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Items: 1 to 50 of 501

1.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, Bricambert J, Saussenthaler S, Anthony E, Jha P, Derop J, Sand O, Rabearivelo I, Leloire A, Pigeyre M, Daujat-Chavanieu M, Gerbal-Chaloin S, Dayeh T, Lassailly G, Mathurin P, Staels B, Auwerx J, Schürmann A, Postic C, Schafmayer C, Hampe J, Bonnefond A, Pattou F, Froguel P.

Diabetes. 2018 May 4. pii: db171539. doi: 10.2337/db17-1539. [Epub ahead of print]

PMID:
29728363
2.

Reduced oxidative capacity in macrophages results in systemic insulin resistance.

Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, Kim KS, Kim HJ, Kim CS, Lee CH, Williams RW, Kim H, Lee HK, Auwerx J, Shong M.

Nat Commun. 2018 Apr 19;9(1):1551. doi: 10.1038/s41467-018-03998-z.

3.

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF.

Aging Cell. 2018 Apr 14:e12751. doi: 10.1111/acel.12751. [Epub ahead of print]

4.

The role of mitochondria in stem cell fate and aging.

Zhang H, Menzies KJ, Auwerx J.

Development. 2018 Apr 13;145(8). pii: dev143420. doi: 10.1242/dev.143420. Review.

PMID:
29654217
5.

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM.

Cardiovasc Res. 2018 Apr 9. doi: 10.1093/cvr/cvy089. [Epub ahead of print]

PMID:
29635338
6.

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.

7.

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

Dong L, Cornaglia M, Krishnamani G, Zhang J, Mouchiroud L, Lehnert T, Auwerx J, Gijs MAM.

PLoS One. 2018 Mar 6;13(3):e0193989. doi: 10.1371/journal.pone.0193989. eCollection 2018.

8.

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.

Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J.

Elife. 2018 Feb 22;7. pii: e31019. doi: 10.7554/eLife.31019.

9.

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

Gaul DS, Weber J, Van Tits LJ, Sluka S, Pasterk L, Reiner MF, Calatayud N, Lohmann C, Klingenberg R, Pahla J, Vdovenko D, Tanner FC, Camici GG, Eriksson U, Auwerx J, Mach F, Windecker S, Rodondi N, L Uuml Scher TF, Winnik S, Matter CM.

Cardiovasc Res. 2018 Feb 10. doi: 10.1093/cvr/cvy036. [Epub ahead of print]

10.

Genetic cartography of longevity in humans and mice: Current landscape and horizons.

Hook M, Roy S, Williams EG, Bou Sleiman M, Mozhui K, Nelson JF, Lu L, Auwerx J, Williams RW.

Biochim Biophys Acta. 2018 Feb 2. pii: S0925-4439(18)30037-1. doi: 10.1016/j.bbadis.2018.01.026. [Epub ahead of print] Review.

PMID:
29410319
11.

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.

Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J.

J Med Chem. 2018 Feb 8;61(3):745-759. doi: 10.1021/acs.jmedchem.7b01254. Epub 2018 Jan 26.

PMID:
29345930
12.

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J.

Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6.

PMID:
29211722
13.

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J.

Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016. Epub 2017 Nov 30.

14.

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress.

Matilainen O, Sleiman MSB, Quiros PM, Garcia SMDA, Auwerx J.

Nat Commun. 2017 Nov 28;8(1):1818. doi: 10.1038/s41467-017-01903-8.

15.

The corepressor NCOR1 regulates the survival of single-positive thymocytes.

Müller L, Hainberger D, Stolz V, Hamminger P, Hassan H, Preglej T, Boucheron N, Sakaguchi S, Wiegers GJ, Villunger A, Auwerx J, Ellmeier W.

Sci Rep. 2017 Nov 21;7(1):15928. doi: 10.1038/s41598-017-15918-0.

16.

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Dahlmans D, Houzelle A, Andreux P, Jörgensen JA, Wang X, de Windt LJ, Schrauwen P, Auwerx J, Hoeks J.

