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Items: 1 to 50 of 445

1.

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17.

PMID:
29653637
2.

Pharmacogenomics and big genomic data: from lab to clinic and back again.

Lavertu A, McInnes G, Daneshjou R, Whirl-Carrillo M, Klein TE, Altman RB.

Hum Mol Genet. 2018 Apr 4. doi: 10.1093/hmg/ddy116. [Epub ahead of print]

PMID:
29635477
3.

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.

4.

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.

5.

PharmGKB summary: clobazam pathway, pharmacokinetics.

Huddart R, Leeder JS, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. No abstract available.

PMID:
29517622
6.

PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics.

Alvarellos M, Guillemette C, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 May;28(5):127-137. doi: 10.1097/FPC.0000000000000331. No abstract available.

PMID:
29517518
7.

A global network of biomedical relationships derived from text.

Percha B, Altman RB.

Bioinformatics. 2018 Feb 27. doi: 10.1093/bioinformatics/bty114. [Epub ahead of print]

PMID:
29490008
8.

Reversals and limitations on high-intensity, life-sustaining treatments.

Chavez G, Richman IB, Kaimal R, Bentley J, Yasukawa LA, Altman RB, Periyakoil VS, Chen JH.

PLoS One. 2018 Feb 28;13(2):e0190569. doi: 10.1371/journal.pone.0190569. eCollection 2018.

9.

PharmGKB: A worldwide resource for pharmacogenomic information.

Barbarino JM, Whirl-Carrillo M, Altman RB, Klein TE.

Wiley Interdiscip Rev Syst Biol Med. 2018 Feb 23. doi: 10.1002/wsbm.1417. [Epub ahead of print] Review.

PMID:
29474005
10.

Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.

Han L, Maciejewski M, Brockel C, Afzelius L, Altman RB.

Inflamm Bowel Dis. 2018 Feb 15;24(3):471-481. doi: 10.1093/ibd/izx087.

PMID:
29462399
11.

Expanding a radiology lexicon using contextual patterns in radiology reports.

Percha B, Zhang Y, Bozkurt S, Rubin D, Altman RB, Langlotz CP.

J Am Med Inform Assoc. 2018 Jan 10. doi: 10.1093/jamia/ocx152. [Epub ahead of print]

PMID:
29329435
12.

Systematic target function annotation of human transcription factors.

Li YF, Altman RB.

BMC Biol. 2018 Jan 10;16(1):4. doi: 10.1186/s12915-017-0469-0.

13.

Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development.

Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Clin Transl Sci. 2018 Mar;11(2):166-174. doi: 10.1111/cts.12531. Epub 2017 Dec 22.

14.

A dynamic map for learning, communicating, navigating and improving therapeutic development.

Wagner J, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Nat Rev Drug Discov. 2018 Feb;17(2):150. doi: 10.1038/nrd.2017.217. Epub 2017 Dec 22. No abstract available.

PMID:
29269942
15.

GeneDive: A gene interaction search and visualization tool to facilitate precision medicine.

Previde P, Thomas B, Wong M, Mallory EK, Petkovic D, Altman RB, Kulkarni A.

Pac Symp Biocomput. 2018;23:590-601.

16.

Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome.

Mallory EK, Acharya A, Rensi SE, Turnbaugh PJ, Bright RA, Altman RB.

Pac Symp Biocomput. 2018;23:56-67.

17.

Aminoglycoside interactions and impacts on the eukaryotic ribosome.

Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10899-E10908. doi: 10.1073/pnas.1715501114. Epub 2017 Dec 5.

18.

Biomarkers: Delivering on the expectation of molecularly driven, quantitative health.

Wilson JL, Altman RB.

Exp Biol Med (Maywood). 2018 Feb;243(3):313-322. doi: 10.1177/1535370217744775. Epub 2017 Dec 3.

PMID:
29199461
19.

Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.

Gottlieb A, Daneshjou R, DeGorter M, Bourgeois S, Svensson PJ, Wadelius M, Deloukas P, Montgomery SB, Altman RB.

Genome Med. 2017 Nov 24;9(1):98. doi: 10.1186/s13073-017-0495-0.

20.

Association of Omics Features with Histopathology Patterns in Lung Adenocarcinoma.

Yu KH, Berry GJ, Rubin DL, Ré C, Altman RB, Snyder M.

Cell Syst. 2017 Dec 27;5(6):620-627.e3. doi: 10.1016/j.cels.2017.10.014. Epub 2017 Nov 15.

PMID:
29153840
21.

Dynamics of P-type ATPase transport revealed by single-molecule FRET.

