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Items: 1 to 50 of 358

1.

In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes.

Potts JR, Farahi N, Howard MR, Taylor MR, Heard S, Shankar AN, Alexander GJ, Chilvers ER, Verma S, Peters AM.

Biosci Rep. 2018 Apr 26. pii: BSR20180466. doi: 10.1042/BSR20180466. [Epub ahead of print]

PMID:
29700216
2.

The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines.

Hirschfield GM, Dyson JK, Alexander GJM, Chapman MH, Collier J, Hübscher S, Patanwala I, Pereira SP, Thain C, Thorburn D, Tiniakos D, Walmsley M, Webster G, Jones DEJ.

Gut. 2018 Mar 28. pii: gutjnl-2017-315259. doi: 10.1136/gutjnl-2017-315259. [Epub ahead of print]

3.

Telomere, telomerase and liver disease.

Aravinthan AD, Alexander GJ.

Liver Int. 2018 Jan;38(1):33-34. doi: 10.1111/liv.13630. No abstract available.

PMID:
29272567
4.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen HR, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY.

Sci Rep. 2017 Nov 20;7(1):15843. doi: 10.1038/s41598-017-16011-2.

5.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.

Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.

PMID:
28671689
6.

Association between progressive hepatic morphology changes on serial MR imaging and clinical outcome in primary sclerosing cholangitis.

Kitzing YX, Whitley SA, Upponi SS, Srivastava B, Alexander GJ, Lomas DJ.

J Med Imaging Radiat Oncol. 2017 Oct;61(5):636-642. doi: 10.1111/1754-9485.12610. Epub 2017 Apr 22.

PMID:
28432731
7.

Early primary biliary cholangitis is characterised by brain abnormalities on cerebral magnetic resonance imaging.

Grover VP, Southern L, Dyson JK, Kim JU, Crossey MM, Wylezinska-Arridge M, Patel N, Fitzpatrick JA, Bak-Bol A, Waldman AD, Alexander GJ, Mells GF, Chapman RW, Jones DE, Taylor-Robinson SD.

Aliment Pharmacol Ther. 2016 Nov;44(9):936-945. doi: 10.1111/apt.13797. Epub 2016 Sep 8.

8.

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial.

Hegade VS, Kendrick SF, Dobbins RL, Miller SR, Richards D, Storey J, Dukes G, Gilchrist K, Vallow S, Alexander GJ, Corrigan M, Hirschfield GM, Jones DE.

BMC Gastroenterol. 2016 Jul 19;16(1):71. doi: 10.1186/s12876-016-0481-9.

9.

Senescence in chronic liver disease: Is the future in aging?

Aravinthan AD, Alexander GJM.

J Hepatol. 2016 Oct;65(4):825-834. doi: 10.1016/j.jhep.2016.05.030. Epub 2016 May 28. Review.

PMID:
27245432
10.

A national survey of the provision of ultrasound surveillance for the detection of hepatocellular carcinoma.

Cross TJS, Villaneuva A, Shetty S, Wilkes E, Collins P, Adair A, Jones RL, Foxton MR, Meyer T, Stern N, Warshow U, Khan N, Prince M, Khakoo S, Alexander GJ, Khan S, Reeves H, Marshall A, Williams R.

Frontline Gastroenterol. 2016 Apr;7(2):82-89. doi: 10.1136/flgastro-2015-100617. Epub 2015 Dec 7.

11.

STAT4-associated natural killer cell tolerance following liver transplantation.

Jamil KM, Hydes TJ, Cheent KS, Cassidy SA, Traherne JA, Jayaraman J, Trowsdale J, Alexander GJ, Little AM, McFarlane H, Heneghan MA, Purbhoo MA, Khakoo SI.

Gut. 2017 Feb;66(2):352-361. doi: 10.1136/gutjnl-2015-309395. Epub 2016 Feb 17.

12.

An ambusher's arsenal: chemical crypsis in the puff adder (Bitis arietans).

Miller AK, Maritz B, McKay S, Glaudas X, Alexander GJ.

Proc Biol Sci. 2015 Dec 22;282(1821):20152182. doi: 10.1098/rspb.2015.2182.

13.

Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C.

Chen AY, Hoare M, Shankar AN, Allison M, Alexander GJ, Michalak TI.