Mol Metab. 2017 Nov;6(11):1429-1442. doi: 10.1016/j.molmet.2017.08.007. Epub 2017 Aug 31.

17.

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress.

Wang X, Auwerx J.

Mol Cell. 2017 Nov 2;68(3):540-551.e5. doi: 10.1016/j.molcel.2017.10.006.

PMID:
29100054
18.

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q.

Nat Commun. 2017 Oct 16;8(1):959. doi: 10.1038/s41467-017-00931-8.

19.

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.

Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A.

Brain Pathol. 2017 Oct 13. doi: 10.1111/bpa.12571. [Epub ahead of print]

PMID:
29027761
20.

Repairing Mitochondrial Dysfunction in Disease.

Sorrentino V, Menzies KJ, Auwerx J.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:353-389. doi: 10.1146/annurev-pharmtox-010716-104908. Epub 2017 Sep 27.

PMID:
28961065
21.

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.

Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Front Immunol. 2017 Aug 28;8:1037. doi: 10.3389/fimmu.2017.01037. eCollection 2017.

22.

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.

Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D.

Nat Commun. 2017 Sep 7;8(1):480. doi: 10.1038/s41467-017-00566-9.

23.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB.

Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30.

PMID:
28859855
24.

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Trouillon R, Letizia MC, Menzies KJ, Mouchiroud L, Auwerx J, Schoonjans K, Gijs MAM.

Integr Biol (Camb). 2017 Oct 16;9(10):810-819. doi: 10.1039/c7ib00015d.

PMID:
28853753
25.

Modulating NAD+ metabolism, from bench to bedside.

Katsyuba E, Auwerx J.

EMBO J. 2017 Sep 15;36(18):2670-2683. doi: 10.15252/embj.201797135. Epub 2017 Aug 7. Review.

PMID:
28784597
26.

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.

McDaid AF, Joshi PK, Porcu E, Komljenovic A, Li H, Sorrentino V, Litovchenko M, Bevers RPJ, Rüeger S, Reymond A, Bochud M, Deplancke B, Williams RW, Robinson-Rechavi M, Paccaud F, Rousson V, Auwerx J, Wilson JF, Kutalik Z.

Nat Commun. 2017 Jul 27;8:15842. doi: 10.1038/ncomms15842.

27.

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy.

Coquoz S, Marchand PJ, Bouwens A, Mouchiroud L, Sorrentino V, Szlag D, Auwerx J, Lasser T.

PLoS One. 2017 Jul 20;12(7):e0181676. doi: 10.1371/journal.pone.0181676. eCollection 2017.

28.

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain.

Preston S, Korhonen PK, Mouchiroud L, Cornaglia M, McGee SL, Young ND, Davis RA, Crawford S, Nowell C, Ansell BRE, Fisher GM, Andrews KT, Chang BCH, Gijs MAM, Sternberg PW, Auwerx J, Baell J, Hofmann A, Jabbar A, Gasser RB.

FASEB J. 2017 Oct;31(10):4515-4532. doi: 10.1096/fj.201700288R. Epub 2017 Jul 7.

PMID:
28687609
29.

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Ciarlo E, Heinonen T, Lugrin J, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Sci Rep. 2017 Jun 20;7(1):3853. doi: 10.1038/s41598-017-04263-x.

30.

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response.

D'Amico D, Sorrentino V, Auwerx J.

Trends Biochem Sci. 2017 Sep;42(9):712-725. doi: 10.1016/j.tibs.2017.05.002. Epub 2017 Jun 1. Review.

PMID:
28579074
31.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

Quirós PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J.

J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31.

32.

PPARδ Promotes Running Endurance by Preserving Glucose.

Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM.

Cell Metab. 2017 May 2;25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006.

33.

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.

Chatzispyrou IA, Alders M, Guerrero-Castillo S, Zapata Perez R, Haagmans MA, Mouchiroud L, Koster J, Ofman R, Baas F, Waterham HR, Spelbrink JN, Auwerx J, Mannens MM, Houtkooper RH, Plomp AS.

