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Blood Pressure in Acute Stroke: To Treat or Not to Treat: That Is Still the Question.

Bath PM, Appleton JP, Krishnan K, Sprigg N.

Stroke. 2018 Jun 12. pii: STROKEAHA.118.021254. doi: 10.1161/STROKEAHA.118.021254. [Epub ahead of print] Review. No abstract available.


Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial.

Ovesen C, Jakobsen JC, Gluud C, Steiner T, Law Z, Flaherty K, Dineen RA, Bath PM, Sprigg N, Christensen H.

BMC Res Notes. 2018 Jun 13;11(1):379. doi: 10.1186/s13104-018-3481-8.


Does therapy with biofeedback improve swallowing in adults with dysphagia? A systematic review and meta-analysis.

Benfield JK, Everton LF, Bath PM, England TJ.

Arch Phys Med Rehabil. 2018 May 30. pii: S0003-9993(18)30322-8. doi: 10.1016/j.apmr.2018.04.031. [Epub ahead of print] Review.


Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Sprigg N, Flaherty K, Appleton JP, Salman RA, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators.

Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.


Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.

Sandset EC, Sanossian N, Woodhouse LJ, Anderson C, Berge E, Lees KR, Potter JF, Robinson TG, Sprigg N, Wardlaw JM, Bath PM; Blood pressure in Acute Stroke Collaboration Investigators.

Int J Stroke. 2018 Jan 1:1747493018772733. doi: 10.1177/1747493018772733. [Epub ahead of print]


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.


Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial.

Minhas JS, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Donnan GA, Kim JS, Lavados PM, Lee TH, Martins SCO, Olavarría VV, Pandian JD, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Thang NH, Wang JG, Woodward M, Chalmers J, Anderson CS, Robinson TG; ENCHANTED Investigators.

Cerebrovasc Dis. 2018 Apr 27;45(5-6):213-220. doi: 10.1159/000488911. [Epub ahead of print]


Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders.

Bath PM, May J, Heptinstall S.

Platelets. 2018 Jul;29(5):425-430. doi: 10.1080/09537104.2018.1445839. Epub 2018 Apr 18.


Haemostatic therapies for acute spontaneous intracerebral haemorrhage.

Al-Shahi Salman R, Law ZK, Bath PM, Steiner T, Sprigg N.

Cochrane Database Syst Rev. 2018 Apr 17;4:CD005951. doi: 10.1002/14651858.CD005951.pub4. Review.


Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial.

Dineen RA, Pszczolkowski S, Flaherty K, Law ZK, Morgan PS, Roberts I, Werring DJ, Salman RA, England T, Bath PM, Sprigg N.

BMJ Open. 2018 Feb 3;8(2):e019930. doi: 10.1136/bmjopen-2017-019930. Erratum in: BMJ Open. 2018 Apr 20;8(4):e019930corr1.


Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke.

Hilkens NA, Algra A, Kappelle LJ, Bath PM, Csiba L, Rothwell PM, Greving JP; CAT Collaboration.

Neurology. 2018 Feb 20;90(8):e683-e689. doi: 10.1212/WNL.0000000000004997. Epub 2018 Jan 26.


Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; TARDIS Investigators.

Lancet. 2018 Mar 3;391(10123):850-859. doi: 10.1016/S0140-6736(17)32849-0. Epub 2017 Dec 20.


Statistical analysis plan for the 'Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage' (TICH-2) trial.

Flaherty K, Bath PM, Dineen R, Law Z, Scutt P, Pocock S, Sprigg N; TICH-2 investigators.

Trials. 2017 Dec 20;18(1):607. doi: 10.1186/s13063-017-2341-5.


Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.

Winkel P, Bath PM, Gluud C, Lindschou J, van der Worp HB, Macleod MR, Szabo I, Durand-Zaleski I, Schwab S; EuroHYP-1 trial investigators.

Trials. 2017 Nov 29;18(1):573. doi: 10.1186/s13063-017-2302-z.


Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial.

