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Brown adipose tissue in morbidly obese subjects.

Vijgen GH, Bouvy ND, Teule GJ, Brans B, Schrauwen P, van Marken Lichtenbelt WD.

PLoS One. 2011 Feb 24;6(2):e17247. doi: 10.1371/journal.pone.0017247.


A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.

Boucher J, Macotela Y, Bezy O, Mori MA, Kriauciunas K, Kahn CR.

Sci Signal. 2010 Dec 7;3(151):ra87. doi: 10.1126/scisignal.2001173.


Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans.

Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, Carpentier AC, Richard D.

J Clin Endocrinol Metab. 2011 Jan;96(1):192-9. doi: 10.1210/jc.2010-0989. Epub 2010 Oct 13.


Cellular bioenergetics as a target for obesity therapy.

Tseng YH, Cypess AM, Kahn CR.

Nat Rev Drug Discov. 2010 Jun;9(6):465-82. doi: 10.1038/nrd3138. Review.


Transcriptional control of brown fat development.

Kajimura S, Seale P, Spiegelman BM.

Cell Metab. 2010 Apr 7;11(4):257-62. doi: 10.1016/j.cmet.2010.03.005. Review.


Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.

Boucher J, Tseng YH, Kahn CR.

J Biol Chem. 2010 May 28;285(22):17235-45. doi: 10.1074/jbc.M110.118620. Epub 2010 Apr 1.


Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans.

Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M, Reimold M, Häring HU, Claussen CD, Stefan N.

Diabetes. 2010 Jul;59(7):1789-93. doi: 10.2337/db10-0004. Epub 2010 Mar 31.


Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects.

Shabalina IG, Hoeks J, Kramarova TV, Schrauwen P, Cannon B, Nedergaard J.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):968-80. doi: 10.1016/j.bbabio.2010.02.033. Epub 2010 Mar 19.


The development and endocrine functions of adipose tissue.

Poulos SP, Hausman DB, Hausman GJ.

Mol Cell Endocrinol. 2010 Jul 8;323(1):20-34. doi: 10.1016/j.mce.2009.12.011. Epub 2009 Dec 16. Review.


The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S.

FASEB J. 2009 Sep;23(9):3113-20. doi: 10.1096/fj.09-133546. Epub 2009 May 5.


High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.

Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M.

Diabetes. 2009 Jul;58(7):1526-31. doi: 10.2337/db09-0530. Epub 2009 Apr 28.


Functional brown adipose tissue in healthy adults.

Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P.

N Engl J Med. 2009 Apr 9;360(15):1518-25. doi: 10.1056/NEJMoa0808949. Erratum in: N Engl J Med. 2009 Sep 10;361(11):1123.


Identification and importance of brown adipose tissue in adult humans.

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR.

N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.


Cold-activated brown adipose tissue in healthy men.

van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ.

N Engl J Med. 2009 Apr 9;360(15):1500-8. doi: 10.1056/NEJMoa0808718. Erratum in: N Engl J Med. 2009 Apr 30;360(18):1917.


UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

Feldmann HM, Golozoubova V, Cannon B, Nedergaard J.

Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014.


Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity.

Wijers SL, Saris WH, van Marken Lichtenbelt WD.

Obes Rev. 2009 Mar;10(2):218-26. doi: 10.1111/j.1467-789X.2008.00538.x. Epub 2008 Oct 23. Review.


New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.

Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR.

Nature. 2008 Aug 21;454(7207):1000-4. doi: 10.1038/nature07221.


Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.

Bäck K, Arnqvist HJ.

Growth Horm IGF Res. 2009 Apr;19(2):101-11. doi: 10.1016/j.ghir.2008.06.004. Epub 2008 Aug 9.


Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth.

Klöting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, Blüher M.

Diabetes. 2008 Aug;57(8):2074-82. doi: 10.2337/db07-1538. Epub 2008 Apr 28.

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