Dyla M, Terry DS, Kjaergaard M, Sørensen TL, Lauwring Andersen J, Andersen JP, Rohde Knudsen C, Altman RB, Nissen P, Blanchard SC.

Nature. 2017 Nov 16;551(7680):346-351. doi: 10.1038/nature24296. Epub 2017 Nov 8.

22.

Challenges for Training Translational Researchers in the Era of Ubiquitous Data.

Altman RB.

Clin Pharmacol Ther. 2018 Feb;103(2):171-173. doi: 10.1002/cpt.918. Epub 2017 Nov 14.

PMID:
29134624
23.

A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.

Han L, Maciejewski M, Brockel C, Gordon W, Snapper SB, Korzenik JR, Afzelius L, Altman RB.

Bioinformatics. 2018 Mar 15;34(6):985-993. doi: 10.1093/bioinformatics/btx651.

24.

Biological and functional relevance of CASP predictions.

Liu T, Ish-Shalom S, Torng W, Lafita A, Bock C, Mort M, Cooper DN, Bliven S, Capitani G, Mooney SD, Altman RB.

Proteins. 2018 Mar;86 Suppl 1:374-386. doi: 10.1002/prot.25396. Epub 2017 Oct 17.

25.

PharmGKB summary: very important pharmacogene information for ABCG2.

Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Nov;27(11):420-427. doi: 10.1097/FPC.0000000000000305. No abstract available.

PMID:
28858993
26.

Shallow Representation Learning via Kernel PCA Improves QSAR Modelability.

Rensi SE, Altman RB.

J Chem Inf Model. 2017 Aug 28;57(8):1859-1867. doi: 10.1021/acs.jcim.6b00694. Epub 2017 Aug 7.

PMID:
28727421
27.

PharmGKB summary: pazopanib pathway, pharmacokinetics.

Thorn CF, Sharma MR, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Aug;27(8):307-312. doi: 10.1097/FPC.0000000000000292. No abstract available.

PMID:
28678138
28.

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.

Daneshjou R, Wang Y, Bromberg Y, Bovo S, Martelli PL, Babbi G, Lena PD, Casadio R, Edwards M, Gifford D, Jones DT, Sundaram L, Bhat RR, Li X, Pal LR, Kundu K, Yin Y, Moult J, Jiang Y, Pejaver V, Pagel KA, Li B, Mooney SD, Radivojac P, Shah S, Carraro M, Gasparini A, Leonardi E, Giollo M, Ferrari C, Tosatto SCE, Bachar E, Azaria JR, Ofran Y, Unger R, Niroula A, Vihinen M, Chang B, Wang MH, Franke A, Petersen BS, Pirooznia M, Zandi P, McCombie R, Potash JB, Altman RB, Klein TE, Hoskins RA, Repo S, Brenner SE, Morgan AA.

Hum Mutat. 2017 Sep;38(9):1182-1192. doi: 10.1002/humu.23280. Epub 2017 Jul 7.

PMID:
28634997
29.

3D deep convolutional neural networks for amino acid environment similarity analysis.

Torng W, Altman RB.

BMC Bioinformatics. 2017 Jun 14;18(1):302. doi: 10.1186/s12859-017-1702-0.

30.

Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.

Vušurović N, Altman RB, Terry DS, Micura R, Blanchard SC.

J Am Chem Soc. 2017 Jun 21;139(24):8186-8193. doi: 10.1021/jacs.7b01549. Epub 2017 Jun 9.

31.

Decaying relevance of clinical data towards future decisions in data-driven inpatient clinical order sets.

Chen JH, Alagappan M, Goldstein MK, Asch SM, Altman RB.

Int J Med Inform. 2017 Jun;102:71-79. doi: 10.1016/j.ijmedinf.2017.03.006. Epub 2017 Mar 18.

32.

Flexible Analog Search with Kernel PCA Embedded Molecule Vectors.

Rensi S, Altman RB.

Comput Struct Biotechnol J. 2017 Mar 24;15:320-327. doi: 10.1016/j.csbj.2017.03.003. eCollection 2017.

33.

Opportunities for developing therapies for rare genetic diseases: focus on gain-of-function and allostery.

Chen B, Altman RB.

Orphanet J Rare Dis. 2017 Apr 17;12(1):61. doi: 10.1186/s13023-017-0614-4.

34.

Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing.

O'Donnell PH, Wadhwa N, Danahey K, Borden BA, Lee SM, Hall JP, Klammer C, Hussain S, Siegler M, Sorrentino MJ, Davis AM, Sacro YA, Nanda R, Polonsky TS, Koyner JL, Burnet DL, Lipstreuer K, Rubin DT, Mulcahy C, Strek ME, Harper W, Cifu AS, Polite B, Patrick-Miller L, Yeo KT, Leung E, Volchenboum SL, Altman RB, Olopade OI, Stadler WM, Meltzer DO, Ratain MJ.

