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Items: 1 to 20 of 53

1.

Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma.

Ning BF, Ding J, Yin C, Zhong W, Wu K, Zeng X, Yang W, Chen YX, Zhang JP, Zhang X, Wang HY, Xie WF.

Cancer Res. 2010 Oct 1;70(19):7640-51. doi: 10.1158/0008-5472.CAN-10-0824. Epub 2010 Sep 28.

2.

What are nuclear receptor ligands?

Sladek FM.

Mol Cell Endocrinol. 2011 Mar 1;334(1-2):3-13. doi: 10.1016/j.mce.2010.06.018. Epub 2010 Jul 6. Review.

3.

Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation.

Stender JD, Kim K, Charn TH, Komm B, Chang KC, Kraus WL, Benner C, Glass CK, Katzenellenbogen BS.

Mol Cell Biol. 2010 Aug;30(16):3943-55. doi: 10.1128/MCB.00118-10. Epub 2010 Jun 14.

4.

Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.

Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F.

J Biomol Screen. 2010 Jul;15(6):663-70. doi: 10.1177/1087057110372257. Epub 2010 Jun 14.

5.

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays.

Bolotin E, Liao H, Ta TC, Yang C, Hwang-Verslues W, Evans JR, Jiang T, Sladek FM.

Hepatology. 2010 Feb;51(2):642-53. doi: 10.1002/hep.23357.

6.

Target identification using drug affinity responsive target stability (DARTS).

Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21984-9. doi: 10.1073/pnas.0910040106. Epub 2009 Dec 7.

7.

Mapping of HNF4alpha target genes in intestinal epithelial cells.

Boyd M, Bressendorff S, Møller J, Olsen J, Troelsen JT.

BMC Gastroenterol. 2009 Sep 17;9:68. doi: 10.1186/1471-230X-9-68.

8.

Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.

Le Guével R, Oger F, Lecorgne A, Dudasova Z, Chevance S, Bondon A, Barath P, Simonneaux G, Salbert G.

Bioorg Med Chem. 2009 Oct 1;17(19):7021-30. doi: 10.1016/j.bmc.2009.07.079. Epub 2009 Aug 5.

PMID:
19729315
9.

Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM.

PLoS One. 2009;4(5):e5609. doi: 10.1371/journal.pone.0005609. Epub 2009 May 19.

10.

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK.

ChemMedChem. 2009 Jul;4(7):1106-19. doi: 10.1002/cmdc.200800447.

11.

Drosophila HNF4 regulates lipid mobilization and beta-oxidation.

Palanker L, Tennessen JM, Lam G, Thummel CS.

Cell Metab. 2009 Mar;9(3):228-39. doi: 10.1016/j.cmet.2009.01.009.

12.

Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha.

Schwartz B, Algamas-Dimantov A, Hertz R, Nataf J, Kerman A, Peri I, Bar-Tana J.

Int J Cancer. 2009 Mar 1;124(5):1081-9. doi: 10.1002/ijc.24041.

13.

Fat and beyond: the diverse biology of PPARgamma.

Tontonoz P, Spiegelman BM.

Annu Rev Biochem. 2008;77:289-312. doi: 10.1146/annurev.biochem.77.061307.091829. Review.

PMID:
18518822
14.
15.

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.

Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH.

Genes Dev. 2007 Apr 1;21(7):756-69.

16.

The NCI60 human tumour cell line anticancer drug screen.

Shoemaker RH.

Nat Rev Cancer. 2006 Oct;6(10):813-23. Review.

PMID:
16990858
17.

Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.

Gerdin AK, Surve VV, Jönsson M, Bjursell M, Björkman M, Edenro A, Schuelke M, Saad A, Bjurström S, Lundgren EJ, Snaith M, Fransson-Steen R, Törnell J, Berg AL, Bohlooly-Y M.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):825-32. Epub 2006 Aug 24.

PMID:
16945327
18.

Drug penetration in solid tumours.

Minchinton AI, Tannock IF.

Nat Rev Cancer. 2006 Aug;6(8):583-92. Review.

PMID:
16862189
19.

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F.

Nat Med. 2006 Mar;12(3):310-6. Epub 2006 Feb 19.

PMID:
16491084
20.

FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators.

Fujimura T, Sakuma H, Konishi S, Oe T, Hosogai N, Kimura C, Aramori I, Mutoh S.

J Pharmacol Sci. 2005 Dec;99(4):342-52. Epub 2005 Nov 26.

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