PLoS One. 2015 Oct 16;10(10):e0140312. doi: 10.1371/journal.pone.0140312. eCollection 2015.

14.

The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways.

Hydes TJ, Moesker B, Traherne JA, Ashraf S, Alexander GJ, Dimitrov BD, Woelk CH, Trowsdale J, Khakoo SI.

Tissue Antigens. 2015 Oct;86(4):267-75. doi: 10.1111/tan.12650.

15.

The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis.

Carbone M, Sharp SJ, Flack S, Paximadas D, Spiess K, Adgey C, Griffiths L, Lim R, Trembling P, Williamson K, Wareham NJ, Aldersley M, Bathgate A, Burroughs AK, Heneghan MA, Neuberger JM, Thorburn D, Hirschfield GM, Cordell HJ, Alexander GJ, Jones DE, Sandford RN, Mells GF; UK-PBC Consortium.

Hepatology. 2016 Mar;63(3):930-50. doi: 10.1002/hep.28017. Epub 2015 Oct 20.

PMID:
26223498
16.

Correction: Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis.

Tachtatzis PM, Marshall A, Aravinthan A, Verma S, Penrhyn-Lowe S, Mela M, Scarpini C, Davies SE, Coleman N, Alexander GJ.

PLoS One. 2015 Jul 28;10(7):e0134315. doi: 10.1371/journal.pone.0134315. eCollection 2015. No abstract available.

17.

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L.

Nat Biotechnol. 2015 Aug;33(8):845-852. doi: 10.1038/nbt.3275. Epub 2015 Jul 13.

18.

Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis.

Tachtatzis PM, Marshall A, Arvinthan A, Verma S, Penrhyn-Lowe S, Mela M, Scarpini C, Davies SE, Coleman N, Alexander GJ.

PLoS One. 2015 May 29;10(5):e0127511. doi: 10.1371/journal.pone.0127511. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134315. Aravinthan, Aloysius [corrected to Arvinthan, Aloysious].

19.

Magnetic resonance elastography in the detection of hepatorenal syndrome in patients with cirrhosis and ascites.

Low G, Owen NE, Joubert I, Patterson AJ, Graves MJ, Alexander GJ, Lomas DJ.

Eur Radiol. 2015 Oct;25(10):2851-8. doi: 10.1007/s00330-015-3723-2. Epub 2015 Apr 23.

PMID:
25903705
20.

Renal impairment in cirrhosis unrelated to hepatorenal syndrome.

Low G, Alexander GJ, Lomas DJ.

Can J Gastroenterol Hepatol. 2015 Jun-Jul;29(5):253-7. Epub 2015 Apr 15. Review.

21.

Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure.

Aravinthan AD, Alexander GJ.

J Hepatol. 2015 Aug;63(2):532-3. doi: 10.1016/j.jhep.2015.03.031. Epub 2015 Apr 1. No abstract available.

22.

Hepatorenal syndrome: aetiology, diagnosis, and treatment.

Low G, Alexander GJ, Lomas DJ.

Gastroenterol Res Pract. 2015;2015:207012. doi: 10.1155/2015/207012. Epub 2015 Jan 12. Review.

23.

Reliability of magnetic resonance elastography using multislice two-dimensional spin-echo echo-planar imaging (SE-EPI) and three-dimensional inversion reconstruction for assessing renal stiffness.

Low G, Owen NE, Joubert I, Patterson AJ, Graves MJ, Glaser KJ, Alexander GJ, Lomas DJ.

J Magn Reson Imaging. 2015 Sep;42(3):844-50. doi: 10.1002/jmri.24826. Epub 2014 Dec 24.

24.

A retrospective 15-year review: survival advantage after switching to sirolimus in hepatitis C virus infected liver graft recipients.

Shah M, Shankar A, Gee I, Nash K, Hoare M, Gibbs P, Davies S, Alexander GJ.

Aliment Pharmacol Ther. 2015 Feb;41(4):379-92. doi: 10.1111/apt.13049. Epub 2014 Dec 11.

25.

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.

Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA.

Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13.

26.

Selective insulin resistance in hepatocyte senescence.

Aravinthan A, Challis B, Shannon N, Hoare M, Heaney J, Alexander GJ.

Exp Cell Res. 2015 Feb 1;331(1):38-45. doi: 10.1016/j.yexcr.2014.09.025. Epub 2014 Sep 28.

