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Items: 1 to 50 of 72

1.

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12.

PMID:
29651054
2.

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.

Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, Orkin SH.

Cell. 2018 Apr 5;173(2):430-442.e17. doi: 10.1016/j.cell.2018.03.016. Epub 2018 Mar 29.

PMID:
29606353
3.

Are commercially-available precontoured anatomical clavicle plating systems offering the purported superior optimum fitting to the clavicle? A cadaveric analysis and review of literature.

Bauer DE, Hingsammer A, Schenk P, Vlachopoulos L, Imam MA, Fürnstahl P, Meyer DC.

Orthop Traumatol Surg Res. 2018 Mar 16. pii: S1877-0568(18)30071-9. doi: 10.1016/j.otsr.2018.01.013. [Epub ahead of print]

PMID:
29555558
4.

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.

Cancer Cell. 2018 Mar 12;33(3):386-400.e5. doi: 10.1016/j.ccell.2018.01.012. Epub 2018 Feb 22.

PMID:
29478914
5.

Risk factors for perioperative morbidity in spine surgeries of different complexities: a multivariate analysis of 1,009 consecutive patients.

Farshad M, Bauer DE, Wechsler C, Gerber C, Aichmair A.

Spine J. 2018 Feb 13. pii: S1529-9430(18)30059-7. doi: 10.1016/j.spinee.2018.02.003. [Epub ahead of print]

PMID:
29452285
6.

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.

Lessard S, Beaudoin M, Orkin SH, Bauer DE, Lettre G.

Hum Mol Genet. 2018 Apr 15;27(8):1411-1420. doi: 10.1093/hmg/ddy051.

PMID:
29432581
7.

Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: A 10-year follow-up.

Eckers F, Bauer DE, Hingsammer A, Sutter R, Brand B, Viehöfer A, Wirth SH.

Haemophilia. 2018 Mar;24(2):307-315. doi: 10.1111/hae.13386. Epub 2017 Dec 22.

PMID:
29271607
8.

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.

Vinjamur DS, Bauer DE, Orkin SH.

Br J Haematol. 2018 Mar;180(5):630-643. doi: 10.1111/bjh.15038. Epub 2017 Nov 28. Review.

PMID:
29193029
9.

Growing and Genetically Manipulating Human Umbilical Cord Blood-Derived Erythroid Progenitor (HUDEP) Cell Lines.

Vinjamur DS, Bauer DE.

Methods Mol Biol. 2018;1698:275-284. doi: 10.1007/978-1-4939-7428-3_17.

PMID:
29076097
10.

Total knee arthroplasty in patients with a history of illicit intravenous drug abuse.

Bauer DE, Hingsammer A, Ernstbrunner L, Aichmair A, Rosskopf AB, Eckers F, Wieser K, Fucentese SF.

Int Orthop. 2018 Jan;42(1):101-107. doi: 10.1007/s00264-017-3655-3. Epub 2017 Oct 14.

PMID:
29032478
11.

Gene Therapy.

Bauer DE, Kohn DB.

Hematol Oncol Clin North Am. 2017 Oct;31(5):xiii-xiv. doi: 10.1016/j.hoc.2017.07.001. Epub 2017 Aug 7. No abstract available.

PMID:
28895857
12.

Curative approaches for sickle cell disease: A review of allogeneic and autologous strategies.

Bauer DE, Brendel C, Fitzhugh CD.

Blood Cells Mol Dis. 2017 Sep;67:155-168. doi: 10.1016/j.bcmd.2017.08.014. Epub 2017 Sep 1.

PMID:
28893518
13.

Technical considerations for the use of CRISPR/Cas9 in hematology research.

Gundry MC, Dever DP, Yudovich D, Bauer DE, Haas S, Wilkinson AC, Singbrant S.

Exp Hematol. 2017 Oct;54:4-11. doi: 10.1016/j.exphem.2017.07.006. Epub 2017 Jul 27. Review.

PMID:
28757433
14.

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.

Lessard S, Gatof ES, Beaudoin M, Schupp PG, Sher F, Ali A, Prehar S, Kurita R, Nakamura Y, Baena E, Ledoux J, Oceandy D, Bauer DE, Lettre G.