Krishnan K, Beishon L, Berge E, Christensen H, Dineen RA, Ozturk S, Sprigg N, Wardlaw JM, Bath PM; VISTA-ICH collaboration and ENOS Investigators.

Int J Stroke. 2018 Jun;13(4):362-373. doi: 10.1177/1747493017744463. Epub 2017 Nov 22.


Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke: Secondary Analysis of the ENCHANTED Randomized Clinical Trial.

Wang X, Robinson TG, Lee TH, Li Q, Arima H, Bath PM, Billot L, Broderick J, Demchuk AM, Donnan G, Kim JS, Lavados P, Lindley RI, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sharma VK, Thang NH, Wang JG, Woodward M, Anderson CS, Chalmers J; Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Investigators.

JAMA Neurol. 2017 Nov 1;74(11):1328-1335. doi: 10.1001/jamaneurol.2017.2286.


Cerebral misery perfusion due to carotid occlusive disease.

Maddula M, Sprigg N, Bath PM, Munshi S.

Stroke Vasc Neurol. 2017 May 18;2(2):88-93. doi: 10.1136/svn-2017-000067. eCollection 2017 Jun. Review.


Assessment of consent models as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review.

Armstrong S, Langlois A, Laparidou D, Dixon M, Appleton JP, Bath PM, Snooks H, Siriwardena AN.

BMC Med Res Methodol. 2017 Sep 16;17(1):142. doi: 10.1186/s12874-017-0423-4.


Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.

Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):530-538. doi: 10.1177/1747493017731947. Epub 2017 Sep 14.


Validating and comparing stroke prognosis scales.

Quinn TJ, Singh S, Lees KR, Bath PM, Myint PK; VISTA Collaborators.

Neurology. 2017 Sep 5;89(10):997-1002. doi: 10.1212/WNL.0000000000004332. Epub 2017 Aug 9.


Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.

Woodhouse LJ, Scutt P, Hamdy S, Smithard DG, Cohen DL, Roffe C, Bereczki D, Berge E, Bladin CF, Caso V, Christensen HK, Collins R, Czlonkowska A, de Silva A, Etribi A, Laska AC, Ntaios G, Ozturk S, Phillips SJ, Prasad K, Szatmari S, Sprigg N, Bath PM.

Transl Stroke Res. 2018 Apr;9(2):120-129. doi: 10.1007/s12975-017-0548-0. Epub 2017 Aug 2.


Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S2TOP-BLEED.

Hilkens NA, Algra A, Diener HC, Reitsma JB, Bath PM, Csiba L, Hacke W, Kappelle LJ, Koudstaal PJ, Leys D, Mas JL, Sacco RL, Amarenco P, Sissani L, Greving JP; Cerebrovascular Antiplatelet Trialists' Collaborative Group.

Neurology. 2017 Aug 29;89(9):936-943. doi: 10.1212/WNL.0000000000004289. Epub 2017 Aug 2.


Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).

Appleton JP, Scutt P, Dixon M, Howard H, Haywood L, Havard D, Hepburn T, England T, Sprigg N, Woodhouse LJ, Wardlaw JM, Montgomery AA, Pocock S, Bath PM; RIGHT-2 Investigators.

Int J Stroke. 2017 Jan 1:1747493017724627. doi: 10.1177/1747493017724627. [Epub ahead of print]


Infections Up to 76 Days After Stroke Increase Disability and Death.

Learoyd AE, Woodhouse L, Shaw L, Sprigg N, Bereczki D, Berge E, Caso V, Christensen H, Collins R, Czlonkowska A, El Etribi A, Farr TD, Gommans J, Laska AC, Ntaios G, Ozturk S, Pocock SJ, Prasad K, Wardlaw JM, Fone KC, Bath PM, Trueman RC; ENOS Trial investigators.

Transl Stroke Res. 2017 Dec;8(6):541-548. doi: 10.1007/s12975-017-0553-3. Epub 2017 Jul 27.


Hypercholesterolaemia and vascular dementia.

Appleton JP, Scutt P, Sprigg N, Bath PM.

