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Items: 1 to 50 of 98

1.

Calcium - Induced Differentiation of Human Colon Adenomas In Colonoid Culture: Calcium alone versus calcium with additional trace elements.

McClintock SD, Colacino JA, Attili D, Dame MK, Richter A, Reddy A, Basrur V, Rizvi AH, Turgeon DK, Varani J, Aslam MN.

Cancer Prev Res (Phila). 2018 Apr 10. pii: canprevres.0308.2017. doi: 10.1158/1940-6207.CAPR-17-0308. [Epub ahead of print]

PMID:
29636350
2.

A novel reporter for real-time, quantitative imaging of AKT-directed K63-poly-ubiquitination in living cells.

Nyati S, Chaudhry N, Chatur A, Gregg BS, Kimmel L, Khare D, Basrur V, Ray D, Rehemtulla A.

Oncotarget. 2018 Jan 25;9(13):11083-11099. doi: 10.18632/oncotarget.24323. eCollection 2018 Feb 16.

3.

The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling.

Hawkins AG, Basrur V, da Veiga Leprevost F, Pedersen E, Sperring C, Nesvizhskii AI, Lawlor ER.

Mol Cell Proteomics. 2018 Jan 31. pii: mcp.RA118.000596. doi: 10.1074/mcp.RA118.000596. [Epub ahead of print]

4.

A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment.

Awasthi A, Rolland DCM, Ayello J, van de Ven C, Basrur V, Conlon K, Fermin D, Barth MJ, Klein C, Elenitoba-Johnson KSJ, Lim MS, Cairo MS.

Oncotarget. 2017 Dec 9;8(69):113895-113909. doi: 10.18632/oncotarget.23040. eCollection 2017 Dec 26.

5.

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF.

EMBO J. 2017 Nov 2;36(21):3232-3249. doi: 10.15252/embj.201796525. Epub 2017 Oct 13.

6.

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

Brady GF, Kwan R, Ulintz PJ, Nguyen P, Bassirian S, Basrur V, Nesvizhskii AI, Loomba R, Omary MB.

Hepatology. 2018 May;67(5):1710-1725. doi: 10.1002/hep.29522. Epub 2018 Mar 24.

PMID:
28902428
7.

IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.

Paul J, Singh AK, Kathania M, Elviche TL, Zeng M, Basrur V, Theiss AL, Venuprasad K.

Mucosal Immunol. 2017 Jun 14. doi: 10.1038/mi.2017.53. [Epub ahead of print]

PMID:
28612841
8.

Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas.

Rolland DCM, Basrur V, Jeon YK, McNeil-Schwalm C, Fermin D, Conlon KP, Zhou Y, Ng SY, Tsou CC, Brown NA, Thomas DG, Bailey NG, Omenn GS, Nesvizhskii AI, Root DE, Weinstock DM, Faryabi RB, Lim MS, Elenitoba-Johnson KSJ.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6581-6586. doi: 10.1073/pnas.1701263114. Epub 2017 Jun 12.

9.

Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.

Hwang SR, Murga-Zamalloa C, Brown N, Basappa J, McDonnell SR, Mendoza-Reinoso V, Basrur V, Wilcox R, Elenitoba-Johnson K, Lim MS.

Lab Invest. 2017 Aug;97(8):962-970. doi: 10.1038/labinvest.2017.39. Epub 2017 Apr 17.

PMID:
28414323
10.

Corrigendum: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani RS, Yocum A, Nyati MK, Castilho RM, Varambally S, Chinnaiyan AM, D'Silva NJ.

Nat Commun. 2016 Feb 24;7:10726. doi: 10.1038/ncomms10726. No abstract available.

11.

Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.

Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL.

J Biol Chem. 2016 Feb 5;291(6):3030-42. doi: 10.1074/jbc.M115.676601. Epub 2015 Nov 24.

12.

Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress.

Maitra D, Elenbaas JS, Whitesall SE, Basrur V, D'Alecy LG, Omary MB.

J Biol Chem. 2015 Sep 25;290(39):23711-24. doi: 10.1074/jbc.M114.636001. Epub 2015 Jul 23.

13.

The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1.

Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, Pascual V, Wei WZ, Massoumi R, Venuprasad K.

Sci Signal. 2015 Feb 24;8(365):ra22. doi: 10.1126/scisignal.2005903.

PMID:
25714464
14.

Differential proteomic analysis of endemic and sporadic Epstein-Barr virus-positive and negative Burkitt lymphoma.

El-Mallawany NK, Day N, Ayello J, Van de Ven C, Conlon K, Fermin D, Basrur V, Elenitoba-Johnson K, Lim M, Cairo MS.

Eur J Cancer. 2015 Jan;51(1):92-100. doi: 10.1016/j.ejca.2014.10.017. Epub 2014 Nov 6.

PMID:
25466511
15.

Intrinsic disorder drives N-terminal ubiquitination by Ube2w.

Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE.

Nat Chem Biol. 2015 Jan;11(1):83-9. doi: 10.1038/nchembio.1700. Epub 2014 Dec 1.

16.

Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin.

