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Do wild-caught urban house sparrows show desensitized stress responses to a novel stressor?

Salleh Hudin N, Teyssier A, Aerts J, Fairhurst GD, Strubbe D, White J, De Neve L, Lens L.

Biol Open. 2018 Apr 9. pii: bio.031849. doi: 10.1242/bio.031849. [Epub ahead of print]


Escalating impacts of climate extremes on critical infrastructures in Europe.

Forzieri G, Bianchi A, Silva FBE, Marin Herrera MA, Leblois A, Lavalle C, Aerts JCJH, Feyen L.

Glob Environ Change. 2018 Jan;48:97-107. doi: 10.1016/j.gloenvcha.2017.11.007.


Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma.

Minnema-Luiting J, Vroman H, Aerts J, Cornelissen R.

Int J Mol Sci. 2018 Mar 30;19(4). pii: E1041. doi: 10.3390/ijms19041041. Review.


Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.

Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4.


Using high-amplitude and focused transcranial alternating current stimulation to entrain physiological tremor.

Khatoun A, Breukers J, Beeck SO, Nica IG, Aerts JM, Seynaeve L, Haeck T, Asamoah B, Mc Laughlin M.

Sci Rep. 2018 Mar 21;8(1):4927. doi: 10.1038/s41598-018-23290-w.


IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

Egli A, Mandal J, Schumann DM, Roth M, Thomas B, Lorne Tyrrell D, Blasi F, Kostikas K, Boersma W, Milenkovic B, Lacoma A, Rentsch K, Rohde GGU, Louis R, Aerts JG, Welte T, Torres A, Tamm M, Stolz D.

BMC Pulm Med. 2018 Mar 21;18(1):51. doi: 10.1186/s12890-018-0616-6.


Erratum: Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat.

Wu H, Ghekiere H, Beeckmans D, Tambuyzer T, van Kuyck K, Aerts JM, Nuttin B.

Sci Rep. 2018 Mar 19;8:46954. doi: 10.1038/srep46954.


Factors affecting local control of pulmonary oligometastases treated with stereotactic body radiotherapy.

Sharma A, Duijm M, Oomen-de Hoop E, Aerts JG, Verhoef C, Hoogeman M, Nuyttens JJ.

Acta Oncol. 2018 Feb 28:1-7. doi: 10.1080/0284186X.2018.1445285. [Epub ahead of print]


Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy.

Bialkowski L, Van der Jeught K, Bevers S, Tjok Joe P, Renmans D, Heirman C, Aerts JL, Thielemans K.

Int J Cancer. 2018 Feb 21. doi: 10.1002/ijc.31331. [Epub ahead of print]


HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

Tol MJ, van der Lienden MJC, Gabriel TL, Hagen JJ, Scheij S, Veenendaal T, Klumperman J, Donker-Koopman WE, Verhoeven AJ, Overkleeft H, Aerts JM, Argmann CA, van Eijk M.

Autophagy. 2018 Feb 17:1-13. doi: 10.1080/15548627.2017.1419118. [Epub ahead of print]


Immunotherapy: a new standard of care in thoracic malignancies? A summary of the European Respiratory Society research seminar of the Thoracic Oncology Assembly.

Costantini A, Grynovska M, Lucibello F, Moisés J, Pagès F, Tsao MS, Shepherd FA, Bouchaab H, Garassino M, Aerts JGJV, Mazières J, Mondini M, Berghmans T, Meert AP, Cadranel J.

Eur Respir J. 2018 Feb 14;51(2). pii: 1702072. doi: 10.1183/13993003.02072-2017. Print 2018 Feb.


Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment.

van den Ham HJ, Cooper JD, Tomasik J, Bahn S, Aerts JL, Osterhaus ADME, Gruters RA, Andeweg AC; DC-TRN trial investigators.

PLoS One. 2018 Feb 1;13(2):e0192278. doi: 10.1371/journal.pone.0192278. eCollection 2018.


Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.

