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Items: 48

1.

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells.

Ali D, Abuelreich S, Alkeraishan N, Shwish NB, Hamam R, Kassem M, Alfayez M, Aldahmash A, Alajez NM.

Biosci Rep. 2018 Jan 30;38(1). pii: BSR20171252. doi: 10.1042/BSR20171252. Print 2018 Feb 28.

2.

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells.

Elsafadi M, Manikandan M, Atteya M, Abu Dawud R, Almalki S, Ali Kaimkhani Z, Aldahmash A, Alajez NM, Alfayez M, Kassem M, Mahmood A.

Sci Rep. 2017 Sep 7;7(1):10797. doi: 10.1038/s41598-017-10983-x.

3.

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers.

Hamam R, Hamam D, Alsaleh KA, Kassem M, Zaher W, Alfayez M, Aldahmash A, Alajez NM.

Cell Death Dis. 2017 Sep 7;8(9):e3045. doi: 10.1038/cddis.2017.440. Review.

4.

MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3.

Elsafadi M, Manikandan M, Alajez NM, Hamam R, Dawud RA, Aldahmash A, Iqbal Z, Alfayez M, Kassem M, Mahmood A.

Stem Cell Res. 2017 Apr;20:94-104. doi: 10.1016/j.scr.2017.03.001. Epub 2017 Mar 8.

5.

Enhanced efficacy of 5-fluorouracil in combination with a dual histone deacetylase and phosphatidylinositide 3-kinase inhibitor (CUDC-907) in colorectal cancer cells.

Hamam R, Ali D, Vishnubalaji R, Alsaaran ZF, Chalisserry EP, Alfayez M, Aldahmash A, Alajez NM.

Saudi J Gastroenterol. 2017 Jan-Feb;23(1):34-38. doi: 10.4103/1319-3767.199136.

6.

Large-Scale Analysis of Gene Expression Data Reveals a Novel Gene Expression Signature Associated with Colorectal Cancer Distant Recurrence.

Alajez NM.

PLoS One. 2016 Dec 9;11(12):e0167455. doi: 10.1371/journal.pone.0167455. eCollection 2016.

7.

CUDC-907 Promotes Bone Marrow Adipocytic Differentiation Through Inhibition of Histone Deacetylase and Regulation of Cell Cycle.

Ali D, Alshammari H, Vishnubalaji R, Chalisserry EP, Hamam R, Alfayez M, Kassem M, Aldahmash A, Alajez NM.

Stem Cells Dev. 2017 Mar 1;26(5):353-362. doi: 10.1089/scd.2016.0183. Epub 2016 Nov 9.

PMID:
27829312
8.
9.

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells.

Vishnubalaji R, Yue S, Alfayez M, Kassem M, Liu FF, Aldahmash A, Alajez NM.

Cancer Cell Int. 2016 Sep 29;16:77. eCollection 2016.

10.

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization.

Elsafadi M, Manikandan M, Dawud RA, Alajez NM, Hamam R, Alfayez M, Kassem M, Aldahmash A, Mahmood A.

Cell Death Dis. 2016 Aug 4;7(8):e2321. doi: 10.1038/cddis.2016.196.

11.

Significance of BMI1 and FSCN1 expression in colorectal cancer.

Alajez NM.

Saudi J Gastroenterol. 2016 Jul-Aug;22(4):288-93. doi: 10.4103/1319-3767.187602.

12.

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells.

Ali D, Hamam R, Alfayez M, Kassem M, Aldahmash A, Alajez NM.

Stem Cells Transl Med. 2016 Aug;5(8):1036-47. doi: 10.5966/sctm.2015-0331. Epub 2016 May 18.

13.

microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection.

Hamam R, Ali AM, Alsaleh KA, Kassem M, Alfayez M, Aldahmash A, Alajez NM.

Sci Rep. 2016 May 16;6:25997. doi: 10.1038/srep25997.

14.

Integrated Study of Globally Expressed microRNAs in IL-1β-stimulated Human Osteoarthritis Chondrocytes and Osteoarthritis Relevant Genes: A Microarray and Bioinformatics Analysis.

Rasheed Z, Al-Shobaili HA, Rasheed N, Al Salloom AA, Al-Shaya O, Mahmood A, Alajez NM, Alghamdi AS, Mehana el-SE.

Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):335-55. doi: 10.1080/15257770.2016.1163380. Epub 2016 May 6.

PMID:
27152662
15.

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1.

Vishnubalaji R, Hamam R, Yue S, Al-Obeed O, Kassem M, Liu FF, Aldahmash A, Alajez NM.

Oncotarget. 2016 Jun 14;7(24):35789-35802. doi: 10.18632/oncotarget.8937.

16.

