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Items: 1 to 20 of 55

1.

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135.

2.

Beneficial role of Nrf2 in regulating NADPH generation and consumption.

Wu KC, Cui JY, Klaassen CD.

Toxicol Sci. 2011 Oct;123(2):590-600. doi: 10.1093/toxsci/kfr183. Epub 2011 Jul 20.

3.

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.

Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P.

Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010.

4.

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK.

PLoS Genet. 2011 Jun;7(6):e1002119. doi: 10.1371/journal.pgen.1002119. Epub 2011 Jun 9.

5.

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J.

Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484.

6.

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM.

Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498.

7.

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.

Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ.

Cell. 2011 May 13;145(4):607-21. doi: 10.1016/j.cell.2011.03.043.

8.

Interplay between FOXO, TOR, and Akt.

Hay N.

Biochim Biophys Acta. 2011 Nov;1813(11):1965-70. doi: 10.1016/j.bbamcr.2011.03.013. Epub 2011 Apr 1. Review.

9.

Activation of mTORC2 by association with the ribosome.

Zinzalla V, Stracka D, Oppliger W, Hall MN.

Cell. 2011 Mar 4;144(5):757-68. doi: 10.1016/j.cell.2011.02.014.

10.

The cell-non-autonomous nature of electron transport chain-mediated longevity.

Durieux J, Wolff S, Dillin A.

Cell. 2011 Jan 7;144(1):79-91. doi: 10.1016/j.cell.2010.12.016.

11.

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans.

Niu W, Lu ZJ, Zhong M, Sarov M, Murray JI, Brdlik CM, Janette J, Chen C, Alves P, Preston E, Slightham C, Jiang L, Hyman AA, Kim SK, Waterston RH, Gerstein M, Snyder M, Reinke V.

Genome Res. 2011 Feb;21(2):245-54. doi: 10.1101/gr.114587.110. Epub 2010 Dec 22.

12.

mTOR: from growth signal integration to cancer, diabetes and ageing.

Zoncu R, Efeyan A, Sabatini DM.

Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15. Review.

13.

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.

Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E.

EMBO J. 2010 Dec 1;29(23):3939-51. doi: 10.1038/emboj.2010.271. Epub 2010 Nov 2.

14.

Stressin' Sestrins take an aging fight.

Budanov AV, Lee JH, Karin M.

EMBO Mol Med. 2010 Oct;2(10):388-400. doi: 10.1002/emmm.201000097. Review.

15.

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001048. doi: 10.1371/journal.pgen.1001048.

16.

A new DAF-16 isoform regulates longevity.

Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA.

Nature. 2010 Jul 22;466(7305):498-502. doi: 10.1038/nature09184. Epub 2010 Jul 7.

17.

Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.

18.

Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.

Schreiber MA, Pierce-Shimomura JT, Chan S, Parry D, McIntire SL.

PLoS Genet. 2010 May 27;6(5):e1000972. doi: 10.1371/journal.pgen.1000972.

19.

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.

Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L.

Cell Metab. 2010 Jun 9;11(6):453-65. doi: 10.1016/j.cmet.2010.05.001. Review.

20.

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.

Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S.

Nucleic Acids Res. 2010 Sep;38(17):5718-34. doi: 10.1093/nar/gkq212. Epub 2010 May 11.

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