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Items: 1 to 50 of 1156

1.

Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194.

Izuta S, Kosaka S, Kawai M, Miyano R, Matsuo H, Matsumoto A, Nonaka K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 Feb 20. doi: 10.1038/s41429-018-0028-0. [Epub ahead of print]

PMID:
29463887
2.

Orthognathic Surgery and Implant-Supported Bridge in a Class III Patient Injured in a Motor Vehicle Accident.

Honda K, Hirota M, Iwai T, Fujita K, Omura S, Ono T, Tohnai I.

J Craniofac Surg. 2018 Feb 7. doi: 10.1097/SCS.0000000000004339. [Epub ahead of print]

PMID:
29420385
3.

Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79.

Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Gen Appl Microbiol. 2018 Jan 25. doi: 10.2323/jgam.2017.06.004. [Epub ahead of print]

4.

Immunoregulation of Theiler's virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses.

Omura S, Sato F, Martinez NE, Range T, Ekshyyan L, Minagar A, Alexander JS, Tsunoda I.

Arch Virol. 2018 Jan 23. doi: 10.1007/s00705-018-3729-6. [Epub ahead of print]

PMID:
29362931
5.

Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes.

Sugawara A, Kubo M, Hirose T, Yahagi K, Tsunoda N, Noguchi Y, Nakashima T, Takahashi Y, Welz C, Mueller D, Mertens C, Koebberling J, Ōmura S, Sunazuka T.

Eur J Med Chem. 2018 Feb 10;145:524-538. doi: 10.1016/j.ejmech.2017.12.031. Epub 2017 Dec 28.

PMID:
29335213
6.

Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.

Ohtawa M, Arima S, Ichida N, Terayama T, Ohno H, Yamazaki T, Ohshiro T, Sato N, Omura S, Tomoda H, Nagamitsu T.

ChemMedChem. 2018 Jan 11. doi: 10.1002/cmdc.201700645. [Epub ahead of print]

PMID:
29323466
7.

Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.

Sato E, Morita M, Ogawa H, Iwatsuki M, Hokari R, Ishiyama A, Ōmura S, Iwasaki A, Suenaga K.

Bioorg Med Chem Lett. 2017 Dec 24. pii: S0960-894X(17)31224-6. doi: 10.1016/j.bmcl.2017.12.050. [Epub ahead of print]

PMID:
29292225
8.

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.

Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE.

FASEB J. 2018 Jan 8:fj201700746R. doi: 10.1096/fj.201700746R. [Epub ahead of print]

PMID:
29269399
9.

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies.

Park AM, Omura S, Fujita M, Sato F, Tsunoda I.

Clin Exp Neuroimmunol. 2017 Aug;8(3):215-232. doi: 10.1111/cen3.12401. Epub 2017 Jul 23.

PMID:
29158778
10.

Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis.

Tuvshintulga B, AbouLaila M, Sivakumar T, Tayebwa DS, Gantuya S, Naranbaatar K, Ishiyama A, Iwatsuki M, Otoguro K, Ōmura S, Terkawi MA, Guswanto A, Rizk MA, Yokoyama N, Igarashi I.

Sci Rep. 2017 Oct 24;7(1):13888. doi: 10.1038/s41598-017-14304-0.

11.

Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters.

Tong Y, Liu M, Zhang Y, Liu X, Huang R, Song F, Dai H, Ren B, Sun N, Pei G, Bian J, Jia XM, Huang G, Zhou X, Li S, Zhang B, Fukuda T, Tomoda H, Ōmura S, Cannon RD, Calderone R, Zhang L.

Synth Syst Biotechnol. 2016 Oct 25;1(3):158-168. doi: 10.1016/j.synbio.2016.10.001. eCollection 2016 Sep.

12.

Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.

Watanabe Y, Asami Y, Narusawa S, Hashimoto S, Iwatsuki M, Nonaka K, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 Oct 11. doi: 10.1038/ja.2017.118. [Epub ahead of print]

PMID:
29018265
13.

Bisoxazolomycin A: a new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603.

Koomsiri W, Inahashi Y, Kimura T, Shiomi K, Takahashi Y, Ōmura S, Thamchaipenet A, Nakashima T.

J Antibiot (Tokyo). 2017 Dec;70(12):1142-1145. doi: 10.1038/ja.2017.113. Epub 2017 Sep 27.

PMID:
28951599
14.

