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Items: 1 to 50 of 97

1.

FoxM1 and β-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells.

Pratheeshkumar P, Divya SP, Parvathareddy SK, Alhoshani NM, Al-Badawi IA, Tulbah A, Al-Dayel F, Siraj AK, Al-Kuraya KS.

Oncotarget. 2017 Dec 16;9(3):3590-3604. doi: 10.18632/oncotarget.23338. eCollection 2018 Jan 9.

2.

Downregulation of SKP2 in papillary thyroid cancer acts synergistically with TRAIL on inducing apoptosis via ROS.

Pratheeshkumar P, Siraj AK, Divya SP, Parvathareddy SK, Begum R, Melosantos R, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

J Clin Endocrinol Metab. 2017 Dec 28. doi: 10.1210/jc.2017-02178. [Epub ahead of print]

PMID:
29300929
3.

Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.

Bu R, Siraj AK, Divya SP, Kong Y, Parvathareddy SK, Al-Rasheed M, Al-Obaisi KAS, Victoria IG, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

Int J Cancer. 2018 May 15;142(10):2028-2039. doi: 10.1002/ijc.31225. Epub 2017 Dec 29.

PMID:
29266240
4.

Expanding the spectrum of germline variants in cancer.

Siraj AK, Masoodi T, Bu R, Parvathareddy SK, Al-Badawi IA, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Sobhi SS, Tulbah A, Ajarim D, Alzoman K, Aljuboury M, Yousef HB, Al-Dawish M, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Hum Genet. 2017 Nov;136(11-12):1431-1444. doi: 10.1007/s00439-017-1845-0. Epub 2017 Oct 3.

PMID:
28975465
5.

XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis.

Hussain AR, Siraj AK, Ahmed M, Bu R, Pratheeshkumar P, Alrashed AM, Qadri Z, Ajarim D, Al-Dayel F, Beg S, Al-Kuraya KS.

BMC Cancer. 2017 Sep 11;17(1):640. doi: 10.1186/s12885-017-3627-4.

6.

Response to Yehia et al.

Siraj AK, Masoodi T, Alkuraya FS, Al-Kuraya KS.

Am J Hum Genet. 2017 Mar 2;100(3):564-565. doi: 10.1016/j.ajhg.2017.01.022. No abstract available.

7.

MED12 is recurrently mutated in Middle Eastern colorectal cancer.

Siraj AK, Masoodi T, Bu R, Pratheeshkumar P, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Gut. 2018 Apr;67(4):663-671. doi: 10.1136/gutjnl-2016-313334. Epub 2017 Feb 9.

8.

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.

Siraj AK, Masoodi T, Bu R, Beg S, Al-Sobhi SS, Al-Dayel F, Al-Dawish M, Alkuraya FS, Al-Kuraya KS.

Am J Hum Genet. 2016 Jun 2;98(6):1170-1180. doi: 10.1016/j.ajhg.2016.04.014. Epub 2016 May 26.

9.

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis.

Bu R, Siraj AK, Al-Obaisi KA, Beg S, Al Hazmi M, Ajarim D, Tulbah A, Al-Dayel F, Al-Kuraya KS.

Int J Cancer. 2016 Sep 1;139(5):1091-7. doi: 10.1002/ijc.30143. Epub 2016 May 3.

10.

Reply to specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations.

Siraj AK, Beg S, Al-Kuraya KS.

Cancer. 2016 Apr 1;122(7):1135-7. doi: 10.1002/cncr.29904. Epub 2016 Feb 5. No abstract available.

11.

Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants.

Shi X, Liu R, Basolo F, Giannini R, Shen X, Teng D, Guan H, Shan Z, Teng W, Musholt TJ, Al-Kuraya K, Fugazzola L, Colombo C, Kebebew E, Jarzab B, Czarniecka A, Bendlova B, Sykorova V, Sobrinho-Simões M, Soares P, Shong YK, Kim TY, Cheng S, Asa SL, Viola D, Elisei R, Yip L, Mian C, Vianello F, Wang Y, Zhao S, Oler G, Cerutti JM, Puxeddu E, Qu S, Wei Q, Xu H, O'Neill CJ, Sywak MS, Clifton-Bligh R, Lam AK, Riesco-Eizaguirre G, Santisteban P, Yu H, Tallini G, Holt EH, Vasko V, Xing M.

