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Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion.

Alholle A, Karanian M, Brini AT, Morris MR, Kannappan V, Niada S, Niblett A, Ranchère-Vince D, Pissaloux D, Delfour C, Gonzalez AM, Antonescu CR, Sumathi V, Tirode F, Latif F.

J Pathol. 2018 Mar 13. doi: 10.1002/path.5071. [Epub ahead of print]


Macrophages and CD8+ T cells mediate the anti-tumor efficacy of combined CD40 ligation and imatinib therapy in gastrointestinal stromal tumors.

Zhang JQ, Zeng S, Vitiello GA, Seifert AM, Medina BD, Beckman MJ, Loo J, Santamaria-Barria J, Maltbaek JH, Param NJ, Moral JA, Zhao JN, Balachandran V, Rossi F, Antonescu CR, DeMatteo RP.

Cancer Immunol Res. 2018 Feb 21. pii: canimm.0345.2017. doi: 10.1158/2326-6066.CIR-17-0345. [Epub ahead of print]


Recurrent RET Gene Rearrangements in Intraductal Carcinomas of Salivary Gland.

Weinreb I, Bishop JA, Chiosea SI, Seethala RR, Perez-Ordonez B, Zhang L, Sung YS, Chen CL, Assaad A, Oliai BR, Antonescu CR.

Am J Surg Pathol. 2018 Apr;42(4):442-452. doi: 10.1097/PAS.0000000000000952.


Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.

D'Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H.

Lancet Oncol. 2018 Mar;19(3):416-426. doi: 10.1016/S1470-2045(18)30006-8. Epub 2018 Jan 19.


COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

Xie Y, Cao Z, Wong EW, Guan Y, Ma W, Zhang JQ, Walczak EG, Murphy D, Ran L, Sirota I, Wang S, Shukla S, Gao D, Knott SR, Chang K, Leu J, Wongvipat J, Antonescu CR, Hannon G, Chi P, Chen Y.

J Clin Invest. 2018 Mar 5. pii: 94840. doi: 10.1172/JCI94840. [Epub ahead of print]


NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors.

Dickson BC, Sung YS, Rosenblum MK, Reuter VE, Harb M, Wunder JS, Swanson D, Antonescu CR.

Am J Surg Pathol. 2018 Jan 19. doi: 10.1097/PAS.0000000000001021. [Epub ahead of print]


Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms.

Kao YC, Flucke U, Eijkelenboom A, Zhang L, Sung YS, Suurmeijer AJH, Antonescu CR.

Am J Surg Pathol. 2018 Apr;42(4):522-528. doi: 10.1097/PAS.0000000000001002.


A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.

Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC.

Am J Surg Pathol. 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010.


BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.

Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR.

Am J Surg Pathol. 2017 Oct 25. doi: 10.1097/PAS.0000000000000965. [Epub ahead of print]


Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor.

Vitiello GA, Medina BD, Zeng S, Bowler TG, Zhang JQ, Loo JK, Param NJ, Liu M, Moral AJ, Zhao JN, Rossi F, Antonescu CR, Balachandran VP, Cross JR, DeMatteo RP.

Clin Cancer Res. 2018 Feb 15;24(4):972-984. doi: 10.1158/1078-0432.CCR-17-2697. Epub 2017 Dec 15.


ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity.

Lewis N, Soslow RA, Delair DF, Park KJ, Murali R, Hollmann TJ, Davidson B, Micci F, Panagopoulos I, Hoang LN, Arias-Stella JA 3rd, Oliva E, Young RH, Hensley ML, Leitao MM Jr, Hameed M, Benayed R, Ladanyi M, Frosina D, Jungbluth AA, Antonescu CR, Chiang S.

Mod Pathol. 2017 Dec 1. doi: 10.1038/modpathol.2017.162. [Epub ahead of print]


FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor.

Ran L, Chen Y, Sher J, Wong EWP, Murphy D, Zhang JQ, Li D, Deniz K, Sirota I, Cao Z, Wang S, Guan Y, Shukla S, Li KY, Chramiec A, Xie Y, Zheng D, Koche RP, Antonescu CR, Chen Y, Chi P.

Cancer Discov. 2018 Feb;8(2):234-251. doi: 10.1158/2159-8290.CD-17-0468. Epub 2017 Nov 21.


High sensitivity of FISH analysis in detecting homozygous SMARCB1 deletions in poorly differentiated chordoma: a clinicopathologic and molecular study of nine cases.

Owosho AA, Zhang L, Rosenblum MK, Antonescu CR.

