Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 26

1.

Protein-binding assays in biological liquids using microscale thermophoresis.

Wienken CJ, Baaske P, Rothbauer U, Braun D, Duhr S.

Nat Commun. 2010 Oct 19;1:100. doi: 10.1038/ncomms1093.

PMID:
20981028
2.

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.

Fang J, Nakamura H, Maeda H.

Adv Drug Deliv Rev. 2011 Mar 18;63(3):136-51. doi: 10.1016/j.addr.2010.04.009. Epub 2010 May 2. Review.

PMID:
20441782
3.

Colloid formation by drugs in simulated intestinal fluid.

Doak AK, Wille H, Prusiner SB, Shoichet BK.

J Med Chem. 2010 May 27;53(10):4259-65. doi: 10.1021/jm100254w.

4.

Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

Thorne N, Auld DS, Inglese J.

Curr Opin Chem Biol. 2010 Jun;14(3):315-24. doi: 10.1016/j.cbpa.2010.03.020. Epub 2010 Apr 22. Review.

5.
6.

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A.

J Med Chem. 2010 Jan 14;53(1):37-51. doi: 10.1021/jm901070c.

7.

Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Coan KE, Maltby DA, Burlingame AL, Shoichet BK.

J Med Chem. 2009 Apr 9;52(7):2067-75. doi: 10.1021/jm801605r.

8.

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.

Coan KE, Shoichet BK.

J Am Chem Soc. 2008 Jul 23;130(29):9606-12. doi: 10.1021/ja802977h. Epub 2008 Jun 28.

9.

Small-molecule aggregates inhibit amyloid polymerization.

Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK.

Nat Chem Biol. 2008 Mar;4(3):197-9. doi: 10.1038/nchembio.65. Epub 2008 Jan 27.

10.

A high-throughput screen for aggregation-based inhibition in a large compound library.

Feng BY, Simeonov A, Jadhav A, Babaoglu K, Inglese J, Shoichet BK, Austin CP.

J Med Chem. 2007 May 17;50(10):2385-90. Epub 2007 Apr 21.

PMID:
17447748
11.

Stability and equilibria of promiscuous aggregates in high protein milieus.

Coan KE, Shoichet BK.

Mol Biosyst. 2007 Mar;3(3):208-13. Epub 2007 Jan 2.

PMID:
17308667
12.
13.

Interpreting steep dose-response curves in early inhibitor discovery.

Shoichet BK.

J Med Chem. 2006 Dec 14;49(25):7274-7.

PMID:
17149857
14.
15.

An efficient rapid system for profiling the cellular activities of molecular libraries.

Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D, Jarnes L, Matzen JT, Garcia ME, Hood TL, Beigi R, Xia G, Harig RA, Asatryan H, Yan SF, Zhou Y, Gu XJ, Saadat A, Zhou V, King FJ, Shaw CM, Su AI, Downs R, Gray NS, Schultz PG, Warmuth M, Caldwell JS.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3153-8. Epub 2006 Feb 21.

16.

Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts.

du Manoir JM, Francia G, Man S, Mossoba M, Medin JA, Viloria-Petit A, Hicklin DJ, Emmenegger U, Kerbel RS.

Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):904-16.

17.

High-throughput assays for promiscuous inhibitors.

Feng BY, Shelat A, Doman TN, Guy RK, Shoichet BK.

Nat Chem Biol. 2005 Aug;1(3):146-8. Epub 2005 Jul 3.

PMID:
16408018
18.

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

Frenkel YV, Clark AD Jr, Das K, Wang YH, Lewi PJ, Janssen PA, Arnold E.

J Med Chem. 2005 Mar 24;48(6):1974-83.

PMID:
15771441
19.

Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Seidler J, McGovern SL, Doman TN, Shoichet BK.

J Med Chem. 2003 Oct 9;46(21):4477-86.

PMID:
14521410
20.

A specific mechanism of nonspecific inhibition.

McGovern SL, Helfand BT, Feng B, Shoichet BK.

J Med Chem. 2003 Sep 25;46(20):4265-72.

PMID:
13678405

Supplemental Content

Support Center