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Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z.

Antioxidants (Basel). 2018 Mar 7;7(3). pii: E40. doi: 10.3390/antiox7030040.


Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate.

Tovmasyan A, Bueno-Janice JC, Jaramillo MC, Sampaio RS, Reboucas JS, Kyui N, Benov LT, Deng B, Huang TT, Tome M, Spasojevic I, Batinic-Haberle I.

Antioxid Redox Signal. 2018 Feb 1. doi: 10.1089/ars.2017.7218. [Epub ahead of print]


Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

Ghandhi SA, Turner HC, Shuryak I, Dugan GO, Bourland JD, Olson JD, Tooze JA, Morton SR, Batinic-Haberle I, Cline JM, Amundson SA.

PLoS One. 2018 Jan 19;13(1):e0191402. doi: 10.1371/journal.pone.0191402. eCollection 2018.


Post-illumination cellular effects of photodynamic treatment.

Charara M, Tovmasyan A, Batinic-Haberle I, Craik J, Benov L.

PLoS One. 2017 Dec 4;12(12):e0188535. doi: 10.1371/journal.pone.0188535. eCollection 2017.


Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency.

Moghnie S, Tovmasyan A, Craik J, Batinic-Haberle I, Benov L.

Photochem Photobiol Sci. 2017 Nov 8;16(11):1709-1716. doi: 10.1039/c7pp00143f.


Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Boss MK, Dewhirst MW, Sampaio RS, Bennett A, Tovmasyan A, Berman KG, Beaven AW, Rizzieri DA, Batinic-Haberle I, Hauck ML, Spasojevic I.

Cancer Chemother Pharmacol. 2017 Aug;80(2):421-431. doi: 10.1007/s00280-017-3372-z. Epub 2017 Jul 6.


Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Birer SR, Lee CT, Choudhury KR, Young KH, Spasojevic I, Batinic-Haberle I, Crapo JD, Dewhirst MW, Ashcraft KA.

Radiat Res. 2017 Jul;188(1):94-104. doi: 10.1667/RR14757.1.S1. Epub 2017 May 18.


CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

Leu D, Spasojevic I, Nguyen H, Deng B, Tovmasyan A, Weitner T, Sampaio RS, Batinic-Haberle I, Huang TT.

Redox Biol. 2017 Aug;12:864-871. doi: 10.1016/j.redox.2017.04.027. Epub 2017 Apr 22.


Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.

Shin SW, Choi C, Lee GH, Son A, Kim SH, Park HC, Batinic-Haberle I, Park W.

Antioxid Redox Signal. 2017 Nov 10;27(14):1067-1082. doi: 10.1089/ars.2016.6889. Epub 2017 Mar 30.


Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B.

Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017. Review.


A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.

Zhao Y, Carroll DW, You Y, Chaiswing L, Wen R, Batinic-Haberle I, Bondada S, Liang Y, St Clair DK.

Redox Biol. 2017 Aug;12:129-138. doi: 10.1016/j.redox.2017.02.005. Epub 2017 Feb 10.


Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.

Rajic Z, Tovmasyan A, de Santana OL, Peixoto IN, Spasojevic I, do Monte SA, Ventura E, Rebouças JS, Batinic-Haberle I.

J Inorg Biochem. 2017 Apr;169:50-60. doi: 10.1016/j.jinorgbio.2017.01.003. Epub 2017 Jan 5.


Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System.

Yin B, Barrionuevo G, Batinic-Haberle I, Sandberg M, Weber SG.

Antioxid Redox Signal. 2017 Sep 20;27(9):534-549. doi: 10.1089/ars.2016.6706. Epub 2017 Mar 7.


Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy.

Alenezi K, Tovmasyan A, Batinic-Haberle I, Benov LT.

Photodiagnosis Photodyn Ther. 2017 Mar;17:154-159. doi: 10.1016/j.pdpdt.2016.11.009. Epub 2016 Nov 22.


Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Weitzel DH, Tovmasyan A, Ashcraft KA, Boico A, Birer SR, Roy Choudhury K, Herndon J 2nd, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Environ Mol Mutagen. 2016 Jun;57(5):372-81. doi: 10.1002/em.22021. Epub 2016 May 25.


Important cellular targets for antimicrobial photodynamic therapy.

Awad MM, Tovmasyan A, Craik JD, Batinic-Haberle I, Benov LT.

Appl Microbiol Biotechnol. 2016 Sep;100(17):7679-88. doi: 10.1007/s00253-016-7632-3. Epub 2016 May 24.


Opinion on Schmidt et al.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Antioxid Redox Signal. 2016 Mar 20;24(9):518-24. doi: 10.1089/ars.2015.6623. No abstract available.


Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Latif AA, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St Clair DK.