Genes Chromosomes Cancer. 2018 Feb;57(2):89-95. doi: 10.1002/gcc.22511. Epub 2017 Nov 23.


Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.

Dalin MG, Katabi N, Persson M, Lee KW, Makarov V, Desrichard A, Walsh LA, West L, Nadeem Z, Ramaswami D, Havel JJ, Kuo F, Chadalavada K, Nanjangud GJ, Ganly I, Riaz N, Ho AL, Antonescu CR, Ghossein R, Stenman G, Chan TA, Morris LGT.

Nat Commun. 2017 Oct 30;8(1):1197. doi: 10.1038/s41467-017-01178-z.


Rectal Gastrointestinal Stromal Tumor (GIST) in the Era of Imatinib: Organ Preservation and Improved Oncologic Outcome.

Cavnar MJ, Wang L, Balachandran VP, Antonescu CR, Tap WD, Keohan M, Singer S, Temple L, Nash GM, Weiser MR, Guillem JG, Aguilar JG, DeMatteo RP, Paty PB.

Ann Surg Oncol. 2017 Dec;24(13):3972-3980. doi: 10.1245/s10434-017-6087-9. Epub 2017 Oct 20.


Size and Location are the Most Important Risk Factors for Malignant Behavior in Resected Solitary Fibrous Tumors.

Gholami S, Cassidy MR, Kirane A, Kuk D, Zanchelli B, Antonescu CR, Singer S, Brennan M.

Ann Surg Oncol. 2017 Dec;24(13):3865-3871. doi: 10.1245/s10434-017-6092-z. Epub 2017 Oct 16.


Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Sep 27;49(10):1558. doi: 10.1038/ng1017-1558b. No abstract available.


In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets.

Arbajian E, Puls F, Antonescu CR, Amary F, Sciot R, Debiec-Rychter M, Sumathi VP, Järås M, Magnusson L, Nilsson J, Hofvander J, Mertens F.

Clin Cancer Res. 2017 Dec 1;23(23):7426-7434. doi: 10.1158/1078-0432.CCR-17-1856. Epub 2017 Sep 22.


Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.

Bosbach B, Rossi F, Yozgat Y, Loo J, Zhang JQ, Berrozpe G, Warpinski K, Ehlers I, Veach D, Kwok A, Manova K, Antonescu CR, DeMatteo RP, Besmer P.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8448-E8457. doi: 10.1073/pnas.1711449114. Epub 2017 Sep 18.


Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma.

Kao YC, Fletcher CDM, Alaggio R, Wexler L, Zhang L, Sung YS, Orhan D, Chang WC, Swanson D, Dickson BC, Antonescu CR.

Am J Surg Pathol. 2018 Jan;42(1):28-38. doi: 10.1097/PAS.0000000000000938.


Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues.

Argani P, Kao YC, Zhang L, Bacchi C, Matoso A, Alaggio R, Epstein JI, Antonescu CR.

Am J Surg Pathol. 2017 Dec;41(12):1702-1712. doi: 10.1097/PAS.0000000000000926.


PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities.

Katabi N, Xu B, Jungbluth AA, Zhang L, Shao SY, Lane J, Ghossein R, Antonescu CR.

Histopathology. 2018 Jan;72(2):285-293. doi: 10.1111/his.13341. Epub 2017 Oct 19.


A Clinicopathologic Study of Head and Neck Malignant Peripheral Nerve Sheath Tumors.

Owosho AA, Estilo CL, Huryn JM, Chi P, Antonescu CR.

Head Neck Pathol. 2017 Jul 31. doi: 10.1007/s12105-017-0841-y. [Epub ahead of print]


Recurrent BRAF Gene Rearrangements in Myxoinflammatory Fibroblastic Sarcomas, but Not Hemosiderotic Fibrolipomatous Tumors.

Kao YC, Ranucci V, Zhang L, Sung YS, Athanasian EA, Swanson D, Dickson BC, Antonescu CR.

Am J Surg Pathol. 2017 Nov;41(11):1456-1465. doi: 10.1097/PAS.0000000000000899.


Benign vascular lesions of the breast diagnosed by core needle biopsy do not require excision.

Sebastiano C, Gennaro L, Brogi E, Morris E, Bowser ZL, Antonescu CR, Pareja F, Brennan S, Murray MP.

Histopathology. 2017 Nov;71(5):795-804. doi: 10.1111/his.13291. Epub 2017 Sep 8.


BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology.

Chiang S, Lee CH, Stewart CJR, Oliva E, Hoang LN, Ali RH, Hensley ML, Arias-Stella JA 3rd, Frosina D, Jungbluth AA, Benayed R, Ladanyi M, Hameed M, Wang L, Kao YC, Antonescu CR, Soslow RA.

