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Items: 1 to 20 of 38

1.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C.

N Engl J Med. 2012 Mar 8;366(10):883-92. doi: 10.1056/NEJMoa1113205. Erratum in: N Engl J Med. 2012 Sep 6;367(10):976.

2.

Epigenetic regulation of normal human mammary cell type-specific miRNAs.

Vrba L, Garbe JC, Stampfer MR, Futscher BW.

Genome Res. 2011 Dec;21(12):2026-37. doi: 10.1101/gr.123935.111. Epub 2011 Aug 26.

3.

miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer.

Zhang Y, Yan LX, Wu QN, Du ZM, Chen J, Liao DZ, Huang MY, Hou JH, Wu QL, Zeng MS, Huang WL, Zeng YX, Shao JY.

Cancer Res. 2011 May 15;71(10):3552-62. doi: 10.1158/0008-5472.CAN-10-2435. Epub 2011 Mar 28.

4.

Mapping and analysis of chromatin state dynamics in nine human cell types.

Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE.

Nature. 2011 May 5;473(7345):43-9. doi: 10.1038/nature09906. Epub 2011 Mar 23.

5.

Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer.

Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L.

Clin Cancer Res. 2011 Apr 1;17(7):1722-30. doi: 10.1158/1078-0432.CCR-10-1800. Epub 2011 Feb 24.

6.

MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer.

Png KJ, Yoshida M, Zhang XH, Shu W, Lee H, Rimner A, Chan TA, Comen E, Andrade VP, Kim SW, King TA, Hudis CA, Norton L, Hicks J, Massagué J, Tavazoie SF.

Genes Dev. 2011 Feb 1;25(3):226-31. doi: 10.1101/gad.1974211.

7.

Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells.

de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin O, Mayer D, Lyko F, Hoheisel JD, Riazalhosseini Y.

Cancer Res. 2010 Nov 15;70(22):9175-84. doi: 10.1158/0008-5472.CAN-10-1318. Epub 2010 Oct 26.

8.

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.

Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, Takamaru H, Niinuma T, Maruyama R, Yamamoto H, Tokino T, Imai K, Toyota M, Shinomura Y.

Carcinogenesis. 2010 Dec;31(12):2066-73. doi: 10.1093/carcin/bgq203. Epub 2010 Oct 5.

PMID:
20924086
9.

Mammalian microRNAs predominantly act to decrease target mRNA levels.

Guo H, Ingolia NT, Weissman JS, Bartel DP.

Nature. 2010 Aug 12;466(7308):835-40. doi: 10.1038/nature09267.

10.

Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.

Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR, Goel A.

Cancer Res. 2010 Aug 15;70(16):6609-18. doi: 10.1158/0008-5472.CAN-10-0622. Epub 2010 Aug 3.

11.

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.

Hawkins RD, Hon GC, Lee LK, Ngo Q, Lister R, Pelizzola M, Edsall LE, Kuan S, Luu Y, Klugman S, Antosiewicz-Bourget J, Ye Z, Espinoza C, Agarwahl S, Shen L, Ruotti V, Wang W, Stewart R, Thomson JA, Ecker JR, Ren B.

Cell Stem Cell. 2010 May 7;6(5):479-91. doi: 10.1016/j.stem.2010.03.018.

12.

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, Savage DA, Mueller-Holzner E, Marth C, Kocjan G, Gayther SA, Jones A, Beck S, Wagner W, Laird PW, Jacobs IJ, Widschwendter M.

Genome Res. 2010 Apr;20(4):440-6. doi: 10.1101/gr.103606.109. Epub 2010 Mar 10.

13.

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW.

PLoS One. 2010 Jan 13;5(1):e8697. doi: 10.1371/journal.pone.0008697.

14.

Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.

Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek AJ, Stampfer MR.

Cancer Res. 2009 Oct 1;69(19):7557-68. doi: 10.1158/0008-5472.CAN-09-0270. Epub 2009 Sep 22.

15.

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Novak P, Jensen TJ, Garbe JC, Stampfer MR, Futscher BW.

Cancer Res. 2009 Jun 15;69(12):5251-8. doi: 10.1158/0008-5472.CAN-08-4977. Epub 2009 Jun 9.

16.

Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression.

Peter ME.

Cell Cycle. 2009 Mar 15;8(6):843-52. Epub 2009 Mar 22. Review.

17.

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.

Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP.

Nat Genet. 2009 Feb;41(2):178-86. doi: 10.1038/ng.298. Epub 2009 Jan 18.

18.

Methylation of polycomb target genes in intestinal cancer is mediated by inflammation.

Hahn MA, Hahn T, Lee DH, Esworthy RS, Kim BW, Riggs AD, Chu FF, Pfeifer GP.

Cancer Res. 2008 Dec 15;68(24):10280-9. doi: 10.1158/0008-5472.CAN-08-1957.

19.

Most mammalian mRNAs are conserved targets of microRNAs.

Friedman RC, Farh KK, Burge CB, Bartel DP.

Genome Res. 2009 Jan;19(1):92-105. doi: 10.1101/gr.082701.108. Epub 2008 Oct 27.

20.

Agglomerative epigenetic aberrations are a common event in human breast cancer.

Novak P, Jensen T, Oshiro MM, Watts GS, Kim CJ, Futscher BW.

Cancer Res. 2008 Oct 15;68(20):8616-25. doi: 10.1158/0008-5472.CAN-08-1419.

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