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Items: 1 to 50 of 54

1.

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.

Zeinyeh W, Esvan YJ, Nauton L, Loaëc N, Meijer L, Théry V, Anizon F, Giraud F, Moreau P.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4327-9. doi: 10.1016/j.bmcl.2016.07.032. Epub 2016 Jul 16.

PMID:
27469128
2.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Esvan YJ, Giraud F, Pereira E, Suchaud V, Nauton L, Théry V, Dezhenkova LG, Kaluzhny DN, Mazov VN, Shtil AA, Anizon F, Moreau P.

Bioorg Med Chem. 2016 Jul 15;24(14):3116-24. doi: 10.1016/j.bmc.2016.05.032. Epub 2016 May 18.

PMID:
27255178
3.

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

Moreau P, Anizon F, Giraud F, Esvan YJ.

Recent Pat Anticancer Drug Discov. 2016;11(3):309-21. Review.

PMID:
27194556
4.

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.

Esvan YJ, Zeinyeh W, Boibessot T, Nauton L, Théry V, Knapp S, Chaikuad A, Loaëc N, Meijer L, Anizon F, Giraud F, Moreau P.

Eur J Med Chem. 2016 Aug 8;118:170-7. doi: 10.1016/j.ejmech.2016.04.004. Epub 2016 Apr 5.

PMID:
27128181
5.

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells.

Giraud F, Bourhis M, Ebrahimi E, Herfindal L, Choudhury RR, Bjørnstad R, Døskeland SO, Anizon F, Moreau P.

Bioorg Med Chem. 2015 Nov 15;23(22):7313-23. doi: 10.1016/j.bmc.2015.10.031. Epub 2015 Oct 24.

PMID:
26526744
6.

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.

Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Härkönen P, Koskinen PJ.

PLoS One. 2015 Jun 15;10(6):e0130340. doi: 10.1371/journal.pone.0130340. eCollection 2015.

7.

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.

Giraud F, Bourhis M, Nauton L, Théry V, Herfindal L, Døskeland SO, Anizon F, Moreau P.

Bioorg Chem. 2014 Dec;57:108-15. doi: 10.1016/j.bioorg.2014.09.004. Epub 2014 Sep 26.

PMID:
25305721
8.

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin.

Moreau P, Dezhenkova LG, Anizon F, Nauton L, Thery V, Liang S, Kaluzhny DN, Shtil AA.

Anticancer Agents Med Chem. 2014;14(9):1228-36.

PMID:
25175798
9.

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition.

Suchaud V, Gavara L, Giraud F, Nauton L, Théry V, Anizon F, Moreau P.

Bioorg Med Chem. 2014 Sep 1;22(17):4704-10. doi: 10.1016/j.bmc.2014.07.011. Epub 2014 Jul 16.

PMID:
25087047
10.

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors.

Suchaud V, Gavara L, Saugues E, Nauton L, Théry V, Anizon F, Moreau P.

Bioorg Med Chem. 2013 Jul 15;21(14):4102-11. doi: 10.1016/j.bmc.2013.05.011. Epub 2013 May 16.

PMID:
23735828
11.

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

Gavara L, Suchaud V, Nauton L, Théry V, Anizon F, Moreau P.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2298-301. doi: 10.1016/j.bmcl.2013.02.074. Epub 2013 Feb 26.

PMID:
23499503
12.

Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.

Saugues E, Debaud AL, Anizon F, Bonnefoy N, Moreau P.

Eur J Med Chem. 2012 Nov;57:112-25. doi: 10.1016/j.ejmech.2012.09.012. Epub 2012 Sep 17.

PMID:
23047228
13.

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Giraud F, Akué-Gédu R, Nauton L, Candelon N, Debiton E, Théry V, Anizon F, Moreau P.

Eur J Med Chem. 2012 Oct;56:225-36. doi: 10.1016/j.ejmech.2012.08.029. Epub 2012 Aug 30.

PMID:
22982527
14.

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

Akué-Gédu R, Letribot B, Saugues E, Debiton E, Anizon F, Moreau P.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3807-9. doi: 10.1016/j.bmcl.2012.03.098. Epub 2012 Apr 3.

PMID:
22543026
15.

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Letribot B, Akué-Gédu R, Santio NM, El-Ghozzi M, Avignant D, Cisnetti F, Koskinen PJ, Gautier A, Anizon F, Moreau P.

Eur J Med Chem. 2012 Apr;50:304-10. doi: 10.1016/j.ejmech.2012.02.009. Epub 2012 Feb 10.

PMID:
22386260
16.

