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Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome.

Wang G, Gormley M, Qiao J, Zhao Q, Wang M, Di Sante G, Deng S, Dong L, Pestell T, Ju X, Casimiro MC, Addya S, Ertel A, Tozeren A, Li Q, Yu Z, Pestell RG.

Theranostics. 2018 Mar 11;8(8):2251-2263. doi: 10.7150/thno.23877. eCollection 2018.


CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.

Jiao X, Velasco-Velázquez MA, Wang M, Li Z, Rui H, Peck AR, Korkola JE, Chen X, Xu S, DuHadaway JB, Guerrero-Rodriguez S, Addya S, Sicoli D, Mu Z, Zhang G, Stucky A, Zhang X, Cristofanilli M, Fatatis A, Gray JW, Zhong JF, Prendergast GC, Pestell RG.

Cancer Res. 2018 Apr 1;78(7):1657-1671. doi: 10.1158/0008-5472.CAN-17-0915. Epub 2018 Jan 22.


Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.

Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB.

Clin Cancer Res. 2018 Mar 15;24(6):1402-1414. doi: 10.1158/1078-0432.CCR-17-2074. Epub 2018 Jan 8.


Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia.

De Dominici M, Porazzi P, Soliera AR, Mariani SA, Addya S, Fortina P, Peterson LF, Spinelli O, Rambaldi A, Martinelli G, Ferrari A, Iacobucci I, Calabretta B.

Cancer Res. 2018 Feb 15;78(4):1097-1109. doi: 10.1158/0008-5472.CAN-17-2644. Epub 2017 Dec 12.


Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.

Peng W, Furuuchi N, Aslanukova L, Huang YH, Brown SZ, Jiang W, Addya S, Vishwakarma V, Peters E, Brody JR, Dixon DA, Sawicki JA.

Mol Cell Biol. 2018 Jan 16;38(3). pii: e00427-17. doi: 10.1128/MCB.00427-17. Print 2018 Feb 1.


HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk.

Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K.

Sci Rep. 2017 Jul 4;7(1):4590. doi: 10.1038/s41598-017-04469-z.


Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone.

Singh J, Mohanty I, Addya S, Phillips B, Mee Yong H, An SS, Penn RB, Rattan S.

Sci Rep. 2017 May 3;7(1):1477. doi: 10.1038/s41598-017-01550-5.


RB Loss Promotes Prostate Cancer Metastasis.

Thangavel C, Boopathi E, Liu Y, Haber A, Ertel A, Bhardwaj A, Addya S, Williams N, Ciment SJ, Cotzia P, Dean JL, Snook A, McNair C, Price M, Hernandez JR, Zhao SG, Birbe R, McCarthy JB, Turley EA, Pienta KJ, Feng FY, Dicker AP, Knudsen KE, Den RB.

Cancer Res. 2017 Feb 15;77(4):982-995. doi: 10.1158/0008-5472.CAN-16-1589. Epub 2016 Dec 6.


Integrative genomic and network analysis identified novel genes associated with the development of advanced cervical squamous cell carcinoma.

Roychowdhury A, Samadder S, Das P, Mandloi S, Addya S, Chakraborty C, Basu PS, Mondal R, Roy A, Chakrabarti S, Roychoudhury S, Panda CK.

Biochim Biophys Acta. 2017 Jan;1861(1 Pt A):2899-2911. doi: 10.1016/j.bbagen.2016.09.014. Epub 2016 Sep 15.


Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a.

Singh J, Boopathi E, Addya S, Phillips B, Rigoutsos I, Penn RB, Rattan S.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G964-G973. doi: 10.1152/ajpgi.00290.2016. Epub 2016 Sep 15.


Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination.

Biswas K, Chatterjee D, Addya S, Khan RS, Kenyon LC, Choe A, Cohrs RJ, Shindler KS, Das Sarma J.

Clin Immunol. 2016 Sep;170:9-19. doi: 10.1016/j.clim.2016.07.004. Epub 2016 Jul 6.


The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells.

Salem I, Alsalahi M, Chervoneva I, Aburto LD, Addya S, Ott GR, Ruggeri BA, Cristofanilli M, Fernandez SV.

Breast Cancer Res. 2016 Mar 24;18(1):37. doi: 10.1186/s13058-016-0694-4.


Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.

Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG.

Oncotarget. 2015 Apr 20;6(11):8525-38.


Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion.

Gupta A, Nitoiu D, Brennan-Crispi D, Addya S, Riobo NA, Kelsell DP, Mahoney MG.

PLoS One. 2015 Mar 18;10(3):e0120091. doi: 10.1371/journal.pone.0120091. eCollection 2015.


The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.

Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG.

Cancer Res. 2015 May 15;75(10):1992-2004. doi: 10.1158/0008-5472.CAN-14-0611. Epub 2015 Mar 13.


Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates.

Debnath S, Addya S.

Springerplus. 2014 Nov 6;3:660. doi: 10.1186/2193-1801-3-660. eCollection 2014.


CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.

Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Andò S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP, Pestell RG.

Cancer Res. 2014 Dec 1;74(23):7103-14. doi: 10.1158/0008-5472.CAN-14-0612.


Mouse hepatitis virus infection upregulates genes involved in innate immune responses.

Chatterjee D, Addya S, Khan RS, Kenyon LC, Choe A, Cohrs RJ, Shindler KS, Sarma JD.

PLoS One. 2014 Oct 31;9(10):e111351. doi: 10.1371/journal.pone.0111351. eCollection 2014.


Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.

Tian L, Wang C, Hagen FK, Gormley M, Addya S, Soccio R, Casimiro MC, Zhou J, Powell MJ, Xu P, Deng H, Sauve AA, Pestell RG.

Oncotarget. 2014 Sep 15;5(17):7303-15.


The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.

Thangavel C, Boopathi E, Ciment S, Liu Y, O'Neill R, Sharma A, McMahon SB, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker AP, Knudsen KE, Den RB.

Clin Cancer Res. 2014 Nov 1;20(21):5468-5482. doi: 10.1158/1078-0432.CCR-14-0326. Epub 2014 Aug 27.


Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.

Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA.

Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H66-72. doi: 10.1152/ajpheart.00166.2014. Epub 2014 May 9.


VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.

Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC.

Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12.


All trans-retinoic acid (ATRA) induces re-differentiation of early transformed breast epithelial cells.

Arisi MF, Starker RA, Addya S, Huang Y, Fernandez SV.

Int J Oncol. 2014 Jun;44(6):1831-42. doi: 10.3892/ijo.2014.2354. Epub 2014 Mar 21.


miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1.

Yu Z, Xu Z, Disante G, Wright J, Wang M, Li Y, Zhao Q, Ren T, Ju X, Gutman E, Wang G, Addya S, Li T, Xiang Z, Wang C, Yang X, Yang X, Pestell R.

Oncotarget. 2014 Feb 28;5(4):1083-90.


Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation.

Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A, Pestell RG.

Cancer Res. 2014 Feb 1;74(3):829-39. doi: 10.1158/0008-5472.CAN-13-2466. Epub 2013 Dec 12.


An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes.

Markova DZ, Kepler CK, Addya S, Murray HB, Vaccaro AR, Shapiro IM, Anderson DG, Albert TJ, Risbud MV.

Arthritis Res Ther. 2013;15(5):R121.


Mechanisms of endothelial cell attachment, proliferation, and differentiation on 4 types of platinum-based endovascular coils.

Pandey AS, San Antonio JD, Addya S, Surrey S, Fortina P, Van Bockstaele EJ, Veznedaroglu E.

World Neurosurg. 2014 Nov;82(5):684-95. doi: 10.1016/j.wneu.2013.08.029. Epub 2013 Aug 30.


Identification of a developmental gene expression signature, including HOX genes, for the normal human colonic crypt stem cell niche: overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis.

Bhatlekar S, Addya S, Salunek M, Orr CR, Surrey S, McKenzie S, Fields JZ, Boman BM.

Stem Cells Dev. 2014 Jan 15;23(2):167-79. doi: 10.1089/scd.2013.0039. Epub 2013 Nov 5.


Cyclin D1 determines estrogen signaling in the mammary gland in vivo.

Casimiro MC, Wang C, Li Z, Di Sante G, Willmart NE, Addya S, Chen L, Liu Y, Lisanti MP, Pestell RG.

Mol Endocrinol. 2013 Sep;27(9):1415-28. doi: 10.1210/me.2013-1065. Epub 2013 Jul 17.


Inflammatory breast cancer (IBC): clues for targeted therapies.

Fernandez SV, Robertson FM, Pei J, Aburto-Chumpitaz L, Mu Z, Chu K, Alpaugh RK, Huang Y, Cao Y, Ye Z, Cai KQ, Boley KM, Klein-Szanto AJ, Devarajan K, Addya S, Cristofanilli M.

Breast Cancer Res Treat. 2013 Jul;140(1):23-33. doi: 10.1007/s10549-013-2600-4. Epub 2013 Jun 21.


Aberrant BAF57 signaling facilitates prometastatic phenotypes.

Balasubramaniam S, Comstock CE, Ertel A, Jeong KW, Stallcup MR, Addya S, McCue PA, Ostrander WF Jr, Augello MA, Knudsen KE.

Clin Cancer Res. 2013 May 15;19(10):2657-67. doi: 10.1158/1078-0432.CCR-12-3049. Epub 2013 Mar 14.


Dachshund binds p53 to block the growth of lung adenocarcinoma cells.

Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG.

Cancer Res. 2013 Jun 1;73(11):3262-74. doi: 10.1158/0008-5472.CAN-12-3191. Epub 2013 Mar 14.


Tumor-suppressive effects of CDK8 in endometrial cancer cells.

Gu W, Wang C, Li W, Hsu FN, Tian L, Zhou J, Yuan C, Xie XJ, Jiang T, Addya S, Tai Y, Kong B, Ji JY.

Cell Cycle. 2013 Mar 15;12(6):987-99. doi: 10.4161/cc.24003. Epub 2013 Mar 1.


MicroRNA-mediated GABA Aα-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats.

Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B.

Pain. 2013 Jan;154(1):59-70. doi: 10.1016/j.pain.2012.09.002. Erratum in: Pain. 2013 Mar;154(3):493. Pochiraju, Soumiya [corrected to Pochiraju, Soumya].


Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.

Thangavel C, Boopathi E, Ertel A, Lim M, Addya S, Fortina P, Witkiewicz AK, Knudsen ES.

Cell Cycle. 2013 Jan 1;12(1):98-111. doi: 10.4161/cc.23029. Epub 2012 Dec 19.


Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression.

Gomme EA, Wirblich C, Addya S, Rall GF, Schnell MJ.

PLoS Pathog. 2012;8(10):e1002971. doi: 10.1371/journal.ppat.1002971. Epub 2012 Oct 11.


ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.

Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG.

J Clin Invest. 2012 Mar;122(3):833-43. doi: 10.1172/JCI60256. Epub 2012 Feb 6. Erratum in: J Clin Invest. 2013 May 1;123(5):2332.


Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.

Soliera AR, Mariani SA, Audia A, Lidonnici MR, Addya S, Ferrari-Amorotti G, Cattelani S, Manzotti G, Fragliasso V, Peterson L, Perini G, Holyoake TL, Calabretta B.

Leukemia. 2012 Jul;26(7):1555-63. doi: 10.1038/leu.2012.19. Epub 2012 Jan 30.


Mammary gland selective excision of c-jun identifies its role in mRNA splicing.

Katiyar S, Jiao X, Addya S, Ertel A, Covarrubias Y, Rose V, Casimiro MC, Zhou J, Lisanti MP, Nasim T, Fortina P, Pestell RG.

Cancer Res. 2012 Feb 15;72(4):1023-34. doi: 10.1158/0008-5472.CAN-11-3647. Epub 2011 Dec 15.


Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro.

Wermuth PJ, Addya S, Jimenez SA.

PLoS One. 2011;6(11):e27110. doi: 10.1371/journal.pone.0027110. Epub 2011 Nov 11.


Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells.

Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

Lab Invest. 2011 Dec;91(12):1739-52. doi: 10.1038/labinvest.2011.144. Epub 2011 Oct 3.


RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.

McClendon AK, Dean JL, Ertel A, Fu Z, Rivadeneira DB, Reed CA, Bourgo RJ, Witkiewicz A, Addya S, Mayhew CN, Grimes HL, Fortina P, Knudsen ES.

Gastroenterology. 2011 Oct;141(4):1439-50. doi: 10.1053/j.gastro.2011.06.046. Epub 2011 Jun 24.


Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate.

Bryant KG, Camacho J, Jasmin JF, Wang C, Addya S, Casimiro MC, Fortina P, Balasubramaniam S, Knudsen KE, Schwarting R, Lisanti MP, Mercier I.

Int J Biochem Cell Biol. 2011 Sep;43(9):1318-29. doi: 10.1016/j.biocel.2011.04.019. Epub 2011 May 12.


A de novo supernumerary genomic discontinuous ring chromosome 21 in a child with mild intellectual disability.

Villa N, Bentivegna A, Ertel A, Redaelli S, Colombo C, Nacinovich R, Broggi F, Lissoni S, Bungaro S, Addya S, Fortina P, Dalprà L.

Am J Med Genet A. 2011 Jun;155A(6):1425-31. doi: 10.1002/ajmg.a.34010. Epub 2011 May 13.


Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.

Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Jun 1;9(11):2201-19.


Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen MT.

Endocr Relat Cancer. 2010 May 18;17(2):481-93. doi: 10.1677/ERC-09-0328. Print 2010 Jun.


Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop T, Bubendorf L, Nevalainen MT.

Am J Pathol. 2010 Apr;176(4):1959-72. doi: 10.2353/ajpath.2010.090653. Epub 2010 Feb 18.


Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells.

Saraiya M, Nasser R, Zeng Y, Addya S, Ponnappan RK, Fortina P, Anderson DG, Albert TJ, Shapiro IM, Risbud MV.

Tissue Eng Part A. 2010 Apr;16(4):1443-55. doi: 10.1089/ten.TEA.2009.0343.

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