Free Radic Biol Med. 2016 Feb;91:68-80. doi: 10.1016/j.freeradbiomed.2015.12.002. Epub 2015 Dec 9.


Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.

Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP, Castro M, Batinic-Haberle I, Fernandes AS, Oliveira NG.

Food Chem Toxicol. 2016 Jan;87:65-76. doi: 10.1016/j.fct.2015.11.018. Epub 2015 Dec 2.


Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Ashcraft KA, Boss MK, Tovmasyan A, Roy Choudhury K, Fontanella AN, Young KH, Palmer GM, Birer SR, Landon CD, Park W, Das SK, Weitner T, Sheng H, Warner DS, Brizel DM, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):892-900. doi: 10.1016/j.ijrobp.2015.07.2283. Epub 2015 Jul 29.


Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Dec;89:1231-47. doi: 10.1016/j.freeradbiomed.2015.10.416. Epub 2015 Oct 20.


Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Yulyana Y, Tovmasyan A, Ho IA, Sia KC, Newman JP, Ng WH, Guo CM, Hui KM, Batinic-Haberle I, Lam PY.

Stem Cell Rev. 2016 Feb;12(1):140-55. doi: 10.1007/s12015-015-9628-2.


A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

Tovmasyan A, Maia CG, Weitner T, Carballal S, Sampaio RS, Lieb D, Ghazaryan R, Ivanovic-Burmazovic I, Ferrer-Sueta G, Radi R, Reboucas JS, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Sep;86:308-21. doi: 10.1016/j.freeradbiomed.2015.05.018. Epub 2015 May 28.


Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.

Thomas M, Craik JD, Tovmasyan A, Batinic-Haberle I, Benov LT.

Future Microbiol. 2015;10(5):709-24. doi: 10.2217/fmb.14.148.


An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Redox Biol. 2015 Aug;5:43-65. doi: 10.1016/j.redox.2015.01.017. Epub 2015 Feb 7. Review. Erratum in: Redox Biol. 2015 Dec;6:656.


Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.

Jaramillo MC, Briehl MM, Batinic-Haberle I, Tome ME.

Free Radic Biol Med. 2015 Jun;83:89-100. doi: 10.1016/j.freeradbiomed.2015.01.031. Epub 2015 Feb 26.


Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.

Li AM, Martins J, Tovmasyan A, Valentine JS, Batinic-Haberle I, Spasojevic I, Gralla EB.

Redox Biol. 2014;3:1-6. doi: 10.1016/j.redox.2014.09.003. Epub 2014 Sep 18.


Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.

Tovmasyan A, Carballal S, Ghazaryan R, Melikyan L, Weitner T, Maia CG, Reboucas JS, Radi R, Spasojevic I, Benov L, Batinic-Haberle I.

Inorg Chem. 2014 Nov 3;53(21):11467-83. doi: 10.1021/ic501329p. Epub 2014 Oct 21.


Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Weitzel DH, Tovmasyan A, Ashcraft KA, Rajic Z, Weitner T, Liu C, Li W, Buckley AF, Prasad MR, Young KH, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Herndon JE 2nd, Batinic-Haberle I, Dewhirst MW.

Mol Cancer Ther. 2015 Jan;14(1):70-9. doi: 10.1158/1535-7163.MCT-14-0343. Epub 2014 Oct 15.


Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy.

Odeh AM, Craik JD, Ezzeddine R, Tovmasyan A, Batinic-Haberle I, Benov LT.

PLoS One. 2014 Sep 24;9(9):e108238. doi: 10.1371/journal.pone.0108238. eCollection 2014.


Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways.

Celic T, Španjol J, Bobinac M, Tovmasyan A, Vukelic I, Reboucas JS, Batinic-Haberle I, Bobinac D.

Free Radic Res. 2014 Dec;48(12):1426-42. doi: 10.3109/10715762.2014.960865. Epub 2014 Oct 10.


Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps.

Alvarez L, Suarez SA, Bikiel DE, Reboucas JS, Batinić-Haberle I, Martí MA, Doctorovich F.

Inorg Chem. 2014 Jul 21;53(14):7351-60. doi: 10.1021/ic5007082. Epub 2014 Jul 8.


Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.

Batinic-Haberle I, Spasojevic I.

Antioxid Redox Signal. 2014 May 20;20(15):2323-5. doi: 10.1089/ars.2014.5921.


Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.

Holley AK, Xu Y, Noel T, Bakthavatchalu V, Batinic-Haberle I, St Clair DK.

Antioxid Redox Signal. 2014 May 20;20(15):2347-60. doi: 10.1089/ars.2013.5204.


Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.

Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar SK, Cai J, Klein JB, Sultana R, Butterfield DA, Vore M, Batinic-Haberle I, Bondada S, St Clair DK.

