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Items: 1 to 20 of 50

1.

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK.

Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936.

2.

Disruption of a ciliary B9 protein complex causes Meckel syndrome.

Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attié-Bitach T, Johnson CA, García-Verdugo JM, Katsanis N, Bergmann C, Reiter JF.

Am J Hum Genet. 2011 Jul 15;89(1):94-110. doi: 10.1016/j.ajhg.2011.06.003. Erratum in: Am J Hum Genet. 2011 Oct 7;89(4):589. Zaghloul, Norran A [corrected to Zaghloul, Norann A].

3.

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF.

Nat Genet. 2011 Jul 3;43(8):776-84. doi: 10.1038/ng.891.

4.

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.

Tukachinsky H, Lopez LV, Salic A.

J Cell Biol. 2010 Oct 18;191(2):415-28. doi: 10.1083/jcb.201004108.

5.

Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.

Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK.

J Med Chem. 2010 Jul 8;53(13):4891-905. doi: 10.1021/jm100488w.

6.

The primary cilium: a signalling centre during vertebrate development.

Goetz SC, Anderson KV.

Nat Rev Genet. 2010 May;11(5):331-44. doi: 10.1038/nrg2774. Review.

7.

Functional genomic screen for modulators of ciliogenesis and cilium length.

Kim J, Lee JE, Heynen-Genel S, Suyama E, Ono K, Lee K, Ideker T, Aza-Blanc P, Gleeson JG.

Nature. 2010 Apr 15;464(7291):1048-51. doi: 10.1038/nature08895.

8.

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics.

Peukert S, Miller-Moslin K.

ChemMedChem. 2010 Apr 6;5(4):500-12. doi: 10.1002/cmdc.201000011. Review.

PMID:
20229564
9.

Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

DeGraw AJ, Keiser MJ, Ochocki JD, Shoichet BK, Distefano MD.

J Med Chem. 2010 Mar 25;53(6):2464-71. doi: 10.1021/jm901613f.

10.
11.

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium.

Milenkovic L, Scott MP, Rohatgi R.

J Cell Biol. 2009 Nov 2;187(3):365-74. doi: 10.1083/jcb.200907126. Epub 2009 Oct 26.

12.

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ.

J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a.

13.

GSK3: a multifaceted kinase in Wnt signaling.

Wu D, Pan W.

Trends Biochem Sci. 2010 Mar;35(3):161-8. doi: 10.1016/j.tibs.2009.10.002. Epub 2009 Oct 31. Review.

14.

Predicting new molecular targets for known drugs.

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL.

Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1.

15.

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.

Peng LF, Stanton BZ, Maloof N, Wang X, Schreiber SL.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6319-25. doi: 10.1016/j.bmcl.2009.09.089. Epub 2009 Sep 25.

16.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.

Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2.

17.

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.

Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA.

N Engl J Med. 2009 Sep 17;361(12):1173-8. doi: 10.1056/NEJMoa0902903. Epub 2009 Sep 2.

18.

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, Dlugosz AA, Reiter JF.

Nat Med. 2009 Sep;15(9):1055-61. doi: 10.1038/nm.2011. Epub 2009 Aug 23.

19.

Dual and opposing roles of primary cilia in medulloblastoma development.

Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A.

Nat Med. 2009 Sep;15(9):1062-5. doi: 10.1038/nm.2020. Epub 2009 Aug 23.

20.

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi: 10.1073/pnas.0907134106. Epub 2009 Aug 5.

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