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Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine.

Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1557-65. doi: 10.1152/ajpcell.00407.2011. Epub 2012 Mar 21.


The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.


Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.

Wang H, Zhang Q, Wen Q, Zheng Y, Lazarovici P, Jiang H, Lin J, Zheng W.

Cell Signal. 2012 Jan;24(1):17-24. doi: 10.1016/j.cellsig.2011.08.010. Epub 2011 Aug 31. Review. Erratum in: Cell Signal. 2012 Nov;24(11):2226. Philip, Lazarovici [corrected to Lazarovici, Philip].


The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin.

Chen S, Synowsky S, Tinti M, MacKintosh C.

Trends Endocrinol Metab. 2011 Nov;22(11):429-36. doi: 10.1016/j.tem.2011.07.005. Epub 2011 Aug 24. Review.


Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.

Hong-Brown LQ, Brown CR, Navaratnarajah M, Huber DS, Lang CH.

Alcohol Clin Exp Res. 2011 Aug;35(8):1445-53. doi: 10.1111/j.1530-0277.2011.01480.x. Epub 2011 Mar 25.


Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

Dennis MD, Baum JI, Kimball SR, Jefferson LS.

J Biol Chem. 2011 Mar 11;286(10):8287-96. doi: 10.1074/jbc.M110.209171. Epub 2011 Jan 14.


mTORC1 signaling: what we still don't know.

Wang X, Proud CG.

J Mol Cell Biol. 2011 Aug;3(4):206-20. doi: 10.1093/jmcb/mjq038. Epub 2010 Dec 7. Review.


Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.

Sengupta S, Peterson TR, Sabatini DM.

Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026. Review.


Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism.

Johnson MD, O'Connell M, Pilcher W.

J Neurooncol. 2011 Feb;101(3):441-8. doi: 10.1007/s11060-010-0281-y. Epub 2010 Jul 2.


Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice.

Guo R, Scott GI, Ren J.

PLoS One. 2010 Jun 23;5(6):e11268. doi: 10.1371/journal.pone.0011268.


Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D.

Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25.


Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.

Winter JN, Fox TE, Kester M, Jefferson LS, Kimball SR.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C335-44. doi: 10.1152/ajpcell.00039.2010. Epub 2010 Apr 28.


Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.

Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1283-94. doi: 10.1152/ajpendo.00676.2009. Epub 2010 Apr 13.


Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.


Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases.

Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J.

J Mol Cell Cardiol. 2010 Aug;49(2):322-9. doi: 10.1016/j.yjmcc.2010.03.017. Epub 2010 Apr 1.


Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.

Kumar A, Lawrence JC Jr, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE.

Diabetes. 2010 Jun;59(6):1397-406. doi: 10.2337/db09-1061. Epub 2010 Mar 23.


Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.

Liangpunsakul S, Sozio MS, Shin E, Zhao Z, Xu Y, Ross RA, Zeng Y, Crabb DW.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G1004-12. doi: 10.1152/ajpgi.00482.2009. Epub 2010 Mar 11.


Skeletal muscle loss: cachexia, sarcopenia, and inactivity.

Evans WJ.

Am J Clin Nutr. 2010 Apr;91(4):1123S-1127S. doi: 10.3945/ajcn.2010.28608A. Epub 2010 Feb 17.


Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.

Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH.

J Cell Biochem. 2010 Apr 15;109(6):1172-84. doi: 10.1002/jcb.22496.


Mechanisms of amino acid sensing in mTOR signaling pathway.

Kim E.

Nutr Res Pract. 2009 Spring;3(1):64-71. doi: 10.4162/nrp.2009.3.1.64. Epub 2009 Mar 31.

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