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Spliceosome structure and function.

Will CL, Lührmann R.

Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a003707. doi: 10.1101/cshperspect.a003707. Review.


Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L, McLean JR, Hazbun TR, Fields S, Vander Kooi C, Ohi MD, Gould KL.

PLoS One. 2011 Feb 28;6(2):e16719. doi: 10.1371/journal.pone.0016719. Erratum in: PLoS One. 2011;6(9). doi: 10.1371/annotation/62e74a1c-c922-495b-9aaf-eebfe6b85ff5.


The splice is right: guarantors of fidelity in pre-mRNA splicing.

Horowitz DS.

RNA. 2011 Apr;17(4):551-4. doi: 10.1261/rna.2577511. Epub 2011 Feb 28.


DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps.

Tseng CK, Liu HL, Cheng SC.

RNA. 2011 Jan;17(1):145-54. doi: 10.1261/rna.2459611. Epub 2010 Nov 22.


Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway.

Yeh TC, Liu HL, Chung CS, Wu NY, Liu YC, Cheng SC.

Mol Cell Biol. 2011 Jan;31(1):43-53. doi: 10.1128/MCB.00801-10. Epub 2010 Oct 18.


RNA helicases at work: binding and rearranging.

Jankowsky E.

Trends Biochem Sci. 2011 Jan;36(1):19-29. doi: 10.1016/j.tibs.2010.07.008. Review.


The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.

Koodathingal P, Novak T, Piccirilli JA, Staley JP.

Mol Cell. 2010 Aug 13;39(3):385-95. doi: 10.1016/j.molcel.2010.07.014.


The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing.

Hogg R, McGrail JC, O'Keefe RT.

Biochem Soc Trans. 2010 Aug;38(4):1110-5. doi: 10.1042/BST0381110. Review.


The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.

Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.

Genes Dev. 2010 Jul 1;24(13):1434-47. doi: 10.1101/gad.1925010.


Spliceosome discards intermediates via the DEAH box ATPase Prp43p.

Mayas RM, Maita H, Semlow DR, Staley JP.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10020-5. doi: 10.1073/pnas.0906022107. Epub 2010 May 12.


The Prp19 WD40 domain contains a conserved protein interaction region essential for its function.

Vander Kooi CW, Ren L, Xu P, Ohi MD, Gould KL, Chazin WJ.

Structure. 2010 May 12;18(5):584-93. doi: 10.1016/j.str.2010.02.015.


Conformational dynamics of single pre-mRNA molecules during in vitro splicing.

Abelson J, Blanco M, Ditzler MA, Fuller F, Aravamudhan P, Wood M, Villa T, Ryan DE, Pleiss JA, Maeder C, Guthrie C, Walter NG.

Nat Struct Mol Biol. 2010 Apr;17(4):504-12. doi: 10.1038/nsmb.1767. Epub 2010 Mar 21.


Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing.

Lardelli RM, Thompson JX, Yates JR 3rd, Stevens SW.

RNA. 2010 Mar;16(3):516-28. doi: 10.1261/rna.2030510. Epub 2010 Jan 20.


Structural studies of the spliceosome: blind men and an elephant.

Newman AJ, Nagai K.

Curr Opin Struct Biol. 2010 Feb;20(1):82-9. doi: 10.1016/ Epub 2010 Jan 19. Review.


The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.

Fabrizio P, Dannenberg J, Dube P, Kastner B, Stark H, Urlaub H, Lührmann R.

Mol Cell. 2009 Nov 25;36(4):593-608. doi: 10.1016/j.molcel.2009.09.040.


Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis.

Bohnsack MT, Martin R, Granneman S, Ruprecht M, Schleiff E, Tollervey D.

Mol Cell. 2009 Nov 25;36(4):583-92. doi: 10.1016/j.molcel.2009.09.039.


Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.

Warkocki Z, Odenwälder P, Schmitzová J, Platzmann F, Stark H, Urlaub H, Ficner R, Fabrizio P, Lührmann R.

Nat Struct Mol Biol. 2009 Dec;16(12):1237-43. doi: 10.1038/nsmb.1729. Epub 2009 Nov 22.


Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

Pena V, Jovin SM, Fabrizio P, Orlowski J, Bujnicki JM, Lührmann R, Wahl MC.

Mol Cell. 2009 Aug 28;35(4):454-66. doi: 10.1016/j.molcel.2009.08.006. Erratum in: Mol Cell. 2011 Feb 4;41(3):366.


Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction.

Chiu YF, Liu YC, Chiang TW, Yeh TC, Tseng CK, Wu NY, Cheng SC.

Mol Cell Biol. 2009 Nov;29(21):5671-8. doi: 10.1128/MCB.00773-09. Epub 2009 Aug 24.


Ntc90 is required for recruiting first step factor Yju2 but not for spliceosome activation.

Chang KJ, Chen HC, Cheng SC.

RNA. 2009 Sep;15(9):1729-39. doi: 10.1261/rna.1625309. Epub 2009 Jul 17.

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