Villeret B, Dieu A, Straube M, Solhonne B, Miklavc P, Hamadi S, Le Borgne R, Mailleux A, Norel X, Aerts J, Diallo D, Rouzet F, Dietl P, Sallenave JM, Garcia-Verdugo I.

ACS Nano. 2018 Feb 27;12(2):1188-1202. doi: 10.1021/acsnano.7b06934. Epub 2018 Jan 30.


Automated Assessment of Endpoint and Kinematic Features of Skilled Reaching in Rats.

Nica I, Deprez M, Nuttin B, Aerts JM.

Front Behav Neurosci. 2018 Jan 4;11:255. doi: 10.3389/fnbeh.2017.00255. eCollection 2017.


Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making.

Mokhles S, Nuyttens JJME, de Mol M, Aerts JGJV, Maat APWM, Birim Ö, Bogers AJJC, Takkenberg JJM.

BMC Cancer. 2018 Jan 15;18(1):79. doi: 10.1186/s12885-018-3986-5.


Activity-Based Probes for Glycosidases: Profiling and Other Applications.

Kuo CL, van Meel E, Kytidou K, Kallemeijn WW, Witte M, Overkleeft HS, Artola ME, Aerts JM.

Methods Enzymol. 2018;598:217-235. doi: 10.1016/bs.mie.2017.06.039. Epub 2017 Dec 8.


Ethnic differences in metabolite signatures and type 2 diabetes: a nested case-control analysis among people of South Asian, African and European origin.

van Valkengoed IGM, Argmann C, Ghauharali-van der Vlugt K, Aerts JMFG, Brewster LM, Peters RJG, Vaz FM, Houtkooper RH.

Nutr Diabetes. 2017 Dec 19;7(12):300. doi: 10.1038/s41387-017-0003-z.


Oxygen saturation measurements in telemonitoring of patients with COPD: a systematic review.

Buekers J, De Boever P, Vaes AW, Aerts JM, Wouters EFM, Spruit MA, Theunis J.

Expert Rev Respir Med. 2018 Feb;12(2):113-123. doi: 10.1080/17476348.2018.1417842. Epub 2017 Dec 20.


Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human.

Aerts JGJV, de Goeje PL, Cornelissen R, Kaijen-Lambers MEH, Bezemer K, van der Leest CH, Mahaweni NM, Kunert A, Eskens FALM, Waasdorp C, Braakman E, van der Holt B, Vulto AG, Hendriks RW, Hegmans JPJJ, Hoogsteden HC.

Clin Cancer Res. 2018 Feb 15;24(4):766-776. doi: 10.1158/1078-0432.CCR-17-2522. Epub 2017 Dec 12.


Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin.

Juenet M, Aid-Launais R, Li B, Berger A, Aerts J, Ollivier V, Nicoletti A, Letourneur D, Chauvierre C.

Biomaterials. 2018 Feb;156:204-216. doi: 10.1016/j.biomaterials.2017.11.047. Epub 2017 Nov 29.


Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles.

Aerts R, Joly L, Szternfeld P, Tsilikas K, De Cremer K, Castelain P, Aerts JM, Van Orshoven J, Somers B, Hendrickx M, Andjelkovic M, Van Nieuwenhuyse A.

Environ Sci Technol. 2018 Jan 2;52(1):298-307. doi: 10.1021/acs.est.7b05039. Epub 2017 Dec 13.


Insights into Flood-Coping Appraisals of Protection Motivation Theory: Empirical Evidence from Germany and France.

Bubeck P, Wouter Botzen WJ, Laudan J, Aerts JCJH, Thieken AH.

Risk Anal. 2017 Nov 17. doi: 10.1111/risa.12938. [Epub ahead of print]


Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.

Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E.

Alzheimers Dement (N Y). 2017 Aug 30;3(4):481-486. doi: 10.1016/j.trci.2017.08.004. eCollection 2017 Nov.


Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.

Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, Overkleeft HS.

Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k.


Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD.