Joe B, Nagaraju A, Gowda LR, Basrur V, Lokesh BR.

PLoS One. 2014 Oct 9;9(10):e107565. doi: 10.1371/journal.pone.0107565. eCollection 2014.

17.

Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.

Chung FZ, Sahasrabuddhe AA, Ma K, Chen X, Basrur V, Lim MS, Elenitoba-Johnson KS.

J Biol Chem. 2014 Oct 10;289(41):28448-59. doi: 10.1074/jbc.M114.561241. Epub 2014 Aug 20.

18.

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani RS, Yocum A, Nyati MK, Castilho RM, Varambally S, Chinnaiyan AM, D'Silva NJ.

Nat Commun. 2014 Jul 31;5:4527. doi: 10.1038/ncomms5527. Erratum in: Nat Commun. 2016;7:10726.

19.

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.

Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, Pagano M, Lim MS, Elenitoba-Johnson KS.

Cell Death Differ. 2014 Oct;21(10):1535-45. doi: 10.1038/cdd.2014.92. Epub 2014 Jul 4.

20.

KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.

Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D.

Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184.

21.

Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas.

Rolland D, Basrur V, Conlon K, Wolfe T, Fermin D, Nesvizhskii AI, Lim MS, Elenitoba-Johnson KS.

Am J Pathol. 2014 May;184(5):1331-42. doi: 10.1016/j.ajpath.2014.01.036. Epub 2014 Mar 22.

22.

Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction.

Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J.

J Biol Chem. 2013 Nov 22;288(47):34249-58. doi: 10.1074/jbc.M113.461020. Epub 2013 Oct 11.

23.

Fusion peptides from oncogenic chimeric proteins as putative specific biomarkers of cancer.

Conlon KP, Basrur V, Rolland D, Wolfe T, Nesvizhskii AI, MacCoss MJ, Lim MS, Elenitoba-Johnson KS.

Mol Cell Proteomics. 2013 Oct;12(10):2714-23. doi: 10.1074/mcp.M113.029926. Epub 2013 Jul 8.

24.

Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.

Chiruvella KK, Liang Z, Birkeland SR, Basrur V, Wilson TE.

PLoS Genet. 2013 Jun;9(6):e1003599. doi: 10.1371/journal.pgen.1003599. Epub 2013 Jun 27.

25.

Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.

McDonnell SR, Hwang SR, Rolland D, Murga-Zamalloa C, Basrur V, Conlon KP, Fermin D, Wolfe T, Raskind A, Ruan C, Jiang JK, Thomas CJ, Hogaboam CM, Burant CF, Elenitoba-Johnson KS, Lim MS.

Blood. 2013 Aug 8;122(6):958-68. doi: 10.1182/blood-2013-01-482026. Epub 2013 Jun 27.

26.

The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.

Scaglione KM, Basrur V, Ashraf NS, Konen JR, Elenitoba-Johnson KS, Todi SV, Paulson HL.

J Biol Chem. 2013 Jun 28;288(26):18784-8. doi: 10.1074/jbc.C113.477596. Epub 2013 May 21.

27.

CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome.

Todd PK, Oh SY, Krans A, He F, Sellier C, Frazer M, Renoux AJ, Chen KC, Scaglione KM, Basrur V, Elenitoba-Johnson K, Vonsattel JP, Louis ED, Sutton MA, Taylor JP, Mills RE, Charlet-Berguerand N, Paulson HL.

Neuron. 2013 May 8;78(3):440-55. doi: 10.1016/j.neuron.2013.03.026. Epub 2013 Apr 18. Erratum in: Neuron. 2013 Jul 24;79(2):402.

28.

Synergistic gelation of silica nanoparticles and a sorbitol-based molecular gelator to yield highly-conductive free-standing gel electrolytes.

Basrur VR, Guo J, Wang C, Raghavan SR.

ACS Appl Mater Interfaces. 2013 Jan 23;5(2):262-7. doi: 10.1021/am301920r. Epub 2013 Jan 7.

PMID:
23294020
29.

MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC.

Min DJ, Ezponda T, Kim MK, Will CM, Martinez-Garcia E, Popovic R, Basrur V, Elenitoba-Johnson KS, Licht JD.

Leukemia. 2013 Mar;27(3):686-94. doi: 10.1038/leu.2012.269. Epub 2012 Sep 13.

30.

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS, Pagano M.

Nat Cell Biol. 2012 Mar 4;14(4):375-85. doi: 10.1038/ncb2463.

31.

Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).

Popovych N, Brender JR, Soong R, Vivekanandan S, Hartman K, Basrur V, Macdonald PM, Ramamoorthy A.

J Phys Chem B. 2012 Mar 22;116(11):3650-8. doi: 10.1021/jp2121577. Epub 2012 Mar 7.

32.

NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis.

McDonnell SR, Hwang SR, Basrur V, Conlon KP, Fermin D, Wey E, Murga-Zamalloa C, Zeng Z, Zu Y, Elenitoba-Johnson KS, Lim MS.

Oncogene. 2012 Aug 9;31(32):3733-40. doi: 10.1038/onc.2011.542. Epub 2011 Dec 19.