J Clin Invest. 2017 Aug 1;127(8):3065-3074. doi: 10.1172/JCI94378. Epub 2017 Jul 17.

15.

Postoperative alignment of TKA in patients with severe preoperative varus or valgus deformity: is there a difference between surgical techniques?

Rahm S, Camenzind RS, Hingsammer A, Lenz C, Bauer DE, Farshad M, Fucentese SF.

BMC Musculoskelet Disord. 2017 Jun 21;18(1):272. doi: 10.1186/s12891-017-1628-8.

16.

Erythropoietin signaling regulates heme biosynthesis.

Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.

Elife. 2017 May 29;6. pii: e24767. doi: 10.7554/eLife.24767.

17.

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.

Hodonsky CJ, Jain D, Schick UM, Morrison JV, Brown L, McHugh CP, Schurmann C, Chen DD, Liu YM, Auer PL, Laurie CA, Taylor KD, Browning BL, Li Y, Papanicolaou G, Rotter JI, Kurita R, Nakamura Y, Browning SR, Loos RJF, North KE, Laurie CC, Thornton TA, Pankratz N, Bauer DE, Sofer T, Reiner AP.

PLoS Genet. 2017 Apr 28;13(4):e1006760. doi: 10.1371/journal.pgen.1006760. eCollection 2017 Apr.

18.

Quantitative assessment of timing, efficiency, specificity and genetic mosaicism of CRISPR/Cas9-mediated gene editing of hemoglobin beta gene in rhesus monkey embryos.

Midic U, Hung PH, Vincent KA, Goheen B, Schupp PG, Chen DD, Bauer DE, VandeVoort CA, Latham KE.

Hum Mol Genet. 2017 Jul 15;26(14):2678-2689. doi: 10.1093/hmg/ddx154.

PMID:
28444193
19.

Conventional Versus Computer-Assisted Corrective Osteotomy of the Forearm: a Retrospective Analysis of 56 Consecutive Cases.

Bauer DE, Zimmermann S, Aichmair A, Hingsammer A, Schweizer A, Nagy L, Fürnstahl P.

J Hand Surg Am. 2017 Jun;42(6):447-455. doi: 10.1016/j.jhsa.2017.03.024. Epub 2017 Apr 20.

PMID:
28434832
20.

Functional interrogation of non-coding DNA through CRISPR genome editing.

Canver MC, Bauer DE, Orkin SH.

Methods. 2017 May 15;121-122:118-129. doi: 10.1016/j.ymeth.2017.03.008. Epub 2017 Mar 10. Review.

PMID:
28288828
21.

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH.

Nat Genet. 2017 Apr;49(4):625-634. doi: 10.1038/ng.3793. Epub 2017 Feb 20.

22.

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. No abstract available.

23.

Strict in vivo specificity of the Bcl11a erythroid enhancer.

Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH.

Blood. 2016 Nov 10;128(19):2338-2342. doi: 10.1182/blood-2016-08-736249. Epub 2016 Oct 5.

24.

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA.

J Clin Invest. 2016 Oct 3;126(10):3868-3878. doi: 10.1172/JCI87885. Epub 2016 Sep 6.

25.

Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck.

Chau NG, Hurwitz S, Mitchell CM, Aserlind A, Grunfeld N, Kaplan L, Hsi P, Bauer DE, Lathan CS, Rodriguez-Galindo C, Tishler RB, Haddad RI, Sallan SE, Bradner JE, French CA.

Cancer. 2016 Dec 1;122(23):3632-3640. doi: 10.1002/cncr.30242. Epub 2016 Aug 10.

26.

Forward genetic screen of human transposase genomic rearrangements.

Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gonen M, Villasante CM, Armstrong SA, Bauer DE, Weng Z, Kentsis A.

BMC Genomics. 2016 Aug 4;17:548. doi: 10.1186/s12864-016-2877-x.

27.

Analyzing CRISPR genome-editing experiments with CRISPResso.

Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, Yuan GC.

Nat Biotechnol. 2016 Jul 12;34(7):695-7. doi: 10.1038/nbt.3583. No abstract available.

28.

Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies.

Lettre G, Bauer DE.

Lancet. 2016 Jun 18;387(10037):2554-64. doi: 10.1016/S0140-6736(15)01341-0. Review.