Saccharomonospora colocasiae sp. nov., an actinomycete isolated from the rhizosphere of Colocasia esculenta.

Wattanasuepsin W, Intra B, Také A, Inahashi Y, Euanorasetr J, Ōmura S, Matsumoto A, Panbangred W.

Int J Syst Evol Microbiol. 2017 Nov;67(11):4572-4577. doi: 10.1099/ijsem.0.002336. Epub 2017 Sep 25.

PMID:
28945543
15.

T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection.

Sato F, Kawai E, Martinez NE, Omura S, Park AM, Takahashi S, Yoh K, Tsunoda I.

Sci Rep. 2017 Sep 5;7(1):10496. doi: 10.1038/s41598-017-10980-0.

16.

Corrigendum: γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Ōmura S, Yoshikawa T, Kobayashi Y.

J Antibiot (Tokyo). 2017 Aug;70(9):979. doi: 10.1038/ja.2017.71.

PMID:
28845046
17.

Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies.

Sennari G, Saito R, Hirose T, Iwatsuki M, Ishiyama A, Hokari R, Otoguro K, Ōmura S, Sunazuka T.

Sci Rep. 2017 Aug 3;7(1):7259. doi: 10.1038/s41598-017-07718-3.

18.

Corrigendum: Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601.

Nakashima T, Miyano R, Iwatsuki M, Shirahata T, Kimura T, Asami Y, Kobayashi Y, Shiomi K, Petersson GA, Takahashi Y, Ōmura S.

J Antibiot (Tokyo). 2017 Jul;70(8):921. doi: 10.1038/ja.2017.68.

PMID:
28747796
19.

Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.

Ando H, Kimishima A, Ohara M, Hirose T, Matsumaru T, Takada H, Morodome K, Miyamoto T, Sugawara A, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2018 Feb;71(2):268-272. doi: 10.1038/ja.2017.77. Epub 2017 Jul 5.

PMID:
28676718
20.

Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis.

Tsunoda I, Sato F, Omura S, Fujita M, Sakiyama N, Park AM.

Clin Exp Neuroimmunol. 2016 Nov;7(4):330-345. doi: 10.1111/cen3.12341. Epub 2016 Oct 25.

21.

Three novel species of the genus Kibdelosporangium; Kibdelosporangium kanagawaense sp. nov., Kibdelosporangiumrhizosphaerae sp. nov. and Kibdelosporangium rhizovicinum sp. nov.

Mingma R, Duangmal K, Ōmura S, Takahashi Y, Matsumoto A.

Int J Syst Evol Microbiol. 2017 Jun;67(6):1758-1765. doi: 10.1099/ijsem.0.001861. Epub 2017 Jun 9.

PMID:
28598312
22.

Cladomarine, a new anti-saprolegniasis compound isolated from the deep-sea fungus, Penicillium coralligerum YK-247.

Takahashi K, Sakai K, Nagano Y, Orui Sakaguchi S, Lima AO, Pellizari VH, Iwatsuki M, Takishita K, Nonaka K, Fujikura K, Ōmura S.

J Antibiot (Tokyo). 2017 Jul;70(8):911-914. doi: 10.1038/ja.2017.58. Epub 2017 May 31. No abstract available.

PMID:
28559580
23.

5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity.

Sugawara A, Maruyama H, Shibusawa S, Matsui H, Hirose T, Tsutsui A, Froyman R, Ludwig C, Koebberling J, Hanaki H, Kleefeld G, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2017 Jul;70(8):878-887. doi: 10.1038/ja.2017.61. Epub 2017 May 31.

PMID:
28559578
24.

Ivermectin and malaria control.

Ōmura S, Crump A.

Malar J. 2017 Apr 24;16(1):172. doi: 10.1186/s12936-017-1825-9.

25.

Computational fluid dynamics study of the pharyngeal airway space before and after mandibular setback surgery in patients with mandibular prognathism.

Yajima Y, Oshima M, Iwai T, Kitajima H, Omura S, Tohnai I.

Int J Oral Maxillofac Surg. 2017 Jul;46(7):839-844. doi: 10.1016/j.ijom.2017.03.028. Epub 2017 Apr 12.

PMID:
28412180
26.

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Ōmura S, Yoshikawa T, Kobayashi Y.

J Antibiot (Tokyo). 2017 May;70(5):695-698. doi: 10.1038/ja.2017.35. Epub 2017 Mar 22. No abstract available. Erratum in: J Antibiot (Tokyo). 2017 Aug;70(9):979.

