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Items: 1 to 20 of 42


Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.

Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2012 Jun;40(11):4954-64. doi: 10.1093/nar/gkr1303. Epub 2012 Feb 14.


A novel zinc-finger nuclease platform with a sequence-specific cleavage module.

Schierling B, Dannemann N, Gabsalilow L, Wende W, Cathomen T, Pingoud A.

Nucleic Acids Res. 2012 Mar;40(6):2623-38. doi: 10.1093/nar/gkr1112. Epub 2011 Dec 1.


Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases.

Fonfara I, Curth U, Pingoud A, Wende W.

Nucleic Acids Res. 2012 Jan;40(2):847-60. doi: 10.1093/nar/gkr788. Epub 2011 Sep 29.


TAL effectors: customizable proteins for DNA targeting.

Bogdanove AJ, Voytas DF.

Science. 2011 Sep 30;333(6051):1843-6. doi: 10.1126/science.1204094. Review.


Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.

Kleinstiver BP, Bérubé-Janzen W, Fernandes AD, Edgell DR.

PLoS One. 2011;6(8):e23804. doi: 10.1371/journal.pone.0023804. Epub 2011 Aug 22.


Tapping natural reservoirs of homing endonucleases for targeted gene modification.

Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13077-82. doi: 10.1073/pnas.1107719108. Epub 2011 Jul 22.


Adding fingers to an engineered zinc finger nuclease can reduce activity.

Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ.

Biochemistry. 2011 Jun 7;50(22):5033-41. doi: 10.1021/bi200393g. Epub 2011 May 11.


Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting.

Cermak T, Doyle EL, Christian M, Wang L, Zhang Y, Schmidt C, Baller JA, Somia NV, Bogdanove AJ, Voytas DF.

Nucleic Acids Res. 2011 Jul;39(12):e82. doi: 10.1093/nar/gkr218. Epub 2011 Apr 14. Erratum in: Nucleic Acids Res. 2011 Sep 1;39(17):7879.


The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites.

Halford SE, Catto LE, Pernstich C, Rusling DA, Sanders KL.

Biochem Soc Trans. 2011 Apr;39(2):584-8. doi: 10.1042/BST0390584. Review.


Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification.

Stoddard BL.

Structure. 2011 Jan 12;19(1):7-15. doi: 10.1016/j.str.2010.12.003. Review.


Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis.

Sokolowska M, Czapinska H, Bochtler M.

Nucleic Acids Res. 2011 Mar;39(4):1554-64. doi: 10.1093/nar/gkq821. Epub 2010 Oct 8.


Folding, DNA recognition, and function of GIY-YIG endonucleases: crystal structures of R.Eco29kI.

Mak AN, Lambert AR, Stoddard BL.

Structure. 2010 Oct 13;18(10):1321-31. doi: 10.1016/j.str.2010.07.006. Epub 2010 Aug 26.


Genome editing with engineered zinc finger nucleases.

Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD.

Nat Rev Genet. 2010 Sep;11(9):636-46. doi: 10.1038/nrg2842. Review.


Targeting DNA double-strand breaks with TAL effector nucleases.

Christian M, Cermak T, Doyle EL, Schmidt C, Zhang F, Hummel A, Bogdanove AJ, Voytas DF.

Genetics. 2010 Oct;186(2):757-61. doi: 10.1534/genetics.110.120717. Epub 2010 Jul 26.


A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.

Kleinstiver BP, Fernandes AD, Gloor GB, Edgell DR.

Nucleic Acids Res. 2010 Apr;38(7):2411-27. doi: 10.1093/nar/gkp1223. Epub 2010 Jan 8.


Homing endonucleases: from basics to therapeutic applications.

Marcaida MJ, Muñoz IG, Blanco FJ, Prieto J, Montoya G.

Cell Mol Life Sci. 2010 Mar;67(5):727-48. doi: 10.1007/s00018-009-0188-y. Review.


Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK.

PLoS One. 2009;4(2):e4348. doi: 10.1371/journal.pone.0004348. Epub 2009 Feb 9.


Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.

Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.

Nucleic Acids Res. 2009 Feb;37(3):877-90. doi: 10.1093/nar/gkn1007. Epub 2008 Dec 22.


Zinc-finger nucleases: the next generation emerges.

Cathomen T, Joung JK.

Mol Ther. 2008 Jul;16(7):1200-7. doi: 10.1038/mt.2008.114. Epub 2008 Jun 10. Review.


Role of the interdomain linker in distance determination for remote cleavage by homing endonuclease I-TevI.

Liu Q, Dansereau JT, Puttamadappa SS, Shekhtman A, Derbyshire V, Belfort M.

J Mol Biol. 2008 Jun 20;379(5):1094-106. doi: 10.1016/j.jmb.2008.04.047. Epub 2008 Apr 27.

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