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Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.

Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, Steegborn C.

PLoS One. 2012;7(9):e45098. doi: 10.1371/journal.pone.0045098. Epub 2012 Sep 19.


The sirtuin SIRT6 regulates lifespan in male mice.

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY.

Nature. 2012 Feb 22;483(7388):218-21. doi: 10.1038/nature10815.


Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.

Moniot S, Weyand M, Steegborn C.

Front Pharmacol. 2012 Feb 9;3:16. doi: 10.3389/fphar.2012.00016. eCollection 2012.


Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH.

Cell. 2012 Feb 3;148(3):421-33. doi: 10.1016/j.cell.2012.01.017.


Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H.

Science. 2011 Nov 11;334(6057):806-9. doi: 10.1126/science.1207861.


Structure-based development of novel sirtuin inhibitors.

Schlicker C, Boanca G, Lakshminarasimhan M, Steegborn C.

Aging (Albany NY). 2011 Sep;3(9):852-72.


SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.


SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E.

Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778.


SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.


Sirtuins inhibitors: the approach to affinity and selectivity.

Cen Y.

Biochim Biophys Acta. 2010 Aug;1804(8):1635-44. doi: 10.1016/j.bbapap.2009.11.010. Epub 2009 Nov 18. Review.


Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.

Gertz M, Steegborn C.

Biochim Biophys Acta. 2010 Aug;1804(8):1658-65. doi: 10.1016/j.bbapap.2009.09.011. Epub 2009 Sep 18. Review.


Structural basis for sirtuin function: what we know and what we don't.

Sanders BD, Jackson B, Marmorstein R.

Biochim Biophys Acta. 2010 Aug;1804(8):1604-16. doi: 10.1016/j.bbapap.2009.09.009. Epub 2009 Sep 18. Review.


Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB.

J Biol Chem. 2009 Sep 4;284(36):24394-405. doi: 10.1074/jbc.M109.014928. Epub 2009 Jun 16.


SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Nakagawa T, Lomb DJ, Haigis MC, Guarente L.

Cell. 2009 May 1;137(3):560-70. doi: 10.1016/j.cell.2009.02.026.


Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol.

Dudley JI, Lekli I, Mukherjee S, Das M, Bertelli AA, Das DK.

J Agric Food Chem. 2008 Oct 22;56(20):9362-73. doi: 10.1021/jf801791d. Epub 2008 Sep 27. Retraction in: J Agric Food Chem. 2012 Mar 14;60(10):2767.


A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.

Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52. doi: 10.1073/pnas.0803790105. Epub 2008 Sep 15.


Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.

Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.

J Mol Biol. 2008 Oct 10;382(3):790-801. doi: 10.1016/j.jmb.2008.07.048. Epub 2008 Jul 25.


A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.

PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081.


Resveratrol: one molecule, many targets.

Pirola L, Fröjdö S.

IUBMB Life. 2008 May;60(5):323-32. doi: 10.1002/iub.47. Review.


Inhibitors of NAD+ dependent histone deacetylases (sirtuins).

Neugebauer RC, Sippl W, Jung M.

Curr Pharm Des. 2008;14(6):562-73. Review.


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