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Items: 34

1.

Advances in the Genetics and Biology of Pancreatic Cancer.

Aguirre AJ, Collisson EA.

Cancer J. 2017 Nov/Dec;23(6):315-320. doi: 10.1097/PPO.0000000000000286.

PMID:
29189326
2.

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, Serna G, Mulet N, Landolfi S, Ramon Y Cajal S, Fasani R, Aguirre AJ, Ng K, Élez E, Ogino S, Tabernero J, Fuchs CS, Hahn WC, Nuciforo P, Meyerson M.

Science. 2017 Dec 15;358(6369):1443-1448. doi: 10.1126/science.aal5240. Epub 2017 Nov 23.

PMID:
29170280
3.

Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.

Gu M, Nishihara R, Chen Y, Li W, Shi Y, Masugi Y, Hamada T, Kosumi K, Liu L, da Silva A, Nowak JA, Twombly T, Du C, Koh H, Li W, Meyerhardt JA, Wolpin BM, Giannakis M, Aguirre AJ, Bass AJ, Drew DA, Chan AT, Fuchs CS, Qian ZR, Ogino S.

Oncotarget. 2017 Sep 18;8(50):87379-87389. doi: 10.18632/oncotarget.20972. eCollection 2017 Oct 20.

4.

Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers.

Aguirre AJ, Hahn WC.

Cold Spring Harb Perspect Med. 2017 Nov 3. pii: a031518. doi: 10.1101/cshperspect.a031518. [Epub ahead of print]

PMID:
29101114
5.

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC.

Elife. 2017 Oct 31;6. pii: e33173. doi: 10.7554/eLife.33173. No abstract available.

6.

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, Damato E, Aguirre AJ, Liang J, Liberzon A, Alexe G, Doench J, Ghandi M, Vazquez F, Weir BA, Tsherniak A, Subramanian A, Meneses-Cime K, Park J, Clemons P, Garraway LA, Thomas D, Boehm JS, Barbie DA, Hahn WC, Mesirov JP, Tamayo P.

Cell Syst. 2017 Aug 23;5(2):105-118.e9. doi: 10.1016/j.cels.2017.08.002.

PMID:
28837809
7.

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL.

Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5.

PMID:
28678785
8.

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.

Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10.

9.

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.

Wang B, Krall EB, Aguirre AJ, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC.

Cell Rep. 2017 Feb 7;18(6):1543-1557. doi: 10.1016/j.celrep.2017.01.031.

10.

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC.

Elife. 2017 Feb 1;6. pii: e18970. doi: 10.7554/eLife.18970. Erratum in: Elife. 2017 Oct 31;6:.

11.

Functional Genomic Characterization of Cancer Genomes.

Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC.

Cold Spring Harb Symp Quant Biol. 2016;81:237-246. doi: 10.1101/sqb.2016.81.031070. Epub 2016 Nov 4. Review.

PMID:
27815544
12.

An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service.

Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE.

Am J Med. 2017 Jan;130(1):47-53. doi: 10.1016/j.amjmed.2016.08.021. Epub 2016 Sep 9.

PMID:
27619354
13.

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, Pantel S, Lee Y, Goodale A, Cherniack AD, Oh C, Kryukov G, Cowley GS, Garraway LA, Stegmaier K, Roberts CW, Golub TR, Meyerson M, Root DE, Tsherniak A, Hahn WC.

Cancer Discov. 2016 Aug;6(8):914-29. doi: 10.1158/2159-8290.CD-16-0154. Epub 2016 Jun 3.

14.

Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.

Swaims-Kohlmeier A, Haaland RE, Haddad LB, Sheth AN, Evans-Strickfaden T, Lupo LD, Cordes S, Aguirre AJ, Lupoli KA, Chen CY, Ofotukun I, Hart CE, Kohlmeier JE.

J Immunol. 2016 Jul 1;197(1):368-76. doi: 10.4049/jimmunol.1502628. Epub 2016 May 27.

15.

