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Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.

Zook EC, Krishack PA, Zhang S, Zeleznik-Le NJ, Firulli AB, Witte PL, Le PT.

Blood. 2011 Nov 24;118(22):5723-31. doi: 10.1182/blood-2011-03-342097. Epub 2011 Sep 9.


Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency.

Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW, Notarangelo LD.

Front Immunol. 2011 May 10;2(15). pii: 00015.


Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

Hubert FX, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A, Proietto AI, Cannon PZ, Forehan S, Smyth GK, Wu L, Goodnow CC, Carbone FR, Scott HS, Heath WR.

Blood. 2011 Sep 1;118(9):2462-72. doi: 10.1182/blood-2010-06-286393. Epub 2011 Apr 19.


Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance.

Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M.

Trends Immunol. 2011 May;32(5):188-93. doi: 10.1016/ Epub 2011 Apr 12.


Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt Rde W, Nitta T, Takahama Y.

J Exp Med. 2011 Feb 14;208(2):383-94. doi: 10.1084/jem.20102327. Epub 2011 Feb 7.


Aire and T cell development.

Anderson MS, Su MA.

Curr Opin Immunol. 2011 Apr;23(2):198-206. doi: 10.1016/j.coi.2010.11.007. Epub 2010 Dec 14. Review.


Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium.

Guo J, Rahman M, Cheng L, Zhang S, Tvinnereim A, Su DM.

J Mol Med (Berl). 2011 Mar;89(3):263-77. doi: 10.1007/s00109-010-0700-8. Epub 2010 Nov 26.


Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.

Wirnsberger G, Hinterberger M, Klein L.

Immunol Cell Biol. 2011 Jan;89(1):45-53. doi: 10.1038/icb.2010.123. Epub 2010 Nov 2. Review.


Immune aging and rheumatoid arthritis.

Goronzy JJ, Shao L, Weyand CM.

Rheum Dis Clin North Am. 2010 May;36(2):297-310. doi: 10.1016/j.rdc.2010.03.001. Review.


Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.

Danzl NM, Donlin LT, Alexandropoulos K.

J Exp Med. 2010 May 10;207(5):999-1013. doi: 10.1084/jem.20092384. Epub 2010 Apr 19.


Is thymocyte development functional in the aged?

Aw D, Silva AB, Palmer DB.

Aging (Albany NY). 2009 Feb 17;1(2):146-53.


Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution.

Sun L, Guo J, Brown R, Amagai T, Zhao Y, Su DM.

Aging Cell. 2010 Jun;9(3):347-57. doi: 10.1111/j.1474-9726.2010.00559.x. Epub 2010 Mar 12.


Checkpoints in lymphocyte development and autoimmune disease.

von Boehmer H, Melchers F.

Nat Immunol. 2010 Jan;11(1):14-20. doi: 10.1038/ni.1794. Epub 2009 Dec 17. Review.


Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM.

J Biol Chem. 2010 Feb 19;285(8):5836-47. doi: 10.1074/jbc.M109.072124. Epub 2009 Dec 2.


The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.

Koble C, Kyewski B.

J Exp Med. 2009 Jul 6;206(7):1505-13. doi: 10.1084/jem.20082449. Epub 2009 Jun 29.


Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity.

Fletcher AL, Seach N, Reiseger JJ, Lowen TE, Hammett MV, Scott HS, Boyd RL.

J Immunol. 2009 Mar 1;182(5):2690-9. doi: 10.4049/jimmunol.0801752.


Thymic microenvironments for T-cell repertoire formation.

Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y.

Adv Immunol. 2008;99:59-94. doi: 10.1016/S0065-2776(08)00603-2. Review.


Thymus organogenesis.

Rodewald HR.

Annu Rev Immunol. 2008;26:355-88. doi: 10.1146/annurev.immunol.26.021607.090408. Review.


Structure of thymic cysts in congenital lymph nodes-lacking mice.

Nakamura Y, Qu N, Terayama H, Naito M, Yi SQ, Moriyama H, Itoh M.

Anat Histol Embryol. 2008 Apr;37(2):126-30. Epub 2007 Nov 6.


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