Mod Pathol. 2017 Sep;30(9):1251-1261. doi: 10.1038/modpathol.2017.42. Epub 2017 Jun 16.


Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor.

Zeng S, Seifert AM, Zhang JQ, Cavnar MJ, Kim TS, Balachandran VP, Santamaria-Barria JA, Cohen NA, Beckman MJ, Medina BD, Rossi F, Crawley MH, Loo JK, Maltbaek JH, Besmer P, Antonescu CR, DeMatteo RP.

Mol Cancer Ther. 2017 Sep;16(9):1954-1966. doi: 10.1158/1535-7163.MCT-17-0139. Epub 2017 Jun 13.


Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.

Miettinen MM, Antonescu CR, Fletcher CDM, Kim A, Lazar AJ, Quezado MM, Reilly KM, Stemmer-Rachamimov A, Stewart DR, Viskochil D, Widemann B, Perry A.

Hum Pathol. 2017 Sep;67:1-10. doi: 10.1016/j.humpath.2017.05.010. Epub 2017 May 24. Review.


ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors.

Ran L, Murphy D, Sher J, Cao Z, Wang S, Walczak E, Guan Y, Xie Y, Shukla S, Zhan Y, Antonescu CR, Chen Y, Chi P.

Cancer Res. 2017 Jul 15;77(14):3758-3765. doi: 10.1158/0008-5472.CAN-16-3510. Epub 2017 May 24.


TFG-MET fusion in an infantile spindle cell sarcoma with neural features.

Flucke U, van Noesel MM, Wijnen M, Zhang L, Chen CL, Sung YS, Antonescu CR.

Genes Chromosomes Cancer. 2017 Sep;56(9):663-667. doi: 10.1002/gcc.22470. Epub 2017 Jun 27.


A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.

Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR.

Am J Surg Pathol. 2017 Jul;41(7):980-988. doi: 10.1097/PAS.0000000000000864.


PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Jul;49(7):1005-1014. doi: 10.1038/ng.3866. Epub 2017 May 15. Erratum in: Nat Genet. 2017 Sep 27;49(10 ):1558.


CIC-DUX4 Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma.

Yoshimoto T, Tanaka M, Homme M, Yamazaki Y, Takazawa Y, Antonescu CR, Nakamura T.

Cancer Res. 2017 Jun 1;77(11):2927-2937. doi: 10.1158/0008-5472.CAN-16-3351. Epub 2017 Apr 12.


Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome: A Clinicopathologic and Molecular Study of 115 Cases.

Antonescu CR, Owosho AA, Zhang L, Chen S, Deniz K, Huryn JM, Kao YC, Huang SC, Singer S, Tap W, Schaefer IM, Fletcher CD.

Am J Surg Pathol. 2017 Jul;41(7):941-949. doi: 10.1097/PAS.0000000000000846.


Head and Neck Round Cell Sarcomas: A Comparative Clinicopathologic Analysis of 2 Molecular Subsets: Ewing and CIC-Rearranged Sarcomas.

Owosho AA, Estilo CL, Huryn JM, Zhang L, Fletcher CDM, Antonescu CR.

Head Neck Pathol. 2017 Dec;11(4):450-459. doi: 10.1007/s12105-017-0808-z. Epub 2017 Mar 23.


RBM10-TFE3 Renal Cell Carcinoma: A Potential Diagnostic Pitfall Due to Cryptic Intrachromosomal Xp11.2 Inversion Resulting in False-negative TFE3 FISH.

Argani P, Zhang L, Reuter VE, Tickoo SK, Antonescu CR.

Am J Surg Pathol. 2017 May;41(5):655-662. doi: 10.1097/PAS.0000000000000835.


SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.

Agaimy A, Hartmann A, Antonescu CR, Chiosea SI, El-Mofty SK, Geddert H, Iro H, Lewis JS Jr, Märkl B, Mills SE, Riener MO, Robertson T, Sandison A, Semrau S, Simpson RH, Stelow E, Westra WH, Bishop JA.

Am J Surg Pathol. 2017 Apr;41(4):458-471. doi: 10.1097/PAS.0000000000000797.


MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation.

Schaefer IM, Wang Y, Liang CW, Bahri N, Quattrone A, Doyle L, Mariño-Enríquez A, Lauria A, Zhu M, Debiec-Rychter M, Grunewald S, Hechtman JF, Dufresne A, Antonescu CR, Beadling C, Sicinska ET, van de Rijn M, Demetri GD, Ladanyi M, Corless CL, Heinrich MC, Raut CP, Bauer S, Fletcher JA.