Validation of a CFD model by using 3D sonic anemometers to analyse the air velocity generated by an air-assisted sprayer equipped with two axial fans.

García-Ramos FJ, Malón H, Aguirre AJ, Boné A, Puyuelo J, Vidal M.

Sensors (Basel). 2015 Jan 22;15(2):2399-418. doi: 10.3390/s150202399.

16.

Design and testing of an agricultural implement for underground application of rodenticide bait.

Malón H, Aguirre AJ, Boné A, Vidal M, García-Ramos FJ.

Sensors (Basel). 2015 Jan 16;15(1):2006-20. doi: 10.3390/s150102006.

17.

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW.

Nat Med. 2014 Mar;20(3):251-4. doi: 10.1038/nm.3480. Epub 2014 Feb 23.

18.

Beyond a broken heart: circulatory dysfunction in the failing Fontan.

Mori M, Aguirre AJ, Elder RW, Kashkouli A, Farris AB, Ford RM, Book WM.

Pediatr Cardiol. 2014 Apr;35(4):569-79. doi: 10.1007/s00246-014-0881-y. Epub 2014 Feb 15. Review.

PMID:
24531876
19.

Comparative analysis of different methods for evaluating quality of Quercus ilex seedlings inoculated with Tuber melanosporum.

Andrés-Alpuente A, Sánchez S, Martín M, Aguirre AJ, Barriuso JJ.

Mycorrhiza. 2014 Apr;24 Suppl 1:S29-37. doi: 10.1007/s00572-014-0563-x. Epub 2014 Feb 13. Review.

PMID:
24522843
20.

Straw management effects on CO2 efflux and C storage in different Mediterranean agricultural soils.

Badía D, Martí C, Aguirre AJ.

Sci Total Environ. 2013 Nov 1;465:233-9. doi: 10.1016/j.scitotenv.2013.04.006. Epub 2013 Apr 30.

PMID:
23642570
21.

Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection.

Vicetti Miguel RD, Hendricks RL, Aguirre AJ, Melan MA, Harvey SA, Terry-Allison T, St Leger AJ, Thomson AW, Cherpes TL.

J Immunol. 2012 Oct 1;189(7):3449-61. Epub 2012 Aug 31.

22.

Novelty-seeking temperament in captive stumptail macaques (Macaca arctoides) and spider monkeys (Ateles geoffroyi).

Santillán-Doherty AM, Cortés-Sotres J, Arenas-Rosas RV, Márquez-Arias A, Cruz C, Medellín A, Aguirre AJ, Muñóz-Delgado J, Díaz JL.

J Comp Psychol. 2010 May;124(2):211-8. doi: 10.1037/a0018267.

PMID:
20476821
23.

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19372-7. doi: 10.1073/pnas.0809966105. Epub 2008 Dec 2.

24.

Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients.

Aguirre AJ, Apiquián R, Fresán A, Cruz-Fuentes C.

Psychiatry Res. 2007 Dec 3;153(3):209-15. Epub 2007 Sep 5.

PMID:
17822780
25.

Common and contrasting genomic profiles among the major human lung cancer subtypes.

Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA.

Cold Spring Harb Symp Quant Biol. 2005;70:11-24.

PMID:
16869734
26.

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52. Epub 2006 Apr 3.

27.

High-resolution genomic profiles of human lung cancer.

Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30. Epub 2005 Jun 27.

28.

High-resolution global profiling of genomic alterations with long oligonucleotide microarray.

Brennan C, Zhang Y, Leo C, Feng B, Cauwels C, Aguirre AJ, Kim M, Protopopov A, Chin L.

Cancer Res. 2004 Jul 15;64(14):4744-8.

29.

High-resolution characterization of the pancreatic adenocarcinoma genome.

Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9067-72.

30.

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.

Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA.

Genes Dev. 2003 Dec 15;17(24):3112-26. Epub 2003 Dec 17.

32.

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.

Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA.

Nature. 2001 Sep 6;413(6851):86-91.

PMID:
11544531

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