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Items: 6


Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.

McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R.

Cancer Discov. 2017 Oct;7(10):1136-1153. doi: 10.1158/2159-8290.CD-17-0399. Epub 2017 Jul 20.


Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.

Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12823-8. doi: 10.1073/pnas.1413933111. Epub 2014 Aug 18.


The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.

Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA.

Nat Cell Biol. 2011 Dec 18;14(1):87-92. doi: 10.1038/ncb2395.


Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.

Austgen K, Oakes SA, Ganem D.

J Virol. 2012 Feb;86(3):1877-82. doi: 10.1128/JVI.06600-11. Epub 2011 Nov 30.


Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.

Reyes NA, Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA.

J Clin Invest. 2010 Oct;120(10):3673-9. doi: 10.1172/JCI42986. Epub 2010 Sep 20.


Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.

Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA.

Mol Cell Biol. 2008 Jun;28(12):3943-51. doi: 10.1128/MCB.00013-08. Epub 2008 Apr 21.

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