Angiogenic Potential of Human Neonatal Foreskin Stromal Cells in the Chick Embryo Chorioallantoic Membrane Model.

Vishnubalaji R, Atteya M, Al-Nbaheen M, Oreffo RO, Aldahmash A, Alajez NM.

Stem Cells Int. 2015;2015:257019. doi: 10.1155/2015/257019. Epub 2015 Jun 29.

17.

CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells.

Al-toub M, Vishnubalaji R, Hamam R, Kassem M, Aldahmash A, Alajez NM.

Stem Cell Res Ther. 2015 Jul 24;6:135. doi: 10.1186/s13287-015-0123-0.

18.

Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.

Vishnubalaji R, Hamam R, Abdulla MH, Mohammed MA, Kassem M, Al-Obeed O, Aldahmash A, Alajez NM.

Cell Death Dis. 2015 Jan 22;6:e1614. doi: 10.1038/cddis.2014.556.

19.

microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells.

Hamam D, Ali D, Kassem M, Aldahmash A, Alajez NM.

Stem Cells Dev. 2015 Feb 15;24(4):417-25. doi: 10.1089/scd.2014.0331. Epub 2014 Dec 31. Review.

20.

microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells.

Hamam D, Ali D, Vishnubalaji R, Hamam R, Al-Nbaheen M, Chen L, Kassem M, Aldahmash A, Alajez NM.

Cell Death Dis. 2014 Oct 30;5:e1499. doi: 10.1038/cddis.2014.462.

21.

Pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells.

Al-toub M, Almusa A, Almajed M, Al-Nbaheen M, Kassem M, Aldahmash A, Alajez NM.

Stem Cell Res Ther. 2013 Sep 17;4(5):114. doi: 10.1186/scrt325.

22.

MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.

How C, Hui AB, Alajez NM, Shi W, Boutros PC, Clarke BA, Yan R, Pintilie M, Fyles A, Hedley DW, Hill RP, Milosevic M, Liu FF.

PLoS One. 2013 Jul 4;8(7):e67846. doi: 10.1371/journal.pone.0067846. Print 2013.

23.

Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway.

Alajez NM, Shi W, Wong D, Lenarduzzi M, Waldron J, Weinreb I, Liu FF.

Oncotarget. 2012 Dec;3(12):1641-52.

24.

MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1.

Lenarduzzi M, Hui AB, Alajez NM, Shi W, Williams J, Yue S, O'Sullivan B, Liu FF.

PLoS One. 2013;8(1):e53765. doi: 10.1371/journal.pone.0053765. Epub 2013 Jan 15.

25.

Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent.

Alajez NM, Mocanu JD, Krushel T, Bell JC, Liu FF.

Cancer Cell Int. 2012 Jun 15;12(1):27. doi: 10.1186/1475-2867-12-27.

26.

In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells.

Vishnubalaji R, Manikandan M, Al-Nbaheen M, Kadalmani B, Aldahmash A, Alajez NM.

BMC Dev Biol. 2012 Jan 27;12:7. doi: 10.1186/1471-213X-12-7.

27.

Cancer stem cells. From characterization to therapeutic implications.

Alajez NM.

Saudi Med J. 2011 Dec;32(12):1229-34. Review.

PMID:
22159375
28.

Significance of dysregulated metadherin and microRNA-375 in head and neck cancer.

Hui AB, Bruce JP, Alajez NM, Shi W, Yue S, Perez-Ordonez B, Xu W, O'Sullivan B, Waldron J, Cummings B, Gullane P, Siu L, Liu FF.

Clin Cancer Res. 2011 Dec 15;17(24):7539-50. doi: 10.1158/1078-0432.CCR-11-2102. Epub 2011 Oct 26.

29.

MicroRNA-301 mediates proliferation and invasion in human breast cancer.

Shi W, Gerster K, Alajez NM, Tsang J, Waldron L, Pintilie M, Hui AB, Sykes J, P'ng C, Miller N, McCready D, Fyles A, Liu FF.

Cancer Res. 2011 Apr 15;71(8):2926-37. doi: 10.1158/0008-5472.CAN-10-3369. Epub 2011 Mar 10.

30.

MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway.

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, Yue S, Huang SH, Xu W, Waldron J, O'Sullivan B, Liu FF.

Cancer Res. 2011 Mar 15;71(6):2381-91. doi: 10.1158/0008-5472.CAN-10-2754. Epub 2011 Mar 8.

31.

Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98.

Alajez NM, Shi W, Hui AB, Bruce J, Lenarduzzi M, Ito E, Yue S, O'Sullivan B, Liu FF.

Cell Death Dis. 2010 Oct 21;1:e85. doi: 10.1038/cddis.2010.64.

32.

The effect of local breast radiotherapy on circulating CD34(+) cells.