Free Radic Biol Med. 2014 Jul;72:55-65. doi: 10.1016/j.freeradbiomed.2014.03.001. Epub 2014 Mar 12.


Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

Gauter-Fleckenstein B, Reboucas JS, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z.

Redox Biol. 2014 Jan 9;2:400-10. doi: 10.1016/j.redox.2013.12.017. eCollection 2014.


Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.

Archambeau JO, Tovmasyan A, Pearlstein RD, Crapo JD, Batinic-Haberle I.

Redox Biol. 2013 Oct 25;1:599-607. doi: 10.1016/j.redox.2013.10.002. eCollection 2013.


Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.

Evans MK, Tovmasyan A, Batinic-Haberle I, Devi GR.

Free Radic Biol Med. 2014 Mar;68:302-14. doi: 10.1016/j.freeradbiomed.2013.11.031. Epub 2013 Dec 12.


Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.

Ezzeddine R, Al-Banaw A, Tovmasyan A, Craik JD, Batinic-Haberle I, Benov LT.

J Biol Chem. 2013 Dec 20;288(51):36579-88. doi: 10.1074/jbc.M113.511642. Epub 2013 Nov 8.


Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications.

Ali DK, Oriowo M, Tovmasyan A, Batinic-Haberle I, Benov L.

Redox Biol. 2013 Sep 20;1:457-66. doi: 10.1016/j.redox.2013.09.005. eCollection 2013.


Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.

Bandarra S, Fernandes AS, Magro I, Guerreiro PS, Pingarilho M, Churchwell MI, Gil OM, Batinic-Haberle I, Gonçalves S, Rueff J, Miranda JP, Marques MM, Beland FA, Castro M, Gaspar JF, Oliveira NG.

Mutagenesis. 2013 Nov;28(6):721-9. doi: 10.1093/mutage/get052. Erratum in: Mutagenesis. 2014 Jan;29(1):97.


Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.

Weitner T, Kos I, Mandić Z, Batinić-Haberle I, Biruš M.

Dalton Trans. 2013 Oct 1;42(41):14757-65. doi: 10.1039/c3dt50767j.


SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

Batinic-Haberle I, Tovmasyan A, Roberts ER, Vujaskovic Z, Leong KW, Spasojevic I.

Antioxid Redox Signal. 2014 May 20;20(15):2372-415. doi: 10.1089/ars.2012.5147. Epub 2013 Oct 1. Review.


Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.

Jumbo-Lucioni PP, Ryan EL, Hopson ML, Bishop HM, Weitner T, Tovmasyan A, Spasojevic I, Batinic-Haberle I, Liang Y, Jones DP, Fridovich-Keil JL.

Antioxid Redox Signal. 2014 May 20;20(15):2361-71. doi: 10.1089/ars.2012.5122. Epub 2013 Jul 20.


Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

Delmastro-Greenwood MM, Votyakova T, Goetzman E, Marre ML, Previte DM, Tovmasyan A, Batinic-Haberle I, Trucco MM, Piganelli JD.

Antioxid Redox Signal. 2013 Dec 1;19(16):1902-15. doi: 10.1089/ars.2012.5167. Epub 2013 Jul 5.


Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

Tovmasyan A, Weitner T, Sheng H, Lu M, Rajic Z, Warner DS, Spasojevic I, Reboucas JS, Benov L, Batinic-Haberle I.

Inorg Chem. 2013 May 20;52(10):5677-91. doi: 10.1021/ic3012519. Epub 2013 May 6.


Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ regulated by their porphyrin ring substituents.

Aitken JB, Shearer EL, Giles NM, Lai B, Vogt S, Reboucas JS, Batinic-Haberle I, Lay PA, Giles GI.

Inorg Chem. 2013 Apr 15;52(8):4121-3. doi: 10.1021/ic300700g. Epub 2013 Apr 3.


Radiation induces aerobic glycolysis through reactive oxygen species.

Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, Batinic-Haberle I, Dewhirst MW.

Radiother Oncol. 2013 Mar;106(3):390-6. doi: 10.1016/j.radonc.2013.02.013. Epub 2013 Mar 28.


The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.

Lee K, Briehl MM, Mazar AP, Batinic-Haberle I, Reboucas JS, Glinsmann-Gibson B, Rimsza LM, Tome ME.

Free Radic Biol Med. 2013 Jul;60:157-67. doi: 10.1016/j.freeradbiomed.2013.02.003. Epub 2013 Feb 14.


Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

Weitner T, Kos I, Sheng H, Tovmasyan A, Reboucas JS, Fan P, Warner DS, Vujaskovic Z, Batinic-Haberle I, Spasojevic I.

Free Radic Biol Med. 2013 May;58:73-80. doi: 10.1016/j.freeradbiomed.2013.01.006. Epub 2013 Jan 15.

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