Clin Sci (Lond). 2017 Jun 30;131(14):1561-1578. doi: 10.1042/CS20160382. Print 2017 Jul 15. Review.


Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack.

Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, Heptinstall S, Investigators T.

Stroke Res Treat. 2017;2017:7365684. doi: 10.1155/2017/7365684. Epub 2017 May 24.


Low- Versus Standard-Dose Alteplase in Patients on Prior Antiplatelet Therapy: The ENCHANTED Trial (Enhanced Control of Hypertension and Thrombolysis Stroke Study).

Robinson TG, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Demchuk AM, Donnan GA, Kim JS, Lavados PM, Lee TH, Lindley RI, Martins SCO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Nguyen TH, Wang JG, Woodward M, Chalmers J, Anderson CS; ENCHANTED Investigators.

Stroke. 2017 Jul;48(7):1877-1883. doi: 10.1161/STROKEAHA.116.016274. Epub 2017 Jun 15.


Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England.

Ban L, Sprigg N, Abdul Sultan A, Nelson-Piercy C, Bath PM, Ludvigsson JF, Stephansson O, Tata LJ.

J Am Heart Assoc. 2017 Apr 21;6(4). pii: e004601. doi: 10.1161/JAHA.116.004601.


Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.

Bath PM, Krishnan K, Appleton JP.

Cochrane Database Syst Rev. 2017 Apr 21;4:CD000398. doi: 10.1002/14651858.CD000398.pub2. Review.


Management of acute intracerebral haemorrhage - an update.

Law ZK, Appleton JP, Bath PM, Sprigg N.

Clin Med (Lond). 2017 Apr;17(2):166-172. doi: 10.7861/clinmedicine.17-2-166.


Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study.

Mazlan-Kepli W, Macisaac RL, Walters M, Bath PMW, Dawson J; VISTA Collaborators.

Br J Clin Pharmacol. 2017 Sep;83(9):2045-2055. doi: 10.1111/bcp.13290. Epub 2017 Apr 20.


RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke.

England TJ, Hedstrom A, O'Sullivan S, Donnelly R, Barrett DA, Sarmad S, Sprigg N, Bath PM.

Stroke. 2017 May;48(5):1412-1415. doi: 10.1161/STROKEAHA.116.016429. Epub 2017 Mar 6.


Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute Stroke: An Individual Patient Data Meta-Analysis.

Woodhouse LJ, Manning L, Potter JF, Berge E, Sprigg N, Wardlaw J, Lees KR, Bath PM, Robinson TG; Blood Pressure in Acute Stroke Collaboration.

Hypertension. 2017 May;69(5):933-941. doi: 10.1161/HYPERTENSIONAHA.116.07982. Epub 2017 Mar 6.


Understanding the relationship between costs and the modified Rankin Scale: A systematic review, multidisciplinary consensus and recommendations for future studies.

Wilson A, Bath PM, Berge E, Cadilhac DA, Cuche M, Ford GA, Macisaac R, Quinn TJ, Taylor M, Walters M, Wolff C, Lees KR; for the ESO-VISTA Health Economics Working Group.

Eur Stroke J. 2017 Mar;2(1):3-12. doi: 10.1177/2396987316684705. Epub 2016 Dec 22.


Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy.

Hosseini AA, Simpson RJ, Altaf N, Bath PM, MacSweeney ST, Auer DP.

Stroke. 2017 Mar;48(3):678-685. doi: 10.1161/STROKEAHA.116.015504. Epub 2017 Feb 14.


Investigating the effect of independent, blinded digital image assessment on the STOP GAP trial.

Patsko E, Godolphin PJ, Thomas KS, Hepburn T, Mitchell EJ, Craig FE, Bath PM, Montgomery AA.

Trials. 2017 Feb 2;18(1):53. doi: 10.1186/s13063-017-1779-9.


Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial.

Bath PM, Scutt P, Blackburn DJ, Ankolekar S, Krishnan K, Ballard C, Burns A, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw JM, Ford GA; PODCAST Trial Investigators.