Alajez NM, Wang W, Biswas D, Teh A, Sutherland R, Pintilie M, Minden M, Messner H, Fyles A, Gospodarowicz M, Keating A, Liu FF.

Radiother Oncol. 2011 Aug;100(2):304-7. doi: 10.1016/j.radonc.2011.01.003. Epub 2011 Feb 11.

PMID:
21316784
33.

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.

Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, O'Sullivan B, Cummings B, Bristow R, Wrana J, Liu FF.

Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.

34.

An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death.

Vlad RM, Saha RK, Alajez NM, Ranieri S, Czarnota GJ, Kolios MC.

Ultrasound Med Biol. 2010 Sep;36(9):1546-58. doi: 10.1016/j.ultrasmedbio.2010.05.025.

PMID:
20800181
35.

Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma.

Kato H, Ito E, Shi W, Alajez NM, Yue S, Lee C, Chan N, Bhogal N, Coackley CL, Vines D, Green D, Waldron J, Gullane P, Bristow R, Liu FF.

Clin Cancer Res. 2010 Feb 1;16(3):898-911. doi: 10.1158/1078-0432.CCR-09-1945. Epub 2010 Jan 26.

36.

Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex.

Sufan RI, Moriyama EH, Mariampillai A, Roche O, Evans AJ, Alajez NM, Vitkin IA, Yang VX, Liu FF, Wilson BC, Ohh M.

EMBO Mol Med. 2009 Apr;1(1):66-78. doi: 10.1002/emmm.200900004.

37.

Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer.

Shi W, Alajez NM, Bastianutto C, Hui AB, Mocanu JD, Ito E, Busson P, Lo KW, Ng R, Waldron J, O'Sullivan B, Liu FF.

Int J Cancer. 2010 May 1;126(9):2036-48. doi: 10.1002/ijc.24880.

38.

Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy.

Alajez NM, Shi W, Hui AB, Yue S, Ng R, Lo KW, Bastianutto C, O'Sullivan B, Gullane P, Liu FF.

Cell Death Differ. 2009 Nov;16(11):1469-79. doi: 10.1038/cdd.2009.85. Epub 2009 Jul 3.

39.

Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.

Hui AB, Yue S, Shi W, Alajez NM, Ito E, Green SR, Frame S, O'Sullivan B, Liu FF.

Clin Cancer Res. 2009 Jun 1;15(11):3716-24. doi: 10.1158/1078-0432.CCR-08-2790. Epub 2009 May 26.

40.

Quantitative ultrasound characterization of cancer radiotherapy effects in vitro.

Vlad RM, Alajez NM, Giles A, Kolios MC, Czarnota GJ.

Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1236-43. doi: 10.1016/j.ijrobp.2008.07.027.

PMID:
18954718
41.

Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma.

Alajez NM, Mocanu JD, Shi W, Chia MC, Breitbach CJ, Hui AB, Knowles S, Bell JC, Busson P, Takada K, Lo KW, O'Sullivan B, Gullane P, Liu FF.

Clin Cancer Res. 2008 Aug 1;14(15):4891-7. doi: 10.1158/1078-0432.CCR-07-4134.

42.

Nuclear factor-Y and Epstein Barr virus in nasopharyngeal cancer.

Chia MC, Leung A, Krushel T, Alajez NM, Lo KW, Busson P, Klamut HJ, Bastianutto C, Liu FF.

Clin Cancer Res. 2008 Feb 15;14(4):984-94. doi: 10.1158/1078-0432.CCR-07-0828.

43.

Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow.

Bastianutto C, Mian A, Symes J, Mocanu J, Alajez N, Sleep G, Shi W, Keating A, Crump M, Gospodarowicz M, Medin J, Minden M, Liu FF.

Cancer Res. 2007 Nov 1;67(21):10112-6.

44.

Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy.

Mocanu JD, Yip KW, Alajez NM, Shi W, Li JH, Lunt SJ, Moriyama EH, Wilson BC, Milosevic M, Lo KW, van Rooijen NV, Busson P, Bastianutto C, Liu FF.

Mol Ther. 2007 May;15(5):921-929. doi: 10.1038/mt.sj.6300119. Epub 2016 Dec 7.

PMID:
28182894
45.

Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy.

Mocanu JD, Yip KW, Alajez NM, Shi W, Li JH, Lunt SJ, Moriyama EH, Wilson BC, Milosevic M, Lo KW, van Rooijen N, Busson P, Bastianutto C, Liu FF.

Mol Ther. 2007 May;15(5):921-9. Epub 2007 Mar 13.

46.
48.

MUC1 immunobiology: from discovery to clinical applications.

Vlad AM, Kettel JC, Alajez NM, Carlos CA, Finn OJ.

Adv Immunol. 2004;82:249-93. Review. No abstract available.

PMID:
14975259

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