J Clin Endocrinol Metab. 2016 Jan;101(1):264-74. doi: 10.1210/jc.2015-2917. Epub 2015 Nov 3.

12.

ALK alteration is a frequent event in aggressive breast cancers.

Siraj AK, Beg S, Jehan Z, Prabhakaran S, Ahmed M, R Hussain A, Al-Dayel F, Tulbah A, Ajarim D, Al-Kuraya KS.

Breast Cancer Res. 2015 Sep 17;17:127. doi: 10.1186/s13058-015-0610-3.

13.

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East.

Beg S, Siraj AK, Prabhakaran S, Bu R, Al-Rasheed M, Sultana M, Qadri Z, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS.

Cancer. 2015 Nov 1;121(21):3799-808. doi: 10.1002/cncr.29580. Epub 2015 Jul 28.

14.

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells.

Ahmed M, Hussain AR, Siraj AK, Uddin S, Al-Sanea N, Al-Dayel F, Al-Assiri M, Beg S, Al-Kuraya KS.

Mol Cancer. 2015 Jul 10;14:131. doi: 10.1186/s12943-015-0406-1.

15.

Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer.

Hussain AR, Al-Romaizan M, Ahmed M, Thangavel S, Al-Dayel F, Beg S, Uddin S, Siraj AK, Al-Kuraya KS.

Mol Med. 2015 May 26;21:466-78. doi: 10.2119/molmed.2014.00238.

16.

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.

Beg S, Siraj AK, Jehan Z, Prabakaran S, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

Br J Cancer. 2015 Jun 9;112(12):1938-43. doi: 10.1038/bjc.2015.169. Epub 2015 May 19.

17.

Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer.

Beg S, Siraj AK, Prabhakaran S, Jehan Z, Ajarim D, Al-Dayel F, Tulbah A, Al-Kuraya KS.

Breast Cancer Res Treat. 2015 Jun;151(3):541-53. doi: 10.1007/s10549-015-3430-3. Epub 2015 May 16.

PMID:
25981902
18.

Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma.

Hussain AR, Bu R, Ahmed M, Jehan Z, Beg S, Al-Sobhi S, Al-Dayel F, Siraj AK, Uddin S, Al-Kuraya KS.

J Clin Endocrinol Metab. 2015 Jul;100(7):E974-85. doi: 10.1210/jc.2014-4356. Epub 2015 May 14.

PMID:
25974735
19.

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS.

Cancer. 2015 Jun 1;121(11):1762-71. doi: 10.1002/cncr.29288. Epub 2015 Feb 24.

20.

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

Siraj AK, Bu R, Prabhakaran S, Bavi P, Beg S, Al Hazmi M, Al-Rasheed M, Alobaisi K, Al-Dayel F, AlManea H, Al-Sanea N, Uddin S, Al-Kuraya KS.

Mol Cancer. 2014 Jul 8;13:168. doi: 10.1186/1476-4598-13-168.

21.

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.

Ahmed M, Hussain AR, Bavi P, Ahmed SO, Al Sobhi SS, Al-Dayel F, Uddin S, Al-Kuraya KS.

Carcinogenesis. 2014 Jul;35(7):1564-72. doi: 10.1093/carcin/bgu051. Epub 2014 Feb 28.

PMID:
24583924
22.

ALK gene amplification is associated with poor prognosis in colorectal carcinoma.

Bavi P, Jehan Z, Bu R, Prabhakaran S, Al-Sanea N, Al-Dayel F, Al-Assiri M, Al-Halouly T, Sairafi R, Uddin S, Al-Kuraya KS.

Br J Cancer. 2013 Nov 12;109(10):2735-43. doi: 10.1038/bjc.2013.641. Epub 2013 Oct 15.

23.

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

Uddin S, Hussain AR, Khan OS, Al-Kuraya KS.

Tumour Biol. 2014 Feb;35(2):871-9. doi: 10.1007/s13277-013-1166-4. Epub 2013 Sep 7. Review.

PMID:
24014051
24.

Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma.

