj AK, Al-Kuraya KS.

Am J Pathol. 2011 Feb;178(2):537-47. doi: 10.1016/j.ajpath.2010.10.020.

25.

Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis.

Siraj AK, Hussain AR, Al-Rasheed M, Ahmed M, Bavi P, Alsobhi SA, Al-Nuaim A, Uddin S, Al-Kuraya K.

J Clin Endocrinol Metab. 2011 Jan;96(1):E215-24. doi: 10.1210/jc.2010-0790. Epub 2010 Oct 6.

PMID:
20926535
26.

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.

Bavi P, Prabhakaran SE, Abubaker J, Qadri Z, George T, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Hussain AR, Uddin S, Al-Kuraya KS.

Mol Cancer. 2010 Jul 30;9:203. doi: 10.1186/1476-4598-9-203.

27.

HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.

Bu R, Uddin S, Bavi P, Hussain AR, Al-Dayel F, Ghourab S, Ahmed M, Al-Kuraya KS.

Lab Invest. 2011 Jan;91(1):124-37. doi: 10.1038/labinvest.2010.136. Epub 2010 Jul 26.

28.

Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

Hussain AR, Uddin S, Ahmed M, Bu R, Ahmed SO, Abubaker J, Sultana M, Ajarim D, Al-Dayel F, Bavi PP, Al-Kuraya KS.

J Pathol. 2010 Oct;222(2):180-90. doi: 10.1002/path.2747.

PMID:
20632385
29.

Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Al-Dayel F, Bu R, Bavi P, Al-Kuraya KS.

Lab Invest. 2010 Sep;90(9):1346-56. doi: 10.1038/labinvest.2010.108. Epub 2010 Jun 7.

30.

Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.

Uddin S, Bu R, Ahmed M, Hussain AR, Ajarim D, Al-Dayel F, Bavi P, Al-kuraya KS.

Leuk Lymphoma. 2010 Jul;51(7):1305-14. doi: 10.3109/10428191003802365.

PMID:
20443680
31.

Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Bu R, Ahmed SO, Ajarim D, Al-Dayel F, Bavi P, Al-Kuraya KS.

Mol Cancer Ther. 2010 May;9(5):1244-55. doi: 10.1158/1535-7163.MCT-09-1061. Epub 2010 Apr 27.

32.

Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.

Uddin S, Bavi P, Siraj AK, Ahmed M, Al-Rasheed M, Hussain AR, Ahmed M, Amin T, Alzahrani A, Al-Dayel F, Abubaker J, Bu R, Al-Kuraya KS.

Endocr Relat Cancer. 2010 Feb 18;17(1):191-202. doi: 10.1677/ERC-09-0153. Print 2010 Mar.

33.

Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.

Morales J, Al-Sharif L, Khalil DS, Shinwari JM, Bavi P, Al-Mahrouqi RA, Al-Rajhi A, Alkuraya FS, Meyer BF, Al Tassan N.

Am J Hum Genet. 2009 Nov;85(5):558-68. doi: 10.1016/j.ajhg.2009.09.011.

34.

Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.

Abubaker J, Bavi P, Al-Haqawi W, Sultana M, Al-Harbi S, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS.

J Pathol. 2009 Dec;219(4):435-45. doi: 10.1002/path.2625.

PMID:
19824059
35.

Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.

Uddin S, Bu R, Ahmed M, Abubaker J, Al-Dayel F, Bavi P, Al-Kuraya KS.

Mol Cancer. 2009 Sep 18;8:74. doi: 10.1186/1476-4598-8-74.

36.

FREM1 mutations cause bifid nose, renal agenesis, and anorectal malformations syndrome.

Alazami AM, Shaheen R, Alzahrani F, Snape K, Saggar A, Brinkmann B, Bavi P, Al-Gazali LI, Alkuraya FS.

Am J Hum Genet. 2009 Sep;85(3):414-8. doi: 10.1016/j.ajhg.2009.08.010. Erratum in: Am J Hum Genet. 2009 Nov;85(5):756.

37.

Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

Jehan Z, Bavi P, Sultana M, Abubaker J, Bu R, Hussain A, Alsbeih G, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS.

J Pathol. 2009 Nov;219(3):337-46. doi: 10.1002/path.2601.

PMID:
19697359
38.

PIK3CA alterations in Middle Eastern ovarian cancers.

