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The enigma of rotator cuff tears and the case for uncertainty.

Littlewood C, Rangan A, Beard DJ, Wade J, Cookson T, Foster NE.

Br J Sports Med. 2018 Apr 12. pii: bjsports-2018-099063. doi: 10.1136/bjsports-2018-099063. [Epub ahead of print] No abstract available.


An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded RCT recruitment.

Jepson M, Elliott D, Conefrey C, Wade J, Rooshenas L, Wilson C, Beard D, Blazeby JM, Birtle A, Halliday A, Stein R, Donovan JL; CSAW study group; Chemorad study group; POUT study group; ACST-2 study group; Optima prelim study group.

J Clin Epidemiol. 2018 Mar 2. pii: S0895-4356(17)31278-7. doi: 10.1016/j.jclinepi.2018.02.018. [Epub ahead of print]


Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats.

Moxley MA, Vinnakota KC, Bazil JN, Qi NR, Beard DA.

PLoS Comput Biol. 2018 Feb 23;14(2):e1005982. doi: 10.1371/journal.pcbi.1005982. eCollection 2018 Feb.


Blinding in trials of interventional procedures is possible and worthwhile.

Wartolowska K, Beard D, Carr A.

Version 2. F1000Res. 2017 Sep 8 [revised 2018 Jan 1];6:1663. doi: 10.12688/f1000research.12528.2. eCollection 2017. Review.


Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework.

Wilson C, Rooshenas L, Paramasivan S, Elliott D, Jepson M, Strong S, Birtle A, Beard DJ, Halliday A, Hamdy FC, Lewis R, Metcalfe C, Rogers CA, Stein RC, Blazeby JM, Donovan JL.

Trials. 2018 Jan 19;19(1):50. doi: 10.1186/s13063-017-2413-6.


Human Cardiac 31P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise.

Bakermans AJ, Bazil JN, Nederveen AJ, Strijkers GJ, Boekholdt SM, Beard DA, Jeneson JAL.

Front Physiol. 2017 Nov 27;8:939. doi: 10.3389/fphys.2017.00939. eCollection 2017.


Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial.

Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group.

Lancet. 2018 Jan 27;391(10118):329-338. doi: 10.1016/S0140-6736(17)32457-1. Epub 2017 Nov 20.


Evidence-Based Evaluation of Practice and Innovation in Physical Therapy Using the IDEAL-Physio Framework.

Beard D, Hamilton D, Davies L, Cook J, Hirst A, McCulloch P, Paez A.

Phys Ther. 2018 Feb 1;98(2):108-121. doi: 10.1093/ptj/pzx103.


Randomized feasibility trial of replacing or discarding the nail plate after nail-bed repair in children.

Greig A, Gardiner MD, Sierakowski A, Zweifel CJ, Pinder RM, Furniss D, Cook JA, Beard D, Farrar N, Cooper CD, Jain A; NINJA Pilot Collaborative.

Br J Surg. 2017 Nov;104(12):1634-1639. doi: 10.1002/bjs.10673.


Patient-reported outcome measures for patients with meniscal tears: a systematic review of measurement properties and evaluation with the COSMIN checklist.

Abram SG, Middleton R, Beard DJ, Price AJ, Hopewell S.

BMJ Open. 2017 Oct 13;7(10):e017247. doi: 10.1136/bmjopen-2017-017247.


The failing medial compartment in the varus knee and its association with CAM deformity of the hip.

Palmer JS, Palmer AJ, Jones LD, Kang S, Bottomley N, Jackson WM, Monk AP, Beard DJ, Javaid K, Glyn-Jones S, Price AJ.

Knee. 2017 Dec;24(6):1383-1391. doi: 10.1016/j.knee.2017.08.003. Epub 2017 Sep 30.


The treatment of segmental tibial fractures: does patient preference differ from surgeon choice?

Little Z, Smith TO, McMahon SE, Cooper C, Trompeter A, Pearse M, Britten S, Rogers B, Sharma H, Narayan B, Costa M, Beard DJ, Hing CB.

Injury. 2017 Oct;48(10):2306-2310. doi: 10.1016/j.injury.2017.08.014. Epub 2017 Aug 9.


Sphingolipid accumulation causes mitochondrial dysregulation and cell death.