Bu R, Hussain AR, Al-Obaisi KA, Ahmed M, Uddin S, Al-Kuraya KS.

Leuk Lymphoma. 2014 Feb;55(2):415-24. doi: 10.3109/10428194.2013.806799. Epub 2013 Jun 24.

PMID:
23697845
25.

Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release.

Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KS.

PLoS One. 2013;8(3):e60540. doi: 10.1371/journal.pone.0060540. Epub 2013 Mar 28.

26.

Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.

Hussain AR, Ahmed SO, Ahmed M, Khan OS, Al Abdulmohsen S, Platanias LC, Al-Kuraya KS, Uddin S.

PLoS One. 2012;7(6):e39945. doi: 10.1371/journal.pone.0039945. Epub 2012 Jun 29. Erratum in: PLoS One. 2014;9(3):e92484.

27.

Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma.

Bavi P, Abubaker J, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Siraj AK, Al-Kuraya KS.

Clin Epigenetics. 2011 Aug;2(2):417-8. doi: 10.1007/s13148-011-0049-z. Epub 2011 Jul 14. No abstract available.

28.

In-situ hybridization as a molecular tool in cancer diagnosis and treatment.

Jehan Z, Uddin S, Al-Kuraya KS.

Curr Med Chem. 2012;19(22):3730-8. Review.

PMID:
22680920
29.

Colorectal cancer risk is not associated with increased levels of homozygosity in Saudi Arabia.

Siraj AK, Khalak HG, Sultana M, Al-Rasheed M, Bavi P, Al-Sanea N, Al-Dayel F, Uddin S, Alkuraya FS, Al-Kuraya KS.

Genet Med. 2012 Apr 5. doi: 10.1038/gim.2012.27. [Epub ahead of print]

PMID:
22481135
30.

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.

Bu R, Bavi P, Abubaker J, Jehan Z, Al-Haqawi W, Ajarim D, Al-Dayel F, Uddin S, Al-Kuraya KS.

Leuk Lymphoma. 2012 Oct;53(10):1971-7. doi: 10.3109/10428194.2012.668286. Epub 2012 Apr 18.

PMID:
22397314
31.

Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Siddiqui K, Al-Dayel F, Bavi P, Al-Kuraya KS.

Haematologica. 2012 Jul;97(7):1092-100. doi: 10.3324/haematol.2011.053421. Epub 2012 Jan 22.

32.

c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death.

Bu R, Uddin S, Ahmed M, Hussain AR, Alsobhi S, Amin T, Al-Nuaim A, Al-Dayel F, Abubaker J, Bavi P, Al-Kuraya KS.

Mol Med. 2012 Mar 27;18:167-77. doi: 10.2119/molmed.2011.00238.

33.

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Uddin S, Hussain AR, Siraj AK, Khan OS, Bavi PP, Al-Kuraya KS.

Int J Clin Exp Pathol. 2011;4(7):637-43. Epub 2011 Oct 3. Review.

34.

FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma.

Ahmed M, Uddin S, Hussain AR, Alyan A, Jehan Z, Al-Dayel F, Al-Nuaim A, Al-Sobhi S, Amin T, Bavi P, Al-Kuraya KS.

J Clin Endocrinol Metab. 2012 Jan;97(1):E1-E13. doi: 10.1210/jc.2011-1506. Epub 2011 Nov 2.

PMID:
22049175
35.

Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma.

Uddin S, Hussain AR, Ahmed M, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Bavi P, Al-Kuraya KS.

Am J Pathol. 2011 Dec;179(6):3032-44. doi: 10.1016/j.ajpath.2011.08.007. Epub 2011 Oct 5.

36.

Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines.

Hussain AR, Uddin S, Bu R, Khan OS, Ahmed SO, Ahmed M, Al-Kuraya KS.

PLoS One. 2011;6(9):e24703. doi: 10.1371/journal.pone.0024703. Epub 2011 Sep 12.

37.

MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer.

Bavi PP, Bu R, Uddin S, Al-Kuraya KS.

Saudi J Gastroenterol. 2011 Sep-Oct;17(5):299-300. doi: 10.4103/1319-3767.84479. No abstract available.

38.

Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.