Abubaker J, Bavi P, Al-Haqawi W, Jehan Z, Munkarah A, Uddin S, Al-Kuraya KS.

Mol Cancer. 2009 Jul 28;8:51. doi: 10.1186/1476-4598-8-51.

39.

Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer.

Uddin S, Ahmed M, Hussain AR, Jehan Z, Al-Dayel F, Munkarah A, Bavi P, Al-Kuraya KS.

Lab Invest. 2009 Oct;89(10):1115-27. doi: 10.1038/labinvest.2009.75. Epub 2009 Jul 27.

40.

Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer.

Uddin S, Ahmed M, Hussain A, Assad L, Al-Dayel F, Bavi P, Al-Kuraya KS, Munkarah A.

Int J Cancer. 2010 Jan 15;126(2):382-94. doi: 10.1002/ijc.24757.

41.

Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication.

Uddin S, Bavi PP, Hussain AR, Alsbeih G, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Ahmed M, Al-Kuraya KS.

Carcinogenesis. 2009 Nov;30(11):1832-40. doi: 10.1093/carcin/bgp145. Epub 2009 Jun 11.

PMID:
19520793
42.

High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.

Uddin S, Hussain AR, Ahmed M, Abubaker J, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Bavi P, Al-Kuraya KS.

Am J Gastroenterol. 2009 Jul;104(7):1790-801. doi: 10.1038/ajg.2009.230. Epub 2009 Jun 2.

PMID:
19491830
43.

Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.

Alazami AM, Al-Saif A, Al-Semari A, Bohlega S, Zlitni S, Alzahrani F, Bavi P, Kaya N, Colak D, Khalak H, Baltus A, Peterlin B, Danda S, Bhatia KP, Schneider SA, Sakati N, Walsh CA, Al-Mohanna F, Meyer B, Alkuraya FS.

Am J Hum Genet. 2008 Dec;83(6):684-91. doi: 10.1016/j.ajhg.2008.10.018. Epub 2008 Nov 20.

44.

S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma.

Uddin S, Hussain A, Ahmed M, Belgaumi A, Al-Dayel F, Ajarim D, Bavi P, Al-Kuraya KS.

J Pathol. 2008 Dec;216(4):483-94. doi: 10.1002/path.2433.

PMID:
18850583
45.

Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma.

Jehan Z, Siraj AK, Abubaker J, Ruiz C, Simon R, Sultana M, Uddin S, Bavi P, Hussain A, Razack S, Ezzat A, Al-Dayel F, Sauter G, Al-Kuraya KS.

Oncology. 2008;75(1-2):71-80. doi: 10.1159/000155144. Epub 2008 Sep 12.

PMID:
18784434
46.

Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.

Uddin S, Siraj AK, Al-Rasheed M, Ahmed M, Bu R, Myers JN, Al-Nuaim A, Al-Sobhi S, Al-Dayel F, Bavi P, Hussain AR, Al-Kuraya KS.

J Clin Endocrinol Metab. 2008 Oct;93(10):4088-97. doi: 10.1210/jc.2008-0503. Epub 2008 Aug 5.

PMID:
18682509
47.

Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

Uddin S, Ahmed M, Bavi P, El-Sayed R, Al-Sanea N, AbdulJabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Hussain AR, Al-Kuraya KS.

Cancer Res. 2008 May 1;68(9):3379-88. doi: 10.1158/0008-5472.CAN-07-6109.

48.

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma.

Bavi P, Abubaker J, Hussain A, Sultana M, Al-Dayel F, Uddin S, Al-Kuraya KS.

Hum Pathol. 2008 Jun;39(6):885-94. doi: 10.1016/j.humpath.2007.10.014. Epub 2008 Apr 8.

PMID:
18400256
49.

Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.

Al-Dayel F, Al-Rasheed M, Ibrahim M, Bu R, Bavi P, Abubaker J, Al-Jomah N, Mohamed GH, Moorji A, Uddin S, Siraj AK, Al-Kuraya K.

Leuk Lymphoma. 2008 Jan;49(1):122-9. doi: 10.1080/10428190701704605.

PMID:
18203021
50.

Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.

Abubaker J, Bavi P, Al-Harbi S, Ibrahim M, Siraj AK, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS.

Oncogene. 2008 Jun 5;27(25):3539-45. doi: 10.1038/sj.onc.1211013. Epub 2008 Jan 14.

PMID:
18193083

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