Clin Pharmacol Ther. 2017 Nov;102(5):859-869. doi: 10.1002/cpt.709. Epub 2017 Jun 15.

PMID:
28398598
35.

Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.

Zheng Q, Jockusch S, Zhou Z, Altman RB, Zhao H, Asher W, Holsey M, Mathiasen S, Geggier P, Javitch JA, Blanchard SC.

Chem Sci. 2017 Jan 1;8(1):755-762. doi: 10.1039/C6SC02976K. Epub 2016 Sep 7.

36.

Development of an automated assessment tool for MedWatch reports in the FDA adverse event reporting system.

Han L, Ball R, Pamer CA, Altman RB, Proestel S.

J Am Med Inform Assoc. 2017 Sep 1;24(5):913-920. doi: 10.1093/jamia/ocx022.

PMID:
28371826
37.

PharmGKB summary: sorafenib pathways.

Gong L, Giacomini MM, Giacomini C, Maitland ML, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Jun;27(6):240-246. doi: 10.1097/FPC.0000000000000279. No abstract available.

PMID:
28362716
38.

PharmGKB summary: voriconazole pathway, pharmacokinetics.

Barbarino JM, Owusu Obeng A, Klein TE, Altman RB.

Pharmacogenet Genomics. 2017 May;27(5):201-209. doi: 10.1097/FPC.0000000000000276. No abstract available.

PMID:
28277330
39.

Artificial intelligence (AI) systems for interpreting complex medical datasets.

Altman RB.

Clin Pharmacol Ther. 2017 May;101(5):585-586. doi: 10.1002/cpt.650. Epub 2017 Mar 17. Review.

PMID:
28182259
40.

PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics.

Fohner AE, Sparreboom A, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Apr;27(4):164-167. doi: 10.1097/FPC.0000000000000270. No abstract available.

41.

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR; Pharmacogenomics Research Network Translational Pharmacogenetics Program.

Clin Pharmacol Ther. 2017 Sep;102(3):502-510. doi: 10.1002/cpt.630. Epub 2017 Jun 9.

PMID:
28090649
42.

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R.

Transl Psychiatry. 2016 Nov 1;6(11):e937. doi: 10.1038/tp.2016.187. No abstract available.

43.

Imputing gene expression to maximize platform compatibility.

Zhou W, Han L, Altman RB.

Bioinformatics. 2017 Feb 15;33(4):522-528. doi: 10.1093/bioinformatics/btw664.

44.

PharmGKB summary: very important pharmacogene information for MT-RNR1.

Barbarino JM, McGregor TL, Altman RB, Klein TE.

Pharmacogenet Genomics. 2016 Dec;26(12):558-567. Review. No abstract available.

45.

Computing disease incidence, prevalence and comorbidity from electronic medical records.

Bagley SC, Altman RB.

J Biomed Inform. 2016 Oct;63:108-111. doi: 10.1016/j.jbi.2016.08.005. Epub 2016 Aug 4.

46.

Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency.

Liu T, Oprea T, Ursu O, Hasselgren C, Altman RB.

Clin Transl Sci. 2016 Dec;9(6):311-320. doi: 10.1111/cts.12422. Epub 2016 Oct 13.

47.

Predicting inpatient clinical order patterns with probabilistic topic models vs conventional order sets.

Chen JH, Goldstein MK, Asch SM, Mackey L, Altman RB.

J Am Med Inform Assoc. 2017 May 1;24(3):472-480. doi: 10.1093/jamia/ocw136.

48.

Response to Open Peer Commentaries on "Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework".

Evitt NH, Mascharak S, Altman RB.

Am J Bioeth. 2016 Oct;16(10):W1-2. doi: 10.1080/15265161.2016.1214308. No abstract available.

PMID:
27653416
49.

Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans.

Daneshjou R, Cavallari LH, Weeke PE, Karczewski KJ, Drozda K, Perera MA, Johnson JA, Klein TE, Bustamante CD, Roden DM, Shaffer C, Denny JC, Zehnder JL, Altman RB.

Mol Genet Genomic Med. 2016 Jun 21;4(5):513-20. doi: 10.1002/mgg3.226. eCollection 2016 Sep.

50.

PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.

Fohner AE, McDonagh EM, Clancy JP, Whirl Carrillo M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Jan;27(1):39-42. No abstract available.

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