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An approach based on ultra-high pressure liquid chromatography-tandem mass spectrometry to quantify O6-methyl and O6-carboxymethylguanine DNA adducts in intestinal cell lines.

Vanden Bussche J, Moore SA, Pasmans F, Kuhnle GG, Vanhaecke L.

J Chromatogr A. 2012 Sep 28;1257:25-33. doi: 10.1016/j.chroma.2012.07.040. Epub 2012 Jul 20.


Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP.

Mol Cell. 2012 Jul 13;47(1):50-60. doi: 10.1016/j.molcel.2012.04.028. Epub 2012 May 31.


Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine.

Millington CL, Watson AJ, Marriott AS, Margison GP, Povey AC, Williams DM.

Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):328-38. doi: 10.1080/15257770.2012.656784.


Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries.

Dahm CC, Keogh RH, Spencer EA, Greenwood DC, Key TJ, Fentiman IS, Shipley MJ, Brunner EJ, Cade JE, Burley VJ, Mishra G, Stephen AM, Kuh D, White IR, Luben R, Lentjes MA, Khaw KT, Rodwell Bingham SA.

J Natl Cancer Inst. 2010 May 5;102(9):614-26. doi: 10.1093/jnci/djq092. Epub 2010 Apr 20. Erratum in: J Natl Cancer Inst. 2011 Oct 5;103(19):1484.


A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.

Cross AJ, Ferrucci LM, Risch A, Graubard BI, Ward MH, Park Y, Hollenbeck AR, Schatzkin A, Sinha R.

Cancer Res. 2010 Mar 15;70(6):2406-14. doi: 10.1158/0008-5472.CAN-09-3929. Epub 2010 Mar 9.


MGMT Ile143Val polymorphism, dietary factors and the risk of breast, colorectal and prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study.

Loh YH, Mitrou PN, Bowman R, Wood A, Jeffery H, Luben RN, Lentjes MA, Khaw KT, Rodwell SA.

DNA Repair (Amst). 2010 Apr 4;9(4):421-8. doi: 10.1016/j.dnarep.2010.01.002. Epub 2010 Jan 21.


Diet, fecal water, and colon cancer--development of a biomarker.

Pearson JR, Gill CI, Rowland IR.

Nutr Rev. 2009 Sep;67(9):509-26. doi: 10.1111/j.1753-4887.2009.00224.x. Review.


Flipping of alkylated DNA damage bridges base and nucleotide excision repair.

Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, Kroeger MD, Peterson LA, Williams DM, Fried MG, Margison GP, Pegg AE, Tainer JA.

Nature. 2009 Jun 11;459(7248):808-13. doi: 10.1038/nature08076.


Effect of processed and red meat on endogenous nitrosation and DNA damage.

Joosen AM, Kuhnle GG, Aspinall SM, Barrow TM, Lecommandeur E, Azqueta A, Collins AR, Bingham SA.

Carcinogenesis. 2009 Aug;30(8):1402-7. doi: 10.1093/carcin/bgp130. Epub 2009 Jun 4.


QCAL--a novel standard for assessing instrument conditions for proteome analysis.

Eyers CE, Simpson DM, Wong SC, Beynon RJ, Gaskell SJ.

J Am Soc Mass Spectrom. 2008 Sep;19(9):1275-80. doi: 10.1016/j.jasms.2008.05.019. Epub 2008 Jul 2.


Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence.

Santarelli RL, Pierre F, Corpet DE.

Nutr Cancer. 2008;60(2):131-44. doi: 10.1080/01635580701684872. Review.


Pathophysiology, clinical presentation, and management of colon cancer.

Cappell MS.

Gastroenterol Clin North Am. 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. Review.


Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N.

Int J Cancer. 2008 Jun 1;122(11):2429-36. doi: 10.1002/ijc.23398.


Molecular classification and correlates in colorectal cancer.

Ogino S, Goel A.

J Mol Diagn. 2008 Jan;10(1):13-27. doi: 10.2353/jmoldx.2008.070082. Epub 2007 Dec 28. Review.


MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

Kaina B, Christmann M, Naumann S, Roos WP.

DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. Review.


O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States).

Tranah GJ, Bugni J, Giovannucci E, Ma J, Fuchs C, Hines L, Samson L, Hunter DJ.

Cancer Causes Control. 2006 Jun;17(5):721-31.


Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).

Shibata T, Glynn N, McMurry TB, McElhinney RS, Margison GP, Williams DM.

Nucleic Acids Res. 2006 Apr 11;34(6):1884-91. Print 2006.


Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk.

Lewin MH, Bailey N, Bandaletova T, Bowman R, Cross AJ, Pollock J, Shuker DE, Bingham SA.

Cancer Res. 2006 Feb 1;66(3):1859-65.


Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli.

Pearson SJ, Ferguson J, Santibanez-Koref M, Margison GP.

Nucleic Acids Res. 2005 Jul 13;33(12):3837-44. Print 2005.


Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

Drabløs F, Feyzi E, Aas PA, Vaagbø CB, Kavli B, Bratlie MS, Peña-Diaz J, Otterlei M, Slupphaug G, Krokan HE.

DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. Review.


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