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

Bouchikhi F, Anizon F, Brun R, Moreau P.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6319-21. doi: 10.1016/j.bmcl.2011.08.116. Epub 2011 Sep 1.

PMID:
21937228
17.

Synthesis and molecular modeling study of new trimeric quinoline derivatives.

Saugues E, Nauton L, Théry V, Anizon F, Moreau P.

Bioorg Chem. 2011 Aug;39(4):143-50. doi: 10.1016/j.bioorg.2011.07.001. Epub 2011 Jul 14.

PMID:
21807395
18.

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Giraud F, Alves G, Debiton E, Nauton L, Théry V, Durieu E, Ferandin Y, Lozach O, Meijer L, Anizon F, Pereira E, Moreau P.

J Med Chem. 2011 Jul 14;54(13):4474-89. doi: 10.1021/jm200464w. Epub 2011 Jun 10.

PMID:
21623630
19.

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion.

Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ.

Mol Cancer. 2010 Oct 19;9:279. doi: 10.1186/1476-4598-9-279.

20.

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.

Anizon F, Shtil AA, Danilenko VN, Moreau P.

Curr Med Chem. 2010;17(34):4114-33. Review.

PMID:
20939820
21.

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

Gavara L, Saugues E, Alves G, Debiton E, Anizon F, Moreau P.

Eur J Med Chem. 2010 Nov;45(11):5520-6. doi: 10.1016/j.ejmech.2010.08.067. Epub 2010 Sep 15.

PMID:
20864224
22.

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

Broch S, Hénon H, Debaud AL, Fogeron ML, Bonnefoy-Bérard N, Anizon F, Moreau P.

Bioorg Med Chem. 2010 Oct 1;18(19):7132-43. doi: 10.1016/j.bmc.2010.07.029. Epub 2010 Jul 16.

PMID:
20800501
23.

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

Akué-Gédu R, Nauton L, Théry V, Bain J, Cohen P, Anizon F, Moreau P.

Bioorg Med Chem. 2010 Sep 15;18(18):6865-73. doi: 10.1016/j.bmc.2010.07.036. Epub 2010 Aug 19.

PMID:
20728368
24.

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

Broch S, Aboab B, Anizon F, Moreau P.

Eur J Med Chem. 2010 Apr;45(4):1657-62. doi: 10.1016/j.ejmech.2010.01.003. Epub 2010 Jan 14.

PMID:
20106562
25.

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.

Akué-Gédu R, Rossignol E, Azzaro S, Knapp S, Filippakopoulos P, Bullock AN, Bain J, Cohen P, Prudhomme M, Anizon F, Moreau P.

J Med Chem. 2009 Oct 22;52(20):6369-81. doi: 10.1021/jm901018f.

PMID:
19788246
26.

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Akue-Gedu R, Debiton E, Ferandin Y, Meijer L, Prudhomme M, Anizon F, Moreau P.

Bioorg Med Chem. 2009 Jul 1;17(13):4420-4. doi: 10.1016/j.bmc.2009.05.017. Epub 2009 May 12.

PMID:
19477650
27.

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

Bouchikhi F, Anizon F, Moreau P.

Eur J Med Chem. 2009 Jun;44(6):2705-10. doi: 10.1016/j.ejmech.2009.01.027. Epub 2009 Feb 5.

PMID:
19232788
28.

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

Marminon C, Anizon F, Moreau P, Pfeiffer B, Pierré A, Golsteyn RM, Peixoto P, Hildebrand MP, David-Cordonnier MH, Lozach O, Meijer L, Prudhomme M.

Mol Pharmacol. 2008 Dec;74(6):1620-9. doi: 10.1124/mol.108.049346. Epub 2008 Sep 2.

29.

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives.

Rossignol E, Debiton E, Fabbro D, Moreau P, Prudhomme M, Anizon F.

Anticancer Drugs. 2008 Sep;19(8):789-92. doi: 10.1097/CAD.0b013e32830ce4d8.

PMID:
18690090
30.

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.

Anizon F, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Eur J Med Chem. 2009 May;44(5):2234-8. doi: 10.1016/j.ejmech.2008.05.023. Epub 2008 Jul 3.

PMID:
18602198
31.

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

Conchon E, Anizon F, Aboab B, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2008 Apr 15;16(8):4419-30. doi: 10.1016/j.bmc.2008.02.061. Epub 2008 Mar 5.

PMID:
18321713
32.

Synthesis and biological evaluation of diversely substituted indolin-2-ones.

