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Items: 1 to 20 of 52


The Renaissance or the cuckoo clock.

Pines J, Hagan I.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3625-34. doi: 10.1098/rstb.2011.0080. Review.


NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells.

Lin JJ, Milhollen MA, Smith PG, Narayanan U, Dutta A.

Cancer Res. 2010 Dec 15;70(24):10310-20. doi: 10.1158/0008-5472.CAN-10-2062.


The roles of cyclin A2, B1, and B2 in early and late mitotic events.

Gong D, Ferrell JE Jr.

Mol Biol Cell. 2010 Sep 15;21(18):3149-61. doi: 10.1091/mbc.E10-05-0393. Epub 2010 Jul 21.


Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division.

Riley BB, Sweet EM, Heck R, Evans A, McFarland KN, Warga RM, Kane DA.

Dev Dyn. 2010 Mar;239(3):828-43. doi: 10.1002/dvdy.22227.


Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.

Mol Cell Biol. 2009 Nov;29(21):5911-22. doi: 10.1128/MCB.00558-09. Epub 2009 Aug 24.


Simple and efficient transgenesis with meganuclease constructs in zebrafish.

Soroldoni D, Hogan BM, Oates AC.

Methods Mol Biol. 2009;546:117-30. doi: 10.1007/978-1-60327-977-2_8.


Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

García-Higuera I, Manchado E, Dubus P, Cañamero M, Méndez J, Moreno S, Malumbres M.

Nat Cell Biol. 2008 Jul;10(7):802-11. doi: 10.1038/ncb1742. Epub 2008 Jun 15.


To cell cycle, swing the APC/C.

van Leuken R, Clijsters L, Wolthuis R.

Biochim Biophys Acta. 2008 Sep;1786(1):49-59. doi: 10.1016/j.bbcan.2008.05.002. Epub 2008 May 21. Review.


Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.

Cell. 2008 May 30;133(5):864-77. doi: 10.1016/j.cell.2008.03.037.


Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function.

Zhang L, Kendrick C, Jülich D, Holley SA.

Development. 2008 Jun;135(12):2065-70. doi: 10.1242/dev.022673. Epub 2008 May 14.


The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.

Liu E, Lee AY, Chiba T, Olson E, Sun P, Wu X.

J Cell Biol. 2007 Nov 19;179(4):643-57.


Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

Verschuren EW, Ban KH, Masek MA, Lehman NL, Jackson PK.

Mol Cell Biol. 2007 Nov;27(22):7955-65. Epub 2007 Sep 17.


Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.

Li M, York JP, Zhang P.

Mol Cell Biol. 2007 May;27(9):3481-8. Epub 2007 Feb 26.


APC/C--the master controller of origin licensing?

Sivaprasad U, Machida YJ, Dutta A.

Cell Div. 2007 Feb 23;2:8.


Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.

Hartwell LH, Mortimer RK, Culotti J, Culotti M.

Genetics. 1973 Jun;74(2):267-86.


The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

Machida YJ, Dutta A.

Genes Dev. 2007 Jan 15;21(2):184-94.


DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.

Genes Dev. 2006 Nov 15;20(22):3117-29. Epub 2006 Nov 3.


Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.

Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18.


Mouse emi1 has an essential function in mitotic progression during early embryogenesis.

Lee H, Lee DJ, Oh SP, Park HD, Nam HH, Kim JM, Lim DS.

Mol Cell Biol. 2006 Jul;26(14):5373-81.

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