PMID:
28325930
27.

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.

Fukumoto A, Kim YP, Matsumoto A, Takahashi Y, Suzuki M, Onodera H, Tomoda H, Matsui H, Hanaki H, Iwatsuki M, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 May;70(5):562-567. doi: 10.1038/ja.2017.28. Epub 2017 Mar 15.

PMID:
28293038
28.

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.

Fukumoto A, Kim YP, Iwatsuki M, Hirose T, Sunazuka T, Hanaki H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 May;70(5):568-573. doi: 10.1038/ja.2017.29. Epub 2017 Mar 15.

PMID:
28293036
29.

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis.

Katz N, Araújo N, Coelho PMZ, Morel CM, Linde-Arias AR, Yamada T, Horimatsu Y, Suzuki K, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2017 May;70(5):680-684. doi: 10.1038/ja.2017.31. Epub 2017 Mar 15.

PMID:
28293033
30.

Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor.

Ohtawa M, Arima S, Shimizu R, Hanatani N, Shimizu E, Shiomi K, Kita K, Ōmura S, Nagamitsu T.

J Antibiot (Tokyo). 2017 May;70(5):647-654. doi: 10.1038/ja.2017.16. Epub 2017 Feb 22.

PMID:
28223689
31.

Nanaomycin H: A new nanaomycin analog.

Nakashima T, Kimura T, Miyano R, Matsuo H, Hirose T, Kimishima A, Nonaka K, Iwatsuki M, Nakanishi J, Takahashi Y, Ōmura S.

J Biosci Bioeng. 2017 Jun;123(6):765-770. doi: 10.1016/j.jbiosc.2017.01.011. Epub 2017 Feb 13.

PMID:
28202308
32.

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.

Watanabe Y, Suga T, Narusawa S, Iwatsuki M, Nonaka K, Nakashima T, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Asami Y, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 Apr;70(4):395-399. doi: 10.1038/ja.2016.164. Epub 2017 Jan 18.

PMID:
28096549
33.

Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening.

Horikoshi R, Goto K, Mitomi M, Oyama K, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2017 Mar;70(3):272-276. doi: 10.1038/ja.2016.155. Epub 2017 Jan 11.

PMID:
28074053
34.

Corrigendum: Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively.

Také A, Matsumoto A, Ōmura S, Takahashi Y.

J Antibiot (Tokyo). 2017 Jan;70(1):113. doi: 10.1038/ja.2016.103. No abstract available.

PMID:
28053352
35.

Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance.

Hirose T, Kojima Y, Matsui H, Hanaki H, Iwatsuki M, Shiomi K, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2017 May;70(5):574-581. doi: 10.1038/ja.2016.141. Epub 2016 Dec 7.

PMID:
27924114
36.

The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-Pyridyl-Xanthones for Use as Insecticides Starting from Pyripyropene A.

Fuse S, Matsumura K, Johmoto K, Uekusa H, Tanaka H, Hirose T, Sunazuka T, Ōmura S, Takahashi T.

Chemistry. 2016 Dec 19;22(51):18450-18455. doi: 10.1002/chem.201603980. Epub 2016 Nov 9.

PMID:
27862416
37.

Computational Fluid Dynamic Study of Nasal Respiratory Function Before and After Bimaxillary Orthognathic Surgery With Bone Trimming at the Inferior Edge of the Pyriform Aperture.

Kita S, Oshima M, Shimazaki K, Iwai T, Omura S, Ono T.

J Oral Maxillofac Surg. 2016 Nov;74(11):2241-2251. doi: 10.1016/j.joms.2016.06.171. Epub 2016 Jun 21.

PMID:
27425883
38.

Search for new compounds from Kitasato microbial library by physicochemical screening.

Nakashima T, Takahashi Y, Ōmura S.

Biochem Pharmacol. 2017 Jun 15;134:42-55. doi: 10.1016/j.bcp.2016.09.026. Epub 2016 Sep 26. Review.

PMID:
27687642
39.

Synthesis and Structural Revision of Cyslabdan.

Ohtawa M, Hishinuma Y, Takagi E, Yamada T, Ito F, Arima S, Uchida R, Kim YP, Ōmura S, Tomoda H, Nagamitsu T.

