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Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo.

Liu Q, Qiao C, Marjuki H, Bawa B, Ma J, Guillossou S, Webby RJ, Richt JA, Ma W.

J Virol. 2012 Jan;86(2):1233-7. doi: 10.1128/JVI.05699-11. Epub 2011 Nov 9.


Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82.

Alymova IV, Green AM, van de Velde N, McAuley JL, Boyd KL, Ghoneim HE, McCullers JA.

J Virol. 2011 Dec;85(23):12324-33. doi: 10.1128/JVI.05872-11. Epub 2011 Sep 21.


Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein.

Bogs J, Kalthoff D, Veits J, Pavlova S, Schwemmle M, Mänz B, Mettenleiter TC, Stech J.

J Virol. 2011 Oct;85(20):10691-8. doi: 10.1128/JVI.00786-11. Epub 2011 Aug 17.


High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses.

Sun Y, Qin K, Wang J, Pu J, Tang Q, Hu Y, Bi Y, Zhao X, Yang H, Shu Y, Liu J.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4164-9. doi: 10.1073/pnas.1019109108. Epub 2011 Feb 28.


The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks.

Song J, Feng H, Xu J, Zhao D, Shi J, Li Y, Deng G, Jiang Y, Li X, Zhu P, Guan Y, Bu Z, Kawaoka Y, Chen H.

J Virol. 2011 Mar;85(5):2180-8. doi: 10.1128/JVI.01975-10. Epub 2010 Dec 22.


Genetic diversity of H9N2 influenza viruses from pigs in China: a potential threat to human health?

Yu H, Zhou YJ, Li GX, Ma JH, Yan LP, Wang B, Yang FR, Huang M, Tong GZ.

Vet Microbiol. 2011 Apr 21;149(1-2):254-61. doi: 10.1016/j.vetmic.2010.11.008. Epub 2010 Nov 9.


PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.

Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE.

J Virol. 2011 Jan;85(1):357-65. doi: 10.1128/JVI.01694-10. Epub 2010 Oct 20.


Phylogenetic and molecular characterization of H9N2 influenza isolates from chickens in Northern China from 2007-2009.

Bi J, Deng G, Dong J, Kong F, Li X, Xu Q, Zhang M, Zhao L, Qiao J.

PLoS One. 2010 Sep 29;5(9). pii: e13063. doi: 10.1371/journal.pone.0013063.


Variability of NS1 proteins among H9N2 avian influenza viruses isolated in Israel during 2000-2009.

Panshin A, Golender N, Davidson I, Nagar S, Garsia M, Jackwood MW, Mundt E, Alturi A, Perk S.

Virus Genes. 2010 Dec;41(3):396-405. doi: 10.1007/s11262-010-0522-3. Epub 2010 Aug 19.


PB2 and hemagglutinin mutations are major determinants of host range and virulence in mouse-adapted influenza A virus.

Ping J, Dankar SK, Forbes NE, Keleta L, Zhou Y, Tyler S, Brown EG.

J Virol. 2010 Oct;84(20):10606-18. doi: 10.1128/JVI.01187-10. Epub 2010 Aug 11.


Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008.

Sun Y, Pu J, Jiang Z, Guan T, Xia Y, Xu Q, Liu L, Ma B, Tian F, Brown EG, Liu J.

Vet Microbiol. 2010 Dec 15;146(3-4):215-25. doi: 10.1016/j.vetmic.2010.05.010. Epub 2010 May 7.


Adaptation of pandemic H1N1 influenza viruses in mice.

Ilyushina NA, Khalenkov AM, Seiler JP, Forrest HL, Bovin NV, Marjuki H, Barman S, Webster RG, Webby RJ.

J Virol. 2010 Sep;84(17):8607-16. doi: 10.1128/JVI.00159-10. Epub 2010 Jun 30.


Phylogenetic analysis of influenza A viruses (H6N8, H1N8, H4N2, H9N2, H10N7) isolated from wild birds, ducks, and ostriches in South Africa from 2007 to 2009.

Abolnik C, Gerdes GH, Sinclair M, Ganzevoort BW, Kitching JP, Burger CE, Romito M, Dreyer M, Swanepoel S, Cumming GS, Olivier AJ.

Avian Dis. 2010 Mar;54(1 Suppl):313-22.


Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection.

To KK, Hung IF, Li IW, Lee KL, Koo CK, Yan WW, Liu R, Ho KY, Chu KH, Watt CL, Luk WK, Lai KY, Chow FL, Mok T, Buckley T, Chan JF, Wong SS, Zheng B, Chen H, Lau CC, Tse H, Cheng VC, Chan KH, Yuen KY.

Clin Infect Dis. 2010 Mar 15;50(6):850-9. doi: 10.1086/650581.


Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission.

Herfst S, Chutinimitkul S, Ye J, de Wit E, Munster VJ, Schrauwen EJ, Bestebroer TM, Jonges M, Meijer A, Koopmans M, Rimmelzwaan GF, Osterhaus AD, Perez DR, Fouchier RA.

J Virol. 2010 Apr;84(8):3752-8. doi: 10.1128/JVI.02634-09. Epub 2010 Feb 3.


Acute respiratory distress syndrome induced by H9N2 virus in mice.

Deng G, Bi J, Kong F, Li X, Xu Q, Dong J, Zhang M, Zhao L, Luan Z, Lv N, Qiao J.

Arch Virol. 2010 Feb;155(2):187-95. doi: 10.1007/s00705-009-0560-0. Epub 2009 Nov 28.


The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model.

Song MS, Pascua PN, Lee JH, Baek YH, Lee OJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2009 Dec;83(23):12325-35. doi: 10.1128/JVI.01373-09. Epub 2009 Sep 30.


Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.

Munster VJ, de Wit E, van den Brand JM, Herfst S, Schrauwen EJ, Bestebroer TM, van de Vijver D, Boucher CA, Koopmans M, Rimmelzwaan GF, Kuiken T, Osterhaus AD, Fouchier RA.

Science. 2009 Jul 24;325(5939):481-3. doi: 10.1126/science.1177127. Epub 2009 Jul 2.

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