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Items: 1 to 20 of 45

1.

Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease.

Kurowska Z, Englund E, Widner H, Lindvall O, Li JY, Brundin P.

J Parkinsons Dis. 2011;1(1):83-92. doi: 10.3233/JPD-2011-11004.

PMID:
23939259
2.

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM.

J Exp Med. 2012 May 7;209(5):975-86. doi: 10.1084/jem.20112457. Epub 2012 Apr 16.

3.

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.

Decressac M, Mattsson B, Lundblad M, Weikop P, Björklund A.

Neurobiol Dis. 2012 Mar;45(3):939-53. doi: 10.1016/j.nbd.2011.12.013. Epub 2011 Dec 11.

PMID:
22182688
4.

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.

Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM.

Neuron. 2011 Oct 6;72(1):57-71. doi: 10.1016/j.neuron.2011.08.033.

5.

Prion-like acceleration of a synucleinopathy in a transgenic mouse model.

Mougenot AL, Nicot S, Bencsik A, Morignat E, Verchère J, Lakhdar L, Legastelois S, Baron T.

Neurobiol Aging. 2012 Sep;33(9):2225-8. doi: 10.1016/j.neurobiolaging.2011.06.022. Epub 2011 Aug 3.

PMID:
21813214
6.

GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.

Decressac M, Ulusoy A, Mattsson B, Georgievska B, Romero-Ramos M, Kirik D, Björklund A.

Brain. 2011 Aug;134(Pt 8):2302-11. doi: 10.1093/brain/awr149. Epub 2011 Jun 28.

PMID:
21712347
7.

Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat.

Kordower JH, Dodiya HB, Kordower AM, Terpstra B, Paumier K, Madhavan L, Sortwell C, Steece-Collier K, Collier TJ.

Neurobiol Dis. 2011 Sep;43(3):552-7. doi: 10.1016/j.nbd.2011.05.001. Epub 2011 May 12.

8.

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P.

J Clin Invest. 2011 Feb;121(2):715-25. doi: 10.1172/JCI43366. Epub 2011 Jan 18.

9.

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ.

FASEB J. 2011 Jan;25(1):326-36. doi: 10.1096/fj.10-164624. Epub 2010 Sep 27.

10.

Are synucleinopathies prion-like disorders?

Angot E, Steiner JA, Hansen C, Li JY, Brundin P.

Lancet Neurol. 2010 Nov;9(11):1128-38. doi: 10.1016/S1474-4422(10)70213-1. Epub 2010 Sep 16. Review.

PMID:
20846907
11.

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.

Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M.

J Biol Chem. 2010 Nov 5;285(45):34885-98. doi: 10.1074/jbc.M110.148460. Epub 2010 Aug 30.

12.

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.

Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L, Vekrellis K.

J Neurosci. 2010 May 19;30(20):6838-51. doi: 10.1523/JNEUROSCI.5699-09.2010.

13.

Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions.

Jang A, Lee HJ, Suk JE, Jung JW, Kim KP, Lee SJ.

J Neurochem. 2010 Jun;113(5):1263-74. doi: 10.1111/j.1471-4159.2010.06695.x. Epub 2010 Mar 24.

14.

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.

Li JY, Englund E, Widner H, Rehncrona S, Björklund A, Lindvall O, Brundin P.

Mov Disord. 2010 Jun 15;25(8):1091-6. doi: 10.1002/mds.23012.

PMID:
20198645
15.

Lewy body pathology in fetal grafts.

Chu Y, Kordower JH.

Ann N Y Acad Sci. 2010 Jan;1184:55-67. doi: 10.1111/j.1749-6632.2009.05229.x. Review.

PMID:
20146690
16.

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.

Waxman EA, Giasson BI.

J Neurochem. 2010 Apr;113(2):374-88. doi: 10.1111/j.1471-4159.2010.06592.x. Epub 2010 Feb 2.

17.

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.

Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ.

J Biol Chem. 2010 Mar 19;285(12):9262-72. doi: 10.1074/jbc.M109.081125. Epub 2010 Jan 13.

18.

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, Beecham GW, Wang L, Züchner S, Konidari I, Wang G, Singer C, Nahab F, Scott B, Stajich JM, Pericak-Vance M, Haines J, Vance JM, Martin ER.

Ann Hum Genet. 2010 Mar;74(2):97-109. doi: 10.1111/j.1469-1809.2009.00560.x. Epub 2010 Jan 8.

19.

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.

Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6. doi: 10.1073/pnas.0908005106. Epub 2009 Nov 5.

20.

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology.

Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B.

J Neurochem. 2009 Oct;111(1):192-203. doi: 10.1111/j.1471-4159.2009.06324.x. Epub 2009 Aug 4.

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