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Items: 1 to 20 of 30

1.

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadahl M, Arking DE, Bergmann S, Boerwinkle E, Bonnycastle LL, Bornstein SR, Brunner E, Bumpstead SJ, Brage S, Carlson OD, Chen H, Chen YD, Chines PS, Collins FS, Couper DJ, Dennison EM, Dowling NF, Egan JS, Ekelund U, Erdos MR, Forouhi NG, Fox CS, Goodarzi MO, Grässler J, Gustafsson S, Hallmans G, Hansen T, Hingorani A, Holloway JW, Hu FB, Isomaa B, Jameson KA, Johansson I, Jonsson A, Jørgensen T, Kivimaki M, Kovacs P, Kumari M, Kuusisto J, Laakso M, Lecoeur C, Lévy-Marchal C, Li G, Loos RJ, Lyssenko V, Marmot M, Marques-Vidal P, Morken MA, Müller G, North KE, Pankow JS, Payne F, Prokopenko I, Psaty BM, Renström F, Rice K, Rotter JI, Rybin D, Sandholt CH, Sayer AA, Shrader P, Schwarz PE, Siscovick DS, Stancáková A, Stumvoll M, Teslovich TM, Waeber G, Williams GH, Witte DR, Wood AR, Xie W, Boehnke M, Cooper C, Ferrucci L, Froguel P, Groop L, Kao WH, Vollenweider P, Walker M, Watanabe RM, Pedersen O, Meigs JB, Ingelsson E, Barroso I, Florez JC, Franks PW, Dupuis J, Wareham NJ, Langenberg C.

Diabetes. 2012 May;61(5):1291-6. doi: 10.2337/db11-0973. Epub 2012 Mar 13.

2.

A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained.

So HC, Sham PC.

PLoS Genet. 2010 Dec 2;6(12):e1001230. doi: 10.1371/journal.pgen.1001230.

3.

Common SNPs explain a large proportion of the heritability for human height.

Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM.

Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20.

4.

The genetic interpretation of area under the ROC curve in genomic profiling.

Wray NR, Yang J, Goddard ME, Visscher PM.

PLoS Genet. 2010 Feb 26;6(2):e1000864. doi: 10.1371/journal.pgen.1000864.

5.

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M, Kivimäki M, Humphries SE.

BMJ. 2010 Jan 14;340:b4838. doi: 10.1136/bmj.b4838.

6.

Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases.

Moonesinghe R, Liu T, Khoury MJ.

Eur J Hum Genet. 2010 Apr;18(4):485-9. doi: 10.1038/ejhg.2009.209. Epub 2009 Nov 25.

7.

Finding the missing heritability of complex diseases.

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM.

Nature. 2009 Oct 8;461(7265):747-53. doi: 10.1038/nature08494. Review.

8.

Common genetic variation and human traits.

Goldstein DB.

N Engl J Med. 2009 Apr 23;360(17):1696-8. doi: 10.1056/NEJMp0806284. Epub 2009 Apr 15. No abstract available.

PMID:
19369660
9.

Genetic risk prediction--are we there yet?

Kraft P, Hunter DJ.

N Engl J Med. 2009 Apr 23;360(17):1701-3. doi: 10.1056/NEJMp0810107. Epub 2009 Apr 15. No abstract available.

PMID:
19369656
10.

Accuracy of predicting the genetic risk of disease using a genome-wide approach.

Daetwyler HD, Villanueva B, Woolliams JA.

PLoS One. 2008;3(10):e3395. doi: 10.1371/journal.pone.0003395. Epub 2008 Oct 14.

11.

Genome-based prediction of common diseases: advances and prospects.

Janssens AC, van Duijn CM.

Hum Mol Genet. 2008 Oct 15;17(R2):R166-73. doi: 10.1093/hmg/ddn250. Review.

PMID:
18852206
12.

Prediction of individual genetic risk of complex disease.

Wray NR, Goddard ME, Visscher PM.

Curr Opin Genet Dev. 2008 Jun;18(3):257-63. doi: 10.1016/j.gde.2008.07.006. Epub 2008 Aug 28. Review.

PMID:
18682292
13.

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2 Consortium.

Lancet Neurol. 2008 Jul;7(7):583-90. doi: 10.1016/S1474-4422(08)70117-0. Epub 2008 Jun 6.

14.

Heritability in the genomics era--concepts and misconceptions.

Visscher PM, Hill WG, Wray NR.

Nat Rev Genet. 2008 Apr;9(4):255-66. doi: 10.1038/nrg2322. Epub 2008 Mar 4. Review.

PMID:
18319743
15.

A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions.

Janssens AC, Gwinn M, Bradley LA, Oostra BA, van Duijn CM, Khoury MJ.

Am J Hum Genet. 2008 Mar;82(3):593-9. doi: 10.1016/j.ajhg.2007.12.020.

16.

Heritability of Threshold Characters.

Dempster ER, Lerner IM.

Genetics. 1950 Mar;35(2):212-36. No abstract available.

17.

The Heritability of All-or-None Traits: Viability of Poultry.

Robertson A, Lerner IM.

Genetics. 1949 Jul;34(4):395-411. No abstract available.

18.

Estimating risk of breast cancer in carriers of BRCA1 and BRCA2 mutations: a meta-analytic approach.

Fu R, Harris EL, Helfand M, Nelson HD.

Stat Med. 2007 Apr 15;26(8):1775-87.

PMID:
17243094
19.

Predictive testing for complex diseases using multiple genes: fact or fiction?

Janssens AC, Aulchenko YS, Elefante S, Borsboom GJ, Steyerberg EW, van Duijn CM.

Genet Med. 2006 Jul;8(7):395-400.

PMID:
16845271
20.

Revisiting the clinical validity of multiplex genetic testing in complex diseases.

Janssens AC, Pardo MC, Steyerberg EW, van Duijn CM.

Am J Hum Genet. 2004 Mar;74(3):585-8; author reply 588-9. No abstract available.

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