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Items: 30


An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.

Mahil SK, Catapano M, Di Meglio P, Dand N, Ahlfors H, Carr IM, Smith CH, Trembath RC, Peakman M, Wright J, Ciccarelli FD, Barker JN, Capon F.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan2514. doi: 10.1126/scitranslmed.aan2514. Erratum in: Sci Transl Med. 2017 Dec 13;9(420):.


Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis.

Omoyinmi E, Standing A, Keylock A, Price-Kuehne F, Melo Gomes S, Rowczenio D, Nanthapisal S, Cullup T, Nyanhete R, Ashton E, Murphy C, Clarke M, Ahlfors H, Jenkins L, Gilmour K, Eleftheriou D, Lachmann HJ, Hawkins PN, Klein N, Brogan PA.

PLoS One. 2017 Jul 27;12(7):e0181874. doi: 10.1371/journal.pone.0181874. eCollection 2017.


Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M.

Nat Immunol. 2017 Jun;18(6):683-693. doi: 10.1038/ni.3724. Epub 2017 Apr 10.


Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

Villa M, Gialitakis M, Tolaini M, Ahlfors H, Henderson CJ, Wolf CR, Brink R, Stockinger B.

EMBO J. 2017 Jan 4;36(1):116-128. doi: 10.15252/embj.201695027. Epub 2016 Nov 14.


The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.

Vogel KU, Bell LS, Galloway A, Ahlfors H, Turner M.

J Immunol. 2016 Oct 1;197(7):2673-2685. doi: 10.4049/jimmunol.1600854. Epub 2016 Aug 26.


The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis.

Villa M, Crotta S, Dingwell KS, Hirst EM, Gialitakis M, Ahlfors H, Smith JC, Stockinger B, Wack A.

Nat Commun. 2016 Aug 24;7:12652. doi: 10.1038/ncomms12652.


Data-driven mechanistic analysis method to reveal dynamically evolving regulatory networks.

Intosalmi J, Nousiainen K, Ahlfors H, Lähdesmäki H.

Bioinformatics. 2016 Jun 15;32(12):i288-i296. doi: 10.1093/bioinformatics/btw274.


The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.

Tiedje C, Diaz-Muñoz MD, Trulley P, Ahlfors H, Laaß K, Blackshear PJ, Turner M, Gaestel M.

Nucleic Acids Res. 2016 Sep 6;44(15):7418-40. doi: 10.1093/nar/gkw474. Epub 2016 May 24.


RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.

Science. 2016 Apr 22;352(6284):453-9. doi: 10.1126/science.aad5978.


Comparative analysis of human and mouse transcriptomes of Th17 cell priming.

Tuomela S, Rautio S, Ahlfors H, Öling V, Salo V, Ullah U, Chen Z, Hämälistö S, Tripathi SK, Äijö T, Rasool O, Soueidan H, Wessels L, Stockinger B, Lähdesmäki H, Lahesmaa R.

Oncotarget. 2016 Mar 22;7(12):13416-28. doi: 10.18632/oncotarget.7963.


Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data.

Intosalmi J, Ahlfors H, Rautio S, Mannerstöm H, Chen ZJ, Lahesmaa R, Stockinger B, Lähdesmäki H.

BMC Syst Biol. 2015 Nov 17;9:81. doi: 10.1186/s12918-015-0223-6.


IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection.

Ahlfors H, Morrison PJ, Duarte JH, Li Y, Biro J, Tolaini M, Di Meglio P, Potocnik AJ, Stockinger B.

J Immunol. 2014 Nov 1;193(9):4602-13. doi: 10.4049/jimmunol.1401244. Epub 2014 Sep 26.


Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.

Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B.

Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019. Epub 2014 Jun 5.


Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity.

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G, Oberste MS, Lahesmaa R, Pesu M, Hyöty H.

J Med Virol. 2014 Aug;86(8):1412-20. doi: 10.1002/jmv.23903. Epub 2014 Feb 20.


IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.

Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B.

J Exp Med. 2013 Dec 16;210(13):2951-65. doi: 10.1084/jem.20130071. Epub 2013 Nov 18.


Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.

Duarte JH, Di Meglio P, Hirota K, Ahlfors H, Stockinger B.