Bavi P, Uddin S, Ahmed M, Jehan Z, Bu R, Abubaker J, Sultana M, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Prabhakaran S, Hussain AR, Al-Kuraya KS.

Am J Pathol. 2011 May;178(5):2109-20. doi: 10.1016/j.ajpath.2011.01.034.

39.

The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL).

Bavi P, Uddin S, Bu R, Ahmed M, Abubaker J, Balde V, Qadri Z, Ajarim D, Al-Dayel F, Hussain AR, Al-Kuraya KS.

J Pathol. 2011 Jul;224(3):355-66. doi: 10.1002/path.2864. Epub 2011 Apr 19.

PMID:
21506127
40.

Localization of death receptor 4 in lipid rafts sensitizes chronic lymphocytic leukemia to chemotherapeutic drug mediated apoptosis.

Uddin S, Al-Kuraya KS.

Leuk Lymphoma. 2011 Jul;52(7):1176-7. doi: 10.3109/10428194.2011.569963. Epub 2011 Apr 4. No abstract available.

PMID:
21463125
41.

Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.

Uddin S, Jehan Z, Ahmed M, Alyan A, Al-Dayel F, Hussain A, Bavi P, Al-Kuraya KS.

Mol Med. 2011;17(7-8):635-45. doi: 10.2119/molmed.2011.00046. Epub 2011 Mar 21.

42.

Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.

Uddin S, Ahmed M, Hussain A, Abubaker J, Al-Sanea N, AbdulJabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Jehan Z, Bavi P, Siraj AK, Al-Kuraya KS.

Am J Pathol. 2011 Feb;178(2):537-47. doi: 10.1016/j.ajpath.2010.10.020.

43.

Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma.

Hussain AR, Ahmed M, Ahmed S, Manogaran P, Platanias LC, Alvi SN, Al-Kuraya KS, Uddin S.

Free Radic Biol Med. 2011 Apr 15;50(8):978-87. doi: 10.1016/j.freeradbiomed.2010.12.034. Epub 2011 Jan 4.

PMID:
21215312
44.

Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis.

Siraj AK, Hussain AR, Al-Rasheed M, Ahmed M, Bavi P, Alsobhi SA, Al-Nuaim A, Uddin S, Al-Kuraya K.

J Clin Endocrinol Metab. 2011 Jan;96(1):E215-24. doi: 10.1210/jc.2010-0790. Epub 2010 Oct 6.

PMID:
20926535
45.

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.

Bavi P, Prabhakaran SE, Abubaker J, Qadri Z, George T, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Hussain AR, Uddin S, Al-Kuraya KS.

Mol Cancer. 2010 Jul 30;9:203. doi: 10.1186/1476-4598-9-203.

46.

HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.

Bu R, Uddin S, Bavi P, Hussain AR, Al-Dayel F, Ghourab S, Ahmed M, Al-Kuraya KS.

Lab Invest. 2011 Jan;91(1):124-37. doi: 10.1038/labinvest.2010.136. Epub 2010 Jul 26.

47.

Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

Hussain AR, Uddin S, Ahmed M, Bu R, Ahmed SO, Abubaker J, Sultana M, Ajarim D, Al-Dayel F, Bavi PP, Al-Kuraya KS.

J Pathol. 2010 Oct;222(2):180-90. doi: 10.1002/path.2747.

PMID:
20632385
48.

Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Al-Dayel F, Bu R, Bavi P, Al-Kuraya KS.

Lab Invest. 2010 Sep;90(9):1346-56. doi: 10.1038/labinvest.2010.108. Epub 2010 Jun 7.

49.

Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.

Uddin S, Bu R, Ahmed M, Hussain AR, Ajarim D, Al-Dayel F, Bavi P, Al-kuraya KS.

Leuk Lymphoma. 2010 Jul;51(7):1305-14. doi: 10.3109/10428191003802365.

PMID:
20443680
50.

Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma.

Uddin S, Hussain AR, Ahmed M, Bu R, Ahmed SO, Ajarim D, Al-Dayel F, Bavi P, Al-Kuraya KS.

Mol Cancer Ther. 2010 May;9(5):1244-55. doi: 10.1158/1535-7163.MCT-09-1061. Epub 2010 Apr 27.

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