Mandal J, Roth M, Papakonstantinou E, Sun Q, Costa L, Boeck L, Scherr A, Rakic J, Louis R, Milenkovic B, Boersma W, Kostikas K, Blasi F, Aerts J, Rohde G, Lacoma A, Torres A, Welte T, Tamm M, Stolz D.

Pulm Pharmacol Ther. 2018 Feb;48:111-116. doi: 10.1016/j.pupt.2017.10.011. Epub 2017 Oct 21.


In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.

van Smeden J, Dijkhoff IM, Helder RWJ, Al-Khakany H, Boer DEC, Schreuder A, Kallemeijn WW, Absalah S, Overkleeft HS, Aerts JMFG, Bouwstra JA.

J Lipid Res. 2017 Dec;58(12):2299-2309. doi: 10.1194/jlr.M079376. Epub 2017 Oct 12.


SCENIC: single-cell regulatory network inference and clustering.

Aibar S, González-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, Rambow F, Marine JC, Geurts P, Aerts J, van den Oord J, Atak ZK, Wouters J, Aerts S.

Nat Methods. 2017 Nov;14(11):1083-1086. doi: 10.1038/nmeth.4463. Epub 2017 Oct 9.


High and individually variable enzymatic activity precludes accurate determination of pemetrexed, methotrexate and their polyglutamate metabolite concentrations in plasma.

Stoop MP, Visser S, van Dijk E, Aerts JGJV, Stricker BH, Luider TM.

J Pharm Biomed Anal. 2018 Jan 30;148:89-92. doi: 10.1016/j.jpba.2017.09.014. Epub 2017 Sep 14.


A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.


Uniform and blinded cause of death verification of the NELSON lung cancer screening participants.

Yousaf-Khan AU, van der Aalst CM, Aerts JGJV, den Bakker MA, de Koning HJ.

Lung Cancer. 2017 Sep;111:131-134. doi: 10.1016/j.lungcan.2017.07.018. Epub 2017 Jul 22.


1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.

Artola M, Wu L, Ferraz MJ, Kuo CL, Raich L, Breen IZ, Offen WA, Codée JDC, van der Marel GA, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2017 Jul 26;3(7):784-793. doi: 10.1021/acscentsci.7b00214. Epub 2017 Jul 13.


Is immunotherapy a viable option in treating mesothelioma?

Dumoulin DW, Aerts JG, Cornelissen R.

Future Oncol. 2017 Aug;13(20):1747-1750. doi: 10.2217/fon-2017-0234. Epub 2017 Aug 4. No abstract available.


Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival.

Gabriel TL, Mirzaian M, Hooibrink B, Ottenhoff R, van Roomen C, Aerts JMFG, van Eijk M.

PLoS One. 2017 Jul 28;12(7):e0182075. doi: 10.1371/journal.pone.0182075. eCollection 2017.


Novel insights into mesothelioma biology and implications for therapy.

Yap TA, Aerts JG, Popat S, Fennell DA.

Nat Rev Cancer. 2017 Jul 25;17(8):475-488. doi: 10.1038/nrc.2017.42. Review.


Immune checkpoint therapy of mesothelioma: Pre-clinical bases and clinical evidences.

Calabrò L, Ceresoli GL, D'Incecco A, Scherpereel A, Aerts J, Maio M.

Cytokine Growth Factor Rev. 2017 Aug;36:25-31. doi: 10.1016/j.cytogfr.2017.07.003. Epub 2017 Jul 12. Review.


Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial.

Maio M, Scherpereel A, Calabrò L, Aerts J, Cedres Perez S, Bearz A, Nackaerts K, Fennell DA, Kowalski D, Tsao AS, Taylor P, Grosso F, Antonia SJ, Nowak AK, Taboada M, Puglisi M, Stockman PK, Kindler HL.

Lancet Oncol. 2017 Sep;18(9):1261-1273. doi: 10.1016/S1470-2045(17)30446-1. Epub 2017 Jul 17.


Oncolytic virus-induced cell death and immunity: a match made in heaven?

De Munck J, Binks A, McNeish IA, Aerts JL.