PMID:
25263463
27.

The senescent hepatocyte gene signature in chronic liver disease.

Aravinthan A, Shannon N, Heaney J, Hoare M, Marshall A, Alexander GJ.

Exp Gerontol. 2014 Dec;60:37-45. doi: 10.1016/j.exger.2014.09.011. Epub 2014 Sep 18.

PMID:
25240687
28.

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.

Liu YL, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JB, Allison ME, Alexander GJ, Piguet AC, Anty R, Donaldson P, Aithal GP, Francque S, Van Gaal L, Clement K, Ratziu V, Dufour JF, Day CP, Daly AK, Anstee QM.

Nat Commun. 2014 Jun 30;5:4309. doi: 10.1038/ncomms5309.

29.

Digestive efficiencies are independent of gut passage times in rainbow skinks (Trachylepis margaritifer).

Miller AK, Erasmus BF, Alexander GJ.

Comp Biochem Physiol A Mol Integr Physiol. 2014 Sep;175:110-4. doi: 10.1016/j.cbpa.2014.06.002. Epub 2014 Jun 15.

PMID:
24937258
30.

Rifaximin is largely safe and well tolerated but caution is necessary when taken with statins.

Cacciottolo TM, Kingdon A, Alexander GJ.

Clin Gastroenterol Hepatol. 2014 Oct;12(10):1765. doi: 10.1016/j.cgh.2014.03.027. Epub 2014 Apr 1. No abstract available.

PMID:
24703862
31.

Extended duration therapy with pegylated interferon and ribavirin for patients with genotype 3 hepatitis C and advanced fibrosis: final results from the STEPS trial.

Shoeb D, Dearden J, Weatherall A, Bargery C, Moreea S, Alam S, White E, Vila X, Freshwater D, Ryder S, Mills PR, Alexander GJ, Forton D, Foster GR.

J Hepatol. 2014 Apr;60(4):699-705. doi: 10.1016/j.jhep.2013.11.011. Epub 2013 Nov 26.

PMID:
24291239
32.

Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease.

Aravinthan A, Pietrosi G, Hoare M, Jupp J, Marshall A, Verrill C, Davies S, Bateman A, Sheron N, Allison M, Alexander GJ.

PLoS One. 2013 Sep 23;8(9):e72904. doi: 10.1371/journal.pone.0072904. eCollection 2013.

33.

Infectious aortitis in a liver transplant recipient.

Gerada J, Ganeshanantham G, Dawwas MF, Winterbottom AP, Sivaprakasam R, Butler AJ, Alexander GJ.

Am J Transplant. 2013 Sep;13(9):2479-82. doi: 10.1111/ajt.12353. Epub 2013 Aug 6. Erratum in: Am J Transplant. 2014 Jan;14(1):243.

34.

Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation.

Khandhadia S, Hakobyan S, Heng LZ, Gibson J, Adams DH, Alexander GJ, Gibson JM, Martin KR, Menon G, Nash K, Sivaprasad S, Ennis S, Cree AJ, Morgan BP, Lotery AJ.

Ophthalmology. 2013 Aug;120(8):1612-8. doi: 10.1016/j.ophtha.2013.01.004. Epub 2013 Apr 4.

PMID:
23562165
35.

Impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC national study.

Mells GF, Pells G, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, Sandford RN, Alexander GJ, Jones DE; UK-PBC Consortium.

Hepatology. 2013 Jul;58(1):273-83. doi: 10.1002/hep.26365.

PMID:
23471852
36.

The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort.

Pells G, Mells GF, Carbone M, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, Neuberger JM, Day DB, Ducker SJ; UK-PBC Consortium, Sandford RN, Alexander GJ, Jones DE.

J Hepatol. 2013 Jul;59(1):67-73. doi: 10.1016/j.jhep.2013.02.019. Epub 2013 Mar 4.

PMID:
23466308
37.

Calcineurin inhibitors and the IL12A locus influence risk of recurrent primary biliary cirrhosis after liver transplantation.

Carbone M, Mells GF, Alexander GJ, Westbrook RH, Heneghan MA, Sandford RN, Neuberger JM.

Am J Transplant. 2013 Apr;13(4):1110-1111. doi: 10.1111/ajt.12132. Epub 2013 Feb 22. No abstract available.