Knupp J, Martinez-Montañés F, Van Den Bergh F, Cottier S, Schneiter R, Beard D, Chang A.

Cell Death Differ. 2017 Dec;24(12):2044-2053. doi: 10.1038/cdd.2017.128. Epub 2017 Aug 11.


The role of the endoplasmic reticulum stress response following cerebral ischemia.

Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, Vekrellis K, DeLuca GC, Papadakis M, Sutherland BA, Buchan AM.

Int J Stroke. 2017 Jan 1:1747493017724584. doi: 10.1177/1747493017724584. [Epub ahead of print]


A unified multi-level model approach to assessing patient responsiveness including; return to normal, minimally important differences and minimal clinically important improvement for patient reported outcome measures.

Sayers A, Wylde V, Lenguerrand E, Gooberman-Hill R, Dawson J, Beard D, Price A, Blom AW.

BMJ Open. 2017 Jul 21;7(7):e014041. doi: 10.1136/bmjopen-2016-014041.


Informed consent in randomised controlled trials: development and preliminary evaluation of a measure of Participatory and Informed Consent (PIC).

Wade J, Elliott D, Avery KNL, Gaunt D, Young GJ, Barnes R, Paramasivan S, Campbell WB, Blazeby JM, Birtle AJ, Stein RC, Beard DJ, Halliday AW, Donovan JL; ProtecT study group; CLASS study group; Chemorad study group; POUT study group; OPTIMA prelim study group; CSAW study group and ACST-2 study group.

Trials. 2017 Jul 17;18(1):327. doi: 10.1186/s13063-017-2048-7.


Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study.

Arden N, Altman D, Beard D, Carr A, Clarke N, Collins G, Cooper C, Culliford D, Delmestri A, Garden S, Griffin T, Javaid K, Judge A, Latham J, Mullee M, Murray D, Ogundimu E, Pinedo-Villanueva R, Price A, Prieto-Alhambra D, Raftery J.

Southampton (UK): NIHR Journals Library; 2017 Jun.


Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform.

Marshall-Colon A, Long SP, Allen DK, Allen G, Beard DA, Benes B, von Caemmerer S, Christensen AJ, Cox DJ, Hart JC, Hirst PM, Kannan K, Katz DS, Lynch JP, Millar AJ, Panneerselvam B, Price ND, Prusinkiewicz P, Raila D, Shekar RG, Shrivastava S, Shukla D, Srinivasan V, Stitt M, Turk MJ, Voit EO, Wang Y, Yin X, Zhu XG.

Front Plant Sci. 2017 May 15;8:786. doi: 10.3389/fpls.2017.00786. eCollection 2017.


Medial meniscal extrusion: a validation study comparing different methods of assessment.

Jones LD, Mellon SJ, Kruger N, Monk AP, Price AJ, Beard DJ.

Knee Surg Sports Traumatol Arthrosc. 2018 Apr;26(4):1152-1157. doi: 10.1007/s00167-017-4544-4. Epub 2017 Apr 21.


Injection versus Decompression for Carpal Tunnel Syndrome-Pilot trial (INDICATE-P)-protocol for a randomised feasibility study.

Mason W, Ryan D, Khan A, Kerr HL, Beard D, Cook J, Rombach I, Cooper C.

Pilot Feasibility Stud. 2017 Apr 24;3:20. doi: 10.1186/s40814-017-0134-y. eCollection 2017.


Tautological Nature of Guyton's Theory of Blood Pressure Control.

Beard DA.

Am J Hypertens. 2017 Jul 1;30(7):e5. doi: 10.1093/ajh/hpx038. No abstract available.


The feasibility of genome-scale biological network inference using Graphics Processing Units.

Thiagarajan R, Alavi A, Podichetty JT, Bazil JN, Beard DA.

Algorithms Mol Biol. 2017 Mar 20;12:8. doi: 10.1186/s13015-017-0100-5. eCollection 2017.


Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension.

Liu A, Philip J, Vinnakota KC, Van den Bergh F, Tabima DM, Hacker T, Beard DA, Chesler NC.

Physiol Rep. 2017 Mar;5(6). pii: e13157. doi: 10.14814/phy2.13157.


The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study.

