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Items: 1 to 20 of 52


Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.

Senechal K, Heaney C, Druker B, Sawyers CL.

Mol Cell Biol. 1998 Sep;18(9):5082-90.


Switching signals on or off by receptor dimerization.

Weiss A, Schlessinger J.

Cell. 1998 Aug 7;94(3):277-80. Review. No abstract available.


Pten is essential for embryonic development and tumour suppression.

Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP.

Nat Genet. 1998 Aug;19(4):348-55.


Akt activation by growth factors is a multiple-step process: the role of the PH domain.

Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P.

Oncogene. 1998 Jul 23;17(3):313-25.


Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.

Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM.

Science. 1998 Jun 5;280(5369):1614-7.


Mechanisms and consequences of activation of protein kinase B/Akt.

Downward J.

Curr Opin Cell Biol. 1998 Apr;10(2):262-7. Review.


Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.

Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5246-50.


Translation control: connecting mitogens and the ribosome.

Peterson RT, Schreiber SL.

Curr Biol. 1998 Mar 26;8(7):R248-50. Review.


4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N.

Genes Dev. 1998 Feb 15;12(4):502-13.


Lipid-regulated kinases: some common themes at last.

Downward J.

Science. 1998 Jan 30;279(5351):673-4. No abstract available.


Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase.

Jimenez C, Jones DR, Rodríguez-Viciana P, Gonzalez-García A, Leonardo E, Wennström S, von Kobbe C, Toran JL, R-Borlado L, Calvo V, Copin SG, Albar JP, Gaspar ML, Diez E, Marcos MA, Downward J, Martinez-A C, Mérida I, Carrera AC.

EMBO J. 1998 Feb 2;17(3):743-53.


Phosphorylation and activation of p70s6k by PDK1.

Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.

Science. 1998 Jan 30;279(5351):707-10.


3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.


MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA, et al.

Cancer Res. 1997 Dec 1;57(23):5221-5.


Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

del Peso L, González-García M, Page C, Herrera R, Nuñez G.

Science. 1997 Oct 24;278(5338):687-9.


3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.


Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.

Furnari FB, Lin H, Huang HS, Cavenee WK.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12479-84.

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