PLoS One. 2017 Jan 17;12(1):e0164608. doi: 10.1371/journal.pone.0164608. eCollection 2017.


Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke.

Appleton JP, Sprigg N, Bath PM.

CNS Drugs. 2017 Jan;31(1):1-9. doi: 10.1007/s40263-016-0387-7. Review.


Granulocyte-Colony Stimulating Factor (G-CSF) for stroke: an individual patient data meta-analysis.

England TJ, Sprigg N, Alasheev AM, Belkin AA, Kumar A, Prasad K, Bath PM.

Sci Rep. 2016 Nov 15;6:36567. doi: 10.1038/srep36567. Review.


Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial.

Bath PM, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Heptinstall S, James M, Krishnan K, Markus HS, Pocock S, Ranta A, Robinson TG, Flaherty K, Scutt P, Venables GS, Woodhouse LJ, Sprigg N.

Int J Stroke. 2017 Jul;12(5):524-538. doi: 10.1177/1747493016677988. Epub 2016 Nov 4.


Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study.

Dziewas R, Mistry S, Hamdy S, Minnerup J, Van Der Tweel I, Schäbitz W, Bath PM; PHAST-TRAC Investigators.

Int J Stroke. 2017 Jun;12(4):430-437. doi: 10.1177/1747493016676618. Epub 2016 Nov 2.


Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730).

Sprigg N, O'Connor R, Woodhouse L, Krishnan K, England TJ, Connell LA, Walker MF, Bath PM.

PLoS One. 2016 Sep 9;11(9):e0161359. doi: 10.1371/journal.pone.0161359. eCollection 2016.


Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients - results from VISTA.

Nolte CH, Erdur H, Grittner U, Schneider A, Piper SK, Scheitz JF, Wellwood I, Bath PM, Diener HC, Lees KR, Endres M; VISTA collaborators.

Eur J Neurol. 2016 Dec;23(12):1750-1756. doi: 10.1111/ene.13115. Epub 2016 Aug 12.


Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study.

Kalladka D, Sinden J, Pollock K, Haig C, McLean J, Smith W, McConnachie A, Santosh C, Bath PM, Dunn L, Muir KW.

Lancet. 2016 Aug 20;388(10046):787-96. doi: 10.1016/S0140-6736(16)30513-X. Epub 2016 Aug 3.


William M. Feinberg Award for Excellence in Clinical Stroke: High Explosive Treatment for Ultra-Acute Stroke: Hype of Hope.

Bath PM.

Stroke. 2016 Sep;47(9):2423-6. doi: 10.1161/STROKEAHA.116.013243. Epub 2016 Jul 21. Review. No abstract available.


The Insulin Resistance Intervention after Stroke trial: A perspective on future practice and research.

Bath PM, Appleton JP, Sprigg N.

Int J Stroke. 2016 Oct;11(7):741-3. doi: 10.1177/1747493016660099. Epub 2016 Jul 12.


Blood pressure management in acute stroke.

Appleton JP, Sprigg N, Bath PM.

Stroke Vasc Neurol. 2016 Jun 24;1(2):72-82. doi: 10.1136/svn-2016-000020. eCollection 2016 Jun. Review.


Early blood pressure lowering treatment in acute stroke. Ordinal analysis of vascular events in the Scandinavian Candesartan Acute Stroke Trial (SCAST).

Jusufovic M, Sandset EC, Bath PM, Berge E; Scandinavian Candesartan Acute Stroke Trial (SCAST) Study Group.

J Hypertens. 2016 Aug;34(8):1594-8. doi: 10.1097/HJH.0000000000000980.


Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials.

Bath PM, Woodhouse L, Krishnan K, Anderson C, Berge E, Ford GA, Robinson TG, Saver JL, Sprigg N, Wardlaw JM, In Acute Stroke Collaboration Basc BP.

Stroke Res Treat. 2016;2016:9706720. doi: 10.1155/2016/9706720. Epub 2016 Apr 17.

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