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Items: 30


Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.


Cancer Evolution: No Room for Negative Selection.

Bakhoum SF, Landau DA.

Cell. 2017 Nov 16;171(5):987-989. doi: 10.1016/j.cell.2017.10.039.


Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.

Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H.

Trends Cancer. 2017 Mar;3(3):225-234. doi: 10.1016/j.trecan.2017.02.001. Epub 2017 Feb 28. Review.


Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution.

Bakhoum SF, Landau DA.

Cold Spring Harb Perspect Med. 2017 Jun 1;7(6). pii: a029611. doi: 10.1101/cshperspect.a029611. Review.


Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.

Laughney AM, Elizalde S, Genovese G, Bakhoum SF.

Cell Rep. 2015 Aug 4;12(5):809-20. doi: 10.1016/j.celrep.2015.06.065. Epub 2015 Jul 23.


Numerical chromosomal instability mediates susceptibility to radiation treatment.

Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA.

Nat Commun. 2015 Jan 21;6:5990. doi: 10.1038/ncomms6990.


Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.

Genovese G, Kähler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landén M, Höglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Grönberg H, Hultman CM, McCarroll SA.

N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26.


DNA-damage response during mitosis induces whole-chromosome missegregation.

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA.

Cancer Discov. 2014 Nov;4(11):1281-9. doi: 10.1158/2159-8290.CD-14-0403. Epub 2014 Aug 8.


Chromosomal instability, aneuploidy, and cancer.

Bakhoum SF, Swanton C.

Front Oncol. 2014 Jun 19;4:161. doi: 10.3389/fonc.2014.00161. eCollection 2014. No abstract available.


Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy.

Zaki BI, Suriawinata AA, Eastman AR, Garner KM, Bakhoum SF.

Cancer. 2014 Jun 1;120(11):1733-42. doi: 10.1002/cncr.28656. Epub 2014 Mar 6.


The mitotic origin of chromosomal instability.

Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D.

Curr Biol. 2014 Feb 17;24(4):R148-9. doi: 10.1016/j.cub.2014.01.019. No abstract available.


A predictive model of complications after spine surgery: the National Surgical Quality Improvement Program (NSQIP) 2005-2010.

Bekelis K, Desai A, Bakhoum SF, Missios S.

Spine J. 2014 Jul 1;14(7):1247-55. doi: 10.1016/j.spinee.2013.08.009. Epub 2013 Oct 4.


Outcome prediction in intracranial tumor surgery: the National Surgical Quality Improvement Program 2005-2010.

Bekelis K, Bakhoum SF, Desai A, Mackenzie TA, Roberts DW.

J Neurooncol. 2013 May;113(1):57-64. doi: 10.1007/s11060-013-1089-3. Epub 2013 Feb 24.


A risk factor-based predictive model of outcomes in carotid endarterectomy: the National Surgical Quality Improvement Program 2005-2010.

Bekelis K, Bakhoum SF, Desai A, Mackenzie TA, Goodney P, Labropoulos N.

Stroke. 2013 Apr;44(4):1085-1090. doi: 10.1161/STROKEAHA.111.674358. Epub 2013 Feb 14.


Chromosomal instability and cancer: a complex relationship with therapeutic potential.

Bakhoum SF, Compton DA.

J Clin Invest. 2012 Apr;122(4):1138-43. doi: 10.1172/JCI59954. Epub 2012 Apr 2. Review.


Kinetochores and disease: keeping microtubule dynamics in check!

Bakhoum SF, Compton DA.

Curr Opin Cell Biol. 2012 Feb;24(1):64-70. doi: 10.1016/ Epub 2011 Dec 21. Review.


Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.

Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA.

Clin Cancer Res. 2011 Dec 15;17(24):7704-11. doi: 10.1158/1078-0432.CCR-11-2049.


CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.

Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA.

EMBO J. 2010 Oct 20;29(20):3531-43. doi: 10.1038/emboj.2010.230. Epub 2010 Sep 17.


Mechanisms of chromosomal instability.

Thompson SL, Bakhoum SF, Compton DA.

Curr Biol. 2010 Mar 23;20(6):R285-95. doi: 10.1016/j.cub.2010.01.034. Review.


Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells.

Kollu S, Bakhoum SF, Compton DA.

Curr Biol. 2009 Dec 29;19(24):2108-13. doi: 10.1016/j.cub.2009.10.056.


Deviant kinetochore microtubule dynamics underlie chromosomal instability.

Bakhoum SF, Genovese G, Compton DA.

Curr Biol. 2009 Dec 1;19(22):1937-42. doi: 10.1016/j.cub.2009.09.055. Epub 2009 Oct 29.


Cancer: CINful centrosomes.

Bakhoum SF, Compton DA.

Curr Biol. 2009 Aug 11;19(15):R642-5. doi: 10.1016/j.cub.2009.06.039. Review.


Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.

Bakhoum SF, Thompson SL, Manning AL, Compton DA.

Nat Cell Biol. 2009 Jan;11(1):27-35. doi: 10.1038/ncb1809. Epub 2008 Dec 7.


Ion-induced nucleation in solution: promotion of solute nucleation in charged levitated droplets.

Draper ND, Bakhoum SF, Haddrell AE, Agnes GR.

J Am Chem Soc. 2007 Sep 19;129(37):11364-77. Epub 2007 Aug 24.


The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA.

Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30.


Bench-to-bedside solution to funding problems.

Bakhoum SF.

Nature. 2006 Oct 5;443(7111):506. No abstract available.


Convergent evolution of clamp-like binding sites in diverse chaperones.

Stirling PC, Bakhoum SF, Feigl AB, Leroux MR.

Nat Struct Mol Biol. 2006 Oct;13(10):865-70. Review.


Archiving and absolute quantitation of solutes separated by single charged droplet coulomb explosion.

Bakhoum SF, Bogan MJ, Agnes GR.

Anal Chem. 2005 Jun 1;77(11):3461-5.


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