Bayliss LE, Culliford D, Monk AP, Glyn-Jones S, Prieto-Alhambra D, Judge A, Cooper C, Carr AJ, Arden NK, Beard DJ, Price AJ.

Lancet. 2017 Apr 8;389(10077):1424-1430. doi: 10.1016/S0140-6736(17)30059-4. Epub 2017 Feb 14.


Methodology for astronaut reconditioning research.

Beard DJ, Cook JA.

Musculoskelet Sci Pract. 2017 Jan;27 Suppl 1:S42-S46. doi: 10.1016/j.msksp.2016.12.007. Epub 2016 Dec 14.


Effectiveness of open and arthroscopic rotator cuff repair (UKUFF): a randomised controlled trial.

Carr A, Cooper C, Campbell MK, Rees J, Moser J, Beard DJ, Fitzpatrick R, Gray A, Dawson J, Murphy J, Bruhn H, Cooper D, Ramsay C.

Bone Joint J. 2017 Jan;99-B(1):107-115. doi: 10.1302/0301-620X.99B1.BJJ-2016-0424.R1.


The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

Cook JA, Beard DJ, Cook JR, MacLennan GS.

Pilot Feasibility Stud. 2016 Dec 13;2:73. eCollection 2016.


Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials.

Rooshenas L, Elliott D, Wade J, Jepson M, Paramasivan S, Strong S, Wilson C, Beard D, Blazeby JM, Birtle A, Halliday A, Rogers CA, Stein R, Donovan JL; ACST-2 study group; By-Band-Sleeve study group; Chemorad study group; CSAW study group; Optima prelim study group; POUT study group.

PLoS Med. 2016 Oct 18;13(10):e1002147. doi: 10.1371/journal.pmed.1002147. eCollection 2016 Oct.


COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): study protocol for a randomised controlled trial.

Barker KL, Beard D, Price A, Toye F, Underwood M, Drummond A, Collins G, Dutton S, Campbell H, Kenealy N, Room J, Lamb SE.

Trials. 2016 Oct 13;17(1):501.


A survival analysis of 1084 knees of the Oxford unicompartmental knee arthroplasty: a comparison between consultant and trainee surgeons.

Bottomley N, Jones LD, Rout R, Alvand A, Rombach I, Evans T, Jackson WF, Beard DJ, Price AJ.

Bone Joint J. 2016 Oct;98-B(10 Supple B):22-27.


Systematic review of measurement properties of patient-reported outcome measures used in patients undergoing hip and knee arthroplasty.

Harris K, Dawson J, Gibbons E, Lim CR, Beard DJ, Fitzpatrick R, Price AJ.

Patient Relat Outcome Meas. 2016 Jul 25;7:101-8. doi: 10.2147/PROM.S97774. eCollection 2016. Review.


Development and initial cohort validation of the Arthritis Research UK Musculoskeletal Health Questionnaire (MSK-HQ) for use across musculoskeletal care pathways.

Hill JC, Kang S, Benedetto E, Myers H, Blackburn S, Smith S, Dunn KM, Hay E, Rees J, Beard D, Glyn-Jones S, Barker K, Ellis B, Fitzpatrick R, Price A.

BMJ Open. 2016 Aug 5;6(8):e012331. doi: 10.1136/bmjopen-2016-012331.


The Urgent Need for Evidence in Arthroscopic Meniscal Surgery.

Monk P, Garfjeld Roberts P, Palmer AJ, Bayliss L, Mafi R, Beard D, Hopewell S, Price A.

Am J Sports Med. 2017 Mar;45(4):965-973. doi: 10.1177/0363546516650180. Epub 2016 Jul 21. Review.


Intracranial Pressure Elevation 24 h after Ischemic Stroke in Aged Rats Is Prevented by Early, Short Hypothermia Treatment.

Murtha LA, Beard DJ, Bourke JT, Pepperall D, McLeod DD, Spratt NJ.

Front Aging Neurosci. 2016 May 27;8:124. doi: 10.3389/fnagi.2016.00124. eCollection 2016.


Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure.

Tewari SG, Bugenhagen SM, Vinnakota KC, Rice JJ, Janssen PML, Beard DA.

J Mol Cell Cardiol. 2016 May;94:162-175. doi: 10.1016/j.yjmcc.2016.04.003. Epub 2016 Apr 13.


Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.

Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, Beard DA, Efimov IR.

FASEB J. 2016 Aug;30(8):2698-707. doi: 10.1096/fj.201500118R. Epub 2016 Apr 13.


Improving the physiological realism of experimental models.

Vinnakota KC, Cha CY, Rorsman P, Balaban RS, La Gerche A, Wade-Martins R, Beard DA, Jeneson JA.

Interface Focus. 2016 Apr 6;6(2):20150076. doi: 10.1098/rsfs.2015.0076. Review.


Surgical versus conservative interventions for treating anterior cruciate ligament injuries.

Monk AP, Davies LJ, Hopewell S, Harris K, Beard DJ, Price AJ.

Cochrane Database Syst Rev. 2016 Apr 3;4:CD011166. doi: 10.1002/14651858.CD011166.pub2. Review.


Open-loop (feed-forward) and feedback control of coronary blood flow during exercise, cardiac pacing, and pressure changes.

Pradhan RK, Feigl EO, Gorman MW, Brengelmann GL, Beard DA.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1683-94. doi: 10.1152/ajpheart.00663.2015. Epub 2016 Apr 1.


Feasibility of surgical randomised controlled trials with a placebo arm: a systematic review.

Wartolowska K, Collins GS, Hopewell S, Judge A, Dean BJ, Rombach I, Beard DJ, Carr AJ.

BMJ Open. 2016 Mar 15;6(3):e010194. doi: 10.1136/bmjopen-2015-010194. Review.


Feedback Regulation and Time Hierarchy of Oxidative Phosphorylation in Cardiac Mitochondria.

Vinnakota KC, Bazil JN, Van den Bergh F, Wiseman RW, Beard DA.

Biophys J. 2016 Feb 23;110(4):972-80. doi: 10.1016/j.bpj.2016.01.003.


Catalytic Coupling of Oxidative Phosphorylation, ATP Demand, and Reactive Oxygen Species Generation.

Bazil JN, Beard DA, Vinnakota KC.

Biophys J. 2016 Feb 23;110(4):962-71. doi: 10.1016/j.bpj.2015.09.036.


Open-Loop Control of Oxidative Phosphorylation in Skeletal and Cardiac Muscle Mitochondria by Ca(2.).

Vinnakota KC, Singhal A, Van den Bergh F, Bagher-Oskouei M, Wiseman RW, Beard DA.

Biophys J. 2016 Feb 23;110(4):954-61. doi: 10.1016/j.bpj.2015.12.018.


Heterogeneous mechanics of the mouse pulmonary arterial network.

Lee P, Carlson BE, Chesler N, Olufsen MS, Qureshi MU, Smith NP, Sochi T, Beard DA.

Biomech Model Mechanobiol. 2016 Oct;15(5):1245-61. doi: 10.1007/s10237-015-0757-y. Epub 2016 Jan 20.


Intracranial Pressure and Collateral Blood Flow.

Beard DJ, Murtha LA, McLeod DD, Spratt NJ.

Stroke. 2016 Jun;47(6):1695-700. doi: 10.1161/STROKEAHA.115.011147. Epub 2016 Jan 19. Review. No abstract available.


The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.

Bassingthwaighte JB, Raymond GM, Dash RK, Beard DA, Nolan M.

Adv Exp Med Biol. 2016;876:103-110. doi: 10.1007/978-1-4939-3023-4_13.


Ischemic penumbra as a trigger for intracranial pressure rise - A potential cause for collateral failure and infarct progression?

Beard DJ, Logan CL, McLeod DD, Hood RJ, Pepperall D, Murtha LA, Spratt NJ.

J Cereb Blood Flow Metab. 2016 May;36(5):917-27. doi: 10.1177/0271678X15625578. Epub 2016 Jan 12.


Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum.

Moxley MA, Beard DA, Bazil JN.

J Biol Chem. 2016 Feb 5;291(6):2712-30. doi: 10.1074/jbc.M115.676619. Epub 2015 Dec 7.


Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy.

Murtha LA, McLeod DD, Pepperall D, McCann SK, Beard DJ, Tomkins AJ, Holmes WM, McCabe C, Macrae IM, Spratt NJ.

J Cereb Blood Flow Metab. 2015 Dec;35(12):2109. doi: 10.1038/jcbfm.2015.209.

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