J Leukoc Biol. 2017 Sep;102(3):631-643. doi: 10.1189/jlb.5RU0117-040R. Epub 2017 Jul 18. Review.


Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors.

Dammeijer F, Lau SP, van Eijck CHJ, van der Burg SH, Aerts JGJV.

Cytokine Growth Factor Rev. 2017 Aug;36:5-15. doi: 10.1016/j.cytogfr.2017.06.011. Epub 2017 Jun 28. Review.


Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes".

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG.

ACS Cent Sci. 2017 Jun 28;3(6):673. doi: 10.1021/acscentsci.7b00185. Epub 2017 May 18.


Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease.

Kytidou K, Beenakker TJM, Westerhof LB, Hokke CH, Moolenaar GF, Goosen N, Mirzaian M, Ferraz MJ, de Geus M, Kallemeijn WW, Overkleeft HS, Boot RG, Schots A, Bosch D, Aerts JMFG.

Front Plant Sci. 2017 Jun 21;8:1026. doi: 10.3389/fpls.2017.01026. eCollection 2017.


Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century.

Veldkamp TIE, Wada Y, Aerts JCJH, Döll P, Gosling SN, Liu J, Masaki Y, Oki T, Ostberg S, Pokhrel Y, Satoh Y, Kim H, Ward PJ.

Nat Commun. 2017 Jun 15;8:15697. doi: 10.1038/ncomms15697.


Activity-based probes for functional interrogation of retaining β-glucuronidases.

Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ.

Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5.


Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples - a short report.

Beije N, Kraan J, den Bakker MA, Maat APWM, van der Leest C, Cornelissen R, Van NM, Martens JWM, Aerts JGJV, Sleijfer S.

Cell Oncol (Dordr). 2017 Oct;40(5):511-519. doi: 10.1007/s13402-017-0327-7. Epub 2017 Jun 2.


Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy.

Dammeijer F, Lievense LA, Kaijen-Lambers ME, van Nimwegen M, Bezemer K, Hegmans JP, van Hall T, Hendriks RW, Aerts JG.

Cancer Immunol Res. 2017 Jul;5(7):535-546. doi: 10.1158/2326-6066.CIR-16-0309. Epub 2017 May 23.


Stabilization of Glucocerebrosidase by Active Site Occupancy.

Ben Bdira F, Kallemeijn WW, Oussoren SV, Scheij S, Bleijlevens B, Florea BI, van Roomen CPAA, Ottenhoff R, van Kooten MJFM, Walvoort MTC, Witte MD, Boot RG, Ubbink M, Overkleeft HS, Aerts JMFG.

ACS Chem Biol. 2017 Jul 21;12(7):1830-1841. doi: 10.1021/acschembio.7b00276. Epub 2017 May 22.


Immunotherapeutic strategies in non-small-cell lung cancer: the present and the future.

Steendam CM, Dammeijer F, Aerts JGJV, Cornelissen R.

Immunotherapy. 2017 May;9(6):507-520. doi: 10.2217/imt-2016-0151. Review.


Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.

Beenakker TJM, Wander DPA, Offen WA, Artola M, Raich L, Ferraz MJ, Li KY, Houben JHPM, van Rijssel ER, Hansen T, van der Marel GA, Codée JDC, Aerts JMFG, Rovira C, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2017 May 17;139(19):6534-6537. doi: 10.1021/jacs.7b01773. Epub 2017 May 5.


Opinions of lung cancer clinicians on shared decision making in early-stage non-small-cell lung cancer.

Mokhles S, Maat APWM, Aerts JGJV, Nuyttens JJME, Bogers AJJC, Takkenberg JJM.

Interact Cardiovasc Thorac Surg. 2017 Aug 1;25(2):278-284. doi: 10.1093/icvts/ivx103.


New-generation CZT cameras: the future of infection imaging?

Rouzet F, Aerts J, Hyafil F, Le Guludec D.

Eur Heart J. 2017 Feb 7;38(6):444-446. doi: 10.1093/eurheartj/ehw376. No abstract available.


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