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Bariatric surgery for type 2 diabetes.

Dixon JB, le Roux CW, Rubino F, Zimmet P.

Lancet. 2012 Jun 16;379(9833):2300-11. doi: 10.1016/S0140-6736(12)60401-2. Epub 2012 Jun 9. Review.


Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes.

Breen DM, Rasmussen BA, Kokorovic A, Wang R, Cheung GW, Lam TK.

Nat Med. 2012 Jun;18(6):950-5. doi: 10.1038/nm.2745.


Bariatric surgery versus intensive medical therapy in obese patients with diabetes.

Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, Thomas S, Abood B, Nissen SE, Bhatt DL.

N Engl J Med. 2012 Apr 26;366(17):1567-76. doi: 10.1056/NEJMoa1200225. Epub 2012 Mar 26.


Bariatric surgery versus conventional medical therapy for type 2 diabetes.

Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Leccesi L, Nanni G, Pomp A, Castagneto M, Ghirlanda G, Rubino F.

N Engl J Med. 2012 Apr 26;366(17):1577-85. doi: 10.1056/NEJMoa1200111. Epub 2012 Mar 26.


TOR complex 2: a signaling pathway of its own.

Cybulski N, Hall MN.

Trends Biochem Sci. 2009 Dec;34(12):620-7. doi: 10.1016/j.tibs.2009.09.004. Epub 2009 Oct 28. Review.


Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.


A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.


First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery.

Salinari S, Bertuzzi A, Asnaghi S, Guidone C, Manco M, Mingrone G.

Diabetes Care. 2009 Mar;32(3):375-80. doi: 10.2337/dc08-1314. Epub 2008 Nov 25.


The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.


Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.

Cozzone D, Fröjdö S, Disse E, Debard C, Laville M, Pirola L, Vidal H.

Diabetologia. 2008 Mar;51(3):512-21. doi: 10.1007/s00125-007-0913-8. Epub 2008 Jan 18.


mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.

Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G.

Diabetes. 2008 Apr;57(4):945-57. doi: 10.2337/db07-0922. Epub 2008 Jan 3.


Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells.

Ciaraldi TP, Nikoulina SE, Bandukwala RA, Carter L, Henry RR.

Endocrinology. 2007 Sep;148(9):4393-9. Epub 2007 Jun 14.


N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.

Goñi-Oliver P, Lucas JJ, Avila J, Hernández F.

J Biol Chem. 2007 Aug 3;282(31):22406-13. Epub 2007 Jun 14.


Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.

Montori-Grau M, Guitart M, Lerin C, Andreu AL, Newgard CB, García-Martínez C, Gómez-Foix AM.

Biochem J. 2007 Jul 1;405(1):107-13. Erratum in: Biochem J. 2007 Aug 1;405(3):625.


The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes.

Rubino F, Forgione A, Cummings DE, Vix M, Gnuli D, Mingrone G, Castagneto M, Marescaux J.

Ann Surg. 2006 Nov;244(5):741-9.


Islet beta cell failure in type 2 diabetes.

Prentki M, Nolan CJ.

J Clin Invest. 2006 Jul;116(7):1802-12. Review.


Insulin resistance and pancreatic beta cell failure.

Kasuga M.

J Clin Invest. 2006 Jul;116(7):1756-60. Review.


Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function.

Mari A, Manco M, Guidone C, Nanni G, Castagneto M, Mingrone G, Ferrannini E.

Diabetologia. 2006 Sep;49(9):2136-43. Epub 2006 Jul 4.


Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery.

Guidone C, Manco M, Valera-Mora E, Iaconelli A, Gniuli D, Mari A, Nanni G, Castagneto M, Calvani M, Mingrone G.

Diabetes. 2006 Jul;55(7):2025-31.


Gut transport of a molybdenum/ascorbic acid complex.

Russell MS, Bailey J, Duffy SJ, Vogels CM, Broderick TL, Westcott SA.

Drugs R D. 2006;7(2):111-7.


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