Nat Commun. 2017 Mar 8;8:14674. doi: 10.1038/ncomms14674.


A clinicopathologic study on SS18 fusion positive head and neck synovial sarcomas.

Owosho AA, Estilo CL, Rosen EB, Yom SK, Huryn JM, Antonescu CR.

Oral Oncol. 2017 Mar;66:46-51. doi: 10.1016/j.oraloncology.2016.12.021. Epub 2017 Jan 10.


Recurrent SRF-RELA Fusions Define a Novel Subset of Cellular Myofibroma/Myopericytoma: A Potential Diagnostic Pitfall With Sarcomas With Myogenic Differentiation.

Antonescu CR, Sung YS, Zhang L, Agaram NP, Fletcher CD.

Am J Surg Pathol. 2017 May;41(5):677-684. doi: 10.1097/PAS.0000000000000811.


ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements.

Kao YC, Sung YS, Chen CL, Zhang L, Dickson BC, Swanson D, Vaiyapuri S, Latif F, Alholle A, Huang SC, Hornick JL, Antonescu CR.

Genes Chromosomes Cancer. 2017 Jun;56(6):501-510. doi: 10.1002/gcc.22454. Epub 2017 Mar 31.


EWSR1 Fusions With CREB Family Transcription Factors Define a Novel Myxoid Mesenchymal Tumor With Predilection for Intracranial Location.

Kao YC, Sung YS, Zhang L, Chen CL, Vaiyapuri S, Rosenblum MK, Antonescu CR.

Am J Surg Pathol. 2017 Apr;41(4):482-490. doi: 10.1097/PAS.0000000000000788.


BCOR upregulation in a poorly differentiated synovial sarcoma with SS18L1-SSX1 fusion-A pathologic and molecular pitfall.

Kao YC, Sung YS, Zhang L, Kenan S, Singer S, Tap WD, Swanson D, Dickson BC, Antonescu CR.

Genes Chromosomes Cancer. 2017 Apr;56(4):296-302. doi: 10.1002/gcc.22435. Epub 2017 Jan 4.


Primary cutaneous adenoid cystic carcinoma with MYB aberrations: report of three cases and comprehensive review of the literature.

Prieto-Granada CN, Zhang L, Antonescu CR, Henneberry JM, Messina JL.

J Cutan Pathol. 2017 Feb;44(2):201-209. doi: 10.1111/cup.12856. Epub 2016 Dec 2.


Long-term effect of chemotherapy-intensity-modulated radiation therapy (chemo-IMRT) on dentofacial development in head and neck rhabdomyosarcoma patients.

Owosho AA, Brady P, Wolden SL, Wexler LH, Antonescu CR, Huryn JM, Estilo CL.

Pediatr Hematol Oncol. 2016 Sep;33(6):383-392. Epub 2016 Sep 30.


TFEB-amplified Renal Cell Carcinomas: An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity.

Argani P, Reuter VE, Zhang L, Sung YS, Ning Y, Epstein JI, Netto GJ, Antonescu CR.

Am J Surg Pathol. 2016 Nov;40(11):1484-1495.


Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma.

Hoang LN, Aneja A, Conlon N, Delair DF, Middha S, Benayed R, Hensley ML, Park KJ, Hollmann TJ, Hameed MR, Antonescu CR, Soslow RA, Chiang S.

Am J Surg Pathol. 2017 Jan;41(1):12-24.


A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma.

Ho AL, Dunn L, Sherman EJ, Fury MG, Baxi SS, Chandramohan R, Dogan S, Morris LG, Cullen GD, Haque S, Sima CS, Ni A, Antonescu CR, Katabi N, Pfister DG.

Ann Oncol. 2016 Oct;27(10):1902-8. doi: 10.1093/annonc/mdw287. Epub 2016 Aug 26.


Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP-BCORL1 and KDM2A-WWTR1.

Kao YC, Sung YS, Zhang L, Chen CL, Huang SC, Antonescu CR.

Genes Chromosomes Cancer. 2017 Jan;56(1):42-50. doi: 10.1002/gcc.22400. Epub 2016 Aug 26.


PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors.

Seifert AM, Zeng S, Zhang JQ, Kim TS, Cohen NA, Beckman MJ, Medina BD, Maltbaek JH, Loo JK, Crawley MH, Rossi F, Besmer P, Antonescu CR, DeMatteo RP.

Clin Cancer Res. 2017 Jan 15;23(2):454-465. doi: 10.1158/1078-0432.CCR-16-1163. Epub 2016 Jul 28.

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