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Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation.

Möröy T, Khandanpour C.

Semin Immunol. 2011 Oct;23(5):368-78. doi: 10.1016/j.smim.2011.08.006. Review.


A new allele of Lyl1 confirms its important role in hematopoietic stem cell function.

Souroullas GP, Goodell MA.

Genesis. 2011 Jun;49(6):441-8. doi: 10.1002/dvg.20743.


Multilayered specification of the T-cell lineage fate.

Rothenberg EV, Zhang J, Li L.

Immunol Rev. 2010 Nov;238(1):150-68. doi: 10.1111/j.1600-065X.2010.00964.x. Review.


Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B.

Cell Stem Cell. 2010 Oct 8;7(4):532-44. doi: 10.1016/j.stem.2010.07.016.


The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation.

Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA.

Leuk Res. 2011 Mar;35(3):405-12. doi: 10.1016/j.leukres.2010.07.023.


Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

Wilson NK, Timms RT, Kinston SJ, Cheng YH, Oram SH, Landry JR, Mullender J, Ottersbach K, Gottgens B.

Mol Cell Biol. 2010 Aug;30(15):3853-63. doi: 10.1128/MCB.00032-10.


CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus.

Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Förster R.

Blood. 2010 Mar 11;115(10):1906-12. doi: 10.1182/blood-2009-07-235721.


Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.

Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL.

Genes Dev. 2009 Oct 15;23(20):2376-81. doi: 10.1101/gad.1836009. Erratum in: Genes Dev. 2013 Sep 15;27(18):2063.


Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.

Beck K, Peak MM, Ota T, Nemazee D, Murre C.

J Exp Med. 2009 Sep 28;206(10):2271-84. doi: 10.1084/jem.20090756.


Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.

Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA.

Cell Stem Cell. 2009 Feb 6;4(2):180-6. doi: 10.1016/j.stem.2009.01.001.


E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.

Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1930-5. doi: 10.1073/pnas.0808866106.


E2A proteins promote development of lymphoid-primed multipotent progenitors.

Dias S, Månsson R, Gurbuxani S, Sigvardsson M, Kee BL.

Immunity. 2008 Aug 15;29(2):217-27. doi: 10.1016/j.immuni.2008.05.015.


The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.

Louis I, Heinonen KM, Chagraoui J, Vainio S, Sauvageau G, Perreault C.

Immunity. 2008 Jul 18;29(1):57-67. doi: 10.1016/j.immuni.2008.04.023.


Hematopoietic fingerprints: an expression database of stem cells and their progeny.

Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA.

Cell Stem Cell. 2007 Nov;1(5):578-91. doi: 10.1016/j.stem.2007.10.003.


Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling.

Wang SF, Aoki M, Nakashima Y, Shinozuka Y, Tanaka H, Taniwaki M, Hattori M, Minato N.

Blood. 2008 Mar 1;111(5):2878-86. doi: 10.1182/blood-2007-07-103119.


Launching the T-cell-lineage developmental programme.

Rothenberg EV, Moore JE, Yui MA.

Nat Rev Immunol. 2008 Jan;8(1):9-21. Review.


Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.

Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C.

Immunity. 2007 Dec;27(6):871-84.


Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice.

Zhong Y, Jiang L, Hiai H, Toyokuni S, Yamada Y.

Oncogene. 2007 Oct 18;26(48):6937-47.


Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

Månsson R, Hultquist A, Luc S, Yang L, Anderson K, Kharazi S, Al-Hashmi S, Liuba K, Thorén L, Adolfsson J, Buza-Vidas N, Qian H, Soneji S, Enver T, Sigvardsson M, Jacobsen SE.

Immunity. 2007 Apr;26(4):407-19.


Zoned out: functional mapping of stromal signaling microenvironments in the thymus.

Petrie HT, Zúñiga-Pflücker JC.

Annu Rev Immunol. 2007;25:649-79. Review.

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