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Aneuploidy drives genomic instability in yeast.

Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, Brito IL, Hiraoka Y, Niwa O, Amon A.

Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412.


Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy.

Ozery-Flato M, Linhart C, Trakhtenbrot L, Izraeli S, Shamir R.

Genome Biol. 2011 Jun 29;12(6):R61. doi: 10.1186/gb-2011-12-6-r61.


Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis.

Barnhart EL, Dorer RK, Murray AW, Schuyler SC.

Mol Biol Cell. 2011 Jul 15;22(14):2448-57. doi: 10.1091/mbc.E09-01-0029. Epub 2011 May 18.


The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.

Stirling PC, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li Z, Kofoed M, Ben-Aroya S, Myung K, Hieter P.

PLoS Genet. 2011 Apr;7(4):e1002057. doi: 10.1371/journal.pgen.1002057. Epub 2011 Apr 28.


Hallmarks of cancer: the next generation.

Hanahan D, Weinberg RA.

Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. Review.


Paradoxical relationship between chromosomal instability and survival outcome in cancer.

Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, Tan IB, Richardson AL, Szallasi Z, Swanton C.

Cancer Res. 2011 May 15;71(10):3447-52. doi: 10.1158/0008-5472.CAN-10-3667. Epub 2011 Jan 26.


Distant metastasis occurs late during the genetic evolution of pancreatic cancer.

Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA.

Nature. 2010 Oct 28;467(7319):1114-7. doi: 10.1038/nature09515.


Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R.

Nature. 2010 Nov 11;468(7321):321-5. doi: 10.1038/nature09529. Epub 2010 Oct 20.


Identification of aneuploidy-tolerating mutations.

Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, Gygi SP, Dunham MJ, Amon A.

Cell. 2010 Oct 1;143(1):71-83. doi: 10.1016/j.cell.2010.08.038. Epub 2010 Sep 16.


Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae.

St Charles J, Hamilton ML, Petes TD.

Genetics. 2010 Oct;186(2):537-50. doi: 10.1534/genetics.110.121533. Epub 2010 Aug 9.


A general lack of compensation for gene dosage in yeast.

Springer M, Weissman JS, Kirschner MW.

Mol Syst Biol. 2010 May 11;6:368. doi: 10.1038/msb.2010.19.


The evolutionary mechanism of cancer.

Heng HH, Stevens JB, Bremer SW, Ye KJ, Liu G, Ye CJ.

J Cell Biochem. 2010 Apr 15;109(6):1072-84. doi: 10.1002/jcb.22497. Review.


Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

Thompson SL, Compton DA.

J Cell Biol. 2010 Feb 8;188(3):369-81. doi: 10.1083/jcb.200905057. Epub 2010 Feb 1.


Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.


A strategy for constructing aneuploid yeast strains by transient nondisjunction of a target chromosome.

Anders KR, Kudrna JR, Keller KE, Kinghorn B, Miller EM, Pauw D, Peck AT, Shellooe CE, Strong IJ.

BMC Genet. 2009 Jul 13;10:36. doi: 10.1186/1471-2156-10-36.


Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective.

Heng HH, Bremer SW, Stevens JB, Ye KJ, Liu G, Ye CJ.

J Cell Physiol. 2009 Sep;220(3):538-47. doi: 10.1002/jcp.21799. Review.


The genome-centric concept: resynthesis of evolutionary theory.

Heng HH.

Bioessays. 2009 May;31(5):512-25. doi: 10.1002/bies.200800182.


The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast.

Gresham D, Desai MM, Tucker CM, Jenq HT, Pai DA, Ward A, DeSevo CG, Botstein D, Dunham MJ.

PLoS Genet. 2008 Dec;4(12):e1000303. doi: 10.1371/journal.pgen.1000303. Epub 2008 Dec 12.


Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.

Bakhoum SF, Thompson SL, Manning AL, Compton DA.

Nat Cell Biol. 2009 Jan;11(1):27-35. doi: 10.1038/ncb1809. Epub 2008 Dec 7.


Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor.

Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, Walton K, Perera A, Staehling-Hampton K, Seidel CW, Li R.

Cell. 2008 Nov 28;135(5):879-93. doi: 10.1016/j.cell.2008.09.039.

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