38.

Prevalence and risk factors for liver involvement in individuals with PiZZ-related lung disease.

Dawwas MF, Davies SE, Griffiths WJ, Lomas DA, Alexander GJ.

Am J Respir Crit Care Med. 2013 Mar 1;187(5):502-8. doi: 10.1164/rccm.201204-0739OC. Epub 2012 Dec 21.

PMID:
23262512
39.

γ-H2AX+CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection.

Hoare M, Shankar A, Shah M, Rushbrook S, Gelson W, Davies S, Akbar A, Alexander GJ.

J Hepatol. 2013 May;58(5):868-74. doi: 10.1016/j.jhep.2012.12.009. Epub 2012 Dec 17.

40.

Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid.

Carbone M, Mells GF, Pells G, Dawwas MF, Newton JL, Heneghan MA, Neuberger JM, Day DB, Ducker SJ; UK PBC Consortium, Sandford RN, Alexander GJ, Jones DE.

Gastroenterology. 2013 Mar;144(3):560-569.e7; quiz e13-4. doi: 10.1053/j.gastro.2012.12.005. Epub 2012 Dec 12.

PMID:
23246637
41.

Induced pluripotent stem cells: from Nobel Prizes to clinical applications.

Rashid ST, Alexander GJ.

J Hepatol. 2013 Mar;58(3):625-9. doi: 10.1016/j.jhep.2012.10.026. Epub 2012 Nov 3. Review.

42.

Gut and intestinal passage time in the Rainbow Skink (Trachylepis margaritifer): implications for stress measures using faecal analysis.

Miller AK, Erasmus BF, Alexander GJ.

J Anim Physiol Anim Nutr (Berl). 2013 Oct;97(5):960-70. doi: 10.1111/jpn.12004. Epub 2012 Sep 24.

PMID:
22998669
43.

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA; UK Primary Biliary Cirrhosis (PBC) Consortium; Wellcome Trust Case Control Consortium 3.

Nat Genet. 2012 Oct;44(10):1137-41. doi: 10.1038/ng.2395. Epub 2012 Sep 9.

44.

A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis.

Godfrey EM, Patterson AJ, Priest AN, Davies SE, Joubert I, Krishnan AS, Griffin N, Shaw AS, Alexander GJ, Allison ME, Griffiths WJ, Gimson AE, Lomas DJ.

Eur Radiol. 2012 Dec;22(12):2790-7. doi: 10.1007/s00330-012-2527-x. Epub 2012 Jul 1.

PMID:
22752441
45.

Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis.

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A; UK-PSC Consortium, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E.

Scand J Gastroenterol. 2012 Jul;47(7):820-6. doi: 10.3109/00365521.2012.682090. Epub 2012 May 4.

PMID:
22554193
46.

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.

Verma S, Tachtatzis P, Penrhyn-Lowe S, Scarpini C, Jurk D, Von Zglinicki T, Coleman N, Alexander GJ.

Hepatology. 2012 Oct;56(4):1510-20. doi: 10.1002/hep.25787. Epub 2012 Aug 27.

PMID:
22504828
47.

Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.

Ling L, Kuc RE, Maguire JJ, Davie NJ, Webb DJ, Gibbs P, Alexander GJ, Davenport AP.

Life Sci. 2012 Oct 15;91(13-14):716-22. doi: 10.1016/j.lfs.2012.02.003. Epub 2012 Feb 18.

48.

A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing.

Daly GM, Bexfield N, Heaney J, Stubbs S, Mayer AP, Palser A, Kellam P, Drou N, Caccamo M, Tiley L, Alexander GJ, Bernal W, Heeney JL.

PLoS One. 2011;6(12):e28879. doi: 10.1371/journal.pone.0028879. Epub 2011 Dec 21.

49.

Renal failure in chronic liver disease and the hepatorenal syndrome.

Srivastava B, Alexander GJ.

Br J Hosp Med (Lond). 2011 Sep;72(9):497-503. Review. No abstract available.

PMID:
22041830
50.

Sirolimus is coming of age.

Alexander GJ.

Am J Transplant. 2011 Nov;11(11):2273-4. doi: 10.1111/j.1600-6143.2011.03768.x. Epub 2011 Oct 3. No abstract available.

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