PLoS One. 2013 Nov 14;8(11):e79819. doi: 10.1371/journal.pone.0079819. eCollection 2013.


NanoMiner - integrative human transcriptomics data resource for nanoparticle research.

Kong L, Tuomela S, Hahne L, Ahlfors H, Yli-Harja O, Fadeel B, Lahesmaa R, Autio R.

PLoS One. 2013 Jul 12;8(7):e68414. doi: 10.1371/journal.pone.0068414. Print 2013.


Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction.

Ylipaasto P, Smura T, Gopalacharyulu P, Paananen A, Seppänen-Laakso T, Kaijalainen S, Ahlfors H, Korsgren O, Lakey JR, Lahesmaa R, Piemonti L, Oresic M, Galama J, Roivainen M.

Diabetologia. 2012 Dec;55(12):3273-83. doi: 10.1007/s00125-012-2713-z. Epub 2012 Sep 16.


Regulation and function of innate and adaptive interleukin-17-producing cells.

Hirota K, Ahlfors H, Duarte JH, Stockinger B.

EMBO Rep. 2012 Feb 1;13(2):113-20. doi: 10.1038/embor.2011.248. Review.


Fate mapping of IL-17-producing T cells in inflammatory responses.

Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B.

Nat Immunol. 2011 Mar;12(3):255-63. doi: 10.1038/ni.1993. Epub 2011 Jan 30.


Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

Elo LL, Järvenpää H, Tuomela S, Raghav S, Ahlfors H, Laurila K, Gupta B, Lund RJ, Tahvanainen J, Hawkins RD, Oresic M, Lähdesmäki H, Rasool O, Rao KV, Aittokallio T, Lahesmaa R.

Immunity. 2010 Jun 25;32(6):852-62. doi: 10.1016/j.immuni.2010.06.011.


SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation.

Ahlfors H, Limaye A, Elo LL, Tuomela S, Burute M, Gottimukkala KV, Notani D, Rasool O, Galande S, Lahesmaa R.

Blood. 2010 Sep 2;116(9):1443-53. doi: 10.1182/blood-2009-11-252205. Epub 2010 Jun 3.


Activating transcription factor 3 is a positive regulator of human IFNG gene expression.

Filén S, Ylikoski E, Tripathi S, West A, Björkman M, Nyström J, Ahlfors H, Coffey E, Rao KV, Rasool O, Lahesmaa R.

J Immunol. 2010 May 1;184(9):4990-9. doi: 10.4049/jimmunol.0903106. Epub 2010 Mar 19.


Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.

Filén JJ, Filén S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R.

Mol Cell Proteomics. 2009 Jan;8(1):32-44. doi: 10.1074/mcp.M800139-MCP200. Epub 2008 Aug 12.


Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response.

Kumar D, Srikanth R, Ahlfors H, Lahesmaa R, Rao KV.

Mol Syst Biol. 2007;3:150. Epub 2007 Dec 4.


Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells.

Lehtonen A, Ahlfors H, Veckman V, Miettinen M, Lahesmaa R, Julkunen I.

J Leukoc Biol. 2007 Sep;82(3):710-20. Epub 2007 Jun 26.


Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation.

Lund RJ, Löytömäki M, Naumanen T, Dixon C, Chen Z, Ahlfors H, Tuomela S, Tahvanainen J, Scheinin J, Henttinen T, Rasool O, Lahesmaa R.

J Immunol. 2007 Mar 15;178(6):3648-60.


Identification of genes involved in the initiation of human Th1 or Th2 cell commitment.

Lund R, Ahlfors H, Kainonen E, Lahesmaa AM, Dixon C, Lahesmaa R.

Eur J Immunol. 2005 Nov;35(11):3307-19.


Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.

Rainio EM, Ahlfors H, Carter KL, Ruuska M, Matikainen S, Kieff E, Koskinen PJ.

Virology. 2005 Mar 15;333(2):201-6.


Topology of the Erwinia chrysanthemi oligogalacturonate porin KdgM.

Pellinen T, Ahlfors H, Blot N, Condemine G.

Biochem J. 2003 Jun 1;372(Pt 2):329-34.

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