Chem Pharm Bull (Tokyo). 2016;64(9):1370-7. doi: 10.1248/cpb.c16-00382.

40.

Analyses of the cell-wall peptidoglycan structures in three genera Micromonospora, Catenuloplanes, and Couchioplanes belonging to the family Micromonosporaceae by derivatization with FDLA and PMP using LC/MS.

Také A, Nakashima T, Inahashi Y, Shiomi K, Takahashi Y, Ōmura S, Matsumoto A.

J Gen Appl Microbiol. 2016 Sep 12;62(4):199-205. doi: 10.2323/jgam.2016.02.007. Epub 2016 Jul 29.

41.

A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture).

Ōmura S.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10190-209. doi: 10.1002/anie.201602164. Epub 2016 Jul 20. Review.

PMID:
27435664
42.

In Vitro Antitrypanosomal Activity of the Secondary Metabolites from the Mutant Strain IU-3 of the Insect Pathogenic Fungus Ophiocordyceps coccidiicola NBRC 100683.

Ganaha M, Yoshii K, Ōtsuki Y, Iguchi M, Okamoto Y, Iseki K, Ban S, Ishiyama A, Hokari R, Iwatsuki M, Otoguro K, Ōmura S, Hashimoto T, Noji M, Umeyama A.

Chem Pharm Bull (Tokyo). 2016;64(7):988-90. doi: 10.1248/cpb.c16-00220.

43.

Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp. Marine Cyanobacterium.

Ogawa H, Iwasaki A, Sumimoto S, Kanamori Y, Ohno O, Iwatsuki M, Ishiyama A, Hokari R, Otoguro K, O̅mura S, Suenaga K.

J Nat Prod. 2016 Jul 22;79(7):1862-6. doi: 10.1021/acs.jnatprod.6b00171. Epub 2016 Jun 30.

PMID:
27359053
44.

Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori.

Yamamoto T, Matsui H, Yamaji K, Takahashi T, Øverby A, Nakamura M, Matsumoto A, Nonaka K, Sunazuka T, Ōmura S, Nakano H.

J Infect Chemother. 2016 Sep;22(9):587-92. doi: 10.1016/j.jiac.2016.05.012. Epub 2016 Jun 23.

PMID:
27346378
45.

Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022.

Suga T, Shiina M, Asami Y, Iwatsuki M, Yamamoto T, Nonaka K, Masuma R, Matsui H, Hanaki H, Iwamoto S, Onodera H, Shiomi K, Ōmura S.

J Antibiot (Tokyo). 2016 Aug;69(8):605-10. doi: 10.1038/ja.2016.70. Epub 2016 Jun 22.

PMID:
27328869
46.

Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid.

Noguchi Y, Hirose T, Ishiyama A, Iwatsuki M, Otoguro K, Sunazuka T, Ōmura S.

J Nat Med. 2016 Jul;70(3):302-17. doi: 10.1007/s11418-016-1012-2. Epub 2016 Jun 21. Review.

47.

Biosynthesis of Trehangelin in Polymorphospora rubra K07-0510: Identification of Metabolic Pathway to Angelyl-CoA.

Inahashi Y, Shiraishi T, Palm K, Takahashi Y, Ōmura S, Kuzuyama T, Nakashima T.

Chembiochem. 2016 Aug 3;17(15):1442-7. doi: 10.1002/cbic.201600208. Epub 2016 Jun 17.

PMID:
27311629
48.

Actinorhabdospora filicis gen. nov., sp. nov., a new member of the family Micromonosporaceae.

Mingma R, Tanaka K, Ōmura S, Takahashi Y, Matsumoto A.

Int J Syst Evol Microbiol. 2016 Aug;66(8):3071-7. doi: 10.1099/ijsem.0.001145. Epub 2016 May 11.

PMID:
27169368
49.

Organocatalytic Site-Selective Acylation of Avermectin B2a, a Unique Endectocidal Drug.

Yamada T, Suzuki K, Hirose T, Furuta T, Ueda Y, Kawabata T, Ōmura S, Sunazuka T.

Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):856-64. doi: 10.1248/cpb.c16-00205. Epub 2016 Apr 12.

50.

Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306.

Kimura T, Iwatsuki M, Asami Y, Ishiyama A, Hokari R, Otoguro K, Matsumoto A, Sato N, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2016 Nov;69(11):818-824. doi: 10.1038/ja.2016.28. Epub 2016 Mar 30.

PMID:
27025350

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