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Items: 1 to 20 of 78

1.

A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse.

Porensky PN, Mitrpant C, McGovern VL, Bevan AK, Foust KD, Kaspar BK, Wilton SD, Burghes AH.

Hum Mol Genet. 2012 Apr 1;21(7):1625-38. doi: 10.1093/hmg/ddr600. Epub 2011 Dec 20.

2.

TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.

Montes M, Cloutier A, Sánchez-Hernández N, Michelle L, Lemieux B, Blanchette M, Hernández-Munain C, Chabot B, Suñé C.

Mol Cell Biol. 2012 Feb;32(4):751-62. doi: 10.1128/MCB.06255-11. Epub 2011 Dec 12.

3.

A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.

Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I.

Cell. 2011 Oct 14;147(2):358-69. doi: 10.1016/j.cell.2011.09.028. Erratum in: Cell. 2011 Nov 11;147(4):947.

4.

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.

Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR.

Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485.

5.

Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions.

Takaku M, Tsujita T, Horikoshi N, Takizawa Y, Qing Y, Hirota K, Ikura M, Ikura T, Takeda S, Kurumizaka H.

Biochemistry. 2011 Aug 16;50(32):6797-805. doi: 10.1021/bi200828g. Epub 2011 Jul 25.

PMID:
21732698
6.

The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers.

Dutertre M, Sanchez G, Barbier J, Corcos L, Auboeuf D.

RNA Biol. 2011 Sep-Oct;8(5):740-7. doi: 10.4161/rna.8.5.16016. Epub 2011 Jun 29. Review.

PMID:
21712650
7.

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.

Singh NN, Singh RN.

RNA Biol. 2011 Jul-Aug;8(4):600-6. doi: 10.4161/rna.8.4.16224. Epub 2011 Jul 1.

8.

The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.

Fallini C, Zhang H, Su Y, Silani V, Singer RH, Rossoll W, Bassell GJ.

J Neurosci. 2011 Mar 9;31(10):3914-25. doi: 10.1523/JNEUROSCI.3631-10.2011.

9.

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy.

Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH.

Sci Transl Med. 2011 Mar 2;3(72):72ra18. doi: 10.1126/scitranslmed.3001777.

10.

Isoform-level microRNA-155 target prediction using RNA-seq.

Deng N, Puetter A, Zhang K, Johnson K, Zhao Z, Taylor C, Flemington EK, Zhu D.

Nucleic Acids Res. 2011 May;39(9):e61. doi: 10.1093/nar/gkr042. Epub 2011 Feb 11.

11.

The COPI vesicle complex binds and moves with survival motor neuron within axons.

Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ.

Hum Mol Genet. 2011 May 1;20(9):1701-11. doi: 10.1093/hmg/ddr046. Epub 2011 Feb 7.

12.

SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress.

Zou T, Yang X, Pan D, Huang J, Sahin M, Zhou J.

Cell Mol Neurobiol. 2011 May;31(4):541-50. doi: 10.1007/s10571-011-9647-8. Epub 2011 Jan 15.

PMID:
21234798
13.

Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA.

Zhang Z, Kelemen O, van Santen MA, Yelton SM, Wendlandt AE, Sviripa VM, Bollen M, Beullens M, Urlaub H, Lührmann R, Watt DS, Stamm S.

J Biol Chem. 2011 Mar 25;286(12):10126-36. doi: 10.1074/jbc.M110.183970. Epub 2011 Jan 10.

14.

Epigenetics in alternative pre-mRNA splicing.

Luco RF, Allo M, Schor IE, Kornblihtt AR, Misteli T.

Cell. 2011 Jan 7;144(1):16-26. doi: 10.1016/j.cell.2010.11.056. Review.

15.

Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain.

Fuentes JL, Strayer MS, Matera AG.

PLoS One. 2010 Dec 30;5(12):e15769. doi: 10.1371/journal.pone.0015769.

16.

TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.

Singh NN, Seo J, Ottesen EW, Shishimorova M, Bhattacharya D, Singh RN.

Mol Cell Biol. 2011 Mar;31(5):935-54. doi: 10.1128/MCB.00945-10. Epub 2010 Dec 28.

17.

Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.

Lenzken SC, Romeo V, Zolezzi F, Cordero F, Lamorte G, Bonanno D, Biancolini D, Cozzolino M, Pesaresi MG, Maracchioni A, Sanges R, Achsel T, Carrì MT, Calogero RA, Barabino SM.

Hum Mutat. 2011 Feb;32(2):168-82. doi: 10.1002/humu.21394. Epub 2011 Jan 25.

PMID:
21120952
18.

Global analysis of nascent RNA reveals transcriptional pausing in terminal exons.

Carrillo Oesterreich F, Preibisch S, Neugebauer KM.

Mol Cell. 2010 Nov 24;40(4):571-81. doi: 10.1016/j.molcel.2010.11.004.

19.

Therapeutics that directly increase SMN expression to treat spinal muscular atrophy.

Shababi M, Mattis VB, Lorson CL.

Drug News Perspect. 2010 Oct;23(8):475-82. doi: 10.1358/dnp.2010.23.8.1507295. Review.

PMID:
21031163
20.

Cotranscriptional exon skipping in the genotoxic stress response.

Dutertre M, Sanchez G, De Cian MC, Barbier J, Dardenne E, Gratadou L, Dujardin G, Le Jossic-Corcos C, Corcos L, Auboeuf D.

Nat Struct Mol Biol. 2010 Nov;17(11):1358-66. doi: 10.1038/nsmb.1912. Epub 2010 Oct 24.

PMID:
20972445

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