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Items: 1 to 20 of 36

1.

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.

Kumar A, Lawrence JC Jr, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE.

Diabetes. 2010 Jun;59(6):1397-406. doi: 10.2337/db09-1061.

2.

Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.

Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1226-35. doi: 10.1152/ajpendo.00033.2010.

3.

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.

Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O, Chervonsky AV, Rudich A, Schoenle EJ, Donath MY, Konrad D.

J Clin Invest. 2010 Jan;120(1):191-202. doi: 10.1172/JCI38388.

4.

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. doi: 10.2337/db08-1571.

5.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI.

Cell Metab. 2009 Mar;9(3):252-64. doi: 10.1016/j.cmet.2009.01.011.

6.

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.

Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM.

FASEB J. 2009 Feb;23(2):586-604. doi: 10.1096/fj.08-119420.

7.

Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

Chen Z, Gropler MC, Norris J, Lawrence JC Jr, Harris TE, Finck BN.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1738-44. doi: 10.1161/ATVBAHA.108.171538.

8.

Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP.

Genes Dev. 2008 Jul 15;22(14):1948-61. doi: 10.1101/gad.1661708.

9.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008.

10.

PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.

Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5223-8.

11.

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.

Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB.

Cell Metab. 2006 Dec;4(6):453-64.

12.

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.

13.

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP.

Cell Metab. 2006 Sep;4(3):199-210.

14.
15.

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Finck BN, Kelly DP.

J Clin Invest. 2006 Mar;116(3):615-22. Review.

16.

Metabolic control through the PGC-1 family of transcription coactivators.

Lin J, Handschin C, Spiegelman BM.

Cell Metab. 2005 Jun;1(6):361-70. Review.

17.

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101.

18.

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM.

Cell. 2005 Jan 28;120(2):261-73.

19.

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.

Cell. 2004 Oct 1;119(1):121-35.

20.

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.

He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7.

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