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Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.

Gökbuget N, Kneba M, Raff T, Trautmann H, Bartram CR, Arnold R, Fietkau R, Freund M, Ganser A, Ludwig WD, Maschmeyer G, Rieder H, Schwartz S, Serve H, Thiel E, Brüggemann M, Hoelzer D; German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia..

Blood. 2012 Aug 30;120(9):1868-76. Epub 2012 Mar 22.


Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.

Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO.

PLoS One. 2012;7(2):e30733. doi: 10.1371/journal.pone.0030733. Epub 2012 Feb 1.


High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment.

Logan AC, Gao H, Wang C, Sahaf B, Jones CD, Marshall EL, Buño I, Armstrong R, Fire AZ, Weinberg KI, Mindrinos M, Zehnder JL, Boyd SD, Xiao W, Davis RW, Miklos DB.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21194-9. doi: 10.1073/pnas.1118357109. Epub 2011 Dec 12.


IMGT/junctionanalysis: IMGT standardized analysis of the V-J and V-D-J junctions of the rearranged immunoglobulins (IG) and T cell receptors (TR).

Giudicelli V, Lefranc MP.

Cold Spring Harb Protoc. 2011 Jun 1;2011(6):716-25. doi: 10.1101/pdb.prot5634. No abstract available.


IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients.

He J, Wu J, Jiao Y, Wagner-Johnston N, Ambinder RF, Diaz LA Jr, Kinzler KW, Vogelstein B, Papadopoulos N.

Oncotarget. 2011 Mar;2(3):178-85.


Biology, risk stratification, and therapy of pediatric acute leukemias: an update.

Pui CH, Carroll WL, Meshinchi S, Arceci RJ.

J Clin Oncol. 2011 Feb 10;29(5):551-65. doi: 10.1200/JCO.2010.30.7405. Epub 2011 Jan 10. Review. Erratum in: J Clin Oncol. 2011 Dec 20;29(36):4847.


Antigen receptor allelic exclusion: an update and reappraisal.

Brady BL, Steinel NC, Bassing CH.

J Immunol. 2010 Oct 1;185(7):3801-8. doi: 10.4049/jimmunol.1001158. Review.


Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements.

Boyd SD, Gaëta BA, Jackson KJ, Fire AZ, Marshall EL, Merker JD, Maniar JM, Zhang LN, Sahaf B, Jones CD, Simen BB, Hanczaruk B, Nguyen KD, Nadeau KC, Egholm M, Miklos DB, Zehnder JL, Collins AM.

J Immunol. 2010 Jun 15;184(12):6986-92. doi: 10.4049/jimmunol.1000445. Epub 2010 May 21.


Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90.

Tallen G, Ratei R, Mann G, Kaspers G, Niggli F, Karachunsky A, Ebell W, Escherich G, Schrappe M, Klingebiel T, Fengler R, Henze G, von Stackelberg A.

J Clin Oncol. 2010 May 10;28(14):2339-47. doi: 10.1200/JCO.2009.25.1983. Epub 2010 Apr 12.


Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing.

Boyd SD, Marshall EL, Merker JD, Maniar JM, Zhang LN, Sahaf B, Jones CD, Simen BB, Hanczaruk B, Nguyen KD, Nadeau KC, Egholm M, Miklos DB, Zehnder JL, Fire AZ.

Sci Transl Med. 2009 Dec 23;1(12):12ra23.


Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia.

Seegmiller AC, Kroft SH, Karandikar NJ, McKenna RW.

Am J Clin Pathol. 2009 Dec;132(6):940-9. doi: 10.1309/AJCP8G5RMTWUEMUU.


Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia.

Brisco MJ, Latham S, Sutton R, Hughes E, Wilczek V, van Zanten K, Budgen B, Bahar AY, Malec M, Sykes PJ, Kuss BJ, Waters K, Venn NC, Giles JE, Haber M, Norris MD, Marshall GM, Morley AA.

J Mol Diagn. 2009 May;11(3):194-200. doi: 10.2353/jmoldx.2009.080047. Epub 2009 Mar 26.


Mechanism of relapse in pediatric acute lymphoblastic leukemia.

Henderson MJ, Choi S, Beesley AH, Sutton R, Venn NC, Marshall GM, Kees UR, Haber M, Norris MD.

Cell Cycle. 2008 May 15;7(10):1315-20. Epub 2008 Feb 29.


Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone.

Choi S, Henderson MJ, Kwan E, Beesley AH, Sutton R, Bahar AY, Giles J, Venn NC, Pozza LD, Baker DL, Marshall GM, Kees UR, Haber M, Norris MD.

Blood. 2007 Jul 15;110(2):632-9. Epub 2007 Mar 19.


Antibody repertoires generated by VH replacement and direct VH to JH joining.

Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K.

Immunity. 2006 Jul;25(1):43-53.


IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukaemia.

Bagnara D, Callea V, Stelitano C, Morabito F, Fabris S, Neri A, Zanardi S, Ghiotto F, Ciccone E, Grossi CE, Fais F.

Br J Haematol. 2006 Apr;133(1):50-8.


Acute lymphoblastic leukemia.

Pui CH, Relling MV, Downing JR.

N Engl J Med. 2004 Apr 8;350(15):1535-48. Review. No abstract available.


The molecular basis and biological significance of VH replacement.

Zhang Z, Burrows PD, Cooper MD.

Immunol Rev. 2004 Feb;197:231-42. Review.


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