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Items: 8

1.

Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.

Palii SS, Cui Y, Innes CL, Paules RS.

Cell Cycle. 2013 Apr 1;12(7):1105-18. doi: 10.4161/cc.24127. Epub 2013 Mar 5.

2.

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.

Seshacharyulu P, Pandey P, Datta K, Batra SK.

Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20. Review.

3.

Targeting the S and G2 checkpoint to treat cancer.

Chen T, Stephens PA, Middleton FK, Curtin NJ.

Drug Discov Today. 2012 Mar;17(5-6):194-202. doi: 10.1016/j.drudis.2011.12.009. Epub 2011 Dec 15. Review.

PMID:
22192883
4.

Beyond ATM: the protein kinase landscape of the DNA damage response.

Bensimon A, Aebersold R, Shiloh Y.

FEBS Lett. 2011 Jun 6;585(11):1625-39. doi: 10.1016/j.febslet.2011.05.013. Epub 2011 May 8. Review.

5.

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics.

Ma CX, Janetka JW, Piwnica-Worms H.

Trends Mol Med. 2011 Feb;17(2):88-96. doi: 10.1016/j.molmed.2010.10.009. Epub 2010 Nov 17. Review.

PMID:
21087899
6.

Serine/threonine phosphatases in the DNA damage response and cancer.

Peng A, Maller JL.

Oncogene. 2010 Nov 11;29(45):5977-88. doi: 10.1038/onc.2010.371. Epub 2010 Sep 13. Review.

PMID:
20838380
7.

Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.

Yan Y, Cao PT, Greer PM, Nagengast ES, Kolb RH, Mumby MC, Cowan KH.

Oncogene. 2010 Jul 29;29(30):4317-29. doi: 10.1038/onc.2010.187. Epub 2010 May 24.

8.

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.

PMID:
20160494

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