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Items: 9

1.

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.

Wall M, Poortinga G, Stanley KL, Lindemann RK, Bots M, Chan CJ, Bywater MJ, Kinross KM, Astle MV, Waldeck K, Hannan KM, Shortt J, Smyth MJ, Lowe SW, Hannan RD, Pearson RB, Johnstone RW, McArthur GA.

Cancer Discov. 2013 Jan;3(1):82-95. doi: 10.1158/2159-8290.CD-12-0404. Epub 2012 Dec 14.

2.

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB.

Oncogene. 2012 Apr 12;31(15):1949-62. doi: 10.1038/onc.2011.394. Epub 2011 Sep 12.

3.

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.

Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Sci Signal. 2011 Aug 30;4(188):ra56. doi: 10.1126/scisignal.2001754.

4.

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.

Astle MV, Ooms LM, Cole AR, Binge LC, Dyson JM, Layton MJ, Petratos S, Sutherland C, Mitchell CA.

J Biol Chem. 2011 Jul 1;286(26):23407-18. doi: 10.1074/jbc.M110.214247. Epub 2011 May 6.

5.

P-Rex1 - a multidomain protein that regulates neurite differentiation.

Waters JE, Astle MV, Ooms LM, Balamatsias D, Gurung R, Mitchell CA.

J Cell Sci. 2008 Sep 1;121(Pt 17):2892-903. doi: 10.1242/jcs.030353. Epub 2008 Aug 12.

6.

The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

Astle MV, Horan KA, Ooms LM, Mitchell CA.

Biochem Soc Symp. 2007;(74):161-81. Review.

PMID:
17233589
7.

Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.

Astle MV, Seaton G, Davies EM, Fedele CG, Rahman P, Arsala L, Mitchell CA.

IUBMB Life. 2006 Aug;58(8):451-6. Review.

8.

The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

Ooms LM, Fedele CG, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, Mitchell CA.

Mol Biol Cell. 2006 Feb;17(2):607-22. Epub 2005 Nov 9.

9.

The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2.

Dyson JM, Kong AM, Wiradjaja F, Astle MV, Gurung R, Mitchell CA.

Int J Biochem Cell Biol. 2005 Nov;37(11):2260-5. Review.

PMID:
15964236

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