Bouchikhi F, Rossignol E, Sancelme M, Aboab B, Anizon F, Fabbro D, Prudhomme M, Moreau P.

Eur J Med Chem. 2008 Nov;43(11):2316-22. doi: 10.1016/j.ejmech.2008.01.010. Epub 2008 Jan 25.

PMID:
18313174
33.

Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.

Conchon E, Anizon F, Aboab B, Prudhomme M.

J Med Chem. 2007 Sep 20;50(19):4669-80. Epub 2007 Aug 28.

PMID:
17722905
34.

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

Sassatelli M, Bouchikhi F, Aboab B, Anizon F, Fabbro D, Prudhomme M, Moreau P.

Anticancer Drugs. 2007 Oct;18(9):1069-74.

PMID:
17704657
35.

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

Bouchikhi F, Anizon F, Moreau P.

Eur J Med Chem. 2008 Apr;43(4):755-62. Epub 2007 Jun 3.

PMID:
17628214
36.

Synthesis and biological activities of isogranulatimide analogues.

Hugon B, Anizon F, Bailly C, Golsteyn RM, Pierré A, Léonce S, Hickman J, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2007 Sep 1;15(17):5965-80. Epub 2007 Jun 7.

PMID:
17582773
37.
38.

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

Hénon H, Messaoudi S, Anizon F, Aboab B, Kucharczyk N, Léonce S, Golsteyn RM, Pfeiffer B, Prudhomme M.

Eur J Pharmacol. 2007 Jan 12;554(2-3):106-12. Epub 2006 Oct 19.

PMID:
17134696
39.

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

Messaoudi S, Anizon F, Peixoto P, David-Cordonnier MH, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2006 Nov 15;14(22):7551-62. Epub 2006 Aug 4.

PMID:
16889964
40.

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

Hénon H, Anizon F, Golsteyn RM, Léonce S, Hofmann R, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2006 Jun 1;14(11):3825-34. Epub 2006 Feb 3.

PMID:
16460946
41.

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

Sassatelli M, Bouchikhi F, Messaoudi S, Anizon F, Debiton E, Barthomeuf C, Prudhomme M, Moreau P.

Eur J Med Chem. 2006 Jan;41(1):88-100. Epub 2005 Dec 5.

PMID:
16330129
42.

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.

Messaoudi S, Anizon F, Léonce S, Pierré A, Pfeiffer B, Prudhomme M.

Eur J Med Chem. 2005 Oct;40(10):961-71.

PMID:
15907347
43.

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

Moreau P, Gaillard N, Marminon C, Anizon F, Dias N, Baldeyrou B, Bailly C, Pierré A, Hickman J, Pfeiffer B, Renard P, Prudhomme M.

Bioorg Med Chem. 2003 Nov 17;11(23):4871-9.

PMID:
14604648
44.

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.

Anizon F, Moreau P, Sancelme M, Laine W, Bailly C, Prudhomme M.

Bioorg Med Chem. 2003 Aug 15;11(17):3709-22.

PMID:
12901916
45.

DNA targeting of two new antitumour rebeccamycin derivatives.

Facompré M, Baldeyrou B, Bailly C, Anizon F, Marminon C, Prudhomme M, Colson P, Houssier C.

Eur J Med Chem. 2002 Dec;37(12):925-32.

PMID:
12660017
46.

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.

Marminon C, Anizon F, Moreau P, Léonce S, Pierré A, Pfeiffer B, Renard P, Prudhomme M.

J Med Chem. 2002 Mar 14;45(6):1330-9.

PMID:
11882002
47.

Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.

Bailly C, Goossens JF, Laine W, Anizon F, Prudhomme M, Ren J, Chaires JB.

J Med Chem. 2000 Nov 30;43(24):4711-20.

PMID:
11101362
48.

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

Goossens JF, Hénichart JP, Anizon F, Prudhomme M, Dugave C, Riou J, Bailly C.

Eur J Pharmacol. 2000 Feb 18;389(2-3):141-6.

PMID:
10688977
49.

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.

Moreau P, Anizon F, Sancelme M, Prudhomme M, Sevère D, Riou JF, Goossens JF, Hénichart JP, Bailly C, Labourier E, Tazzi J, Fabbro D, Meyer T, Aubertin AM.

J Med Chem. 1999 May 20;42(10):1816-22.

PMID:
10346933
50.

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.

Moreau P, Anizon F, Sancelme M, Prudhomme M, Bailly C, Sevère D, Riou JF, Fabbro D, Meyer T, Aubertin AM.

J Med Chem. 1999 Feb 25;42(4):584-92.

PMID:
10052965

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