33.

Urine glycoprotein profile reveals novel markers for chronic kidney disease.

Vivekanandan-Giri A, Slocum JL, Buller CL, Basrur V, Ju W, Pop-Busui R, Lubman DM, Kretzler M, Pennathur S.

Int J Proteomics. 2011;2011:214715. doi: 10.1155/2011/214715. Epub 2011 Oct 10.

34.

Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes.

Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE.

J Biol Chem. 2011 Nov 25;286(47):40486-93. doi: 10.1074/jbc.M111.284448. Epub 2011 Oct 3.

35.

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KS, Allis CD, Roeder RG.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15751-6. doi: 10.1073/pnas.1111498108. Epub 2011 Sep 6.

36.

Isolation and characterization of BetaM protein encoded by ATP1B4--a unique member of the Na,K-ATPase β-subunit gene family.

Pestov NB, Zhao H, Basrur V, Modyanov NN.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):543-8. doi: 10.1016/j.bbrc.2011.07.112. Epub 2011 Aug 10.

PMID:
21855530
37.

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.

Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Cao X, Mehra R, Sabolch A, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KS, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM.

Cancer Cell. 2011 May 17;19(5):664-78. doi: 10.1016/j.ccr.2011.04.010. Erratum in: Cancer Cell. 2013 Apr 15;23(4):557.

38.

Abacus: a computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis.

Fermin D, Basrur V, Yocum AK, Nesvizhskii AI.

Proteomics. 2011 Apr;11(7):1340-5. doi: 10.1002/pmic.201000650. Epub 2011 Feb 17.

39.

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y.

PLoS One. 2010 Nov 23;5(11):e14102. doi: 10.1371/journal.pone.0014102.

40.

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.

Todi SV, Scaglione KM, Blount JR, Basrur V, Conlon KP, Pastore A, Elenitoba-Johnson K, Paulson HL.

J Biol Chem. 2010 Dec 10;285(50):39303-13. doi: 10.1074/jbc.M110.181610. Epub 2010 Oct 13.

41.

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.

Monroe SC, Jo SY, Sanders DS, Basrur V, Elenitoba-Johnson KS, Slany RK, Hess JL.

Exp Hematol. 2011 Jan;39(1):77-86.e1-5. doi: 10.1016/j.exphem.2010.09.003. Epub 2010 Sep 18.

42.

A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis.

Maine GN, Li H, Zaidi IW, Basrur V, Elenitoba-Johnson KS, Burstein E.

Nat Protoc. 2010 Aug;5(8):1447-59. doi: 10.1038/nprot.2010.109. Epub 2010 Jul 22.

PMID:
20671728
43.

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.

Muntean AG, Tan J, Sitwala K, Huang Y, Bronstein J, Connelly JA, Basrur V, Elenitoba-Johnson KS, Hess JL.

Cancer Cell. 2010 Jun 15;17(6):609-21. doi: 10.1016/j.ccr.2010.04.012.

44.

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

Milne TA, Kim J, Wang GG, Stadler SC, Basrur V, Whitcomb SJ, Wang Z, Ruthenburg AJ, Elenitoba-Johnson KS, Roeder RG, Allis CD.

Mol Cell. 2010 Jun 25;38(6):853-63. doi: 10.1016/j.molcel.2010.05.011. Epub 2010 Jun 10.

45.

Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.

Brady GF, Galbán S, Liu X, Basrur V, Gitlin JD, Elenitoba-Johnson KS, Wilson TE, Duckett CS.

Mol Cell Biol. 2010 Apr;30(8):1923-36. doi: 10.1128/MCB.00900-09. Epub 2010 Feb 12.

46.

The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis.

Rajesh C, Gruver AM, Basrur V, Pittman DL.

Proteomics. 2009 Aug;9(16):4071-86. doi: 10.1002/pmic.200800977.

47.

Regulation of folate receptor internalization by protein kinase C alpha.

Elnakat H, Gonit M, Salazar MD, Zhang J, Basrur V, Gunning W, Kamen B, Ratnam M.

Biochemistry. 2009 Sep 1;48(34):8249-60. doi: 10.1021/bi900565t.

PMID:
19639961
48.

VLHL plasminogen activator inhibitor spontaneously reactivates from the latent to active form.

Jankun J, Aleem AM, Selman SH, Basrur V, Skrzypczak-Jankun E.

Int J Mol Med. 2009 Jan;23(1):57-63.

PMID:
19082507
49.

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.

Frescas D, Guardavaccaro D, Kuchay SM, Kato H, Poleshko A, Basrur V, Elenitoba-Johnson KS, Katz RA, Pagano M.

Cell Cycle. 2008 Nov 15;7(22):3539-47. Epub 2008 Nov 24.

50.

Conformational analysis of an alpha3beta1 integrin-binding peptide from thrombospondin-1: implications for antiangiogenic drug design.

Furrer J, Luy B, Basrur V, Roberts DD, Barchi JJ Jr.

J Med Chem. 2006 Oct 19;49(21):6324-33.

PMID:
17034138

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