Hum Mol Genet. 2017 Jul 1;26(13):2541-2550. doi: 10.1093/hmg/ddx152.

PMID:
28449065
34.

Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress.

Matilainen O, Quirós PM, Auwerx J.

Trends Cell Biol. 2017 Jun;27(6):453-463. doi: 10.1016/j.tcb.2017.02.004. Epub 2017 Mar 6. Review.

PMID:
28274652
35.

Analysis of mtDNA/nDNA Ratio in Mice.

Quiros PM, Goyal A, Jha P, Auwerx J.

Curr Protoc Mouse Biol. 2017 Mar 2;7(1):47-54. doi: 10.1002/cpmo.21.

36.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440. doi: 10.1073/pnas.1700232114. Epub 2017 Feb 6. Erratum in: Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. Paszek, Miles [added].

37.

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL.

Hum Mol Genet. 2017 Feb 1;26(3):582-598. doi: 10.1093/hmg/ddw418.

PMID:
28053050
38.

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M.

J Cell Biol. 2017 Jan 2;216(1):149-165. doi: 10.1083/jcb.201607110. Epub 2016 Dec 16.

39.

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.

Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P.

J Hepatol. 2017 Mar;66(3):589-600. doi: 10.1016/j.jhep.2016.10.023. Epub 2016 Oct 29.

PMID:
27984176
40.

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J, Cantó C, Amati F.

Cell Metab. 2017 Feb 7;25(2):301-311. doi: 10.1016/j.cmet.2016.11.004. Epub 2016 Dec 1.

41.

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J.

Sci Transl Med. 2016 Oct 19;8(361):361ra139.

42.

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity.

Vannini N, Girotra M, Naveiras O, Nikitin G, Campos V, Giger S, Roch A, Auwerx J, Lutolf MP.

Nat Commun. 2016 Oct 12;7:13125. doi: 10.1038/ncomms13125.

43.

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.

Ratajczak J, Joffraud M, Trammell SA, Ras R, Canela N, Boutant M, Kulkarni SS, Rodrigues M, Redpath P, Migaud ME, Auwerx J, Yanes O, Brenner C, Cantó C.

Nat Commun. 2016 Oct 11;7:13103. doi: 10.1038/ncomms13103.

44.

The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.

Mouchiroud L, Sorrentino V, Williams EG, Cornaglia M, Frochaux MV, Lin T, Nicolet-Dit-Félix AA, Krishnamani G, Ouhmad T, Gijs MA, Deplancke B, Auwerx J.

Curr Protoc Neurosci. 2016 Oct 3;77:8.37.1-8.37.21. doi: 10.1002/cpns.17.

PMID:
27696358
45.

Track C. Biomedical Instrumentation & Micro and Nano Systems.

Cornaglia M, Mouchiroud L, Krishnamani G, Marette A, Narasimhan S, Jovaisaite V, Sorrentino V, Lehnert T, Auwerx J, Gijs MA.

Biomed Tech (Berl). 2016 Sep 1;61(s1):24-29. doi: 10.1515/bmt-2016-5002. No abstract available.

PMID:
27682684
46.

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.

Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J.

J Hepatol. 2017 Jan;66(1):132-141. doi: 10.1016/j.jhep.2016.08.024. Epub 2016 Sep 20.

47.

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice.

Yang H, Zhou H, Zhuang L, Auwerx J, Schoonjans K, Wang X, Feng C, Lu L.

Liver Transpl. 2017 Jan;23(1):63-74. doi: 10.1002/lt.24628.

48.

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Koopman M, Michels H, Dancy BM, Kamble R, Mouchiroud L, Auwerx J, Nollen EA, Houtkooper RH.

Nat Protoc. 2016 Oct;11(10):1798-816. doi: 10.1038/nprot.2016.106. Epub 2016 Sep 1.

49.

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J.

Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.

PMID:
27400265
50.

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K.

Genes Dev. 2016 Jun 1;30(11):1255-60. doi: 10.1101/gad.277483.116.

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