PMID:
27353686
29.

A genome editing primer for the hematologist.

Hoban MD, Bauer DE.

Blood. 2016 May 26;127(21):2525-35. doi: 10.1182/blood-2016-01-678151. Epub 2016 Apr 6. Review.

30.

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.

31.

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Hoban MD, Orkin SH, Bauer DE.

Blood. 2016 Feb 18;127(7):839-48. doi: 10.1182/blood-2015-09-618587. Epub 2016 Jan 12. Review.

32.

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression.

Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI.

Blood. 2015 Dec 24;126(26):2811-20. doi: 10.1182/blood-2015-07-659276. Epub 2015 Sep 18.

33.

Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer DE, Orkin SH.

Curr Opin Genet Dev. 2015 Aug;33:62-70. doi: 10.1016/j.gde.2015.08.001. Epub 2015 Sep 14. Review.

34.

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.

Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16.

35.

Functional footprinting of regulatory DNA.

Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, Bauer DE, Holmes MC, Orkin SH, Papayannopoulou T, Stamatoyannopoulos G, Rebar EJ, Gregory PD, Urnov FD, Stamatoyannopoulos JA.

Nat Methods. 2015 Oct;12(10):927-30. doi: 10.1038/nmeth.3554. Epub 2015 Aug 31.

36.

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL.

Blood. 2015 Oct 15;126(16):1930-9. doi: 10.1182/blood-2015-06-649087. Epub 2015 Aug 28.

37.

Influence of El Niño Southern Oscillation phenomenon on coastal phytoplankton in a mixohaline ecosystem on the southeastern of South America: Río de la Plata estuary.

Sathicq MB, Bauer DE, Gómez N.

Mar Pollut Bull. 2015 Sep 15;98(1-2):26-33. doi: 10.1016/j.marpolbul.2015.07.017. Epub 2015 Jul 13.

PMID:
26183307
38.

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA.

Mol Ther. 2015 Sep;23(9):1465-74. doi: 10.1038/mt.2015.113. Epub 2015 Jun 17.

39.

Embryonic stem cells as sources of donor-independent platelets.

Canver MC, Bauer DE, Orkin SH.

J Clin Invest. 2015 Jun;125(6):2261-3. doi: 10.1172/JCI82348. Epub 2015 May 11.

40.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH.

Sci Signal. 2015 Apr 14;8(372):ra34. doi: 10.1126/scisignal.aaa5903.

41.

Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9.

Bauer DE, Canver MC, Orkin SH.

J Vis Exp. 2015 Jan 3;(95):e52118. doi: 10.3791/52118.

42.

TMEM14C is required for erythroid mitochondrial heme metabolism.

Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH.

J Clin Invest. 2014 Oct;124(10):4294-304. doi: 10.1172/JCI76979. Epub 2014 Aug 26.

43.

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2014 Aug 1;289(31):21312-24. doi: 10.1074/jbc.M114.564625. Epub 2014 Jun 6. Erratum in: J Biol Chem. 2017 Feb 10;292(6):2556.

44.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH.

Science. 2013 Oct 11;342(6155):253-7. doi: 10.1126/science.1242088.

45.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

46.

Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis.

Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH.

Dev Cell. 2012 Oct 16;23(4):796-811. doi: 10.1016/j.devcel.2012.09.003. Epub 2012 Oct 4.

47.

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.

Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF.

Genes Dev. 2012 Sep 15;26(18):2075-87. doi: 10.1101/gad.197020.112. Epub 2012 Aug 28.

48.

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.

Bauer DE, Kamran SC, Orkin SH.

Blood. 2012 Oct 11;120(15):2945-53. doi: 10.1182/blood-2012-06-292078. Epub 2012 Aug 17. Review.

49.

Clinicopathologic features and long-term outcomes of NUT midline carcinoma.

Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA.

Clin Cancer Res. 2012 Oct 15;18(20):5773-9. doi: 10.1158/1078-0432.CCR-12-1153. Epub 2012 Aug 15.

50.

The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism.

Bauer DE, Jackson JG, Genda EN, Montoya MM, Yudkoff M, Robinson MB.

Neurochem Int. 2012 Sep;61(4):566-74. doi: 10.1016/j.neuint.2012.01.013. Epub 2012 Jan 28.

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