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Items: 1 to 20 of 33


Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.

Exner N, Lutz AK, Haass C, Winklhofer KF.

EMBO J. 2012 Jun 26;31(14):3038-62. doi: 10.1038/emboj.2012.170. Review.


Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Desler C, Hansen TL, Frederiksen JB, Marcker ML, Singh KK, Juel Rasmussen L.

J Aging Res. 2012;2012:192503. doi: 10.1155/2012/192503. Epub 2012 Jun 5.


Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.

Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA.

Nat Protoc. 2012 May 10;7(6):1068-85. doi: 10.1038/nprot.2012.048.


Alzheimer mechanisms and therapeutic strategies.

Huang Y, Mucke L.

Cell. 2012 Mar 16;148(6):1204-22. doi: 10.1016/j.cell.2012.02.040. Review.


Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.

van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL.

Immunity. 2012 Jan 27;36(1):68-78. doi: 10.1016/j.immuni.2011.12.007. Epub 2011 Dec 28.


Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease.

Johri A, Calingasan NY, Hennessey TM, Sharma A, Yang L, Wille E, Chandra A, Beal MF.

Hum Mol Genet. 2012 Mar 1;21(5):1124-37. doi: 10.1093/hmg/ddr541. Epub 2011 Nov 17.


Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.

Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF.

J Alzheimers Dis. 2011;27(1):211-23. doi: 10.3233/JAD-2011-110209.


Hugging tight in Huntington's.

Johri A, Chaturvedi RK, Beal MF.

Nat Med. 2011 Mar;17(3):245-6. doi: 10.1038/nm0311-245. No abstract available. Erratum in: Nat Med. 2011 Apr;17(4):514.


Mitochondrial stress signals revise an old aging theory.

Woo DK, Shadel GS.

Cell. 2011 Jan 7;144(1):11-2. doi: 10.1016/j.cell.2010.12.023.


Alzheimer's disease: clinical trials and drug development.

Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M.

Lancet Neurol. 2010 Jul;9(7):702-16. doi: 10.1016/S1474-4422(10)70119-8. Review. Erratum in: Lancet Neurol. 2011 Jun;10(6):501.


Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.

Dranka BP, Hill BG, Darley-Usmar VM.

Free Radic Biol Med. 2010 Apr 1;48(7):905-14. doi: 10.1016/j.freeradbiomed.2010.01.015. Epub 2010 Jan 20.


Clinical aspects of coenzyme Q10: an update.

Littarru GP, Tiano L.

Nutrition. 2010 Mar;26(3):250-4. doi: 10.1016/j.nut.2009.08.008. Epub 2009 Nov 22. Review.


Prolonged intake of coenzyme Q10 impairs cognitive functions in mice.

Sumien N, Heinrich KR, Shetty RA, Sohal RS, Forster MJ.

J Nutr. 2009 Oct;139(10):1926-32. doi: 10.3945/jn.109.110437. Epub 2009 Aug 26.


Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure.

Choi SW, Gerencser AA, Nicholls DG.

J Neurochem. 2009 May;109(4):1179-91. doi: 10.1111/j.1471-4159.2009.06055.x. Epub 2009 Mar 23.


Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.

Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW.

Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z.


Neuroprotection for Huntington's disease: ready, set, slow.

Hersch SM, Rosas HD.

Neurotherapeutics. 2008 Apr;5(2):226-36. doi: 10.1016/j.nurt.2008.01.003. Review.


Targeting mitochondria.

Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE.

Acc Chem Res. 2008 Jan;41(1):87-97. doi: 10.1021/ar700135m. Review. Erratum in: Acc Chem Res. 2012 Dec 18;45(12):2222.


Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants.

Fink MP, Macias CA, Xiao J, Tyurina YY, Jiang J, Belikova N, Delude RL, Greenberger JS, Kagan VE, Wipf P.

Biochem Pharmacol. 2007 Sep 15;74(6):801-9. Epub 2007 May 29. Review.


Coenzyme Q, oxidative stress and aging.

Sohal RS, Forster MJ.

Mitochondrion. 2007 Jun;7 Suppl:S103-11. Epub 2007 Mar 30. Review.

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